keyword
https://read.qxmd.com/read/38488146/covalent-fragment-screening-and-optimization-identifies-the-chloroacetohydrazide-scaffold-as-inhibitors-for-ubiquitin-c-terminal-hydrolase-l1
#21
JOURNAL ARTICLE
Ryan D Imhoff, Rishi Patel, Muhammad Hassan Safdar, Hannah B L Jones, Adan Pinto-Fernandez, Iolanda Vendrell, Hao Chen, Christine S Muli, Aaron D Krabill, Benedikt M Kessler, Michael K Wendt, Chittaranjan Das, Daniel P Flaherty
Dysregulation of the ubiquitin-proteasome systems is a hallmark of various disease states including neurodegenerative diseases and cancer. Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme, is expressed primarily in the central nervous system under normal physiological conditions, however, is considered an oncogene in various cancers, including melanoma, lung, breast, and lymphoma. Thus, UCHL1 inhibitors could serve as a viable treatment strategy against these aggressive cancers. Herein, we describe a covalent fragment screen that identified the chloroacetohydrazide scaffold as a covalent UCHL1 inhibitor...
March 15, 2024: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38484586/recent-development-of-vegfr-small-molecule-inhibitors-as-anticancer-agents-a-patent-review-2021-2023
#22
REVIEW
Jing Zeng, Qichuan Deng, Zheng Chen, Shuang Yan, Qin Dong, Yuyu Zhang, Yuan Cui, Ling Li, Yuxin He, Jianyou Shi
VEGFR, a receptor tyrosine kinase inhibitor (TKI), is an important regulatory factor that promotes angiogenesis and vascular permeability. It plays a significant role in processes such as tumor angiogenesis, tumor cell invasion, and metastasis. VEGFR is mainly composed of three subtypes: VEGFR-1, VEGFR-2, and VEGFR-3. Among them, VEGFR-2 is the crucial signaling receptor for VEGF, which is involved in various pathological and physiological functions. At present, VEGFR-2 is closely related to a variety of cancers, such as non-small cell lung cancer (NSCLC), Hepatocellular carcinoma, Renal cell carcinoma, breast cancer, gastric cancer, glioma, etc...
March 9, 2024: Bioorganic Chemistry
https://read.qxmd.com/read/38484298/deciphering-breast-cancer-metastasis-cascade-a-systems-biology-approach-integrating-transcriptome-and-interactome-insights-for-target-discovery
#23
JOURNAL ARTICLE
Bikashita Kalita, Mohane Selvaraj Coumar
Breast cancer is the lead cause of cancer-related deaths among women globally. Breast cancer metastasis is a complex and still inadequately understood process and a key dimension of mortality attendant to breast cancer. This study reports dysregulated genes across metastatic stages and tissues, shedding light on their molecular interplay in disease pathogenesis and new possibilities for drug discovery. Comprehensive analyses of gene expression data from primary breast tumor, circulating tumor cells, and distant metastatic sites in the brain, lung, liver, and bone were conducted...
March 14, 2024: Omics: a Journal of Integrative Biology
https://read.qxmd.com/read/38476641/the-role-of-ki-67-in-hr-her2-breast-cancer-a-real-world-study-of-956-patients
#24
JOURNAL ARTICLE
Qin Ma, Yao-Bang Liu, Tong She, Xin-Lan Liu
OBJECTIVE: This study determined the cut-off value of Ki-67 expression and discussed the interaction between Ki-67 and histological grade, further explored the prognostic role of Ki-67 in hormone receptor-positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) breast cancer;. MATERIALS AND METHODS: We assessed the Ki-67 expression of 956 patients with HR+/HER2 breast cancer diagnosed in the General Hospital of Ningxia Medical University from 2015 to 2019 by immunohistochemistry (IHC), The disease-free survival (DFS) was defined as the time from postoperative to the first local recurrence, distant metastasis or death of the disease...
2024: Breast Cancer: Targets and Therapy
https://read.qxmd.com/read/38474093/bridging-the-gap-in-understanding-bone-metastasis-a-multifaceted-perspective
#25
REVIEW
Basant Elaasser, Nour Arakil, Khalid S Mohammad
The treatment of patients with advanced cancer poses clinical problems due to the complications that arise as the disease progresses. Bone metastases are a common problem that cancer patients may face, and currently, there are no effective drugs to treat these individuals. Prostate, breast, and lung cancers often spread to the bone, causing significant and disabling health conditions. The bone is a highly active and dynamic tissue and is considered a favorable environment for the growth of cancer. The role of osteoblasts and osteoclasts in the process of bone remodeling and the way in which their interactions change during the progression of metastasis is critical to understanding the pathophysiology of this disease...
February 29, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38474044/the-role-of-transglutaminase-2-in-cancer-an-update
#26
REVIEW
Elisabetta Zaltron, Federica Vianello, Alessia Ruzza, Alberta Palazzo, Valentina Brillo, Ilaria Celotti, Matteo Scavezzon, Federica Rossin, Luigi Leanza, Filippo Severin
Transglutaminase type 2 (TG2) is the most ubiquitously expressed and well characterized member of the transglutaminase family. It is a ubiquitous multifunctional enzyme implicated in the regulation of several cellular pathways that support the survival, death, and general homeostasis of eukaryotic cells. Due to its multiple localizations both inside and outside the cell, TG2 participates in the regulation of many crucial intracellular signaling cascades in a tissue- and cell-specific manner, making this enzyme an important player in disease development and progression...
February 28, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473273/breast-tumor-metastasis-and-its-microenvironment-it-takes-both-seed-and-soil-to-grow-a-tumor-and-target-it-for-treatment
#27
REVIEW
Shirin Bonni, David N Brindley, M Dean Chamberlain, Nima Daneshvar-Baghbadorani, Andrew Freywald, Denise G Hemmings, Sabine Hombach-Klonisch, Thomas Klonisch, Afshin Raouf, Carrie Simone Shemanko, Diana Topolnitska, Kaitlyn Visser, Franco J Vizeacoumar, Edwin Wang, Spencer B Gibson
Metastasis remains a major challenge in treating breast cancer. Breast tumors metastasize to organ-specific locations such as the brain, lungs, and bone, but why some organs are favored over others remains unclear. Breast tumors also show heterogeneity, plasticity, and distinct microenvironments. This contributes to treatment failure and relapse. The interaction of breast cancer cells with their metastatic microenvironment has led to the concept that primary breast cancer cells act as seeds, whereas the metastatic tissue microenvironment (TME) is the soil...
February 23, 2024: Cancers
https://read.qxmd.com/read/38469918/dendritic-polymer-based-nanomedicines-remodel-the-tumor-stroma-improve-drug-penetration-and-enhance-anti-tumor-immune-response
#28
JOURNAL ARTICLE
Yuxin Zhang, Zaixiang Fang, Dayi Pan, Yunkun Li, Jie Zhou, Hongying Chen, Zhiqian Li, Mengli Zhu, Cong Li, Liwen Qin, Xiangyi Ren, Qiyong Gong, Kui Luo
The dense extracellular matrix (ECM) in solid tumors, contributed by cancer-associated fibroblasts (CAFs), hinders penetration of drugs and diminishes their therapeutic outcomes. We proposed a sequential treatment strategy of remodeling the ECM via a CAF modifier (dasatinib, DAS) to promote penetration of an immunogenic cell death (ICD) inducer (epirubicin, Epi) via apoptotic vesicles, ultimately enhancing the treatment efficacy against breast cancer. We developed dendritic poly(oligo(ethylene glycol) methyl ether methacrylate) (POEGMA)-based nanomedicines (P-DAS and P-Epi) for sequential delivery of DAS and Epi, respectively...
March 12, 2024: Advanced Materials
https://read.qxmd.com/read/38468326/cell-morphology-best-predicts-tumorigenicity-and-metastasis-in-vivo-across-multiple-tnbc-cell-lines-of-different-metastatic-potential
#29
JOURNAL ARTICLE
Sydney J Conner, Justinne R Guarin, Thanh T Le, Jackson P Fatherree, Charlotte Kelley, Samantha L Payne, Savannah R Parker, Hanan Bloomer, Crystal Zhang, Kenneth Salhany, Rachel A McGinn, Emily Henrich, Anna Yui, Deepti Srinivasan, Hannah Borges, Madeleine J Oudin
BACKGROUND: Metastasis is the leading cause of death in breast cancer patients. For metastasis to occur, tumor cells must invade locally, intravasate, and colonize distant tissues and organs, all steps that require tumor cell migration. The majority of studies on invasion and metastasis rely on human breast cancer cell lines. While it is known that these cells have different properties and abilities for growth and metastasis, the in vitro morphological, proliferative, migratory, and invasive behavior of these cell lines and their correlation to in vivo behavior is poorly understood...
March 11, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38462033/unlocking-c-met-a-comprehensive-journey-into-targeted-therapies-for-breast-cancer
#30
REVIEW
Parham Jabbarzadeh Kaboli, Hsiao-Fan Chen, Ali Babaeizad, Kiarash Roustai Geraylow, Hirohito Yamaguchi, Mien-Chie Hung
Breast cancer is the most common malignancy among women, posing a formidable health challenge worldwide. In this complex landscape, the c-MET (cellular-mesenchymal epithelial transition factor) receptor tyrosine kinase (RTK), also recognized as the hepatocyte growth factor (HGF) receptor (HGFR), emerges as a prominent protagonist, displaying overexpression in nearly 50% of breast cancer cases. Activation of c-MET by its ligand, HGF, secreted by neighboring mesenchymal cells, contributes to a cascade of tumorigenic processes, including cell proliferation, metastasis, angiogenesis, and immunosuppression...
March 8, 2024: Cancer Letters
https://read.qxmd.com/read/38458555/multifaced-roles-of-the-long-non-coding-rna-draic-in-cancer-progression
#31
REVIEW
Kouhei Sakurai, Hiroyasu Ito
Long non-coding RNAs (lncRNA) are functional RNAs, with over 200 nucleotides in length and lacking protein-coding potential. Studies have indicated that lncRNAs are important gene regulators under physiological conditions. Aberrant lncRNA expression is associated with the initiation and progression of various diseases, including cancers. High-throughput transcriptome analyses have revealed thousands of lncRNAs as putative tumor suppressors or promoters in various cancers, but the detailed molecular mechanisms of each lncRNA remain unclear...
March 6, 2024: Life Sciences
https://read.qxmd.com/read/38458512/printing-of-3d-biomimetic-structures-for-the-study-of-bone-metastasis-a-review
#32
REVIEW
Mehdi Khanmohammadi, Marina Volpi, Ewa Walejewska, Alicja Olszewska, Wojciech Swieszkowski
Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in severe cases, paralysis resulting from spinal cord compression. Unfortunately, our understanding of pathophysiological mechanisms is incomplete and the translation of bone metastasis research into the clinic has been slow, mainly due to the lack of credible ex vivo and in vivo models to study the disease progression. Development of reliable and rational models to study how tumor cells become circulating cells and then invade and sequentially colonize the bone are in great need...
March 6, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38455556/revisiting-luteolin-an-updated-review-on-its-anticancer-potential
#33
REVIEW
Abdur Rauf, Polrat Wilairatana, Payal B Joshi, Zubair Ahmad, Ahmed Olatunde, Nabia Hafeez, Hassan A Hemeg, Mohammad S Mubarak
Numerous natural products found in our diet, such as polyphenols and flavonoids, can prevent the progression of cancer. Luteolin, a natural flavone, present in significant amounts in various fruits and vegetables plays a key role as a chemopreventive agent in treating various types of cancer. By inducing apoptosis, initiating cell cycle arrest, and decreasing angiogenesis, metastasis, and cell proliferation, luteolin is used to treat cancer. Its anticancer properties are attributed to its capability to engage with multiple molecular targeted sites and modify various signaling pathways in tumor cells...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38455134/bridging-the-gap-predicting-brain-metastasis-in-breast-cancer
#34
JOURNAL ARTICLE
Daniela Gonsalves, Raquel Ciérvide, Felipe Couñago
Chen et al explored clinicopathological features and prognostic factors, revealing advanced tumor stage, lung metastases, HER-2 overexpression, and triple-negative status as key contributors. Recent research connects astrocytes' role in brain metastasis with signaling pathways and the impact of Trastuzumab on HER-2 tumor survival. Factors such as positive HER2 status, lack of estrogen receptor expression, and liver metastasis are identified as additional risk factors. The routine use of magnetic resonance imaging, insights into gene mutations associated with metastasis, and the role of radiotherapy, including prophylaxis possibilities, is controversial in clinical practice...
February 24, 2024: World Journal of Clinical Oncology
https://read.qxmd.com/read/38454812/fragmentation-patterns-of-cell-free-dna-and-somatic-mutations-in-the-urine-of-metastatic-breast-cancer-patients
#35
JOURNAL ARTICLE
Shaoyan Lin, Shusen Wang, Binghe Xu
BACKGROUND: Urinary cell-free deoxyribonucleic acid (DNA) (ucfDNA) holds promise as a biomarker; however, its potential remains largely unexplored. We examined the fragmentation pattern of ucfDNA and identified somatic mutations within urine samples from metastatic breast cancer (MBC) patients. METHODS: Urine and blood specimens were collected before treatment from 45 MBC patients and posttreatment urine samples from 16 of the 45 patients at the China National Cancer Center...
March 8, 2024: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38449391/the-deubiquitinase-brcc3-increases-the-stability-of-zeb1-and-promotes-the-proliferation-and-metastasis-of-triple-negative-breast-cancer-cells
#36
JOURNAL ARTICLE
Qidi Huang, Shurong Zheng, Huayan Gu, Zhi Yang, Yiqiao Lu, Xia Yu, Guilong Guo
Triple negative breast cancer (TNBC) has a high recurrence rate, metastasis rate and mortality rate. The aim of this study is to identify new targets for the treatment of TNBC. Clinical samples are used for screening deubiquitinating enzymes (DUBs). MDA-MB-231 cells and a TNBC mouse model are used for in vitro and in vivo experiments, respectively. Western blot analysis is used to detect the protein expressions of DUBs, zinc finger E-box binding homeobox 1 (ZEB1), and epithelial-mesenchymal transition (EMT)-related markers...
March 7, 2024: Acta Biochimica et Biophysica Sinica
https://read.qxmd.com/read/38446366/immunohistochemical-and-molecular-evaluation-of-tusc2-expression-in-breast-cancer
#37
JOURNAL ARTICLE
Leyla Tekin, Tuba Edgünlü, Deniz Genç
OBJECTIVE: Tumor suppressor candidate 2 has shown to be deleted in lung, colon, and bladder cancer types. In the present study, we aimed to investigate the expression of TUSC2 in breast cancer. MATERIALS AND METHODS: A total of thirty patients with breast cancer were included in the study. Normal and tumor tissue samples from fresh mastectomy materials were stored at -80 C until the number of cases was completed for gene expression analysis. Histopathological examination was carried out with routine hematoxylin & eosin method...
March 6, 2024: Molecular Biology Reports
https://read.qxmd.com/read/38445558/novel-ph-responsive-alginate-stabilized-curcumin-selenium-zif-8-nanocomposites-for-synergistic-breast-cancer-therapy
#38
JOURNAL ARTICLE
Emma Frouhar, Arghavan Adibifar, Maryam Salimi, Zahra Karami, Nasim Shadmani, Kobra Rostamizadeh
In this study, a novel selenium@Zeolitic imidazolate framework core/shell nanocomposite stabilized with alginate was used to improve the anti-tumor activity of curcumin. The developed alginate-stabilized curcumin-loaded selenium@Zeolitic imidazolate framework (Alg@Cur@Se@ZIF-8) had a mean diameter of 159.6 nm and polydispersity index < 0.25. The release of curcumin from the nanocarrier at pH 5.4 was 2.69 folds as high as at pH 7.4. The bare nanoparticles showed hemolytic activity of about 12.16% at a concentration of 500 µg/mL while covering their surface with alginate reduced this value to 5...
March 6, 2024: Journal of Drug Targeting
https://read.qxmd.com/read/38442372/pkmyt1-promotes-epithelial-mesenchymal-transition-process-in-triple-negative-breast-cancer-by-activating-notch-signaling
#39
JOURNAL ARTICLE
Bin Li, Lin Huang, Jian Ruan
Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) that lacks receptors for targeted therapy. Deeper insight into the molecular mechanisms regulating TNBC metastasis is urgently needed. The epithelial-mesenchymal transition process facilitates the metastasis of neighboring epithelial tumor cells. Protein kinase, membrane-associated tyrosine/threonine 1 (PKMYT1), a member of the Wee family of protein kinases, is upregulated in BC, and its high expression predicts poor prognosis in BC patients...
2024: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://read.qxmd.com/read/38436249/simultaneous-visualization-and-depletion-of-peroxynitrite-by-a-simple-aggregation-induced-emission-nanoprobe-for-preventing-breast-cancer-metastasis-after-surgery
#40
JOURNAL ARTICLE
Zhongtao Zhang, Yuanyuan Yu, Shaoxia Liu, Jiaming Li, Bin Zhao, Fang Wang, Ze Zhao, Qingbin Ni, Fulei Liu, Jingwei Xue
Inflammation has been confirmed to be closely related to the development of tumors, while peroxynitrite (ONOO- ) is one of the most powerful oxidative pro-inflammatory factors. Although ONOO- can kill bacteria through oxidation, it will activate matrix metalloproteinases (MMPs), accelerate the degradation of the extracellular matrix (ECM), and subsequently lead to the activation and release of other tumor promotion factors existing in the ECM, promoting tumor metastasis and invasion. Herein, we report a simple aggregation-induced emission (AIE) nanoprobe (NP), TPE-4NMB, that can simultaneously visualize and deplete ONOO- ...
March 4, 2024: Analytical Chemistry
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