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https://www.readbyqxmd.com/read/28091678/pepsin-egg-white-hydrolysate-modulates-gut-microbiota-in-zucker-obese-rats
#1
Teresa Requena, Marta Miguel, Marta Garcés-Rimón, M Carmen Martínez-Cuesta, Rosina López-Fandiño, Carmen Peláez
There is limited information that relates the intake of food-derived bioactive peptides and the gut microbiota. We have previously described a pepsin hydrolysate of egg white (EWH) that ameliorates fat accumulation and dyslipidemia, while reducing oxidative stress and inflammation markers in obese Zucker rats. The aim of this study was to associate the beneficial effects of EWH with gut microbiota changes in these animals. Obese Zucker rats received daily 750 mg kg(-1) EWH in drinking water for 12 weeks and faeces were analysed for microbial composition and metabolic compounds in comparison with Zucker lean rats and obese controls...
January 16, 2017: Food & Function
https://www.readbyqxmd.com/read/28070968/bacterial-short-chain-fatty-acid-metabolites-modulate-the-inflammatory-response-against-infectious-bacteria
#2
R O Corrêa, A Vieira, E M Sernaglia, M Lancellotti, A T Vieira, M J Avila-Campos, H G Rodrigues, M A R Vinolo
Short chain fatty acids (SCFAs), predominately acetic, propionic and butyric acids, are bacterial metabolites with an important role in the maintenance of homeostasis due to their metabolic and immunomodulatory actions. Some evidence suggests that they may also be relevant during infections. Therefore, we aimed to investigate the effects of SCFAs in the effector functions of neutrophils to an opportunistic pathogenic bacteria, Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans). Using a subcutaneous model to generate a mono, isolated infection of A...
January 9, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28063208/effect-of-supplementation-of-calf-starter-with-fennel-powder-on-performance-weaning-age-and-fermentation-characteristics-in-holstein-dairy-calves
#3
S Saeedi, O Dayani, R Tahmasbi, A Khezri
The objective of this experiment was to investigate the effects on performance, weaning age and rumen fermentation characteristics in Holstein calves when fennel powder was added to their starter diets. Thirty Holstein calves with a mean birth weight 40 kg (SD = 0.5) were allocated randomly to one of the following experimental diets: (i) control (starter diet without fennel powder), (ii) starter diet containing 0.4% of fennel powder and (iii) starter diet containing 0.8% of fennel powder (DM basis). The effect of treatments on mean dry matter intake was significant (p < 0...
February 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28062009/reduced-particle-size-wheat-bran-is-butyrogenic-and-lowers-salmonella-colonization-when-added-to-poultry-feed
#4
K Vermeulen, J Verspreet, C M Courtin, F Haesebrouck, R Ducatelle, F Van Immerseel
Feed additives, including prebiotics, are commonly used alternatives to antimicrobial growth promoters to improve gut health and performance in broilers. Wheat bran is a highly concentrated source of (in)soluble fiber which is partly degraded by the gut microbiota. The aim of the present study was to investigate the potential of wheat bran as such to reduce colonization of the cecum and shedding of Salmonella bacteria in vivo. Also, the effect of particle size was evaluated. Bran with an average reduced particle size of 280μm decreased levels of cecal Salmonella colonization and shedding shortly after infection when compared to control groups and groups receiving bran with larger particle sizes...
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28045429/impact-of-glycosidic-bond-configuration-on-short-chain-fatty-acid-production-from-model-fermentable-carbohydrates-by-the-human-gut-microbiota
#5
Hannah C Harris, Christine A Edwards, Douglas J Morrison
Short chain fatty acids (SCFA) are the major products of carbohydrate fermentation by gut bacteria. Different carbohydrates are associated with characteristic SCFA profiles although the mechanisms are unclear. The individual SCFA profile may determine any resultant health benefits. Understanding determinants of individual SCFA production would enable substrate choice to be tailored for colonic SCFA manipulation. To test the hypothesis that the orientation and position of the glycosidic bond is a determinant of SCFA production profile, a miniaturized in vitro human colonic batch fermentation model was used to study a range of isomeric glucose disaccharides...
January 1, 2017: Nutrients
https://www.readbyqxmd.com/read/28003537/ileal-digesta-nondietary-substrates-from-cannulated-pigs-are-major-contributors-to-in-vitro-human-hindgut-short-chain-fatty-acid-production
#6
Carlos A Montoya, Shane M Rutherfurd, Paul J Moughan
BACKGROUND: It has been assumed that short-chain fatty acids (SCFAs) in the colon originate mainly from dietary fiber fermentation. However, SCFAs in the colon are also produced from the fermentation of nondietary material. OBJECTIVES: We aimed to predict the relative contributions of dietary and nondietary substrates in the production of SCFAs with the use of a human fecal inoculum for diets containing kiwifruit as a model fiber. METHODS: Terminal ileal digesta were collected from ileal-cannulated male pigs [n = 7; mean ± SD: 41...
December 21, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27999002/metformin-is-associated-with-higher-relative-abundance-of-mucin-degrading-akkermansia-muciniphila-and-several-short-chain-fatty-acid-producing-microbiota-in-the-gut
#7
Jacobo de la Cuesta-Zuluaga, Noel T Mueller, Vanessa Corrales-Agudelo, Eliana P Velásquez-Mejía, Jenny A Carmona, José M Abad, Juan S Escobar
OBJECTIVE: Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined the association of type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On the basis of previous research, we hypothesized that metformin is associated with higher levels of short-chain fatty acid (SCFA)-producing and mucin-degrading microbiota. RESEARCH DESIGN AND METHODS: Participants were selected from a larger cohort of 459 participants...
January 2017: Diabetes Care
https://www.readbyqxmd.com/read/27997168/cooking-has-variable-effects-on-the-fermentability-in-the-large-intestine-of-the-fraction-of-meats-grain-legumes-and-insects-that-is-resistant-to-digestion-in-the-small-intestine-in-an-in-vitro-model-of-the-pig-s-gastro-intestinal-tract
#8
Christine Poelaert, Xavier Despret, Marianne Sindic, Yves Beckers, Frederic Francis, Daniel Portetelle, Hélène Soyeurt, André Théwis, Jérôme Bindelle
This study aimed to evaluate the fermentation in the large intestine of indigestible dietary proteins sources from animal, insect and plant origin using an in vitro model of the pig's gastro-intestinal tract. Protein sources were used raw and after a cooking treatment. Results showed that the category of the ingredient (meats, insects or grain legumes) exerts a stronger impact on enzymatic digestibility, fermentation patterns and bacterial metabolites such as short-chain fatty acids (SCFA) and hydrogen sulfide (H2S) than the cooking treatment...
December 20, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27987975/preparation-and-characterization-of-in-situ-ionic-cross-linked-pectin-films-ii-biodegradation-and-drug-diffusion
#9
Adel Penhasi
In the present study the enzymatic biodegradation of a series of calcium pectinate (CaP) films, produced by in-situ crosslinking of pre-formed low methoxy pectin films in a calcium chloride (CaCl2) solution, has been assessed. The degradation level was determined by measuring the concentration of short chain fatty acid salts (SCFA), which are the natural metabolites of pectin. To this end an ex-vivo model, mimicking the colon's environment, was utilized. The results showed that a fully calcified film from a high concentration of CaCl2 solution did not exhibit any tendency to biodegradability throughout the test time...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27966574/acute-increases-in-serum-colonic-short-chain-fatty-acids-elicited-by-inulin-do-not-increase-glp-1-or-pyy-responses-but-may-reduce-ghrelin-in-lean-and-overweight-humans
#10
S Rahat-Rozenbloom, J Fernandes, J Cheng, T M S Wolever
BACKGROUND: Colonic fermentation of dietary fibre to short-chain fatty acids (SCFA) influences appetite hormone secretion in animals, but SCFA production is excessive in obese animals. This suggests there may be resistance to the effect of SCFA on appetite hormones in obesity. OBJECTIVES: To determine the effects of inulin (IN) and resistant starch (RS) on postprandial SCFA, and gut hormone (glucagon-like peptide (GLP-1), peptide-tyrosine-tyrosine (PYY) and ghrelin) responses in healthy overweight/obese (OWO) vs lean (LN) humans...
December 14, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27966565/the-acute-effects-of-inulin-and-resistant-starch-on-postprandial-serum-short-chain-fatty-acids-and-second-meal-glycemic-response-in-lean-and-overweight-humans
#11
S Rahat-Rozenbloom, J Fernandes, J Cheng, G B Gloor, T M S Wolever
BACKGROUND/OBJECTIVES: Colonic fermentation of dietary fiber to short-chain fatty acids (SCFA) may protect against obesity and diabetes, but excess production of colonic SCFA has been implicated in the promotion of obesity. We aimed to compare the effects of two fermentable fibers on postprandial SCFA and second-meal glycemic response in healthy overweight or obese (OWO) vs lean (LN) participants. SUBJECTS/METHODS: Using a randomized crossover design, 13 OWO and 12 LN overnight fasted participants were studied for 6 h on three separate days after consuming 300 ml water containing 75 g glucose (GLU) as control or with 24 g inulin (IN) or 28 g resistant starch (RS)...
December 14, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27959892/ffa2-contribution-to-gestational-glucose-tolerance-is-not-disrupted-by-antibiotics
#12
Miles Fuller, Xiaoran Li, Robert Fisch, Moneb Bughara, Barton Wicksteed, Petia Kovatcheva-Datchary, Brian T Layden
During the insulin resistant phase of pregnancy, the mRNA expression of free fatty acid 2 receptor (Ffar2) is upregulated and as we recently reported, this receptor contributes to insulin secretion and pancreatic beta cell mass expansion in order to maintain normal glucose homeostasis during pregnancy. As impaired gestational glucose levels can affect metabolic health of offspring, we aimed to explore the role of maternal Ffar2 expression during pregnancy on the metabolic health of offspring and also the effects of antibiotics, which have been shown to disrupt gut microbiota fermentative activity (the source of the FFA2 ligands) on gestational glucose homeostasis...
2016: PloS One
https://www.readbyqxmd.com/read/27959345/new-roles-in-hemicellulosic-sugar-fermentation-for-the-uncultivated-bacteroidetes-family-bs11
#13
Lindsey M Solden, David W Hoyt, William B Collins, Johanna E Plank, Rebecca A Daly, Erik Hildebrand, Timothy J Beavers, Richard Wolfe, Carrie D Nicora, Sam O Purvine, Michelle Carstensen, Mary S Lipton, Donald E Spalinger, Jeffrey L Firkins, Barbara A Wolfe, Kelly C Wrighton
Ruminants have co-evolved with their gastrointestinal microbial communities that digest plant materials to provide energy for the host. Some arctic and boreal ruminants have already shown to be vulnerable to dietary shifts caused by changing climate, yet we know little about the metabolic capacity of the ruminant microbiome in these animals. Here, we use meta-omics approaches to sample rumen fluid microbial communities from Alaskan moose foraging along a seasonal lignocellulose gradient. Winter diets with increased hemicellulose and lignin strongly enriched for BS11, a Bacteroidetes family lacking cultivated or genomically sampled representatives...
December 13, 2016: ISME Journal
https://www.readbyqxmd.com/read/27943364/the-inflammation-induced-by-lipopolysaccharide-can-be-mitigated-by-short-chain-fatty-acid-butyrate-through-up-regulation-of-il-10-in-septic-shock
#14
Fangyan Wang, Jiaming Liu, Tingting Wong, Kaiyi Shen, Zhisong Chen, Ying Yu, Qiong Huang, Guocan Wang, Zhanguo Liu, Shengwei Jin
Short chain fatty acids (SCFAs) with the anti-inflammatory capacity are produced by intestinal bacteria, however, their effect on the acute systematical inflammation remains unclear. The current study aimed to investigate the effects of SCFAs, acetate, propionate and butyrate, on septic shock and the underlying mechanism. The LPS-induced septic model was used to evaluate the function of SCFAs by survival rate observation. Only butyrate, but not acetate or propionate, significantly decrease the mortality of septic mice...
December 10, 2016: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/27936165/enzymatically-modified-starch-favorably-modulated-intestinal-transit-time-and-hindgut-fermentation-in-growing-pigs
#15
M A Newman, Q Zebeli, K Velde, D Grüll, T Molnar, W Kandler, B U Metzler-Zebeli
Aside from being used as stabilizing agents in many processed foods, chemically modified starches may act as functional dietary ingredients. Therefore, development of chemically modified starches that are less digestible in the upper intestinal segments and promote fermentation in the hindgut receives considerable attention. This study aimed to investigate the impact of an enzymatically modified starch (EMS) on nutrient flow, passage rate, and bacterial activity at ileal and post-ileal level. Eight ileal-cannulated growing pigs were fed 2 diets containing 72% purified starch (EMS or waxy cornstarch as control) in a cross-over design for 10 d, followed by a 4-d collection of feces and 2-d collection of ileal digesta...
2016: PloS One
https://www.readbyqxmd.com/read/27933160/post-sensitization-administration-of-non-digestible-oligosaccharides-and-bifidobacterium-breve-m-16v-reduces-allergic-symptoms-in-mice
#16
Betty C A M van Esch, Suzanne Abbring, Mara A P Diks, Gemma M Dingjan, Lucien F Harthoorn, A Paul Vos, Johan Garssen
To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non-digestible oligosaccharides and Bifidobacterium breve M-16V (B. breve) was designed from source materials that are completely cow's milk-free. It was investigated whether this specific synbiotic concept can reduce an established food allergic response in a research model for hen's egg allergy. Mice were orally sensitized once a week for 5 weeks to ovalbumin (OVA) using cholera toxin (CT) as an adjuvant. Non-sensitized mice received CT in PBS only...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27928878/formation-of-propionate-and-butyrate-by-the-human-colonic-microbiota
#17
REVIEW
Petra Louis, Harry J Flint
The human gut microbiota ferments dietary non-digestible carbohydrates into short-chain fatty acids (SCFA). These microbial products are utilized by the host and propionate and butyrate in particular exert a range of health-promoting functions. Here an overview of the metabolic pathways utilized by gut microbes to produce these two SCFA from dietary carbohydrates and from amino acids resulting from protein breakdown is provided. This overview emphasizes the important role played by cross-feeding of intermediary metabolites (in particular lactate, succinate and 1,2-propanediol) between different gut bacteria...
November 5, 2016: Environmental Microbiology
https://www.readbyqxmd.com/read/27927713/high-fibre-diet-and-acetate-supplementation-change-the-gut-microbiota-and-prevent-the-development-of-hypertension-and-heart-failure-in-doca-salt-hypertensive-mice
#18
Francine Z Marques, Erin M Nelson, Po-Yin Chu, Duncan Horlock, April Fiedler, Mark Ziemann, Jian K Tan, Sanjaya Kuruppu, Niwanthi W Rajapakse, Assam El-Osta, Charles R Mackay, David M Kaye
BACKGROUND: -Dietary intake of fruit and vegetables is associated with lower incidence of hypertension, but the mechanisms involved have not been elucidated. Here we evaluated the effect of a high fibre diet and supplementation with the short-chain fatty acid (SFCA) acetate on the gut microbiota and the prevention of cardiovascular disease. METHODS: -Gut microbiome, cardiorenal structure/function and blood pressure were examined in sham and mineralocorticoid-excess treated mice with a control diet, high fibre diet or acetate supplementation...
December 7, 2016: Circulation
https://www.readbyqxmd.com/read/27927266/enzymatically-modified-starch-up-regulates-expression-of-incretins-and-sodium-coupled-monocarboxylate-transporter-in-jejunum-of-growing-pigs
#19
B U Metzler-Zebeli, R Ertl, D Grüll, T Molnar, Q Zebeli
Dietary effects on the host are mediated via modulation of the intestinal mucosal responses. The present study investigated the effect of an enzymatically modified starch (EMS) product on the mucosal expression of genes related to starch digestion, sugar and short-chain fatty acid (SCFA) absorption and incretins in the jejunum and cecum in growing pigs. Moreover, the impact of the EMS on hepatic expression of genes related to glucose and lipid metabolism, and postprandial serum metabolites were assessed. Barrows (n=12/diet; initial BW 29 kg) were individually fed three times daily with free access to a diet containing either EMS or waxy corn starch as control (CON) for 10 days...
December 8, 2016: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/27921383/consumption-of-the-total-western-diet-differentially-affects-the-response-to-green-tea-in-rodent-models-of-chronic-disease-compared-to-the-ain93g-diet
#20
Robert E Ward, Abby D Benninghoff, Brett J Healy, Minghao Li, Bharath Vagu, Korry J Hintze
SCOPE: In pre-clinical studies investigating bioactive components, the efficacy of the bioactive is likely influenced by the basal diet provided to rodents. In this study, we hypothesized that a model bioactive, green tea extract (GTE), would have different effects on colon carcinogenesis, body composition, and lipid metabolism in mice fed a basal diet formulated to promote animal health and growth (AIN93G) as compared to a Western diet that emulates typical American intakes of micro- and macronutrients, the total Western diet (TWD)...
December 6, 2016: Molecular Nutrition & Food Research
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