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https://www.readbyqxmd.com/read/29666214/metabolic-abnormalities-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-a-mini-review
#1
REVIEW
Cara Tomas, Julia Newton
Chronic fatigue syndrome (CFS), commonly known as myalgic encephalomyelitis (ME), is a debilitating disease of unknown etiology. CFS/ME is a heterogeneous disease associated with a myriad of symptoms but with severe, prolonged fatigue as the core symptom associated with the disease. There are currently no known biomarkers for the disease, largely due to the lack of knowledge surrounding the eitopathogenesis of CFS/ME. Numerous studies have been conducted in an attempt to identify potential biomarkers for the disease...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29650052/weighting-of-orthostatic-intolerance-time-measurements-with-standing-difficulty-score-stratifies-me-cfs-symptom-severity-and-analyte-detection
#2
Alice M Richardson, Don P Lewis, Badia Kita, Helen Ludlow, Nigel P Groome, Mark P Hedger, David M de Kretser, Brett A Lidbury
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. METHODS: This study introduces the weighted standing time (WST) as a proxy for ME/CFS severity, and investigates its behaviour in an Australian cohort. WST was calculated from standing time and subjective standing difficulty data, collected via orthostatic intolerance assessments...
April 12, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29607759/-it-s-like-being-a-slave-to-your-own-body-in-a-way-a-qualitative-study-of-adolescents-with-chronic-fatigue-syndrome
#3
Berit Widerøe Njølstad, Anne Marit Mengshoel, Unni Sveen
BACKGROUND: Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a relatively common disabling illness in adolescents that may limit participation in daily life. AIM: This study explored interactions between the illness experiences of adolescents with CFS/ME, their occupational lives and expectations for the future. METHODS: Seven adolescents with CFS/ME were interviewed. The interviews were analyzed using thematic analysis. RESULTS: Three themes were developed...
April 1, 2018: Scandinavian Journal of Occupational Therapy
https://www.readbyqxmd.com/read/29602463/treating-patients-suffering-from-myalgic-encephalopathy-chronic-fatigue-syndrome-me-cfs-with-sodium-dichloroacetate-an-open-label-proof-of-principle-pilot-trial
#4
Frank Comhaire
Twenty-two consecutive patients suffering from refractory myalgic encephalitis/chronic fatigue syndrome (ME/CFS) were treated with an innovative nutriceutical containing sodium dichloroacetate in a proof-of-principle, pilot, open-label prospective cohort trial. Ten patients experienced significant improvement of their health condition with reduction to almost half of their score in the fatigue severity scale. In twelve patients treatment failed to exert any beneficial effect. In the latter patients several other diseases have commonly been revealed by extensive biological and imaging investigations...
May 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29600930/-report-of-the-dutch-national-health-council-on-chronic-fatigue-syndrome
#5
J W M van der Meer, M E Roerink, E M van de Putte
In our opinion, the recent report of the Dutch National Health Council on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) lacks balance: it is very critical on the quality of evidence regarding behavioural interventions, but lacks a critical attitude regarding the presumed somatic components of the disorder. Without solid evidence, the report coins ME/CFS as a severe multisystem disease, and it embraces the diagnostic criteria of the American Institute of Medicine. We underscore the remarks in the report that physicians should not be reluctant to make diagnosis in patients with the disorder, and that these patients should be approached with empathy and respect...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29587879/rituximab-impedes-natural-killer-cell-function-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients-a-pilot-in-vitro-investigation
#6
Natalie Eaton, Hélène Cabanas, Cassandra Balinas, Anne Klein, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: A recent in vitro pilot investigation reported Rituximab significantly reduced natural killer (NK) cell cytotoxicity in healthy donors. Chronic fatigue syndrome/Myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown etiology. A consistent finding is a significant reduction in NK cell cytotoxicity. Rituximab has been reported having questionable potential therapeutic benefits for the treatment of CFS/ME, however, the potential effects of Rituximab on NK cell cytotoxicity in CFS/ME patients are yet to be determined...
March 27, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29543914/immunoadsorption-to-remove-%C3%A3-2-adrenergic-receptor-antibodies-in-chronic-fatigue-syndrome-cfs-me
#7
Carmen Scheibenbogen, Madlen Loebel, Helma Freitag, Anne Krueger, Sandra Bauer, Michaela Antelmann, Wolfram Doehner, Nadja Scherbakov, Harald Heidecke, Petra Reinke, Hans-Dieter Volk, Patricia Grabowski
INTRODUCTION: Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) point to an autoimmune disease directed against neurotransmitter receptors. We had observed elevated autoantibodies against ß2 adrenergic receptors, and muscarinic 3 and 4 acetylcholine receptors in a subset of patients. Immunoadsorption (IA) was shown to be effective in removing autoantibodies and improve outcome in various autoimmune diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29536371/functional-status-and-well-being-in-people-with-myalgic-encephalomyelitis-chronic-fatigue-syndrome-compared-with-people-with-multiple-sclerosis-and-healthy-controls
#8
Caroline C Kingdon, Erinna W Bowman, Hayley Curran, Luis Nacul, Eliana M Lacerda
BACKGROUND: People with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) continue to struggle to have their condition recognised as disabling in the face of public and professional prejudice and discrimination. OBJECTIVE: The aim of this study was to compare the functional status and well-being of people with well-characterised ME/CFS with people with multiple sclerosis (PWMS), as well as healthy controls (HCs). METHODS: In this cross-sectional study, we used data collected as part of the UK ME/CFS Biobank to compare actual participant scores from the Medical Outcomes Survey Short Form-36 v2™ (SF-36v2™) between groups, as a proxy for impact of disability, and from a bespoke questionnaire seeking data on employment and income...
March 13, 2018: PharmacoEconomics Open
https://www.readbyqxmd.com/read/29523751/does-the-microbiome-and-virome-contribute-to-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#9
REVIEW
Fiona Newberry, Shen-Yuan Hsieh, Tom Wileman, Simon R Carding
Myalgic encephalomyelitis (ME)/chronic fatigue syndrome (CFS) (ME/CFS) is a disabling and debilitating disease of unknown aetiology. It is a heterogeneous disease characterized by various inflammatory, immune, viral, neurological and endocrine symptoms. Several microbiome studies have described alterations in the bacterial component of the microbiome (dysbiosis) consistent with a possible role in disease development. However, in focusing on the bacterial components of the microbiome, these studies have neglected the viral constituent known as the virome...
March 15, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29497420/infection-elicited-autoimmunity-and-myalgic-encephalomyelitis-chronic-fatigue-syndrome-an-explanatory-model
#10
Jonas Blomberg, Carl-Gerhard Gottfries, Amal Elfaitouri, Muhammad Rizwan, Anders Rosén
Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent findings and placed them in the context of the clinical picture and natural history of the disease. A pattern emerged, giving rise to an explanatory model. ME/CFS often starts after or during an infection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29486769/association-of-chronic-fatigue-syndrome-with-premature-telomere-attrition
#11
Mangalathu S Rajeevan, Janna Murray, Lisa Oakley, Jin-Mann S Lin, Elizabeth R Unger
BACKGROUND: Chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME), is a severely debilitating condition of unknown etiology. The symptoms and risk factors of ME/CFS share features of accelerated aging implicated in several diseases. Using telomere length as a marker, this study was performed to test the hypothesis that ME/CFS is associated with accelerated aging. METHODS: Participant (n = 639) data came from the follow-up time point of the Georgia CFS surveillance study...
February 27, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29471861/investigating-the-effectiveness-and-cost-effectiveness-of-fitnet-nhs-fatigue-in-teenagers-on-the-internet-in-the-nhs-compared-to-activity-management-to-treat-paediatric-chronic-fatigue-syndrome-cfs-myalgic-encephalomyelitis-me-protocol-for-a-randomised-controlled
#12
Sarah Baos, Amberly Brigden, Emma Anderson, William Hollingworth, Simon Price, Nicola Mills, Lucy Beasant, Daisy Gaunt, Kirsty Garfield, Chris Metcalfe, Roxanne Parslow, Harriet Downing, David Kessler, John Macleod, Paul Stallard, Hans Knoop, Elise Van de Putte, Sanne Nijhof, Gijs Bleijenberg, Esther Crawley
BACKGROUND: Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition. The National Institute for Health and Clinical Excellence (NICE) recommends Cognitive Behavioural Therapy (CBT) as a treatment option for paediatric CFS/ME because there is good evidence that it is effective. Despite this, most young people in the UK are unable to access local specialist CBT for CFS/ME. A randomised controlled trial (RCT) showed FITNET was effective in the Netherlands but we do not know if it is effective in the National Health Service (NHS) or if it is cost-effective...
February 22, 2018: Trials
https://www.readbyqxmd.com/read/29464501/a-systematic-review-of-probiotic-interventions-for-gastrointestinal-symptoms-and-irritable-bowel-syndrome-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-cfs-me
#13
REVIEW
Matthew Corbitt, N Campagnolo, D Staines, S Marshall-Gradisnik
Gastrointestinal (GI) symptoms and irritable bowel (IB) symptoms have been associated with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME). The aim of this study was to conduct a systematic review of these symptoms in CFS/ME, along with any evidence for probiotics as treatment. Pubmed, Scopus, Medline (EBSCOHost) and EMBASE databases were searched to source relevant studies for CFS/ME. The review included any studies examining GI symptoms, irritable bowel syndrome (IBS) and/or probiotic use. Studies were required to report criteria for CFS/ME and study design, intervention and outcome measures...
February 20, 2018: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29426834/value-of-circulating-cytokine-profiling-during-submaximal-exercise-testing-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#14
Kegan J Moneghetti, Mehdi Skhiri, Kévin Contrepois, Yukari Kobayashi, Holden Maecker, Mark Davis, Michael Snyder, Francois Haddad, Jose G Montoya
Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS) is a heterogeneous syndrome in which patients often experience severe fatigue and malaise following exertion. Immune and cardiovascular dysfunction have been postulated to play a role in the pathophysiology. We therefore, examined whether cytokine profiling or cardiovascular testing following exercise would differentiate patients with ME/CFS. Twenty-four ME/CFS patients were matched to 24 sedentary controls and underwent cardiovascular and circulating immune profiling...
February 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29411266/a-molecular-neurobiological-approach-to-understanding-the-aetiology-of-chronic-fatigue-syndrome-myalgic-encephalomyelitis-or-systemic-exertion-intolerance-disease-with-treatment-implications
#15
REVIEW
Jean A Monro, Basant K Puri
Currently, a psychologically based model is widely held to be the basis for the aetiology and treatment of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME)/systemic exertion intolerance disease (SEID). However, an alternative, molecular neurobiological approach is possible and in this paper evidence demonstrating a biological aetiology for CFS/ME/SEID is adduced from a study of the history of the disease and a consideration of the role of the following in this disease: nitric oxide and peroxynitrite, oxidative and nitrosative stress, the blood-brain barrier and intestinal permeability, cytokines and infections, metabolism, structural and chemical brain changes, neurophysiological changes and calcium ion mobilisation...
February 6, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29409505/open-label-pilot-for-treatment-targeting-gut-dysbiosis-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-neuropsychological-symptoms-and-sex-comparisons
#16
Amy Wallis, Michelle Ball, Henry Butt, Donald P Lewis, Sandra McKechnie, Phillip Paull, Amber Jaa-Kwee, Dorothy Bruck
BACKGROUND: Preliminary evidence suggests that the enteric microbiota may play a role in the expression of neurological symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Overlapping symptoms with the acute presentation of D-lactic acidosis has prompted the use of antibiotic treatment to target the overgrowth of species within the Streptococcus genus found in commensal enteric microbiota as a possible treatment for neurological symptoms in ME/CFS. METHODS: An open-label, repeated measures design was used to examine treatment efficacy and enable sex comparisons...
February 6, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29391028/improvement-of-severe-myalgic-encephalomyelitis-chronic-fatigue-syndrome-symptoms-following-surgical-treatment-of-cervical-spinal-stenosis
#17
Peter C Rowe, Colleen L Marden, Scott Heinlein, Charles C Edwards
BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a potentially disabling disorder. Little is known about the contributors to severe forms of the illness. We describe three consecutive patients with severe ME/CFS whose symptoms improved after recognition and surgical management of their cervical spinal stenosis. METHODS: All patients satisfied clinical criteria for ME/CFS and orthostatic intolerance, and were later found to have cervical spinal stenosis...
February 2, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29375937/eukaryotes-in-the-gut-microbiota-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome
#18
Alexandra H Mandarano, Ludovic Giloteaux, Betsy A Keller, Susan M Levine, Maureen R Hanson
Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often suffer from gastrointestinal symptoms and many are diagnosed with irritable bowel syndrome (IBS). Previous studies, including from our laboratory, have demonstrated that the ME/CFS gut bacterial composition is altered and less diverse when compared to healthy individuals. Patients have increased biomarkers of inflammation and leaky gut syndrome. To further investigate dysbiosis in the ME/CFS gut microbiome, we sought to characterize the eukaryotes present in the gut of 49 individuals with ME/CFS and 39 healthy controls...
2018: PeerJ
https://www.readbyqxmd.com/read/29348374/-neurologic-abnormalities-in-myalgic-encephalomyelitis-chronic-fatigue-syndrome-a-review
#19
Anthony L Komaroff, Ryosuke Takahashi, Takashi Yamamura, Masanori Sawamura
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is an illness characterized by fatigue lasting for at least six months, post-exertional malaise, unrefreshing sleep, cognitive impairment and orthostatic intolerance. ME/CFS has been a controversial illness because it is defined exclusively by subjective complaints. However, recent studies of neuroimaging as well as analysis of blood markers, energy metabolism and mitochondrial function have revealed many objective biological abnormalities. Specifically, it is suspected that the symptoms of ME/CFS may be triggered by immune activation - either inside or outside the brain - through release of inflammatory cytokines...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29348373/-immunopathogenesis-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs
#20
Takashi Yamamura, Hirohiko Ono, Wakiro Sato
A recent study on the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has revealed an elevation of inflammatory and anti-inflammatory cytokines in the sera and cerebrospinal fluids of the patients and presence of autoantibodies in subgroups of ME/CFS patients. Furthermore, investigator-initiated clinical trials have proved the efficacy of anti-CD20 antibody (rituximab), that eliminate B cells, in the treatment of ME/CFS. Based on these findings, we hypothesize that immune abnormalities, such as enhanced autoimmune responses, may play an essential role in the neuroinflammatory pathogenesis of ME/CFS...
January 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
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