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https://www.readbyqxmd.com/read/29909601/assessment-of-the-dual-role-of-clumping-factor-a-in-s-aureus-adhesion-to-endothelium-in-absence-and-presence-of-plasma
#1
Jorien Claes, Bartosz Ditkowski, Laurens Liesenborghs, Tiago Rafael Veloso, Jose M Entenza, Philippe Moreillon, Thomas Vanassche, Peter Verhamme, Marc F Hoylaerts, Ruth Heying
Adhesion of Staphylococcus aureus to endothelial cells (ECs) is paramount in infective endocarditis. Bacterial proteins such as clumping factor A (ClfA) and fibronectin binding protein A (FnbpA) mediate adhesion to EC surface molecules and (sub)endothelial matrix proteins including fibrinogen (Fg), fibrin, fibronectin (Fn) and von Willebrand factor (vWF). We studied the influence of shear flow and plasma on the binding of ClfA and FnbpA (including its sub-domains A, A16+ , ABC, CD) to coverslip-coated vWF, Fg/fibrin, Fn or confluent ECs, making use of Lactococcus lactis , expressing these adhesins heterologously...
June 17, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29909597/recent-advances-and-future-of-gene-therapy-for-bone-regeneration
#2
REVIEW
Galina Shapiro, Raphael Lieber, Dan Gazit, Gadi Pelled
PURPOSE OF REVIEW: The purpose of this review is to discuss the recent advances in gene therapy as a treatment for bone regeneration. While most fractures heal spontaneously, patients who present with fracture nonunion suffer from prolonged pain, disability, and often require additional operations to regain musculoskeletal function. RECENT FINDINGS: In the last few years, BMP gene delivery by means of electroporation and sonoporation resulted in repair of nonunion bone defects in mice, rats, and minipigs...
June 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29909578/ferdinando-calabria-and-orazio-schillaci-eds-radiopharmaceuticals-metabolic-pathways-for-pet-ct-and-pet-mri-imaging-servizi-scientifici-roma-2018-isbn-978-88-99117-03-0
#3
Michelangelo Bombaci, Luigi Mansi
No abstract text is available yet for this article.
June 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29909573/efficient-removal-of-atrazine-from-aqueous-solutions-using-magnetic-saccharomyces-cerevisiae-bionanomaterial
#4
Xin Wu, Huijun He, William L Yang, Jiaping Yu, Chunping Yang
A novel bionanomaterial comprising Saccharomyces cerevisiae (S. cerevisiae) and Fe3 O4 nanoparticles encapsulated in a sodium alginate-polyvinyl alcohol (SA-PVA) matrix was synthesized for the efficient removal of atrazine from aqueous solutions. The effects of the operating parameters, nitrogen source, and glucose and Fe3+ contents on atrazine removal were investigated, and the intermediates were detected by gas chromatography-mass spectrometry (GC-MS). In addition, the synthesized Fe3 O4 particles were characterized by XRD, EDX, HR-TEM, FTIR, and hysteresis loops, and the bionanomaterial was characterized by SEM...
June 17, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29909547/modulation-of-mg-2-influx-and-cytoplasmic-free-mg-2-concentration-in-rat-ventricular-myocytes
#5
Michiko Tashiro, Hana Inoue, Masato Konishi
To examine whether TRPM7, a member of the melastatin family of transient receptor potential channels, is a physiological pathway for Mg2+ entry in mammalian cells, we studied the effect of TRPM7 regulators on cytoplasmic free Mg2+ concentration ([Mg2+ ]i ) of rat ventricular myocytes. Acutely isolated single cells were AM-loaded with the fluorescent indicator furaptra, and [Mg2+ ]i was estimated at 25 °C. After [Mg2+ ]i was lowered by soaking the cells with a high-K+ and Mg2+ -Ca2+ -free solution, [Mg2+ ]i was recovered by extracellular perfusion of Ca2+ -free Tyrode's solution that contained 1 mM Mg2+ ...
June 16, 2018: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/29909543/sensitive-vs-tolerant-nitzschia-palea-k%C3%A3-tzing-w-smith-strains-to-atrazine-a-biochemical-perspective
#6
S M Esteves, S F P Almeida, S Gonçalves, F Rimet, A Bouchez, E Figueira
Organic contaminants, and herbicides in particular, represent a risk for aquatic ecosystems. The primary target of herbicides are producers, the base of food webs, but frequently they end up far from the application point affecting non-target species. Its presence can work as sub-lethal stimulus, which sort the genetic and phenotypic differences within a species. Intraspecific variation allows adaptation to changes in the environment but also to new niches due to variations in species' sensitivity and biochemical response to a certain chemical...
June 16, 2018: Ecotoxicology
https://www.readbyqxmd.com/read/29909540/a-contemporary-view-of-atrioventricular-nodal-physiology
#7
Steven M Markowitz, Bruce B Lerman
In delaying transmission of the cardiac impulse from the atria to the ventricles, the atrioventricular (AV) node serves a critical function in augmenting ventricular filling during diastole and limiting the ventricular response during atrial tachyarrhythmias. The complex structure of the nodal region, however, also provides the substrate for reentrant rhythms. Recent discoveries have elucidated the cellular basis and anatomical determinants of slow conduction in the node. Based on analysis of gap junction proteins, distinct structural components of the AV node have been defined, including the compact node, right and left inferior nodal extensions, the lower nodal bundle, and transitional tissue...
June 16, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29909538/resistant-hypertension-time-to-consider-the-best-fifth-anti-hypertensive-treatment
#8
REVIEW
Andrea Pio-Abreu, Luciano F Drager
PURPOSE OF REVIEW: Resistant hypertension (RH) is a growing clinical condition worldwide associated with target-organ damage and poor prognosis compared to non-resistant counterparts. The purpose of this review is to perform a critical evaluation of preferable drug choices for managing RH highlighting the evidence that significant proportion of patients remained uncontrolled despite using four anti-hypertensive drugs. RECENT FINDINGS: Until recently, the fourth drug therapy was main derived from personal opinion or small interventional studies...
June 16, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29909531/characterization-of-mg-based-bimetal-treatment-of-insensitive-munition-2-4-dinitroanisole
#9
Emese Hadnagy, Andrew Mai, Benjamin Smolinski, Washington Braida, Agamemnon Koutsospyros
The manufacturing of insensitive munition 2,4-dinitroanisole (DNAN) generates waste streams that require treatment. DNAN has been treated previously with zero-valent iron (ZVI) and Fe-based bimetals. Use of Mg-based bimetals offers certain advantages including potential higher reactivity and relative insensitivity to pH conditions. This work reports preliminary findings of DNAN degradation by three Mg-based bimetals: Mg/Cu, Mg/Ni, and Mg/Zn. Treatment of DNAN by all three bimetals is highly effective in aqueous solutions (> 89% removal) and wastewater (> 91% removal) in comparison with treatment solely with zero-valent magnesium (ZVMg; 35% removal)...
June 16, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29909521/genome-wide-identification-expansion-and-evolution-analysis-of-homeobox-genes-and-their-expression-profiles-during-root-development-in-carrot
#10
Feng Que, Guang-Long Wang, Tong Li, Ya-Hui Wang, Zhi-Sheng Xu, Ai-Sheng Xiong
The homeobox gene family, a large family represented by transcription factors, has been implicated in secondary growth, early embryo patterning, and hormone response pathways in plants. However, reports about the information and evolutionary history of the homeobox gene family in carrot are limited. In the present study, a total of 130 homeobox family genes were identified in the carrot genome. Specific codomain and phylogenetic analyses revealed that the genes were classified into 14 subgroups. Whole genome and proximal duplication participated in the homeobox gene family expansion in carrot...
June 16, 2018: Functional & Integrative Genomics
https://www.readbyqxmd.com/read/29909495/the-neuro-immune-regulators-niregs-promote-tissue-resilience-a-vital-component-of-the-host-s-defense-strategy-against-neuroinflammation
#11
REVIEW
Yosra Bedoui, Jim W Neal, Philippe Gasque
An effective protective inflammatory response in the brain is crucial for the clearance of pathogens (e.g. microbes, amyloid fibrils, prionSC ) and should be closely regulated. However, the CNS seems to have limited tissue resilience to withstand the detrimental effects of uncontrolled inflammation compromising functional recovery and tissue repair. Newly described neuro-immune-regulators (NIREGs) are functionally related proteins regulating the severity and duration of the host inflammatory response. NIREGs such as CD200, CD47 and CX3CL1 are vital for increasing tissue resilience and are constitutively expressed by neurons...
June 16, 2018: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/29909489/ets1-regulates-twist1-transcription-in-a-kras-g12d-lkb1-metastatic-lung-tumor-model-of-non-small-cell-lung-cancer
#12
Guetchyn Millien, Yuxia Cao, Carl J O'Hara, Jean-Bosco Tagne, Anne Hinds, Mary C Williams, Maria I Ramirez, Hasmeena Kathuria
Distinct members of the Ets family of transcription factors act as positive or negative regulators of genes involved in cellular proliferation, development, and tumorigenesis. In human lung cancer, increased ETS1 expression is associated with poor prognosis and metastasis. We tested whether ETS1 contributes to lung tumorigenesis by binding to Twist1, a gene involved in tumor cell motility and dissemination. We used a mouse lung cancer model with metastasis driven by conditionally activated Kras and concurrent tumor suppressor Lkb1 loss (Kras G12D / Lkb1-/- model) and a similar model of lung cancer that does not metastasize, driven by conditionally activated Kras alone (Kras G12D model)...
June 16, 2018: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/29909482/risky-sexual-behavior-the-indirect-effects-between-parent-child-relationship-quality-and-quality-of-life-in-emerging-adults
#13
Erica Szkody, Mary Moussa Rogers, Cliff McKinney
PURPOSE: Parent-child relationship quality is an important factor when examining adolescent's risk for problem behaviors. For this reason, many researchers have explored the impacts of parent-child relationship quality on adolescent and child behavior, yet the parent-child relationship has lasting consequences into adulthood. METHODS: The current study examined the mediating role of risky sexual behavior (as measured by the Youth Risk Behavior Survey) on the relationship between parent-child relationship quality (as measured by the Parental Environment Questionnaire) and quality of life (as measured by the World Health Organizations Quality of Life Questionnaire) beyond adolescence, during emerging adulthood...
June 16, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29909475/stress-genes-and-hypertension-contribution-of-the-isiah-rat-strain-study
#14
REVIEW
Olga E Redina, Arcady L Markel
PURPOSE OF REVIEW: Acute psychoemotional stress is one of the causes of a sharp increase in blood pressure. However, the question if the stress may promote the hypertensive disease development is still open. This review aims, firstly, to show that the genetically determined enhanced responsiveness to stress is linked to sustained hypertension development and, secondly, to characterize the main physiological mechanisms and genetic factors implicated in the pathogenesis of stress-sensitive hypertension...
June 16, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29909462/inhibition-of-semaphorin-3a-suppresses-lipopolysaccharide-induced-acute-kidney-injury
#15
Xiaofang Tian, Hua Gan, Yizhou Zeng, Hongfei Zhao, Rong Tang, Yunfeng Xia
Semaphorin-3a (Sema3A), a soluble axon guidance cue, appears to play an important role in the development of acute kidney injury (AKI) and has been regarded as an early diagnostic marker to evaluate the progression of AKI. However, the role of Sema3A in sepsis-associated AKI remains unknown. In this study, lipopolysaccharide (LPS) was used to simulate sepsis-associated AKI and the role of Sema3A in LPS-induced AKI was investigated in vivo and in vitro. In our in vivo study, Sema3A was found in tubular epithelial cells (TECs), which presented a higher level after LPS treatment...
June 16, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29909460/modulation-of-brain-ace-and-ace2-may-be-a-promising-protective-strategy-against-cerebral-ischemia-reperfusion-injury-an-experimental-trial-in-rats
#16
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29909450/zebrin-ii-is-ectopically-expressed-in-microglia-in-the-cerebellum-of-neurogenin-2-null-mice
#17
Maryam Rahimi-Balaei, Xiaodan Jiao, Shahin Shabanipour, Rajiv Dixit, Carol Schuurmans, Hassan Marzban
Zebrin II/aldolase C expression in the normal cerebellum is restricted to a Purkinje cell subset and is the canonical marker for stripes and zones. This spatial restriction has been confirmed in over 30 species of mammals, birds, fish, etc. In a transgenic mouse model in which the Neurogenin 2 gene has been disrupted (Neurog2 -/- ), the cerebellum is smaller than normal and Purkinje cell dendrites are disordered, but the basic zone and stripe architecture is preserved. Here, we show that in the Neurog2 -/- mouse, in addition to the normal Purkinje cell expression, zebrin II is also expressed in a population of cells with a morphology characteristic of microglia...
May 16, 2018: Cerebellum
https://www.readbyqxmd.com/read/29909440/thrombospondin-1-interactions-regulate-eicosanoid-metabolism-and-signaling-in-cancer-related-inflammation
#18
Manuel U Ramirez, Elizabeth R Stirling, Nancy J Emenaker, David D Roberts, David R Soto-Pantoja
The metabolism of arachidonic acid and other polyunsaturated fatty acids produces eicosanoids, a family of biologically active lipids that are implicated in homeostasis and in several pathologies that involve inflammation. Inflammatory processes mediated by eicosanoids promote carcinogenesis by exerting direct effects on cancer cells and by affecting the tumor microenvironment. Therefore, understanding how eicosanoids mediate cancer progression may lead to better approaches and chemopreventive strategies for the treatment of cancer...
June 16, 2018: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29909423/prucalopride-inhibits-proliferation-of-ovarian-cancer-cells-via-phosphatidylinositol-3-kinase-pi3k-signaling-pathway
#19
Xiaolin Liu, Yintao Xu, Lu Zhang, Ting Liu, Hui Zhang
BACKGROUND Ovarian cancer is the second most common malignant tumor of the female reproductive system and is the leading cause of death of gynecological malignancies, but at present there is no effective and safe therapy. There is no previously published report on the anti-cancer effect of prucalopride, which is a high-affinity 5-HT4 receptor. The aim of the present study was to determine whether prucalopride can inhibit proliferation of ovarian cancer cells. MATERIAL AND METHODS The cell viability was detected by use of the Cell Counting Kit-8 (CCK-8) assay...
June 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29909410/what-is-the-role-of-soluble-urokinase-type-plasminogen-activator-in-renal-disease
#20
Moin A Saleem
Soluble urokinase-type plasminogen activator -(suPAR) is an inflammatory signal with pleiotropic biological effects depending on context and post-translational modifications. Recently, [Hayek, et al: Nat Med 2017; 23: 945-953] it has been found that there is a link between suPAR and renal disease in several guises, and a key question is whether it is a driver or a marker of renal disease, and if so of which types of kidney damage. Subject of Review: Circulating suPAR has been postulated to cause acute proteinuric kidney disease, specifically focal segmental glomerulosclerosis (FSGS), though both the animal models and clinical data in the original reports have been challenged...
June 15, 2018: Nephron
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