keyword
MENU ▼
Read by QxMD icon Read
search

Snare

keyword
https://www.readbyqxmd.com/read/27920656/successful-transanal-removal-of-a-rectal-foreign-body-by-abdominal-compression-under-endoscopic-and-x-ray-fluoroscopic-observation-a-case-report
#1
Hironobu Mikami, Norihisa Ishimura, Akihiko Oka, Ichiro Moriyama, Takafumi Yuki, Kousaku Kawashima, Shuichi Sato, Shunji Ishihara, Yoshikazu Kinoshita
We occasionally encounter patients with various types of rectal foreign bodies. When too large to grasp, transanal removal can be difficult. Here, we report a case of successful manual transanal removal of an 18 × 4 × 4 cm silicon rod without complications. A 50-year-old male came to the emergency department of our hospital 12 h after transanal insertion of a whole silicon rod. An abdominal examination showed no evidence of peritonitis, while X-ray and computed tomography findings revealed a large foreign body in the rectum, without any sign of perforation...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27913592/complexin-mutants-reveal-partial-segregation-between-recycling-pathways-that-drive-evoked-and-spontaneous-neurotransmission
#2
Nadezhda Sabeva, Richard W Cho, Alexander Vasin, Agustin Gonzalez, J Troy Littleton, Maria Bykhovskaia
: Synaptic vesicles fuse at morphological specializations in the presynaptic terminal termed active zones (AZs). Vesicle fusion can occur spontaneously or in response to an action potential. Following fusion, vesicles are retrieved and recycled within nerve terminals. It is still unclear whether vesicles that fuse spontaneously or following evoked release share similar recycling mechanisms. Genetic deletion of the SNARE-binding protein complexin dramatically increases spontaneous fusion, with the protein serving as the synaptic vesicle fusion clamp at Drosophila synapses...
December 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27911771/stability-folding-dynamics-and-long-range-conformational-transition-of-the-synaptic-t-snare-complex
#3
Xinming Zhang, Aleksander A Rebane, Lu Ma, Feng Li, Junyi Jiao, Hong Qu, Frederic Pincet, James E Rothman, Yongli Zhang
Synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) couple their stepwise folding to fusion of synaptic vesicles with plasma membranes. In this process, three SNAREs assemble into a stable four-helix bundle. Arguably, the first and rate-limiting step of SNARE assembly is the formation of an activated binary target (t)-SNARE complex on the target plasma membrane, which then zippers with the vesicle (v)-SNARE on the vesicle to drive membrane fusion. However, the t-SNARE complex readily misfolds, and its structure, stability, and dynamics are elusive...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27902705/neuronal-ndrg4-is-essential-for-nodes-of-ranvier-organization-in-zebrafish
#4
Laura Fontenas, Flavia De Santis, Vincenzo Di Donato, Cindy Degerny, Béatrice Chambraud, Filippo Del Bene, Marcel Tawk
Axon ensheathment by specialized glial cells is an important process for fast propagation of action potentials. The rapid electrical conduction along myelinated axons is mainly due to its saltatory nature characterized by the accumulation of ion channels at the nodes of Ranvier. However, how these ion channels are transported and anchored along axons is not fully understood. We have identified N-myc downstream-regulated gene 4, ndrg4, as a novel factor that regulates sodium channel clustering in zebrafish. Analysis of chimeric larvae indicates that ndrg4 functions autonomously within neurons for sodium channel clustering at the nodes...
November 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27900839/multicenter-midterm-follow-up-results-using-the-gore-septal-occluder-for-atrial-septal-defect-closure-in-pediatric-patients
#5
Jochen Grohmann, Christian Wildberg, Peter Zartner, Tariq Abu-Tair, Gleb Tarusinov, Erwin Kitzmüller, Claudia Schmoor, Brigitte Stiller, Christoph Kampmann
OBJECTIVES: To assess the safety and efficacy of the Gore Septal Occluder (GSO) used for device-closure of significant secundum-type atrial septal defects (ASD II) focusing on pediatric patients. BACKGROUND: The GSO is a patch-like double disc device. Due to its design, it is assumed to be safe, even when implanted in ASDs with deficient retro-aortic rims. METHODS: Multicenter retrospective analysis of consecutive children and adolescents with a GSO in situ for at least 12 months according to a 1- to 4-year midterm follow-up...
November 30, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27888110/tubby-domain-superfamily-protein-is-required-for-the-formation-of-the-7s-snare-complex-in-drosophila
#6
Eun Jang Yoon, Yong Taek Jeong, Ji Eun Lee, Seok Jun Moon, Chul Hoon Kim
Tubby domain superfamily protein (TUSP) is a distant member of the Tubby-like protein (TULP) family. Although other TULPs play important roles in sensation, metabolism, and development, the molecular functions of TUSP are completely unknown. Here, we explore the function of TUSP in the Drosophila nervous system where it is expressed in all neurons. Tusp mutant flies exhibit a temperature-sensitive paralysis. This paralysis can be rescued by tissue-specific expression of Tusp in the giant fibers and peripherally synapsing interneurons of the giant fiber system, a well-characterized neuronal circuit that mediates rapid escape behavior in flies...
November 22, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27885029/the-atg-conjugation-systems-are-important-for-degradation-of-the-inner-autophagosomal-membrane
#7
Kotaro Tsuboyama, Ikuko Koyama-Honda, Yuriko Sakamaki, Masato Koike, Hideaki Morishita, Noboru Mizushima
In macroautophagy, cytoplasmic contents are sequestered into the double-membrane autophagosome, which fuses with the lysosome to become the autolysosome. It has been thought that the autophagy-related (ATG) conjugation systems are required for autophagosome formation. Here, we found that autophagosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) syntaxin 17-positive autophagosome-like structures could be generated even in the absence of the ATG conjugation systems, although at a reduced rate...
November 25, 2016: Science
https://www.readbyqxmd.com/read/27881774/interactions-between-snap-25-and-synaptotagmin-1-are-involved-in-vesicle-priming-clamping-spontaneous-and-stimulating-evoked-neurotransmission
#8
Melanie Schupp, Jörg Malsam, Marvin Ruiter, Andrea Scheutzow, Keimpe D B Wierda, Thomas H Söllner, Jakob B Sørensen
: Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated. We examined five SNAP-25 mutations designed to interfere with syt-1 interactions. One mutation, D51/E52/E55A, targeted negative charges within region II of the primary interface (Zhou et al., 2015); two mutations targeted region I (D166A and D166/E170A) and one mutation targeted both (D51/E52/E55/D166A). The final mutation (D186/D193A) targeted C-terminal residues not expected to interact with syt-1...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881666/how-and-why-intralumenal-membrane-fragments-form-during-vacuolar-lysosome-fusion
#9
Sevan Mattie McNally, Erin K Karim, Mahmoud A Vali, Hojatollah Brett, Christopher L Brett
Lysosomal membrane fusion mediates the last step of the autophagy and endocytosis pathways, and supports organelle remodeling and biogenesis. Because fusogenic proteins and lipids concentrate in a ring at the vertex between apposing organelle membranes, the encircled area of membrane can be severed and internalized within the lumen as a fragment upon lipid bilayer fusion. How or why this intralumenal fragment forms during fusion, however, is not entirely clear. To better understand this process, we studied fragment formation during homotypic vacuolar lysosome membrane fusion in Saccharomyces cerevisiae Using cell-free fusion assays and light microscopy, we find that GTPase activation and trans-SNARE complex zippering have opposing effects on fragment formation, and verify that this impacts the morphology of the fusion product and regulates transporter protein degradation...
November 23, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27881461/lysosomal-dysfunction-disrupts-presynaptic-maintenance-and-restoration-of-presynaptic-function-prevents-neurodegeneration-in-lysosomal-storage-diseases
#10
Irene Sambri, Rosa D'Alessio, Yulia Ezhova, Teresa Giuliano, Nicolina Cristina Sorrentino, Vincenzo Cacace, Maria De Risi, Mauro Cataldi, Lucio Annunziato, Elvira De Leonibus, Alessandro Fraldi
Lysosomal storage disorders (LSDs) are inherited diseases characterized by lysosomal dysfunction and often showing a neurodegenerative course. There is no cure to treat the central nervous system in LSDs. Moreover, the mechanisms driving neuronal degeneration in these pathological conditions remain largely unknown. By studying mouse models of LSDs, we found that neurodegeneration develops progressively with profound alterations in presynaptic structure and function. In these models, impaired lysosomal activity causes massive perikaryal accumulation of insoluble α-synuclein and increased proteasomal degradation of cysteine string protein α (CSPα)...
November 25, 2016: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/27866894/syp73-anchors-the-er-to-the-actin-cytoskeleton-for-maintenance-of-er-integrity-and-streaming-in-arabidopsis
#11
Pengfei Cao, Luciana Renna, Giovanni Stefano, Federica Brandizzi
The endoplasmic reticulum (ER) is an essential organelle that spreads throughout the cytoplasm as one interconnected network of narrow tubules and dilated cisternae that enclose a single lumen. The ER network undergoes extensive remodeling, which critically depends on membrane-cytoskeleton interactions [1]. In plants, the ER is also highly mobile, and its streaming contributes significantly to the movement of other organelles [2, 3]. The remodeling and motility of the plant ER rely mainly on actin [4] and to a minor extent on microtubules [5]...
December 5, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27860188/techniques-for-transcatheter-retrieval-of-the-occlutech-asd-device-united-kingdom-european-multicenter-report
#12
Suhair O Shebani, Rizwan Rehman, Demetris Taliotis, Alan Magee, Nicholas J Hayes, Osman Baspinar, Zunzunegui Martínez, Nikolaus Haas, Christopher Duke
To gather current experience in Occlutech ASD device retrieval, to determine whether snaring is an effective technique and to highlight alternative retrieval techniques; METHODS AND RESULTS: United Kingdom and European Occlutech ASD device implanters reported their experience in dealing with device embolization and retrieval. Six operators reported 12 retrieval cases. Retrieval was successful in 92% (11/12), although in most cases it was not straightforward and required multiple attempts using different techniques and equipment...
November 10, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27855700/snap23-promotes-the-malignant-process-of-ovarian-cancer
#13
Qi Sun, Xing Huang, Quanli Zhang, Junwei Qu, Yang Shen, Xin Wang, Haijun Sun, Jie Wang, Lin Xu, Xiaoxiang Chen, Binhui Ren
BACKGROUND: Ovarian cancer (OC) was the primary malignant gynecological cancer and SNARE protein is closely related with tumor progression. Here, we identified SNAP23, a member of SNARE complex, as a potential oncogene in OC. METHODS: We determined the expression of SNAP23 in OC tissues and explored the clinical significance through bioinformatics analysis. The effects of SNAP23 on OC cell proliferation, migration, invasion, cell cycle and apoptosis were then evaluated in vitro...
November 17, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27852901/multivalent-rab-interactions-determine-tether-mediated-membrane-fusion
#14
Anna Lürick, Jieqiong Gao, Anne Kuhlee, Erdal Yavavli, Lars Langemeyer, Angela Perz, Stefan Raunser, Christian Ungermann
Membrane fusion at endomembranes requires crosstalk between Rab GTPases and tethers to drive SNARE-mediated lipid bilayer mixing. Several tethers have multiple Rab binding sites with largely untested function. Here, we dissected the lysosomal HOPS complex as a tethering complex with just two binding sites for the Rab7-like Ypt7 protein to determine their relevance for fusion. Using tethering and fusion assays combined with HOPS mutants we show that HOPS-dependent fusion requires both Rab binding sites, with Vps39 being the stronger Ypt7-interactor than Vps41...
November 16, 2016: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27852880/endovascular-treatment-of-complex-carotid-jugular-fistula-case-report-of-an-alternative-technique-using-the-superficial-temporal-artery
#15
Gonzalo Alonso-Argüeso, Alejandro Rodriguez-Morata, Blanca Vera-Arroyo, Maria Jesus Lara-Villoslada, Rafael Gomez-Medialdea
Inadvertent complications of jugular vein catheterization are not uncommon, however, a persistent symptomatic carotid-jugular fistula has been rarely reported. A 72-year-old male with infected surgical wound after coxofemoral disarticulation for sarcoma presented with symptoms of acute right heart failure. A fistula between the right common carotid artery (CCA) and the internal jugular vein was demonstrated on Doppler ultrasound and confirmed on computed tomography angiogram. Catheterization of the right CCA seemed not possible using a conventional femoral approach due to the tortuosity and elongation of the brachiocephalic artery...
November 16, 2016: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27851940/a-coiled-coil-peptide-shaping-lipid-bilayers-upon-fusion
#16
Martin Rabe, Christopher Aisenbrey, Kristyna Pluhackova, Vincent de Wert, Aimee L Boyle, Didjay F Bruggeman, Sonja A Kirsch, Rainer A Böckmann, Alexander Kros, Jan Raap, Burkhard Bechinger
A system based on two designed peptides, namely the cationic peptide K, (KIAALKE)3, and its complementary anionic counterpart called peptide E, (EIAALEK)3, has been used as a minimal model for membrane fusion, inspired by SNARE proteins. Although the fact that docking of separate vesicle populations via the formation of a dimeric E/K coiled-coil complex can be rationalized, the reasons for the peptides promoting fusion of vesicles cannot be fully explained. Therefore it is of significant interest to determine how the peptides aid in overcoming energetic barriers during lipid rearrangements leading to fusion...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27851936/hidden-markov-modeling-with-detailed-balance-and-its-application-to-single-protein-folding
#17
Yongli Zhang, Junyi Jiao, Aleksander A Rebane
Hidden Markov modeling (HMM) has revolutionized kinetic studies of macromolecules. However, results from HMM often violate detailed balance when applied to the transitions under thermodynamic equilibrium, and the consequence of such violation has not been well understood. Here, to our knowledge, we developed a new HMM method that satisfies detailed balance (HMM-DB) and optimizes model parameters by gradient search. We used free energy of stable and transition states as independent fitting parameters and considered both normal and skew normal distributions of the measurement noise...
November 15, 2016: Biophysical Journal
https://www.readbyqxmd.com/read/27851892/the-sec-domain-protein-scfd1-facilitates-trafficking-of-ecm-components-during-chondrogenesis
#18
Ningning Hou, Yuxi Yang, Ian C Scott, Xin Lou
Chondrogenesis in the developing skeleton requires transformation of chondrocytes from a simple mesenchymal condensation to cells with a highly enriched extracellular matrix (ECM). This transition is in part accomplished by alterations in the chondrocyte protein transport machinery to cope with both the increased amount and large size of ECM components. In a zebrafish mutagenesis screen to identify genes essential for cartilage development, we uncovered a mutant that disrupts the gene encoding Sec1 family domain containing 1 (scfd1)...
November 13, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27848265/the-nuts-and-bolts-of-the-platelet-release-reaction
#19
Smita Joshi, Sidney W Whiteheart
Secretion is essential to many of the roles that platelets play in the vasculature, e.g., thrombosis, angiogenesis, and inflammation, enabling platelets to modulate the microenvironment at sites of vascular lesions with a myriad of bioactive molecules stored in their granules. Past studies demonstrate that granule cargo release is mediated by Soluble NSF Attachment Protein Receptor (SNARE) proteins, which are required for granule-plasma membrane fusion. Several SNARE regulators, which control when, where, and how the SNAREs interact, have been identified in platelets...
November 16, 2016: Platelets
https://www.readbyqxmd.com/read/27843431/two-patients-with-large-colonic-lipomas-for-which-endoscopic-unroofing-was-ineffective
#20
Yuichi Tomiki, Koichiro Niwa, Kiichi Nagayasu, Yu Okazawa, Shingo Ito, Ryosuke Ichikawa, Hisashi Ro, Shun Ishiyama, Kiichi Sugimoto, Kazuhiro Sakamoto
Endoscopic unroofing is effective for treating large colonic lipomas. However, additional endoscopic resection is occasionally required when the outcomes of initial unroofing are incomplete. The colonoscopy of an 82-year-old woman with abdominal pain revealed a yellowish lipoma of about 20 mm in the transverse colon. The mass was treated by unroofing, but a follow-up colonoscopy 5 days later revealed residual lipoma. One month later, the regenerated surface had become covered with mucosa, and the status of the lipoma had returned to that before unroofing...
September 2016: Case Reports in Gastroenterology
keyword
keyword
72076
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"