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https://www.readbyqxmd.com/read/28652373/materials-and-processing-approaches-for-foundry-compatible-transient-electronics
#1
Jan-Kai Chang, Hui Fang, Christopher A Bower, Enming Song, Xinge Yu, John A Rogers
Foundry-based routes to transient silicon electronic devices have the potential to serve as the manufacturing basis for "green" electronic devices, biodegradable implants, hardware secure data storage systems, and unrecoverable remote devices. This article introduces materials and processing approaches that enable state-of-the-art silicon complementary metal-oxide-semiconductor (CMOS) foundries to be leveraged for high-performance, water-soluble forms of electronics. The key elements are (i) collections of biodegradable electronic materials (e...
June 26, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28648619/nuclear-import-of-glucokinase-in-pancreatic-beta-cells-is-mediated-by-a-nuclear-localization-signal-and-modulated-by-sumoylation
#2
Bente Berg Johansson, Karianne Fjeld, Marie Holm Solheim, Jun Shirakawa, Enming Zhang, Magdalena Keindl, Jiang Hu, Andreas Lindqvist, Anne Døskeland, Gunnar Mellgren, Torgeir Flatmark, Pål Rasmus Njølstad, Rohit N Kulkarni, Nils Wierup, Ingvild Aukrust, Lise Bjørkhaug
The localization of glucokinase in pancreatic beta-cell nuclei is a controversial issue. Although previous reports suggest such a localization, the mechanism for its import has so far not been identified. Using immunofluorescence, subcellular fractionation and mass spectrometry, we here present evidence in support of glucokinase localization in beta-cell nuclei of human and mouse pancreatic sections, as well as in human and mouse isolated islets, and murine MIN6 cells. We have identified a conserved, seven-residue nuclear localization signal ((30)LKKVMRR(36)) in the human enzyme...
June 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28639026/regulation-of-engineered-nanomaterials-current-challenges-insights-and-future-directions
#3
Racliffe W S Lai, Katie W Y Yeung, Mana M N Yung, Aleksandra B Djurišić, John P Giesy, Kenneth M Y Leung
Substantial production and wide applications of engineered nanomaterials (ENMs) have raised concerns over their potential influences on the environment and humans. However, regulations of products containing ENMs are scarce, even in countries with the greatest volume of ENMs produced, such as the United States and China. After a comprehensive review of life cycles of ENMs, five major challenges to regulators posed by ENMs are proposed in this review: (a) ENMs exhibit variable physicochemical characteristics, which makes them difficult for regulators to establish regulatory definition; (b) Due to diverse sources and transport pathways for ENMs, it is difficult to monitor or predict their fates in the environment; (c) There is a lack of reliable techniques for quantifying exposures to ENMs; (d) Because of diverse intrinsic properties of ENMs and dynamic environmental conditions, it is difficult to predict bioavailability of ENMs on wildlife and the environment; and (e) There are knowledge gaps in toxicity and toxic mechanisms of ENMs from which to predict their hazards...
June 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28632040/engineered-nanomaterial-induced-lysosomal-membrane-permeabilization-and-anti-cathepsin-agents
#4
Melisa Bunderson-Schelvan, Andrij Holian, Raymond F Hamilton
Engineered nanomaterials (ENMs), or small anthropogenic particles approximately < 100 nm in size and of various shapes and compositions, are increasingly incorporated into commercial products and used for industrial and medical purposes. There is an exposure risk to both the population at large and individuals in the workplace with inhalation exposures to ENMs being a primary concern. Further, there is increasing evidence to suggest that certain ENMs may represent a significant health risk, and many of these ENMs exhibit distinct similarities with other particles and fibers that are known to induce adverse health effects, such as asbestos, silica, and particulate matter (PM)...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28626041/reply-to-yang-et-al-coastal-wetlands-are-not-well-represented-by-protected-areas-for-endangered-birds
#5
Weihua Xu, Yi Xiao, Jingjing Zhang, Wu Yang, Lu Zhang, Vanessa Hull, Zhi Wang, Hua Zheng, Jianguo Liu, Stephen Polasky, Ling Jiang, Yang Xiao, Xuewei Shi, Enming Rao, Fei Lu, Xiaoke Wang, Gretchen C Daily, Zhiyun Ouyang
No abstract text is available yet for this article.
June 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28609256/nano-metal-oxides-exposure-and-engineering-control-assessment
#6
Alberto Garcia, Adrienne Eastlake, Jennifer L Topmiller, Christopher Sparks, Kenneth Martinez, Charles L Geraci
In January 2007, the National Institute for Occupational Safety and Health (NIOSH) conducted a field study to evaluate process specific emissions during the production of ENMs. This study was performed using the nanoparticle emission assessment technique (NEAT). During this study, it was determined that ENMs were released during production and cleaning of the process reactor. Airborne concentrations of silver, nickel, and iron were found both in the employee's personal breathing zone and area samples during reactor cleaning...
June 13, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28597893/observing-the-dynamic-hot-spots-on-two-dimensional-au-nanoparticles-monolayer-film
#7
Chenjie Zhang, Enming You, Qi Jin, Yaxian Yuan, Minmin Xu, Songyuan Ding, Jianlin Yao, Zhongqun Tian
Interparticle spacing was controlled by evaporating water on 2D Au nanoparticles arrays. Relationships among SERS effect, SPR catalysis, and gap distance were experimentally and theoretically studied.
June 9, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28596957/heterogeneous-vascular-bed-responses-to-pulmonary-titanium-dioxide-nanoparticle-exposure
#8
Alaeddin B Abukabda, Phoebe A Stapleton, Carroll R McBride, Jinghai Yi, Timothy R Nurkiewicz
A growing body of research links engineered nanomaterial (ENM) exposure to adverse cardiovascular endpoints. The purpose of this study was to evaluate the impact of ENM exposure on vascular reactivity in discrete segments so that we may determine the most sensitive levels of the vasculature where these negative cardiovascular effects are manifest. We hypothesized that acute nano-TiO2 exposure differentially affects reactivity with a more robust impairment in the microcirculation. Sprague-Dawley rats (8-10 weeks) were exposed to nano-TiO2via intratracheal instillation (20, 100, or 200 µg suspended per 250 µL of vehicle) 24 h prior to vascular assessments...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28555214/the-maximum-penalty-criterion-for-ridge-regression-application-to-the-calibration-of-the-force-constant-in-elastic-network-models
#9
Yves Dehouck, Ugo Bastolla
Tikhonov regularization, or ridge regression, is a popular technique to deal with collinearity in multivariate regression. We unveil a formal analogy between ridge regression and statistical mechanics, where the objective function is comparable to a free energy, and the ridge parameter plays the role of temperature. This analogy suggests two novel criteria for selecting a suitable ridge parameter: specific-heat (Cv) and maximum penalty (MP). We apply these fits to evaluate the relative contributions of rigid-body and internal fluctuations, which are typically highly collinear, to crystallographic B-factors...
May 30, 2017: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://www.readbyqxmd.com/read/28552424/physicochemical-and-colloidal-aspects-of-food-matrix-effects-on-gastrointestinal-fate-of-ingested-inorganic-nanoparticles
#10
REVIEW
David Julian McClements, Hang Xiao, Philip Demokritou
Inorganic nanoparticles, such as titanium dioxide, silicon dioxide, iron oxide, zinc oxide, or silver nanoparticles, are added to some food products and food packaging materials to obtain specific functional attributes, such as lightening, powder flow, nutrition, or antimicrobial properties. These engineered nanomaterials (ENMs) all have dimensions below 100nm, but may still vary considerably in composition, morphology, charge, surface properties and aggregation state, which effects their gastrointestinal fate and potential toxicity...
May 9, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28546894/needs-and-challenges-for-assessing-the-environmental-impacts-of-engineered-nanomaterials-enms
#11
REVIEW
Michelle Romero-Franco, Hilary A Godwin, Muhammad Bilal, Yoram Cohen
The potential environmental impact of nanomaterials is a critical concern and the ability to assess these potential impacts is top priority for the progress of sustainable nanotechnology. Risk assessment tools are needed to enable decision makers to rapidly assess the potential risks that may be imposed by engineered nanomaterials (ENMs), particularly when confronted by the reality of limited hazard or exposure data. In this review, we examine a range of available risk assessment frameworks considering the contexts in which different stakeholders may need to assess the potential environmental impacts of ENMs...
2017: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/28536203/reply-to-bridgewater-and-babin-need-for-a-new-protected-area-category-for-ecosystem-services
#12
Weihua Xu, Yi Xiao, Jingjing Zhang, Wu Yang, Lu Zhang, Vanessa Hull, Zhi Wang, Hua Zheng, Jianguo Liu, Stephen Polasky, Ling Jiang, Yang Xiao, Xuewei Shi, Enming Rao, Fei Lu, Xiaoke Wang, Gretchen C Daily, Zhiyun Ouyang
No abstract text is available yet for this article.
May 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28533976/phylogenetic-climatic-niche-conservatism-and-evolution-of-climatic-suitability-in-neotropical-angraecinae-vandeae-orchidaceae-and-their-closest-african-relatives
#13
Marta Kolanowska, Elżbieta Grochocka, Kamil Konowalik
In the present study we investigate the concept of phylogenetic niche conservatism (PNC) within the American species of angraecoid orchids (Campylocentrum and Dendrophylax) and their closest relatives in the Old World (Angraecum) using ecological niche modelling (ENM). The predicted niche occupancy profiles were matched with the outcomes of previous phylogenetic studies to reconstruct the evolution of climatic suitability within the orchid group studied and evaluate the role of niche differentiation in the speciation of Angraecinae...
2017: PeerJ
https://www.readbyqxmd.com/read/28529146/multiple-endpoints-to-evaluate-pristine-and-remediated-titanium-dioxide-nanoparticles-genotoxicity-in-lung-epithelial-a549-cells
#14
Andrea Stoccoro, Sebastiano Di Bucchianico, Fabio Coppedè, Jessica Ponti, Chiara Uboldi, Magda Blosi, Camilla Delpivo, Simona Ortelli, Anna Luisa Costa, Lucia Migliore
Titanium dioxide nanoparticles (TiO2 NP) are broadly used in a wide range of applications. Several studies have reported that TiO2 NP possess cytotoxic and genotoxic properties that could induce adverse health effects in humans. The FP7 Sanowork project was aimed to minimize occupational hazard and exposure to engineered nanomaterials (ENM), including TiO2 NP, through the surface modification in order to avoid possible adverse toxic effects for humans. In this study we investigated cytotoxicity, genotoxicity and epigenetic properties of TiO2 NP uncoated and coated with silica or citrate, as well as of the benchmark material P25...
July 5, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28524743/nanoparticle-exposures-from-nano-enabled-toner-based-printing-equipment-and-human-health-state-of-science-and-future-research-needs
#15
Sandra Vanessa Pirela, John Martin, Dhimiter Bello, Philip Demokritou
Toner formulations used by laser printers (LP) and photocopiers (PC), collectively called "toner-based printing equipment" (TPE), are nano-enabled products (NEP) because they contain several engineered nanomaterials (ENM) that improve toner performance. It has been shown that during consumer use (printing), these ENM are released in the air, together with other semi-volatile organic nanoparticles, and newly formed gaseous co-pollutants such as volatile organic compounds (VOC). The aim of this review is to detail and analyze physico-chemical and morphological (PCM), as well as the toxicological properties of particulate matter (PM) emissions from TPE...
May 19, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28524186/taurine-modified-ru-ii-complex-targets-cancerous-brain-cells-for-photodynamic-therapy
#16
Enming Du, Xunwu Hu, Sona Roy, Peng Wang, Kieran Deasy, Toshiaki Mochizuki, Ye Zhang
The precision and efficacy of photodynamic therapy (PDT) is essential for the treatment of brain tumors because the cancer cells are within or adjacent to the delicate nervous system. Taurine is an abundant amino acid in the brain that serves the central nervous system (CNS). A taurine-modified polypyridyl Ru-complex was shown to have optimized intracellular affinity in cancer cells through accumulation in lysosomes. Symmetrical modification of this Ru-complex by multiple taurine molecules enhanced the efficiency of molecular emission with boosted generation of reactive oxygen species...
May 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28524032/-preoperative-risk-factors-analysis-of-pulmonary-hypertension-crisis-during-perioperative-period-for-caesarean-section-of-woman-with-severe-pulmonary-hypertension
#17
Chunlei Zhang, Yaguang Liu, Enming Qing, Jun Ma
OBJECTIVE: To analyze preoperative risk factors of perioperative pulmonary hypertension crisis (PHC) for pregnant woman with severe pulmonary artery hypertension (PAH), and approach its clinical value. METHODS: A retrospective analysis was conducted. The clinical data from 152 pregnant women with severe PAH underwent cesarean delivery admitted to Beijing Anzhen Hospital from January 1st 2008 to December 31st 2016 was collected. The patients were divided into two groups according to with perioperative PHC or not...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28515660/environmental-factors-associated-with-the-distribution-of-visceral-leishmaniasis-in-endemic-areas-of-bangladesh-modeling-the-ecological-niche
#18
Abu Yousuf Md Abdullah, Ashraf Dewan, Md Rakibul Islam Shogib, Md Masudur Rahman, Md Faruk Hossain
BACKGROUND: Visceral leishmaniasis (VL) is a parasitic infection (also called kala-azar in South Asia) caused by Leishmania donovani that is a considerable threat to public health in the Indian subcontinent, including densely populated Bangladesh. The disease seriously affects the poorest subset of the population in the subcontinent. Despite the fact that the incidence of VL results in significant morbidity and mortality, its environmental determinants are relatively poorly understood, especially in Bangladesh...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/28515184/trends-and-population-attributable-risk-estimates-for-predictors-of-early-neonatal-mortality-in-nigeria-2003-2013-a-cross-sectional-analysis
#19
Osita Kingsley Ezeh
OBJECTIVES: To assess trends in early neonatal mortality (ENM) and population-attributable risk (PAR) estimates for predictors of ENM in Nigeria. DESIGN, SETTING AND PARTICIPANTS: A cross-sectional data on 63 844 singleton live births within the preceding 5 years from the 2003, 2008 and 2013 Nigeria Demographic and Health Surveys were used. Adjusted PARs were used to estimate the number of early neonatal deaths attributable to each predictor in the final multivariable Cox regression model...
May 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28490217/antimicrobial-proteins-in-the-response-to-graphene-oxide-in-caenorhabditis-elegans
#20
Mingxia Ren, Li Zhao, Xiao Lv, Dayong Wang
Upon exposure to environmental engineered nanomaterials (ENMs), animals will activate certain response signals to protect themselves from the toxic effects. However, the underlying molecular mechanisms for this response are still largely unclear. Using in vivo assay system of Caenorhabditis elegans, we here found that antimicrobial proteins of LYS-1, LYS-8, SPP-1, DOD-6, and F55G11.4 were activated by graphene oxide (GO) exposure. These antimicrobial proteins functioned as molecular targets of transcriptional factor DAF-16 in insulin signaling pathway, and acted in intestine to regulate the response to GO...
May 19, 2017: Nanotoxicology
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