keyword
https://read.qxmd.com/read/38536757/maintenance-of-persistent-transmission-of-a-plant-arbovirus-in-its-insect-vector-mediated-by-the-toll-dorsal-immune-pathway
#21
JOURNAL ARTICLE
Yu-Juan He, Gang Lu, Bo-Jie Xu, Qian-Zhuo Mao, Yu-Hua Qi, Gao-Yang Jiao, Hai-Tao Weng, Yan-Zhen Tian, Hai-Jian Huang, Chuan-Xi Zhang, Jian-Ping Chen, Jun-Min Li
Throughout evolution, arboviruses have developed various strategies to counteract the host's innate immune defenses to maintain persistent transmission. Recent studies have shown that, in addition to bacteria and fungi, the innate Toll-Dorsal immune system also plays an essential role in preventing viral infections in invertebrates. However, whether the classical Toll immune pathway is involved in maintaining the homeostatic process to ensure the persistent and propagative transmission of arboviruses in insect vectors remain unclear...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38536743/inducer-of-cbf-expression-1-promotes-cold-enhanced-immunity-by-directly-activating-salicylic-acid-signaling
#22
JOURNAL ARTICLE
Shaoqin Li, Li He, Yongping Yang, Yixin Zhang, Xiao Han, Yanru Hu, Yanjuan Jiang
Cold stress affects plant immune responses, and this process may involve the salicylic acid (SA) signaling pathway. However, the underlying mechanism by which low temperature signals coordinate with SA signaling to regulate plant immunity remains unclear. Here, we found that low temperatures enhanced the disease resistance of Arabidopsis thaliana against Pseudomonas syringae pv. tomato (Pst) DC3000. This process required INDUCER OF CBF EXPRESSION 1 (ICE1), the core transcription factor in cold-signal cascades...
March 27, 2024: Plant Cell
https://read.qxmd.com/read/38536735/solvent-induced-dual-nucleophiles-and-the-%C3%AE-effect-in-the-s-n-2-versus-e2-competition
#23
JOURNAL ARTICLE
Xiangyu Wu, F Matthias Bickelhaupt, Jing Xie
We have quantum chemically investigated how microsolvation affects the various E2 and SN 2 pathways, their mutual competition, and the α-effect of the model reaction system HOO- (H2 O) n + CH3 CH2 Cl, at the CCSD(T) level. Interestingly, we identify the dual nature of the α-nucleophile HOO- which, upon solvation, is in equilibrium with HO- . This solvent-induced dual appearance gives rise to a rich network of competing reaction channels. Among both nucleophiles, SN 2 is always favored over E2, and this preference increases upon increasing microsolvation...
March 27, 2024: Physical Chemistry Chemical Physics: PCCP
https://read.qxmd.com/read/38536716/scratching-beneath-the-surface-an-evaluation-of-the-management-of-scabies-2017-2023
#24
JOURNAL ARTICLE
Bryony Broster, Amanda Clarke, Collins Iwuji, Suneeta Soni
INTRODUCTION: Possible resistance to recommended treatments for scabies has emerged recently. In response to anecdotal reports of a recent increase in treatment failure with permethrin, the British Association for Sexual Health and HIV (BASHH) released a statement alerting members to this. AIMS: To examine attendances and the treatment pathways for scabies cases seen at local sexual health clinics. METHODOLOGY: A case note review of scabies attendances between January 2017 and December 2023 was conducted...
March 27, 2024: International Journal of STD & AIDS
https://read.qxmd.com/read/38536704/networks-of-hydrogen-bond-networks-in-water-clusters
#25
JOURNAL ARTICLE
Andrey M Tokmachev
Water clusters play a prominent role in atmospheric and solution chemistry. Numerous arrangements of protons, H-bond configurations or networks, shape the cluster properties. Studies of small water clusters by cryogenic scanning tunneling microscopy and high-resolution rovibrational spectroscopy have established proton rearrangement mechanisms forming pathways between H-bond networks. The mechanisms, concerted tunneling in particular, describe the local processes connecting pairs of configurations. Here, proton rearrangement networks mapping these transformations are defined and explored to provide a global view of the H-bond configurations in clusters...
March 27, 2024: Journal of Physical Chemistry. A
https://read.qxmd.com/read/38536665/proteomic-examination-of-polyester-polyurethane-degradation-by-streptomyces-sp-pu10-diverting-polyurethane-intermediates-to-secondary-metabolite-production
#26
JOURNAL ARTICLE
Brana Pantelic, Romanos Siaperas, Clémence Budin, Tjalf de Boer, Evangelos Topakas, Jasmina Nikodinovic-Runic
Global plastic waste accumulation has become omnipresent in public discourse and the focus of scientific research. Ranking as the sixth most produced polymer globally, polyurethanes (PU) significantly contribute to plastic waste and environmental pollution due to the toxicity of their building blocks, such as diisocyanates. In this study, the effects of PU on soil microbial communities over 18 months were monitored revealing that it had marginal effects on microbial diversity. However, Streptomyces sp...
March 2024: Microbial Biotechnology
https://read.qxmd.com/read/38536659/sorcin-promotes-proliferation-of-hepatocellular-carcinoma-by-regulating-vegfa-b-via-pi3k-pathway
#27
JOURNAL ARTICLE
Huan Zhang, Shanshan Hu, Jaceline Gislaine Pires Sanches, Yizi Li, Yuanyi Wei, Chunwen Pu, Jun Zhang
Hepatocellular carcinoma (HCC) is a highly vascularized tumor, one of the most common and lethal cancer-related tumor deaths worldwide, with cell proliferation playing a key role. In this study our western blot results and data from TAGC demonstrate a strong association between Sorcin (SRI) overexpression and poor outcomes in HCC. Moreover, SRI overexpression was remarkably effective in promoting proliferation in vitro and increasing tumor growth in vivo, which were attenuated by knocking down SRI. Mechanistically, SRI regulated vascular endothelial growth factor A (VEGFA) and vascular endothelial growth factor B (VEGFB) through PI3K/Akt/FOXO1 signal pathway...
March 27, 2024: Journal of Physiology and Biochemistry
https://read.qxmd.com/read/38536652/potential-cause-and-effect-relationship-between-gut-microbiota-and-childhood-neuroblastoma-a-mendelian-randomization-analysis
#28
JOURNAL ARTICLE
Jing Chu
OBJECTIVES: To analyze the potential causal-effect of gut microbiota (GM) on neuroblastoma (NB) risk using a Mendelian randomization (MR) study. METHODS: A two-sample MR study was conducted using summary statistics of the GM from the largest available meta-analysis of genome-wide association studies conducted by the MiBioGen consortium. Pooled statistics for childhood NB were obtained from the IEU Consortium release data (1627 cases and 3254 controls). Inverse variance-weighted, weighted median, MR-Egger, and weighted mod were used to examine the causal relationship between GM and childhood NB...
March 27, 2024: Indian Journal of Pediatrics
https://read.qxmd.com/read/38536650/ifit1-modulates-the-proliferation-migration-and-invasion-of-pancreatic-cancer-cells-via-wnt-%C3%AE-catenin-signaling
#29
JOURNAL ARTICLE
Tian-Hao Li, Bang-Bo Zhao, Cheng Qin, Yuan-Yang Wang, Ze-Ru Li, Hong-Tao Cao, Xiao-Ying Yang, Xing-Tong Zhou, Wei-Bin Wang
OBJECTIVES: Previously, Interferon-induced Protein with Tetratricopeptide Repeats 1 (IFIT1) has been shown to promote cancer development. Here, we aimed to explore the role of IFIT1 in the development and progression of pancreatic cancer, including the underlying mechanisms. METHODS: We explored IFIT1 expression in pancreatic cancer samples using The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. Cell Counting Kit-8 (CCK8), colony formation, scratch wound-healing and Transwell assays were performed to assess the proliferation, migration and invasion abilities of pancreatic cancer cells...
March 27, 2024: Cellular Oncology (Dordrecht)
https://read.qxmd.com/read/38536635/the-acetic-acid-produced-by-lactobacillus-species-regulates-immune-function-to-alleviate-pedv-infection-in-piglets
#30
JOURNAL ARTICLE
Ming-Jie Sun, Jun Hong Xing, Qing-Song Yan, Bo-Shi Zou, Ying-Jie Wang, Tian-Ming Niu, Tong Yu, Hai-Bin Huang, Di Zhang, Shu-Min Zhang, Wu-Sheng Sun, Ruo-Nan Zou, Chun-Feng Wang, Chun-Wei Shi
Porcine epidemic diarrhea virus (PEDV) infection results in significant mortality among newborn piglets, leading to substantial economic setbacks in the pig industry. Short-chain fatty acids (SCFA), the metabolites of intestinal probiotics, play pivotal roles in modulating intestinal function, enhancing the intestinal barrier, and bolstering immune responses through diverse mechanisms. The protective potential of Lactobacillus delbrueckii, Lactobacillus johnsonii, and Lactococcus lactis was first noted when administered to PEDV-infected piglets...
March 27, 2024: Probiotics and Antimicrobial Proteins
https://read.qxmd.com/read/38536633/the-significance-of-m6a-rna-methylation-regulators-in-diagnosis-and-subtype-classification-of-hbv-related-hepatocellular-carcinoma
#31
JOURNAL ARTICLE
Qijuan Zang, Yalin Ju, Siyi Liu, Shaobo Wu, Chengbin Zhu, Liangru Liu, Weicheng Xu, Yingli He
In recent years, abnormal m6A alteration in hepatocellular carcinoma (HCC) has been a focus on investigating the biological implications. In this study, our objective is to determine whether m6A modification contributes to the progression of HBV-related HCC. To achieve this, we employed a random forest model to screen top 8 characteristic m6A regulators from 19 candidate genes. Subsequently, we developed a nomogram model that utilizes these 8 characteristic m6A regulators to predict the prevalence of HBV-related HCC...
March 27, 2024: Human Cell
https://read.qxmd.com/read/38536617/whole-transcriptome-mapping-reveals-the-lncrna-regulatory-network-of-tfp5-treatment-in-diabetic-nephropathy
#32
JOURNAL ARTICLE
Hongyan Luo, Lirong Yang, Guoqing Zhang, Xi Bao, Danna Ma, Bo Li, Li Cao, Shilu Cao, Shunyao Liu, Li Bao, Jing E, Yali Zheng
BACKGROUND: TFP5 is a Cdk5 inhibitor peptide, which could restore insulin production. However, the role of TFP5 in diabetic nephropathy (DN) is still unclear. OBJECTIVE: This study aims to characterize the transcriptome profiles of mRNA and lncRNA in TFP5-treated DN mice to mine key lncRNAs associated with TFP5 efficacy. METHODS: We evaluated the role of TFP5 in DN pathology and performed RNA sequencing in C57BL/6J control mice, C57BL/6J db/db model mice, and TFP5 treatment C57BL/6J db/db model mice...
March 27, 2024: Genes & Genomics
https://read.qxmd.com/read/38536579/cell-cycle-related-protein-centromere-protein-f-deficiency-inhibits-cervical-cancer-cell-growth-by-inducing-ferroptosis-via-nrf2-inactivation
#33
JOURNAL ARTICLE
Xin Hui Tang, Tian Nan Zhao, Li Guo, Xin Yue Liu, Wei Na Zhang, Ping Zhang
Cervical cancer (CC) is one of the severe cancers that pose a threat to women's health and result in death. CENPF, the centromere protein F, plays a crucial role in mitosis by regulating numerous cellular processes, such as chromosome segregation during mitosis. According to bioinformatics research, CENPF serves as a master regulator that is upregulated and activated in cervical cancer. Nevertheless, the precise biological mechanism that CENPF operates in CC remains unclear. The aim of this study was to analyze the function of CENPF on cervical cancer and its mechanism...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536578/the-role-of-macrophages-in-lung-fibrosis-and-the-signaling-pathway
#34
REVIEW
Xingmei Wang, Jiaxu Zhou, Xinrui Li, Chang Liu, Lan Liu, Hong Cui
Lung fibrosis is a dysregulated repair process caused by excessive deposition of extracellular matrix that can severely affect respiratory function. Macrophages are a group of immune cells that have multiple functions and can perform a variety of roles. Lung fibrosis develops with the involvement of pro-inflammatory and pro-fibrotic factors secreted by macrophages. The balance between M1 and M2 macrophages has been proposed to play a role in determining the trend and severity of lung fibrosis. New avenues and concepts for preventing and treating lung fibrosis have emerged in recent years through research on mitochondria, Gab proteins, and exosomes...
March 27, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38536567/mir-374a-b-5p-suppresses-cell-growth-in-papillary-thyroid-carcinoma-through-blocking-exosomal-anxa1-induced-macrophage-m2-polarization
#35
JOURNAL ARTICLE
Sanbao Liu
Papillary thyroid carcinoma (PTC), comprising 85% of all thyroid cancers, is an epithelial malignancy. The potential for malignant transformation in normal cells by thyroid cancer cells via exosomal Annexin A1 (ANXA1) delivery is investigated in this study. Our aim is to determine the impact of PTC cells on macrophage polarization through exosomal ANXA1 secretion and its implications for tumor progression. Exosomes in PTC cells were examined using transmission electron microscopy, exosome labeling, and nanoparticle tracking analysis...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38536556/correction-to-melatonin-antagonizes-oxidative-stress-induced-apoptosis-in-retinal-ganglion-cells-through-activating-the-thioredoxin-1-pathway
#36
Shan Gao, Qiaochu Cheng, Yaguang Hu, Xiaojuan Fan, Chen Liang, Chen Niu, Qianyan Kang, Ting Wei
No abstract text is available yet for this article.
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38536555/folate-induces-stemness-and-increases-oxygen-consumption-under-glucose-deprivation-by-notch-1-pathway-activation-in-colorectal-cancer-cell
#37
JOURNAL ARTICLE
Juan Rodríguez Silva, Matías Monsalves-Álvarez, Carlos Sepúlveda, Camila Donoso-Barraza, Rodrigo Troncoso, Sandra Hirsch
Evidence for folate's protective effects on neural tube defects led the USA and Chile to start mandatory folic acid (FA) fortification programs, decreasing up to 50%. However, ∼30% of the population consuming fortified foods reach supraphysiologic serum levels. Although controversial, several epidemiological and clinical observations suggest that folate increases cancer risk, giving concern about the risks of FA supplementation. The Cancer stem cells (CSCs) model has been used to explain survival to anticancer therapies...
March 27, 2024: Molecular and Cellular Biochemistry
https://read.qxmd.com/read/38536552/il-6-enhances-the-activation-of-pi3k-akt-mtor-gsk-3%C3%AE-by-upregulating-grpr-in-hippocampal-neurons-of-autistic-mice
#38
JOURNAL ARTICLE
Heli Li, Xinyuan Wang, Cong Hu, Jinru Cui, Hao Li, Xiaoping Luo, Yan Hao
Autism spectrum disorder (ASD) is a neurological disorder associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in the inflamed brain of ASD. Multiple studies highlight the role of GRPR in regulating ASD like abnormal behavior and enhancing the PI3K signaling. However, the molecular mechanism by which GRPR regulates PI3K signaling in neurons of individuals with ASD is still unclear. In this study, we utilized a maternal immune activation model to investigate the effects of GRPR on PI3K signaling in the inflamed brain of ASD mice...
March 27, 2024: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/38536541/bone-marrow-mesenchymal-stem-cell-derived-exosomes-promote-the-recovery-of-spinal-cord-injury-and-inhibit-ferroptosis-by-inactivating-il-17-pathway
#39
JOURNAL ARTICLE
Wen Tang, Kai Zhao, Xiaobo Li, Xiaozhong Zhou, Peigen Liao
Mesenchymal stem cell (MSC)-derived exosomes are considered as alternative to cell therapy in various diseases. This study aimed to understand the effect of bone marrow MSC-derived exosomes (BMMSC-exos) on spinal cord injury (SCI) and to unveil its regulatory mechanism on ferroptosis. Exosomes were isolated from BMMSCs and the uptake of BMMSCs-exos by PC12 cells was determined using PKH67 staining. The effect of BMMSC-exos on SCI in rats was studied by evaluating pathological changes of spinal cord tissues, inflammatory cytokines, and ferroptosis-related proteins...
March 27, 2024: Journal of Molecular Neuroscience: MN
https://read.qxmd.com/read/38536538/competing-endogenous-rnas-crosstalk-in-hippocampus-a-potential-mechanism-for-neuronal-developing-defects-in-down-syndrome
#40
JOURNAL ARTICLE
Huiru Zhao, Guiyu Lou, Yupu Shao, Tao Wang, Hongdan Wang, Qiannan Guo, Wenke Yang, Hongyan Liu, Shixiu Liao
Down syndrome (DS) is the most example of aneuploidy, resulting from an additional copy of all or part of chromosome 21. Competing endogenous RNAs (ceRNAs) play important roles in neuronal development and neurological defects. This study aimed to identify hub genes and synergistic crosstalk among ceRNAs in the DS fetal hippocampus as potential targets for the treatment of DS-related neurodegenerative diseases. We profiled differentially expressed long non-coding RNAs (DElncRNAs), differentially expressed circular RNAs (DEcircRNAs), differentially expressed microRNAs (DEmiRNAs), and differentially expressed messenger RNAs (DEmRNAs) in hippocampal samples from patients with or without DS...
March 27, 2024: Journal of Molecular Neuroscience: MN
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