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https://www.readbyqxmd.com/read/28223539/thymol-mitigates-lipopolysaccharide-induced-endometritis-by-regulating-the-tlr4-and-ros-mediated-nf-%C3%AE%C2%BAb-signaling-pathways
#1
Haichong Wu, Kangfeng Jiang, Nannan Yin, Xiaofei Ma, Gan Zhao, Changwei Qiu, Ganzhen Deng
The purpose of this study was to investigate the effects of thymol on lipopolysaccharide (LPS)-induced inflammatory responses and to clarify the potential mechanism of these effects. LPS-induced mouse endometritis was used to confirm the anti-inflammatory action of thymol in vivo. RAW264.7 cells were used to examine the molecular mechanism and targets of thymol in vitro. In vivo, thymol markedly alleviated LPS-induced pathological injury, myeloperoxidase (MPO) activity, and the production of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in mice...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28217668/endometrial-polyp-surveillance-in-premenopausal-breast-cancer-patients-using-tamoxifen
#2
Se Jeong Jeon, Jae Il Lee, Maria Lee, Hee Seung Kim, Jae Weon Kim, Noh Hyun Park, Yong Sang Song
OBJECTIVE: To describe the endometrial pathologic lesions in premenopausal breast cancer patients with a history of tamoxifen (TMX) use. METHODS: We retrospectively reviewed the medical records of 120 premenopausal breast cancer patients with a history of TMX use that had undergone a gynecological examination. RESULTS: Among 120 patients, 44.2% (n=53) were asymptomatic with an endometrial thickness ≥5 mm, as assessed by transvaginal ultrasonography...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28216459/hysteroscopic-markers-in-chronic-endometritis
#3
Alka Kumar, Atul Kumar
No abstract text is available yet for this article.
February 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28215895/short-communication-repeat-breeder-cows-with-fluid-in-the-uterine-lumen-had-poorer-fertility
#4
M Jaureguiberry, M J Giuliodori, A V Mang, L V Madoz, H Pothmann, M Drillich, R L de la Sota
The objective of the present study was to test the association between the presence of fluid in uterine lumen and the fertility of repeat breeder cows (RBC). Grazing Holstein cows that were clinically normal and were not pregnant after at least 3 consecutive inseminations were defined as RBC and included in the study (n = 358). A cut-point ≥2 mm of uterine lumen visible by ultrasonography was used as indicative of the presence of fluid in the uterus. The effect of this fluid on the fertility of RBC was assessed by mixed logistic regression...
February 16, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28188901/trueperella-pyogenes-isolated-from-dairy-cows-with-endometritis-in-inner-mongolia-china-tetracycline-susceptibility-and-tetracycline-resistance-gene-distribution
#5
Dexian Zhang, Jingcui Zhao, Qiuxia Wang, Yaochuan Liu, Chunlian Tian, Yujun Zhao, Lihui Yu, Mingchun Liu
Trueperella pyogenes plays a crucial role in endometritis pathogenesis and is also associated with many infections, including metritis, mastitis, arthritis and liver abscessation, in many domestic animals. In this study, we investigated the prevalence of tetracycline resistance in T. pyogenes isolated from dairy cows with endometritis in Inner Mongolia, China, and we assessed tetracycline-resistance gene distribution among the isolates. Our results indicated that 68.7% and 62.5% of the isolates were resistant to tetracycline and doxycycline, respectively, and the rate of resistance to metacycline was 18...
February 8, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28178058/risk-factors-for-postcesarean-maternal-infection-in-a-trial-of-extended-spectrum-antibiotic-prophylaxis
#6
Kim A Boggess, Alan Tita, Victoria Jauk, George Saade, Sherri Longo, Erin A S Clark, Sean Esplin, Kristin Cleary, Ronald Wapner, Kelli Letson, Michelle Owens, Sean Blackwell, Carmen Beamon, Jeffrey M Szychowski, William Andrews
OBJECTIVE: To identify maternal clinical risk factors for postcesarean maternal infection in a randomized clinical trial of preincision extended-spectrum antibiotic prophylaxis. METHODS: We conducted a planned secondary analysis of a randomized clinical trial. Patients were 24 weeks of gestation or greater and delivered by cesarean after a minimum of 4 hours of ruptured membranes or labor. All participants received standard preincision prophylaxis and were randomized to receive azithromycin or placebo...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28166989/dose-dependent-inhibition-of-uterine-contractility-by-nitric-oxide-a-potential-mechanism-underlying-persistent-breeding-induced-endometritis-in-the-mare
#7
Firdous A Khan, Tracey S Chenier, Coral L Murrant, Robert A Foster, Joanne Hewson, Elizabeth L Scholtz
Nitric oxide (NO) may have a role in persistent breeding-induced endometritis in mares through an inhibitory effect on uterine contractility. The objectives of this study were to test the effect of NO on spontaneous uterine contractility in-vitro and to evaluate whether this effect varied between the longitudinal and circular muscle layers of the uterus. Reproductive tracts were collected from eight euthanized non-pregnant mares (age 4-19 years; body weight 405-530 kg). Transrectal examination of the reproductive tract was performed before euthanasia to evaluate stage of the estrous cycle and presence of any apparent abnormality...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28166974/endometrial-mrna-expression-of-selected-pro-inflammatory-factors-and-mucins-in-repeat-breeder-cows-with-and-without-subclinical-endometritis
#8
K Wagener, H Pothmann, I Prunner, S Peter, R Erber, C Aurich, M Drillich, C Gabler
Repeat breeder cows (RBC) are defined as cyclic cows without clinical abnormalities that fail to conceive after at least three subsequent inseminations. Previous studies have elucidated cellular defence mechanisms in the bovine uterus but detailed information on inflammatory events of endometrial cells in RBC is still lacking. Thus, the objective of this study was to analyse endometrial mRNA expression of selected transcripts associated with uterine inflammatory processes. Cytobrush samples from 91 RBC and 11 synchronised heifers with no history of gynaecological abnormalities (controls, CON) were collected...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28161186/a-dairy-herd-level-study-of-postpartum-diseases-and-their-association-with-reproductive-performance-and-culling
#9
J Dubuc, J Denis-Robichaud
The objectives of this study were to quantify the herd-level prevalence of postpartum diseases in a large number of dairy farms, and to identify prevalence alarm levels of these diseases based on association with a low prevalence of success at first service, with a high prevalence of pregnancy loss following pregnancy diagnosis at first service, and with a high prevalence of postpartum culling. A total of 126 commercial dairy herds were enrolled in this cohort study, and the herd was the unit of interest. Twenty cows from every herd were enrolled during the study period (a total of 2,520 lactating cows in the study)...
February 1, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28153660/attempted-operative-vaginal-delivery-vs-repeat-cesarean-in-the-second-stage-among-women-undergoing-a-trial-of-labor-after-cesarean-delivery
#10
Moeun Son, Archana Roy, William A Grobman
BACKGROUND: It is not well-characterized whether attempting operative vaginal delivery is a safe and effective alternative among women who undergo a trial of labor after cesarean delivery who are unable to complete second-stage labor with a spontaneous vaginal delivery. OBJECTIVE: The purpose of this study was to compare maternal and neonatal outcomes that are associated with attempted operative vaginal delivery with those that are associated with second-stage repeat cesarean delivery without an operative vaginal delivery attempt among women who undergo a trial of labor after cesarean delivery...
January 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28144921/comparative-transcriptome-analysis-of-trueperella-pyogenes-reveals-a-novel-antimicrobial-strategy
#11
Kelei Zhao, Wujiao Li, Ting Huang, Xuhao Song, Xiuyue Zhang, Bisong Yue
Trueperella pyogenes is a prevalent opportunistic bacterium that normally causes diverse suppurative lesions, endometritis and pneumonia in various economically important animals. Although the genomic information of this species has been announced, little is known about its functional profiles. In this study, by performing a comparative transcriptome analysis between the highly and moderately virulent T. pyogenes isolates, we found the expression of a LuxR-type DNA-binding response regulator, PloR, was significantly up-regulated in the highly virulent T...
January 31, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28119161/expression-of-toll-like-receptors-2-4-and-6-in-equine-endometrial-epithelial-cells-a-comparative-in-situ-and-in-vitro-study
#12
Sandra Schöniger, Denny Böttcher, Tobias Theuß, Heinz-Adolf Schoon
Endometrial epithelial cells form a luminal barrier and are exposed to pathogens and non-infectious antigens. Toll-like receptors (TLRs) mediate pathogen defenses and tissue homeostasis, but are also involved in the pathogenesis of inflammatory and fibrosing alterations. Endometrial diseases are important causes of subfertility in mares. The pathogenesis of some types of persistent inflammation and periglandular fibrosis (endometrosis) is unknown. The aim of this study was to compare by in situ and in vitro immunohistochemistry the expression of TLRs 2, 4 and 6 in equine endometrial epithelial cells...
January 12, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28105630/histopathological-features-of-endometritis-eosinophilica-in-mares
#13
Anna Lena Grimm, Heinz-Adolf Schoon, Sandra Schöniger
Equine endometritis eosinophilica (EE) is rarely described and its diagnostic criteria are not defined. The aim of this study was to characterize histological features of EE. A data base (1995-2013) was searched for biopsies with increased eosinophils. This study included all biopsies with this diagnosis and representative biopsies without this record. The definition of equine EE was based on criteria for EE in women and the results of the determination of physiological numbers of eosinophils within the equine endometrium...
January 20, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/28100003/neonatal-morbidity-after-spontaneous-labor-onset-prior-to-intended-cesarean-delivery-at-term-a-cohort-study
#14
Julie Glavind, Ioanna Milidou, Niels Uldbjerg, Rikke Maimburg, Tine Brink Henriksen
INTRODUCTION: We aimed to investigate if labor onset before planned cesarean delivery (CD) affects the risk of neonatal admission, respiratory distress, or neonatal infectious morbidity. MATERIAL AND METHODS: Our cohort included singleton term pregnant women with intended CD who delivered at Aarhus University Hospital from 1990 to 2012. Two groups of women were identified: Women with intended CD performed prior to labor (non-labor CD) and women with intended CD performed after spontaneous labor onset (labor onset CD); in both groups there was no other maternal or fetal medical indication for an immediate CD or for early term CD scheduling...
January 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28090456/chronic-endometritis-and-infertility
#15
REVIEW
Hyun Jong Park, You Shin Kim, Tae Ki Yoon, Woo Sik Lee
Chronic endometritis (CE) is a condition involving the breakdown of the peaceful co-existence between microorganisms and the host immune system in the endometrium. A majority of CE cases produce no noticeable signs or mild symptoms, and the prevalence rate of CE has been found to be approximately 10%. Gynecologists and pathologists often do not focus much clinical attention on CE due to the time-consuming microscopic examinations necessary to diagnose CE, its mild clinical manifestations, and the benign nature of the disease...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28070584/changes-in-protein-expression-profiles-in-bovine-endometrial-epithelial-cells-exposed-to-e-coli-lps-challenge
#16
Cristian Piras, Yongzhi Guo, Alessio Soggiu, Metasu Chanrot, Viviana Greco, Andrea Urbani, Gilles Charpigny, Luigi Bonizzi, Paola Roncada, Patrice Humblot
E. coli is one of the most frequently involved bacteria in uterine diseases. Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria involved in pathogenic processes leading to post-partum metritis and endometritis in cattle. It also causes inflammation of the endometrium. The increase of cell proliferation by LPS is part of the inflammatory process. The aim of this study was to investigate possible changes in protein expression in relation to the proliferative response of bEECs after challenge with E...
January 10, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28050900/planned-early-birth-versus-expectant-management-waiting-for-prelabour-rupture-of-membranes-at-term-37-weeks-or-more
#17
REVIEW
Philippa Middleton, Emily Shepherd, Vicki Flenady, Rosemary D McBain, Caroline A Crowther
BACKGROUND: Prelabour rupture of membranes (PROM) at term is managed expectantly or by planned early birth. It is not clear if waiting for birth to occur spontaneously is better than intervening, e.g. by inducing labour. OBJECTIVES: The objective of this review is to assess the effects of planned early birth (immediate intervention or intervention within 24 hours) when compared with expectant management (no planned intervention within 24 hours) for women with term PROM on maternal, fetal and neonatal outcomes...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27976471/coxiella-burnetii-serological-reactions-and-bacterial-shedding-in-primiparous-dairy-cows-in-an-endemically-infected-herd-impact-on-milk-yield-and-fertility
#18
M Freick, H Enbergs, J Walraph, R Diller, J Weber, A Konrath
Coxiella burnetii (C. burnetii) is the causative agent of Q fever both in humans and animals. The objectives of this study were to investigate seropositivity and bacterial shedding in heifers and primiparous cows in an endemically infected herd and to assess the effects on post-partum diseases, fertility and milk production. At the age of 9 months, 96 Holstein heifers were included. Sampling was performed reproduction-orientated: at the beginning of the study, at detection of first pregnancy, 3 weeks before expected calving date (blood serum), at parturition and after 21, 42, 100 and 150 days in milk (DIM) (blood serum, vaginal swabs and milk)...
December 15, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27966806/efficiency-of-uterine-fluid-cytology-in-the-diagnosis-of-subclinical-endometritis-in-the-water-buffalo-bubalus-bubalis
#19
S C Gahlot, S Kumar, A Kumaresan, S Chand, R K Baithalu, S Lathika, T K Patbandha, S S Lathwal, T K Mohanty
This study compared endometrial cytology vis-a-vis uterine fluid cytology for assessment of uterine health in clinically normal and subclinical endometritis (SE)-affected buffaloes. Uterine fluid samples and endometrial samples were collected from the buffaloes (n = 38) at oestrus using blue sheath and cytobrush, respectively. The smears were stained with Field stain for 3 minutes, and a minimum of 400 cells were counted in each smear for determination of the percentage of polymorphonuclear (PMN) leucocyte...
December 14, 2016: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/27955662/lipopolysaccharide-derived-from-the-digestive-tract-triggers-an-inflammatory-response-in-the-uterus-of-mid-lactating-dairy-cows-during-sara
#20
Muhammad Shahid Bilal, Juma Ahamed Abaker, Zain Ul Aabdin, Tianle Xu, Hongyu Dai, Kai Zhang, Xinxin Liu, Xiangzhen Shen
BACKGROUND: The aims of the current study were to evaluate the inflammatory response in cow uterus and to explore the molecular mechanism triggered by high concentrate-induced subacute ruminal acidosis (SARA) in mid-lactating dairy cows. Twelve mid-lactating Holstein cows with an average weight of 455 kg were allocated into two groups subjected to two diets for 18-weeks either a low-concentrate (LC) group containing 4:6 (NDF: NFC) and a high-concentrate (HC) group containing 6:4 (non-forage carbohydrates, NFC): (neutral detergent fiber, NDF) ratio based on dry matter...
December 12, 2016: BMC Veterinary Research
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