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https://www.readbyqxmd.com/read/29055276/nonadiabatic-dynamics-simulation-of-photoisomerization-mechanism-of-the-second-stablest-isomer-of-n-salicilydenemethylfurylamine
#1
Aihua Gao, Jianpeng Li, Dehua Wang, Xiaoguang Ma, Meishan Wang
The photoisomerization processes of the second stablest isomer in the aromatic Schiff base, N-salicilydenemethylfurylamine, in the gas phase have been studied by static electronic structure calculations and surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Various stable structures are obtained in the optimization because of different orientations of methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring. Upon photoexcitation into the first excited state, bond isomerization in the salicylaldimine part is completely suppressed until the strong excited-state hydrogen bond is broken...
October 14, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29055260/swimming-exercise-reverses-cums-induced-changes-in-depression-like-behaviors-and-hippocampal-plasticity-related-proteins
#2
Weina Liu, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi
BACKGROUND: Stress-induced failed resilience of brain plasticity can contribute to the onset and recurrence of depression. Chronic stress has been reported to open windows of epigenetic plasticity in hippocampus. However, how hippocampal plasticity underlies depression-like behaviors and how it adapts in response to stress has not been addressed. The present study aimed to investigate the signaling mechanisms of CUMS affecting hippocampal plasticity-related proteins expression and the regulation of swimming exercise in mice...
October 6, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29055190/pinocembrin-attenuates-allergic-airway-inflammation-via-inhibition-of-nf-%C3%AE%C2%BAb-pathway-in-mice
#3
Xiaoyan Gu, Qian Zhang, Qiang Du, Hong Shen, Zhenghua Zhu
Pinocembrin, one of the primary flavonoids in propolis, possesses many biological activities, including anti-inflammation, anti-oxidation and immunoregulation. This study aimed to evaluate whether pinocembrin could attenuate ovalbumin (OVA)-induced allergic airway inflammation in mice and to explore the possible mechanism. BALB/c mice sensitized and challenged with OVA were administered intraperitoneally with pinocembrin. Airway inflammation and airway hyperresponsiveness were examined. T-helper type (Th) 2 cytokines in bronchoalveolar lavage fluid (BALF) and OVA-specific immunoglobulin E (IgE) in serum were determined...
October 18, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29055114/sorafenib-response-in-hepatocellular-carcinoma-micrornas-as-tuning-forks-mirnas-as-regulators-of-sorafenib-response-in-hcc
#4
REVIEW
Shruthi Kanthaje, Ankita Makol, Anuradha Chakraborti
Hepatocellular carcinoma (HCC), the primary liver malignancy attributes towards the second foremost cause of cancer related mortality. The targeted chemotherapeutic agent, sorafenib is known to exhibit a statistically significant but limited overall survival advantage in advanced HCC. However, the individual patient response towards sorafenib varies drastically with most of them demonstrating stable disease (SD), few with partial response (PR) and very rare complete response (CR). Progressive disease (PD) despite the treatment has also been demonstrated in many patients indicating drug resistance...
October 20, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29055107/targeting-class-i-histone-deacetylases-by-the-novel-small-molecule-inhibitor-4sc-202-blocks-oncogenic-hedgehog-gli-signaling-and-overcomes-smoothened-inhibitor-resistance
#5
Wolfgang Gruber, Elisabeth Peer, Dominik P Elmer, Christina Sternberg, Suzana Tesanovic, Pedro Del Burgo, Sonia Coni, Gianluca Canettieri, Daniel Neureiter, René Bartz, Hella Kohlhof, Daniel Vitt, Fritz Aberger
Aberrant activation of Hedgehog (HH)/GLI signaling is causally involved in numerous human malignancies, including basal cell carcinoma (BCC) and medulloblastoma. HH pathway antagonists targeting Smoothened (SMO), an essential effector of canonical HH/GLI signaling, show significant clinical success in BCC patients and have recently been approved for the treatment of advanced and metastatic BCC. However, rapid and frequent development of drug resistance to SMO inhibitors (SMOi) together with severe side effects caused by prolonged SMOi treatment call for alternative treatment strategies targeting HH/GLI signaling downstream of SMO...
October 21, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29055052/pregnancy-prior-to-recurrent-pregnancy-loss-more-often-complicated-by-post-term-birth-and-perinatal-death
#6
Marise M Wagner, Jantien Visser, Harjo Verburg, Chantal W P M Hukkelhoven, Jan M M van Lith, Kitty W M Bloemenkamp
INTRODUCTION: The cause of recurrent pregnancy loss remains often unknown. Possibly, pathophysiological pathways are shared with other pregnancy complications. MATERIAL AND METHODS: All women with secondary recurrent pregnancy loss (SRPL) visiting Leiden University Medical Centre (January 2000-2015) were included in this retrospective cohort to assess whether women with SRPL have a more complicated first pregnancy compared to control women. SRPL was defined as ≥ 3 consecutive pregnancy losses before 22 weeks' gestation, with a previous birth...
October 21, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29055030/identification-of-absorbed-constituents-and-in-vivo-metabolites-in-rats-after-oral-administration-of-physalisalkekengi-var-franchetii-by-ultrahigh-pressure-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry
#7
Xinchi Feng, Xiaoguang Huo, Hongxia Liu, Liwei Chai, Liqin Ding, Feng Qiu
The calyces of Physalisalkekengi var. franchetii (Chinese Lantern, JDL) are well-known traditional Chinese medicine owing to its various therapeutic effects. However, the bioactive constituents responsible for the pharmacological effects of JDL and their metabolites in vivo are still unclear to date. In this paper, an ultrahigh-pressure liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC/Q-TOF-MS/MS) method was established to identify absorbed constituents and in vivo metabolites in rat biological fluids after oral administration of JDL...
October 20, 2017: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29055027/pharmacological-and-gene-regulation-properties-point-to-the-slhak5-k-transporter-as-a-system-for-high-affinity-cs-uptake-in-tomato-plants
#8
Reyes Rodenas, Manuel Nieves-Cordones, Rosa María Rivero, Vicente Martinez, Francisco Rubio
Potassium (K(+) ) and Cesium (Cs(+) ) are chemically similar but while K(+) is an essential nutrient, Cs(+) can be toxic for living organisms, plants included. Two different situations could lead to problems derived from the presence of Cs(+) in agricultural systems: (1) presence of Cs(+) at high concentrations that could produce toxic effects on plants and (2) presence of micromolar concentrations of radiocesium, which can be accumulated in the plant and affect animal and human health through the food chain...
October 21, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29055022/the-addition-of-a-developmental-factor-unc-62-to-already-long-lived-worms-increases-lifespan-and-healthspan
#9
Dror Sagi
Aging is a complex trait that is affected by multiple genetic pathways. A relatively unexplored approach is to manipulate multiple independent aging pathways simultaneously in order to observe their cumulative effect on lifespan. Here, we report the phenotypic characterization of a strain with changes in five aging pathways: 1) mitochondrial ROS production, 2) innate immunity, 3) stress response, 4) metabolic control and 5) developmental regulation in old age. The quintuply-modified strain has a lifespan that is 160% longer than the transgenic control strain...
October 20, 2017: Biology Open
https://www.readbyqxmd.com/read/29055019/-18-f-fluorothymidine-positron-emission-tomography-informs-the-synergistic-efficacy-of-capecitabine-and-trifluridine-tipiracil-in-colon-cancer
#10
Seog-Young Kim, Jin Hwa Jung, Haeng Jung Lee, Hyunsu Soh, Sang Ju Lee, Seung Jun Oh, Sun Young Chae, Jai Hyuen Lee, Seung Jin Lee, Yong Sang Hong, Tae Won Kim, Dae Hyuk Moon
In cancer therapy, enhanced thymidine uptake by the salvage pathway can bypass dTMP depletion, thereby conferring resistance to thymidylate synthase inhibition. We investigated whether sequential combination therapy of capecitabine and trifluridine/tipiracil (TAS-102) could synergistically enhance antitumor efficacy in colon cancer xenograft models. We also examined 3'-deoxy-3'-[(18)F]fluorothymidine ([(18)F]FLT) positron emission tomography (PET) as a means to predict therapeutic response to a sequential combination of capecitabine and trifluridine/tipiracil...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29055016/sgk1-is-a-critical-component-of-an-akt-independent-pathway-essential-for-pi3k-mediated-tumor-development-and-maintenance
#11
Arturo Orlacchio, Michela Ranieri, Martina Brave, Valeria Antico Arciuch, Toni Forde, Daniela De Martino, Karen E Anderson, Phillip Hawkins, Antonio Di Cristofano
Activation of the PI3K-AKT signaling cascade is a common critical event during malignant transformation. In this study, we used thyroid gland epithelial cells and a series of genetically engineered mouse strains as model systems to demonstrate that, while necessary, AKT activation is not sufficient for PI3K-driven transformation. Instead, transformation requires the activity of the PDK1-regulated AGC family of protein kinases. In particular, SGK1 was found to be essential for proliferation and survival of thyroid cancer cells harboring PI3K-activating mutations...
October 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/29055005/induction-of-systemic-autoimmunity-by-a-xenobiotic-requires-endosomal-tlr-trafficking-and-signaling-from-the-late-endosome-and-endolysosome-but-not-type-i-ifn
#12
K Michael Pollard, Gabriela M Escalante, Hua Huang, Katarina M Haraldsson, Per Hultman, Joseph M Christy, Rahul D Pawar, Jessica M Mayeux, Rosana Gonzalez-Quintial, Roberto Baccala, Bruce Beutler, Argyrios N Theofilopoulos, Dwight H Kono
Type I IFN and nucleic acid-sensing TLRs are both strongly implicated in the pathogenesis of lupus, with most patients expressing IFN-induced genes in peripheral blood cells and with TLRs promoting type I IFNs and autoreactive B cells. About a third of systemic lupus erythematosus patients, however, lack the IFN signature, suggesting the possibility of type I IFN-independent mechanisms. In this study, we examined the role of type I IFN and TLR trafficking and signaling in xenobiotic systemic mercury-induced autoimmunity (HgIA)...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29055002/transient-baff-blockade-inhibits-type-1-diabetes-development-in-nonobese-diabetic-mice-by-enriching-immunoregulatory-b-lymphocytes-sensitive-to-deletion-by-anti-cd20-cotherapy
#13
Qiming Wang, Jeremy J Racine, Jeremy J Ratiu, Shu Wang, Rachel Ettinger, Clive Wasserfall, Mark A Atkinson, David V Serreze
In NOD mice and also likely humans, B lymphocytes play an important role as APC-expanding autoreactive T cell responses ultimately causing type 1 diabetes (T1D). Currently, humans at high future T1D risk can only be identified at late prodromal stages of disease indicated by markers such as insulin autoantibodies. When commenced in already insulin autoantibody(+) NOD mice, continuous BAFFR-Fc treatment alone or in combination with anti-CD20 (designated combo therapy) inhibited T1D development. Despite eliciting broader B lymphocyte depletion, continuous combo therapy afforded no greater T1D protection than did BAFFR-Fc alone...
October 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29054984/overcoming-resistance-to-cetuximab-with-honokiol-a-small-molecule-polyphenol
#14
Hannah E Pearson, Mari Iida, Rachel A Orbuch, Nellie K McDaniel, Kwangok P Nickel, Randall J Kimple, Jack Arbiser, Deric L Wheeler
Overexpression and activation of the Epidermal Growth Factor Receptor (EGFR) have been linked to poor prognosis in several human cancers. Cetuximab is a monoclonal antibody against EGFR, that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer. Unfortunately, most tumors have intrinsic or acquire resistance to cetuximab during the course of therapy. Honokiol is a natural compound found in the bark and leaves of the Chinese Magnolia tree and is established to have several anti-cancer properties without appreciable toxicity...
October 20, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29054976/regulation-of-insulin-like-growth-factor-receptors-by-ubiquilin1
#15
Zimple Kurlawala, Rain Dunaway, Parag P Shah, Julie A Gosney, Leah J Siskind, Brian P Ceresa, Levi J Beverly
Insulin-like growth factor-1 receptor (IGF1R) is a receptor tyrosine kinase that mediates growth, proliferation and survival. Dysregulation of IGF pathway contributes to initiation, progression and metastasis of cancer and is also involved in diseases of glucose metabolism, such as Diabetes. We have identified Ubiquilin1 (UBQLN1) as a novel interaction partner of IGF1R, IGF2R and Insulin Receptor. UBQLN family of proteins have been studied primarily in the context of protein quality control and in the field of neurodegenerative disorders...
October 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29054975/nuclear-transport-of-the-neurospora-crassa-nit-2-transcription-factor-is-mediated-by-importin-%C3%AE
#16
Natália E Bernardes, Agnes Alessandra S Takeda, Thiago Revers Dreyer, Fernanda B Cupertino, Stela Virgilio, Nelly Pante, Maria Célia Bertolini, Marcos R M Fontes
The Neurospora crassa NIT-2 transcription factor belongs to the GATA transcription factor family and plays a fundamental role in the regulation of nitrogen metabolism by N. crassa Because NIT-2 acts by accessing DNA inside the nucleus, understanding the nuclear import process of NIT-2 is necessary to characterize its function. Thus, in this study, NIT-2 nuclear transport was investigated using a combination of biochemical, cellular and biophysical methods. A complemented strain that produced a sfGFP-NIT-2 fusion protein was constructed, and nuclear localization assessments were made under conditions that favored protein translocation to the nucleus...
October 20, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/29054970/mir-19a-protects-cardiomyocytes-from-hypoxia-reoxygenation-induced-apoptosis-via-pten-pi3k-p-akt-pathway
#17
Guochao Sun, Ying Lu, Yingxia Li, Jun Mao, Jun Zhang, Yanling Jin, Yan Li, Yan Sun, Lei Liu, Lianhong Li
MicroRNAs have been implicated in processing of cardiac hypoxia/reoxygenation (H/R)-induced injury. Recent studies demonstrated that miR-19a might provide a potential cardioprotective effect on myocardial disease. However, the effect of miR-19a in regulating myocardial ischemic injury has not been previously addressed. This study was to investigate the function of miR-19a on myocardial ischemic injury and identified the potential molecular mechanisms involved. Using the hypoxia/reoxygenation (H/R) model of rat cardiomyocytes H9C2 in vitro, we found that miR-19a was low expression in H9C2 cells after H/R treatment and hypoxia/reoxygenation (H/R) dramatically decreased cardiomyocyte viability, increased LDH release and cardiomyocyte apoptosis, which were attenuated by co-transfection with miR-19a mimic...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054964/gene-expression-profiling-of-the-notch-ahr-il22-axis-at-homeostasis-and-in-response-to-tissue-injury
#18
Marc Weidenbusch, Severin Rodler, Shangqing Song, Simone Romoli, Julian A Marschner, Franziska Kraft, Alexander Holderied, Santosh Kumar, Shrikant R Mulay, Mohsen Honarpisheh, Satish Kumar Devarapu, Maciej Lech, Hans-Joachim Anders
Notch and Interleukin-22 signaling are known to regulate tissue homeostasis and response to injury in humans and mice, and the induction of endogenous arylhydrocarbon receptor ligands through Notch links the two pathways in a hierarchical fashion. However, in adults the species-, organ- and injury-specific gene expression of the Notch-AhR-IL22 axis components is unknown. We therefore performed gene expression profiling of DLL1, DLL3, DLL4, DLK1, DLK2, JAG1, JAG2, Notch1, Notch2, Notch3, Notch4, ADAM17/TACE, PSEN1, BSG/CD147, RBP-J, HES1, HES5, HEY1, HEYL, AHR, ARNT, ARNT2, CYP1A1, CYP24A1, IL22, IL22RA1, IL22RA2, IL10RB, and STAT3 under homeostatic conditions in 10 mature murine and human organs...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054961/cytoplasmic-transport-and-nuclear-import-of-plasmid-dna
#19
Haiqing Bai, Gillian M Schiralli Lester, Laura C Petishnok, David A Dean
Productive transfection and gene transfer requires not simply entry of DNA into cells and subsequent transcription from an appropriate promoter, but also a number of intracellular events that allow the DNA to move from the extracellular surface of the cell into and through the cytoplasm, and ultimately across the nuclear envelope and into the nucleus before any transcription can initiate. Immediately upon entry into the cytoplasm, naked DNA, either delivered through physical techniques or after disassembly of DNA-carrier complexes, associates with a large number of cellular proteins that mediate subsequent interactions with the microtubule network for movement towards the microtubule organizing center and the nuclear envelope...
October 20, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29054930/the-transcription-factor-mef2a-fine-tunes-gene-expression-in-the-atrial-and-ventricular-chambers-of-the-adult-heart
#20
Jose L Medrano, Francisco J Naya
The distinct morphological and functional properties of the cardiac chambers arise from an elaborate developmental program involving cell lineage determination, morphogenesis, and dynamic spatiotemporal gene expression patterns. While a number of transcription factors have been identified for proper gene regulation in the chambers, the complete transcriptional network that controls these patterns remains poorly defined. Previous studies have implicated the MEF2C transcription factor in the regulation of chamber-restricted enhancers...
October 20, 2017: Journal of Biological Chemistry
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