Mahnaz Shariatzadeh, Nicole M A Nagtzaam, Leonie van Vark-van der Zee, Conny van Holten-Neelen, Adrie J M Verhoeven, Jonas Dehairs, Johannes V Swinnen, Frank Leijten, Josianne C Ten Berge, Jose P Martinez Ciriano, King T Wong, Monique Mulder, Pieter J M Leenen, Willem A Dik
PURPOSE: Diabetic retinopathy (DR) is a complication of type 2 diabetes mellitus (T2DM). Lipoprotein(a) (Lp(a)) contributes to the progression of DR, but how is unclear. In homeostasis of the retinal microvasculature, myeloid-derived pro-angiogenic cells (PACs) also play a pivotal role, and fail to function properly in diabetic conditions. Here, we explored the putative contribution of Lp(a) from patients with T2DM with/without DR and healthy controls on inflammation and angiogenesis of retinal endothelial cells (RECs), and on PAC differentiation...
May 1, 2023: Investigative Ophthalmology & Visual Science