keyword
MENU ▼
Read by QxMD icon Read
search

SCFA

keyword
https://www.readbyqxmd.com/read/28806487/gut-microbiome-response-to-short-term-dietary-interventions-in-reactive-hypoglycemia-subjects
#1
Sara Quercia, Silvia Turroni, Jessica Fiori, Matteo Soverini, Simone Rampelli, Elena Biagi, Andrea Castagnetti, Clarissa Consolandi, Marco Severgnini, Mario Pianesi, Francesco Fallucca, Paolo Pozzilli, Patrizia Brigidi, Marco Candela
BACKGROUND: Reactive hypoglycemia (RH) is a metabolic disorder that provokes severe hypoglycemic episodes after meal. Over recent years, the gut microbiota (GM) has been recognized as potential target for the control of metabolic diseases, and the possibility to correct GM dysbioses through diet, favoring the recovery of metabolic homeostasis, has been considered. METHODS: We investigate the impact of two short-term (3-day) nutritional interventions, based on the macrobiotic Ma-Pi 2 diet and a control Mediterranean diet, on the structure and functionality of the GM in 12 patients affected by RH...
August 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28791008/free-fatty-acids-profiles-are-related-to-gut-microbiota-signatures-and-short-chain-fatty-acids
#2
Javier Rodríguez-Carrio, Nuria Salazar, Abelardo Margolles, Sonia González, Miguel Gueimonde, Clara G de Los Reyes-Gavilán, Ana Suárez
A growing body of evidence highlights the relevance of free fatty acids (FFA) for human health, and their role in the cross talk between the metabolic status and immune system. Altered serum FFA profiles are related to several metabolic conditions, although the underlying mechanisms remain unclear. Recent studies have highlighted the link between gut microbiota and host metabolism. However, although most of the studies have focused on different clinical conditions, evidence on the role of these mediators in healthy populations is lacking...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28789729/adherence-to-the-mediterranean-diet-is-associated-with-the-gut-microbiota-pattern-and-gastrointestinal-characteristics-in-an-adult-population
#3
Evdokia K Mitsou, Aimilia Kakali, Smaragdi Antonopoulou, Konstantinos C Mountzouris, Mary Yannakoulia, Demosthenes B Panagiotakos, Adamantini Kyriacou
This study aimed to explore the potential associations of adherence to the Mediterranean diet with gut microbiota characteristics and gastrointestinal symptomatology in an adult population. Other long-term dietary habits (e.g. consumption of snacks and junk food or stimulant intake) were also evaluated in terms of the gut microbiota profile. Participants (n 120) underwent anthropometric, dietary, physical activity and lifestyle evaluation. Adherence to the Mediterranean diet was assessed using a Mediterranean diet score, the MedDietScore, and subjects were classified into three tertiles according to individual adherence scoring...
June 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28783689/inhibition-of-hdac8-and-hdac9-by-microbial-short-chain-fatty-acids-breaks-immune-tolerance-of-the-epidermis-to-tlr-ligands
#4
James A Sanford, Ling-Juan Zhang, Michael R Williams, Jon A Gangoiti, Chun-Ming Huang, Richard L Gallo
Epidermal keratinocytes participate in immune defense through their capacity to recognize danger, trigger inflammation, and resist infection. However, normal skin immune function must tolerate contact with an abundant community of commensal microbes without inflammation. We hypothesized that microbial environmental conditions dictate the production of molecules that influence epigenetic events and cause keratinocytes to break innate immune tolerance. Propionibacterium acnes, a commensal skin bacterium, produced the short-chain fatty acids (SCFAs) propionate and valerate when provided a lipid source in hypoxic growth conditions, and these SCFAs inhibited histone deacetylase (HDAC) activity...
October 28, 2016: Science Immunology
https://www.readbyqxmd.com/read/28782784/lactobacillus-casei-ccfm419-attenuates-type-2-diabetes-via-a-gut-microbiota-dependent-mechanism
#5
Gang Wang, Xiangfei Li, Jianxin Zhao, Hao Zhang, Wei Chen
Probiotics, as dietary supplements, transmit their major effects through the regulation of gut microbiota. According to a previous study, one possible mechanism of Lactobacillus casei CCFM419 protection against diabetes may involve gut flora. To test this hypothesis, high fat and streptozotocin-induced C57BL/6J mice were fed L. casei CCFM419 at 10(8), 10(9), and 10(10) colony forming units (CFU). Compared to untreated mice, 10(9) CFU of L. casei CCFM419 attenuated several symptoms of diabetes, including fasting blood glucose, postprandial blood glucose, glucose intolerance, and insulin resistance...
August 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28772139/understanding-and-mitigating-the-toxicity-of-cadmium-to-the-anaerobic-fermentation-of-waste-activated-sludge
#6
Qiuxiang Xu, Xiaoming Li, Rongrong Ding, Dongbo Wang, Yiwen Liu, Qilin Wang, Jianwei Zhao, Fei Chen, Guangming Zeng, Qi Yang, Hailong Li
Cadmium (Cd) is present in significant levels in waste activated sludge, but its potential toxicities on anaerobic fermentation of sludge remain largely unknown. This work therefore aims to provide such support. Experimental results showed that the impact of Cd on short-chain fatty acids (SCFA) production from sludge anaerobic fermentation was dose-dependent. The presence of environmentally relevant level of Cd (e.g., 0.1 mg/g VSS) enhanced SCFA production by 10.6%, but 10 mg/g VSS of Cd caused 68.1% of inhibition...
July 26, 2017: Water Research
https://www.readbyqxmd.com/read/28770123/prevention-of-histological-changes-after-colonic-diversion-in-rats-an-experimental-study
#7
Pathak M, Srinivas M, Shariff A
AIM: To determine the beneficial effects of Glutamine, Psyllium, Short Chain Fatty Acids (SCFA), and Maharishi Amrit Kalash (MAK), in preventing the histological changes after diversion colostomy. MATERIAL AND METHODS: After ethical clearance, male wistar rats (n=40) underwent diversion colostomy. Rats were divided into five groups of 8 rats each. Each group was given, after diversion colostomy, per rectally, one of the five agents being tested as an enema (3 ml/kg/day)...
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28742883/effects-of-oral-florfenicol-and-azithromycin-on-gut-microbiota-and-adipogenesis-in-mice
#8
Rui Li, Hexing Wang, Qingfeng Shi, Na Wang, Zhijie Zhang, Chenglong Xiong, Jianxiang Liu, Yue Chen, Lufang Jiang, Qingwu Jiang
Certain antibiotics detected in urine are associated with childhood obesity. In the current experimental study, we investigated two representative antibiotics detected in urine, florfenicol and azithromycin, for their early effects on adipogenesis, gut microbiota, short-chain fatty acids (SCFAs), and bile acids in mice. Thirty C57BL/6 mice aged four weeks were randomly divided into three groups (florfenicol, azithromycin and control). The two experimental groups were administered florfenicol or azithromycin at 5 mg/kg/day for four weeks...
2017: PloS One
https://www.readbyqxmd.com/read/28736144/evaluating-the-potential-impact-of-hydrochar-on-the-production-of-short-chain-fatty-acid-from-sludge-anaerobic-digestion
#9
Xiaolin Wang, Jianwei Zhao, Qi Yang, Jian Sun, Chuan Peng, Fei Chen, Qiuxiang Xu, Shana Wang, Dongbo Wang, Xiaoming Li, Guangming Zeng
In this study, waste activated sludge (WAS) was used as feedstock to generate hydrochars at different temperatures (220°C and 260°C) and their effect on sludge anaerobic digestion was evaluated. Experimental results showed that the maximum yield of short-chain fatty acid (SCFA) enhanced by hydrochar (220°C) and hydrochar (260°C) were 507.33 and 270.80mg chemical oxygen demand (COD)/L respectively, which were much higher than that in blank (141.49mg COD/L). Mechanism investigation confirmed that hydrochar remarkably accelerated the solubilization and hydrolysis of organic matters, enhanced the acidification of hydrolyzed products, and inhibited the activity of methanogenic bacteria as well as promoted the activities of key enzymes...
July 11, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28733671/short-chain-fatty-acids-and-inulin-but-not-guar-gum-prevent-diet-induced-obesity-and-insulin-resistance-through-differential-mechanisms-in-mice
#10
Karolin Weitkunat, Christin Stuhlmann, Anna Postel, Sandra Rumberger, Maria Fankhänel, Anni Woting, Klaus Jürgen Petzke, Sabrina Gohlke, Tim J Schulz, Michael Blaut, Susanne Klaus, Sara Schumann
The role of dietary fibre and short-chain fatty acids (SCFA) in obesity development is controversially discussed. Here, we investigated how various types of dietary fibre and different SCFA ratios affect metabolic syndrome-related disorders. Male mice (B6) were fed high-fat diets supplemented with dietary fibres (either cellulose, inulin or guar gum) or different Ac:Pr ratios (high acetate (HAc) or propionate (HPr)) for 30 weeks. Body-fat gain and insulin resistance were greatly reduced by inulin, but not by guar gum, and completely prevented by SCFA supplementation...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28727837/differing-roles-for-short-chain-fatty-acids-and-gpr43-agonism-in-the-regulation-of-intestinal-barrier-function-and-immune-responses
#11
Warren N D'Souza, Jason Douangpanya, Sharon Mu, Peter Jaeckel, Ming Zhang, Joseph R Maxwell, James B Rottman, Katja Labitzke, Angela Willee, Holger Beckmann, Yingcai Wang, Yang Li, Ralf Schwandner, James A Johnston, Jennifer E Towne, Hailing Hsu
Inflammatory bowel disease (IBD) is associated with a loss of intestinal barrier function and dysregulated immune responses. It has been shown that short chain fatty acids (SCFAs) are protective in IBD and that GPR43 mediates the protective effects of SCFAs. In this study, we investigated the effects of SCFAs in comparison to highly specific GPR43 agonists on human intestinal epithelial and immune cells. Our results confirm that SCFAs are enhancers of barrier function in intestinal epithelial cells. Additionally, SCFAs also displayed potent immunoregulatory properties based upon the ability to inhibit LPS-induced cytokine production in PBMC, and human T cell proliferation and cytokine production...
2017: PloS One
https://www.readbyqxmd.com/read/28727033/the-effect-of-age-and-carbohydrate-and-protein-sources-on-digestibility-fecal-microbiota-fermentation-products-fecal-iga-and-immunological-blood-parameters-in-dogs
#12
A P J Maria, L Ayane, T C Putarov, B A Loureiro, B P Neto, M F Casagrande, M O S Gomes, M B A Glória, A C Carciofi
The present study compared the effects of diets formulated with fibers of different fermentability and protein sources of animal or vegetable origins on old and adult dogs. The experiment was organized in a 3 (diets) × 2 (ages) factorial arrangement, totaling 6 treatments. Thirty-six Beagle dogs were used (18 old dogs [10.2 ± 1.0 yr] and 18 young adult dogs [2.6 ± 0.9 yr]), with 6 dogs per treatment. Three diets with similar compositions were used: a nonfermentable insoluble fiber source (sugarcane fiber) and chicken byproduct meal (nonfermentable fiber [NFF] diet), a fermentable fiber source (beet pulp) and chicken byproduct meal (fermentable fiber [FF] diet), and soybean meal as a protein and fiber source (soybean meal [SM] diet)...
June 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726987/effect-of-butyrate-infusion-into-the-rumen-on-butyrate-flow-to-the-duodenum-selected-gene-expression-in-the-duodenum-epithelium-and-nutrient-digestion-in-sheep
#13
P Górka, B Śliwiński, J Flaga, J Wieczorek, M M Godlewski, E Wierzchoś, R Zabielski, Z M Kowalski
The aim of the study was to determine the effect of butyrate infusion into the rumen on butyrate flow to the duodenum, expression of short-chain fatty acid (SCFA) transporters (monocarboxylate transporter-1, -2, and -4) and receptors (G protein coupled receptor-41 and -43) in the duodenal epithelium and nutrient digestion in sheep. Eight wethers (39.0 ± 3.00 kg; mean ± SD) with ruminal and T-shape duodenal cannulas were allocated to 4 × 4 replicated Latin square design with each experimental period lasting for 21 d (12 d of adaptation and 9 d for data and sample collection)...
May 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28722751/graded-replacement-of-maize-grain-with-molassed-sugar-beet-pulp-modulated-ruminal-microbial-community-and-fermentation-profile-in-vitro
#14
Matthias Münnich, Annabella Khol-Parisini, Fenja Klevenhusen, Barbara Metzler-Zebeli, Qendrim Zebeli
BACKGROUND: Molassed sugar beet pulp (Bp) is a viable alternative to grains in cattle nutrition for reducing human edible energy input. Yet, little is known about the effects of high inclusion rates of Bp on rumen microbiota. This study used an in vitro approach and the qPCR technique to establish the effects of a graded replacement of maize grain (MG) by Bp on the ruminal microbial community, fermentation profile, and nutrient degradation. RESULTS: Six different amounts of Bp (0 to 400 g kg(-1) ) which replaced MG in the diet were tested, using the in vitro semi continuous rumen simulation technique...
July 19, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28721502/mucin-cross-feeding-of-infant-bifidobacteria-and-eubacterium-hallii
#15
Vera Bunesova, Christophe Lacroix, Clarissa Schwab
Mucus production is initiated before birth and provides mucin glycans to the infant gut microbiota. Bifidobacteria are the major bacterial group in the feces of vaginally delivered and breast milk-fed infants. Among the bifidobacteria, only Bifidobacterium bifidum is able to degrade mucin and to release monosaccharides which can be used by other gut microbes colonizing the infant gut. Eubacterium hallii is an early occurring commensal that produces butyrate and propionate from fermentation metabolites but that cannot degrade complex oligo- and polysaccharides...
July 18, 2017: Microbial Ecology
https://www.readbyqxmd.com/read/28714277/free-fatty-acid-receptor-3-activation-suppresses-neurogenic-motility-in-rat-proximal-colon
#16
I Kaji, Y Akiba, T Furuyama, D W Adelson, K Iwamoto, M Watanabe, A Kuwahara, J D Kaunitz
BACKGROUND: Short-chain fatty acids (SCFA) are microbial fermentation products absorbed by the colon. We recently reported that activation of the SCFA receptor termed free fatty acid receptor 3 (FFA3), expressed on cholinergic nerves, suppresses nicotinic acetylcholine receptor (nAChR)-mediated transepithelial anion secretion. This study aimed to clarify how activation of neurally expressed FFA3 affects colonic motor function. METHODS: FFA3-expressing myenteric neurons were identified by immunostaining; contractions of isolated circular muscle strips obtained from rat proximal colon were measured by isometric transducers...
July 17, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28713353/functional-characterization-of-novel-faecalibacterium-prausnitzii-strains-isolated-from-healthy-volunteers-a-step-forward-in-the-use-of-f-prausnitzii-as-a-next-generation-probiotic
#17
Rebeca Martín, Sylvie Miquel, Leandro Benevides, Chantal Bridonneau, Véronique Robert, Sylvie Hudault, Florian Chain, Olivier Berteau, Vasco Azevedo, Jean M Chatel, Harry Sokol, Luis G Bermúdez-Humarán, Muriel Thomas, Philippe Langella
Faecalibacterium prausnitzii is a major member of the Firmicutes phylum and one of the most abundant bacteria in the healthy human microbiota. F. prausnitzii depletion has been reported in several intestinal disorders, and more consistently in Crohn's disease (CD) patients. Despite its importance in human health, only few microbiological studies have been performed to isolate novel F. prausnitzii strains in order to better understand the biodiversity and physiological diversity of this beneficial commensal species...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28710833/effect-of-cellobiose-supplementation-on-in-vitro-fermentation-activity-and-bacterial-numbers-of-porcine-inocula
#18
S N Heinritz, E Weiss, J Seifert, R Mosenthin, S Kuß, A G Degenhardt, T J Koch
In this in vitro study, the modified Hohenheim gas test (HGT) was applied to determine fermentation activity and bacterial composition of pig's faecal microbial inoculum using different concentrations of cellobiose. Incubation procedures included normal buffered and osmotic stress conditions (elevated medium salinity). After 24 hr of fermentation, production of gas, ammonia and short-chain fatty acid (SCFA) was measured, and the gene copy numbers of total bacteria, Lactobacillus spp., Bifidobacterium spp., Roseburia spp...
July 15, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28709869/protective-effect-of-bacillopeptidase-cfr5-from-bacillus-subtilis-cfr5-on-cerulein-induced-pancreatitis
#19
G R Sharmila, G Venkateswaran
Bacillopeptidase is a serine peptidase, known for its fibrinolytic activity. However, a very little information is known about its in vivo inflammatory and/or anti-inflammatory properties. Thus, to understand whether bacillopeptidase incorporation can regulate pancreatitis or not, the cerulein-induced pancreatitis model was used, and the role of bacillopeptidase on pancreatitis was studied. In this study, 46 kDa protein was purified from Bacillus subtilis and identified as bacillopeptidase CFR5 (BPC) through MS/MS analysis...
July 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28704610/effects-of-medium-and-long-chain-triacylglycerols-on-lipid-metabolism-and-gut-microbiota-composition-in-c57bl-6j-mice
#20
Shengmin Zhou, Yueqiang Wang, Jörg J Jacoby, Yuanrong Jiang, Yaqiong Zhang, Liangli Lucy Yu
Obesity is related to an increasing risk of chronic diseases. Medium- and long-chain triacylglycerols (MLCT) have been recognized as a promising choice to reduce body weight. In this study, three MLCT with different contents of medium-chain fatty acids (MCFA) (10-30%, w/w) were prepared, and their effects on lipid metabolism and fecal gut microbiota composition of C57BL/6J mice were systematically investigated. MLCT with 30% (w/w) MCFA showed the best performance in decreasing body weight gain as well as optimizing serum lipid parameters and liver triacylglycerol content...
August 9, 2017: Journal of Agricultural and Food Chemistry
keyword
keyword
7208
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"