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Bharti Chogtu, Sanitha Kuriachan, Rahul Magazine, K Ranjan Shetty, Asha Kamath, Manu Mathew George, Amruta Tripathy, D Mahesh Kumar
OBJECTIVES: Statins by their anti-inflammatory and endothelial stabilizing effect can be beneficial in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH). The present study was done to evaluate the effect of rosuvastatin on pulmonary functions and quality of life (QOL) in patients with concomitant COPD and PH. MATERIALS AND METHODS: It was a prospective, randomized, double-blind, placebo-controlled, study conducted in patients with COPD and PH...
September 2016: Indian Journal of Pharmacology
D C Watchorn, A Sahadevan, J J Egan, S J Lane
There is an unmet need for new therapies in severe persistent asthma. Bronchial thermoplasty is a bronchoscopic procedure which employs radiofrequency energy to reduce airway smooth muscle and has been demonstrated to improve symptomatic control in severe persistent asthma in other populations. Seven patients have completed bronchial thermoplasty at a tertiary referral centre in Ireland. Asthma Control Test scores and data on hospitalisations, exacerbations, maintenance corticosteroid requirements, rescue bronchodilator use and peak expiratory flow rate (PEFR) were compared one year before and one year post treatment...
2016: Irish Medical Journal
O O Olujimi, G R E E Ana, O O Ogunseye, V T Fabunmi
Charcoal production is often accompanied with gaseous and particulate emission into the atmosphere and occupationally exposed workers could be affected. This cross sectional comparative study was carried out to assess the levels of carbon monoxide (CO), carbon dioxide (CO2), sulphur dioxide (SO2), nitrogen dioxide (NO2) and particulate matter (PM2.5) generated during the phases of charcoal production and their relationship with certain biomarkers among charcoal workers (subjects) and non-charcoal workers (controls) such as carboxyhaemoglobin (COHb), forced expiratory volume in the first second of expiration (FEV1), peak expiratory flow rate (PEFR) and body mass index (BMI) in Igbo-Ora, Oyo State and Alabata, Ogun State, which are two of the major hubs of charcoal production in South Western Nigeria...
2016: SpringerPlus
Paul Dienye, Alex Akani, Ita Okokon
BACKGROUD: The aim was to study the prevalence of respiratory symptoms and assess the lung function of fish smokers in Nigeria. METHODS: A case control study was done among fish smokers in Nigeria. Women aged 15 years or older (n=210) involved in fish smoking and equal number of matched controls were interviewed on respiratory symptoms and their peak expiratory flow rate (PEFR) measured. Data was analysed using chi square test, student's t-test and odd ratios. RESULTS: Both groups were similar in their personal characteristics...
June 2016: African Health Sciences
Liuba Soldatova, Candace Hrelec, Laura Matrka
OBJECTIVE: To determine if the results of routine spirometry and flow volume loops (Pulmonary Function Tests (PFTs)) can be used to distinguish Paradoxic Vocal Fold Movement Disorder (PVFMD) from Subglottic Stenosis (SGS). METHODS: PFT records and medical history of 49 patients with diagnosis of PVFMD and 39 patients with SGS were compared. Groups were then subdivided to compare PFTs in patients with and without smoking history or lung disease. RESULTS: Peak expiratory flow rate (PEFR) and Expiratory Disproportion Index (ratio of forced expiratory volume in 1 second (FEV1) over PEFR (FEV1/PEFR)) were both significantly different between patients with SGS and those with PVFMD (p<0...
August 23, 2016: Annals of Otology, Rhinology, and Laryngology
Gopala Krishna Alaparthi, Alfred Joseph Augustine, R Anand, Ajith Mahale
Objective. To evaluate the effects of diaphragmatic breathing exercises and flow and volume-oriented incentive spirometry on pulmonary function and diaphragm excursion in patients undergoing laparoscopic abdominal surgery. Methodology. We selected 260 patients posted for laparoscopic abdominal surgery and they were block randomization as follows: 65 patients performed diaphragmatic breathing exercises, 65 patients performed flow incentive spirometry, 65 patients performed volume incentive spirometry, and 65 patients participated as a control group...
2016: Minimally Invasive Surgery
Gianluca Campo, Rita Pavasini, Carlo Barbetta, Elisa Maietti, Susanna Mascetti, Simone Biscaglia, Fatima Zaraket, Giosafat Spitaleri, Francesco Gallo, Elisabetta Tonet, Alberto Papi, Roberto Ferrari, Marco Contoli
BACKGROUND: Several studies suggested that chronic obstructive pulmonary disease (COPD) is largely underdiagnosed in patients with acute coronary syndrome (ACS) contributing to further affect clinical outcome. Our aim was to validate a screening procedure to identify, in ACS patients, those with negligible risk of undiagnosed COPD. METHODS: From December 2014 to August 2015, 169 ACS patients with smoking history underwent screening procedure. Screening procedure combined peak expiratory flow rate (PEFR, defined as positive if <80% of predicted) and respiratory health status questionnaire (RHSQ, defined as positive if >19...
November 1, 2016: International Journal of Cardiology
Anindita Singha Roy, Amit Bandyopadhyay
Singing performance is based on the efficiency of the respiratory system. The present study was aimed to evaluate the results of pulmonary function tests (PFTs) in female singers of Kolkata, India and to compare the data with their sedentary counterparts from India and abroad. The study was also aimed to propose prediction norms for PFTs in both the groups. Fifty-six female singers and fifty-two female non-singers (control group) with similar socioeconomic backgrounds were randomly sampled from the Rabindrabharati University, Kolkata...
December 2015: Journal of Human Ergology
Süreyya Yılmaz, Yasar Yildirim, Zülfükar Yilmaz, Ali Veysel Kara, Mahsuk Taylan, Melike Demir, Mehmet Coskunsel, Ali Kemal Kadiroglu, Mehmet Emin Yilmaz
BACKGROUND Respiratory system disorders are one of the most prevalent complications in end-stage renal disease patients on hemodialysis. However, the pathogenesis of impaired pulmonary functions has not been completely elucidated in these patients. We designed a study to investigate acute effects of hemodialysis treatment on spirometry parameters, focusing on the relationship between pulmonary function and fluid status in hemodialysis patients. MATERIAL AND METHODS We enrolled 54 hemodialysis patients in this study...
2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Hatem A Sarhan, Omar H El-Garhy, Mohamed A Ali, Nouran A Youssef
OBJECTIVE: Evaluation of the efficacy of nebulized magnesium sulfate (MgSO4) alone and in combination with salbutamol in acute asthma. METHODS: A double-blind randomized controlled study was conducted in Chest and Emergency Departments. Thirty patients of acute attack of bronchial asthma were randomized into three groups: MgSO4 nebulization (group A), salbutamol nebulization (group B), and their combination (group C). All patients were monitored before and after nebulization (each 20 minutes) for peak expiratory flow rate (PEFR), respiratory rate (RR), heart rate (HR), blood pressure, pulsus paradoxus, oxygen saturation, clinical examination, and Fischl index...
2016: Drug Design, Development and Therapy
Alphonsus Rukevwe Isara, Vincent Yakubu Adam, Adesuwa Queen Aigbokhaode, Innocent Osi Alenoghena
INTRODUCTION: Workers in the quarry industries are exposed to hazards resulting from the inhalation of air borne particulates. The study determined the prevalence of respiratory symptoms and assessed ventilatory functions among quarry workers in Edo state, Nigeria. METHODS: Quarry workers (site workers and office workers) were interviewed using structured questionnaire. FEV1, FVC, FEV1/FVC and PEFR were measured using a KoKo Legend spirometer. RESULTS: A total of 113 quarry workers (76 exposure and 37 controls) were studied...
2016: Pan African Medical Journal
Şule Cömert, Esen Kıyan, Gülfer Okumuş, Orhan Arseven, Turhan Ece, Halim İşsever
INTRODUCTION: Conflicting results has been achieved in a small number of clinical studies evaluating the efficiency of magnesium sulphate (MS) in COPD exacerbations. We aimed to investigate the efficiency of nebulised MS in COPD exacerbations. PATIENTS AND METHODS: Twenty patients who met the study criteria were randomized into two groups. All patients were treated with O2, antibiotics and oral corticosteroids. Additionally one group received ipratropium bromide (IB) 500 µg together with MS 151 mg/dose, while the other group received IB together with placebo...
March 2016: Tüberküloz Ve Toraks
Rahul Magazine, Hameed Aboobackar Shahul, Bharti Chogtu, Asha Kamath
BACKGROUND: Leukotriene modifiers have an established role in the management of chronic asthma but their role in acute asthma is still under evaluation. OBJECTIVE: To study and compare the effects of oral montelukast with oral zileuton in acute asthma. MATERIALS AND METHODS: This study included 120 asthmatics and was conducted from September 2012 to March 2014. Patients were randomized into three different groups to receive montelukast or zileuton or placebo in addition to standard treatment for asthma exacerbation...
May 2016: Lung India: Official Organ of Indian Chest Society
Andrzej Emeryk, Rabih Klink, Tammy McIver, Prashant Dalvi
OBJECTIVES: The present study was conducted to assess the efficacy, safety and tolerability of fluticasone propionate/formoterol fumarate combination therapy (FP/FORM; Flutiform®) compared with fluticasone propionate/salmeterol xinafoate (FP/SAL; Seretide® Evohaler®) in children with asthma. METHODS: This was an open-label, randomized, controlled, phase III trial and extension. Patients aged 4-12 years with reversible asthma [% predicted forced expiratory volume in 1 second (FEV1) 60-100%; documented reversibility of ⩾15% in FEV1] were randomized to receive FP/FORM (100/10 µg b...
August 2016: Therapeutic Advances in Respiratory Disease
Johannah L Shergis, Lei Wu, Anthony L Zhang, Xinfeng Guo, Chuanjian Lu, Charlie C Xue
BACKGROUND: Many people with asthma use herbal medicines to help reduce symptoms and improve asthma control. OBJECTIVE: To update the systematic review and meta-analysis of randomised controlled trials of herbal medicine for adult asthma. DATA SOURCES: Nine English and Chinese databases were searched (PubMed, Embase, CINAHL, CENTRAL, AMED, CBM, CNKI, CQVIP, Wanfang). STUDY SELECTIONS: Herbal medicines combined with routine pharmacotherapies compared with the same pharmacotherapies alone or placebo...
August 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Iyamanda B Udaya, Chettangada C Laxmi, Hulegar A Abhishekh, Trichur R Raju, Talakad N Sathyaprabha
BACKGROUND: Pulmonary function is one of the important physiological measures that is known to be affected during the changes in the altitude. There is dearth of literature on changes in the pulmonary function variables in the cold climate conditions of Antarctica. We carried out spirometry before, during and after one year stay at Antarctica in members of the Indian expedition. METHODS: Spirometry was carried out on 23 members of the XXVI Indian Scientific Expedition to Antarctica at baseline, after six months of expedition and at the end of one year, using standard guidelines...
October 2015: Indian Journal of Chest Diseases & Allied Sciences
S Kumar, F Khaliq, S Singh, R Ahmed, R Kumar, P S Deshmukh, B D Banerjee
BACKGROUND: Occupational exposure to excessive level of copper results in many adverse health effects. OBJECTIVE: To measure pulmonary function, oxidative stress, and extent of DNA damage in workers of a copper processing industry. METHODS: 30 men working in a copper processing industry and 30 men matched for age and socioeconomic status (comparison group) were included in this study. Pulmonary function test parameters were measured for all participants...
April 2016: International Journal of Occupational and Environmental Medicine
Daniel J Weiner, Erick Forno, Leanna Sullivan, Gabriel A Weiner, Geoffrey Kurland
RATIONALE: Analysis of maximal expiratory flow-volume curves (MEFVCs) allows for determination of airway obstruction, but quantitative methods to describe these curves are not commonly used. OBJECTIVES: We sought to determine the variability in MEFVC concavity assessment by pulmonary physicians, whether objective indices of concavity can be substituted for subjective expert impression, and whether MEFVC concavity correlates with clinical outcomes. METHODS: A survey of 37 MEFVCs (plus 3 duplicates) was sent to pulmonologists for quantitative assessment of MEFVC concavity...
July 2016: Annals of the American Thoracic Society
Marjorie Slankard, Mary Ann Michelis, Mahesh Mansukhani, Barbara McGoey, Amy Paige, Howard Andrews, David Lederer, Stephen Canfield, Emily DiMango
INTRODUCTION: Long-acting beta agonists (LABAs) are effective for controlling asthma, however questions about their safety have led to concerns over use. Genetic polymorphisms at the 16 amino acid position of the beta-2 adrenergic receptor gene (B2AR) may be associated with increased risk. METHODS: A randomized, double blind study was conducted in patients with moderate to severe asthma being treated with combined inhaled corticosteroids/LABA (ICS/LABA), comparing the effect of LABA continuation versus withdrawal on asthma outcomes among patients stratified by B2AR genotype (Arg/Arg vs...
October 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Jacqui Schewitz, Ronel Roos, Heleen van Aswegen, Samuel Manda
BACKGROUND AND PURPOSE: A head-down tilt position could influence diaphragm excursion due to abdominal content displacement. The purpose of the study was to determine if excursion could be influenced by a head-down tilt position and if this change in excursion alters the diaphragm function. DESIGN: Prospective quasi-experimental study. PARTICIPANTS: Seventy healthy adult students. INTERVENTION: Four head-down tilt positions: 1) 15° (30 seconds); 2) 15° (120 seconds); 3) 30° (30 seconds); and 4) 30° (120 seconds)...
2016: Physiotherapy Theory and Practice
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