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https://www.readbyqxmd.com/read/29774225/polypectomy-for-recurrent-inflammatory-cap-polyposis-combined-with-argon-plasma-coagulation
#1
Soros Anuchapreeda, Patduangpuk Phengsuthi, Prapimphan Aumpansub, Naruemon Wisedopas, Thawee Ratanachuek
A 15-year-old adolescent boy presented with chronic constipation, difficulty in defecation, and episodic bloody stools. A rectal mass lesion was digitally palpated. Colonoscopy showed a large circumferential polypoid lesion of the mid-rectum. Snare polypectomy was performed, and histopathology confirmed a diagnosis of benign inflammatory cap polyposis. At 3-month follow-up, sigmoidoscopy showed multiple recurrences of polyps at the site of the previous rectal polypectomy, which were removed by combined hot snare polypectomy and argon plasma coagulation...
2018: ACG Case Reports Journal
https://www.readbyqxmd.com/read/29771640/phosphorylation-of-snap-23-at-ser95-causes-a-structural-alteration-and-negatively-regulates-fc-receptor-mediated-phagosome-formation-and-maturation-in-macrophages
#2
Chiye Sakurai, Makoto Itakura, Daiki Kinoshita, Seisuke Arai, Hitoshi Hashimoto, Ikuo Wada, Kiyotaka Hatsuzawa
SNAP-23 is a plasma membrane-localized SNARE protein involved in Fc receptor (FcR)-mediated phagocytosis. However, the regulatory mechanism underlying its function remains elusive. Using phosphorylation specific-antibodies, SNAP-23 was found to be phosphorylated at Ser95 in macrophages. To understand the role of this phosphorylation, we established macrophage lines overexpressing the non-phosphorylatable S95A or the phospho-mimicking S95D mutation. The efficiency of phagosome formation and maturation was severely reduced in SNAP-23-S95D-overexpressing cells...
May 17, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29770746/-express-chronic-inflammatory-pain-decreases-the-glutamate-vesicles-in-presynaptic-terminals-of-the-nucleus-accumbens
#3
Chuchu Qi, Baolin Guo, Keke Ren, Han Yao, Mengmeng Wang, Tangna Sun, Guohong Cai, Haiying Liu, Rui Li, Ceng Luo, Wenting Wang, Sheng-Xi Wu
Reward system has been proved to be important to nociceptive behavior, and the nucleus accumbens (NAc) is a key node in reward circuitry. It has been further revealed that dopamine system modulates the NAc to influence the pain sensation, whereas the role of glutamatergic projection in the NAc in the modulation of chronic pain is still elusive. In this study, we used a Complete Freund adjuvant (CFA) -induced chronic inflammatory pain model to explore the changes of the glutamatergic terminals in the NAc, and we found that following the chronic inflammation, the protein level of vesicular glutamate transporters1 (VGLUT1) was significant decreased in the NAc...
January 1, 2018: Molecular Pain
https://www.readbyqxmd.com/read/29769303/how-alternative-splicing-affects-membrane-trafficking-dynamics
#4
REVIEW
R Eric Blue, Ennessa G Curry, Nichlas M Engels, Eunice Y Lee, Jimena Giudice
The cell biology field has outstanding working knowledge of the fundamentals of membrane-trafficking pathways, which are of critical importance in health and disease. Current challenges include understanding how trafficking pathways are fine-tuned for specialized tissue functions in vivo and during development. In parallel, the ENCODE project and numerous genetic studies have revealed that alternative splicing regulates gene expression in tissues and throughout development at a post-transcriptional level. This Review summarizes recent discoveries demonstrating that alternative splicing affects tissue specialization and membrane-trafficking proteins during development, and examines how this regulation is altered in human disease...
May 16, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29768434/plasma-membrane-insertion-of-kca2-3-sk3-is-dependent-upon-the-snare-proteins-syntaxin-4-and-snap23
#5
Claudia A Bertuccio, Tony T Wang, Kirk L Hamilton, Diego J Rodriguez-Gil, Steven B Condliffe, Daniel C Devor
We previously demonstrated endocytosis of KCa2.3 is caveolin-1-, dynamin II- and Rab5-dependent. KCa2.3 then enters Rab35/EPI64C- and RME-1-containing recycling endosomes and is returned to the plasma membrane (PM). Herein, we report on the mechanism by which KCa2.3 is inserted into the PM during recycling and following exit from the Golgi. We demonstrate KCa2.3 colocalizes with SNAP-23 and Syntaxin-4 in the PM of HEK and endothelial cells by confocal immunofluorescence microscopy. We further show KCa2.3 can be co-immunoprecipitated with SNAP-23 and Syntaxin-4...
2018: PloS One
https://www.readbyqxmd.com/read/29767852/membrane-tethered-syntaxin-4-locally-abrogates-e-cadherin-function-and-activates-smad-signals-contributing-to-asymmetric-mammary-epithelial-morphogenesis
#6
Yuina Hirose, Kota Shirai, Yohei Hirai
Spatial and temporal epithelial-mesenchymal transition (EMT) is a critical event for the generation of asymmetric epithelial architectures. We found that only restricted cell populations in the morphogenic mammary epithelia extrude syntaxin-4, a plasmalemmal t-SNARE protein, and that epithelial cell clusters with artificial heterogenic presentation of extracellular syntaxin-4 undergo asymmetric morphogenesis. A previous study revealed that inducible expression of cell surface syntaxin-4 causes EMT-like cell behaviors in the clonal mammary epithelial cells, where laminin-mediated signals were abolished so that cells readily succumb to initiate EMT...
May 16, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29764714/bronchoscopic-resection-of-a-tracheobronchial-leiomyoma-in-a-pregnant-patient
#7
K Falce, E Guy, D Hyman, T Hotze, D Lazarus, V Bandi, J Parchem, C Davidson, U Munnur
Flexible bronchoscopy, therapeutic bronchoscopy and other procedures requiring anesthesia are generally avoided in pregnancy and postponed until after delivery if possible. We report a case of a parturient with an abnormal chest radiograph and mild obstructive symptoms of unknown etiology. At bronchoscopy, a tumor associated with post-obstructive suppuration was found and excised using electrocautery snare and cryotherapy, for restoration of airway patency. Coordination between pulmonary, obstetric, anesthesia, neonatology and thoracic surgery services was essential in ensuring success and the safety of the mother and fetus...
April 10, 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29764010/the-tenting-into-an-external-snare-technique-a-novel-singlechannel-traction-approach-for-endoscopic-resection-of-difficultto-access-lesions-using-a-wide-necked-cap
#8
https://www.readbyqxmd.com/read/29763988/adjusting-the-length-and-direction-of-the-redundant-duodenal-stent-using-a-detachable-snare-and-endoclips
#9
Takashi Sasaki, Toshiyuki Yoshio, Junko Fujisaki
A 43-year-old woman with advanced gastric cancer was presented with gastric outlet obstruction. Duodenal stent (WallFlex duodenal soft 22mm x 12cm, Boston Scientific, Japan) was deployed to cover the stricture between antrum and 2nd part of duodenum. The stent did not expand fully because of the tight stricture even after balloon dilation. The stent became longer than expected which caused the kinking at the stomach (Figure 1). This article is protected by copyright. All rights reserved.
May 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29756168/transsplenic-splenoportography-and-portal-venous-interventions-in-pediatric-patients
#10
Eric J Monroe, Ethan J Speir, C Matthew Hawkins, Giri Shivaram, Kevin S H Koo, Anne E Gill
BACKGROUND: Data regarding transsplenic portal venous access for diagnostic imaging and endovascular intervention in children are limited, possibly due to concerns regarding high bleeding risks and resultant underutilization. OBJECTIVE: To investigate the safety and utility of transsplenic splenoportography and portal venous interventions in children. MATERIALS AND METHODS: A retrospective review was performed of all pediatric patients undergoing percutaneous transsplenic portal venous access and intervention at two large tertiary pediatric institutions between January 2012 and April 2017 was performed...
May 13, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29756021/full-thickness-resection-with-an-over-the-scope-device-possible-translocation-of-adenoma-tissue-in-a-case-of-an-incomplete-resection-at-the-appendix
#11
Franz Ludwig Dumoulin, Dominik G Gorris, Susanne Berger, Ralf Hildenbrand, Bernd Sido
Background and study aims  Clip-assisted endoscopic full-thickness resection has great potential for treatment of difficult-to-resect colorectal neoplasia. Here, we report on endoscopic full-thickness resection at the appendiceal orifice with the appendix in situ requiring emergency surgery due to acute appendicitis. Final histopathology showed appendicitis and residual serrated adenoma within the appendiceal stump, but unexpectedly, also a displaced adenoma fragment at the serosal surface of the cecum. Given the transmural placement of the clip prior to snare resection, translocation of neoplastic tissue to the extra luminal site in cases of incomplete adenoma/carcinoma resection could be a concern...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29756018/a-structured-light-laser-probe-for-gastrointestinal-polyp-size-measurement-a-preliminary-comparative-study
#12
Marco Visentini-Scarzanella, Hiroshi Kawasaki, Ryo Furukawa, Marco Augusto Bonino, Simone Arolfo, Giacomo Lo Secco, Alberto Arezzo, Arianna Menciassi, Paolo Dario, Gastone Ciuti
Background and study aims:  Polyp size measurement is an important diagnostic step during gastrointestinal endoscopy, and is mainly performed by visual inspection. However, lack of depth perception and objective reference points are acknowledged factors contributing to measurement errors in polyp size. In this paper, we describe the proof-of-concept of a polyp measurement device based on structured light technology for future endoscopes. Patients and methods:  Measurement accuracy, time, user confidence, and satisfaction were evaluated for polyp size assessment by (a) visual inspection, (b) open biopsy forceps of known size, (c) ruled snare, and (d) structured light probe, for a total of 392 independent polyp measurements in ex vivo porcine stomachs...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29752624/g%C3%AE-%C3%AE-snare-interactions-and-their-behavioral-effects
#13
Simon Alford, Heidi Hamm, Shelagh Rodriguez, Zack Zurawski
Presynaptic terminals possess interlocking molecular mechanisms that control exocytosis. An example of such complexity is the modulation of release by presynaptic G Protein Coupled Receptors (GPCRs). GPCR ubiquity at synapses-GPCRs are present at every studied presynaptic terminal-underlies their critical importance in synaptic function. GPCRs mediate presynaptic modulation by mechanisms including via classical Gα effectors, but membrane-delimited actions of Gβγ can also alter probability of release by altering presynaptic ionic conductances...
May 11, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29746582/assembly-hub-function-of-er-localized-snare-proteins-in-biogenesis-of-tombusvirus-replication-compartment
#14
Zsuzsanna Sasvari, Nikolay Kovalev, Paulina Alatriste Gonzalez, Kai Xu, Peter D Nagy
Positive-strand RNA viruses assemble numerous membrane-bound viral replicase complexes within large replication compartments to support their replication in infected cells. Yet the detailed mechanism of how given subcellular compartments are subverted by viruses is incompletely understood. Although, Tomato bushy stunt virus (TBSV) uses peroxisomal membranes for replication, in this paper, we show evidence that the ER-resident SNARE (soluble NSF attachment protein receptor) proteins play critical roles in the formation of active replicase complexes in yeast model host and in plants...
May 10, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29736249/activation-of-disease-resistance-against-botryosphaeria-dothidea-by-downregulating-the-expression-of-mdsyp121-in-apple
#15
Xiaowen He, Yanhong Huo, Xiuxia Liu, Qianqian Zhou, Shouqian Feng, Xiang Shen, Baohua Li, Shujing Wu, Xuesen Chen
In plants, the vesicle fusion process plays a vital role in pathogen defence. However, the importance of the vesicle fusion process in apple ring rot has not been studied. Here, we isolated and characterised the apple syntaxin gene MdSYP121 . Silencing the MdSYP121 gene in transgenic apple calli increased tolerance to Botryosphaeria dothidea infection; this increased tolerance was correlated with salicylic acid (SA) synthesis-related and signalling-related gene transcription. In contrast, overexpressing MdSYP121 in apple calli resulted in the opposite phenotypes...
2018: Horticulture Research
https://www.readbyqxmd.com/read/29719552/direct-aspiration-catheter-fracture-and-retrieval-during-neurothrombectomy
#16
Pouria Moshayedi, Ashutosh P Jadhav
Background: Application of direct aspiration catheters has revolutionized acute stroke care and has led to significant improvement in clinical outcome with a good safety profile. Catheter fracture and retention is a rare but potentially devastating complication. Case Description: Here we present two cases of acute stroke complicated by aspiration catheter fracture and retention. Successful catheter retrieval and revascularization was achieved in both cases. The stenosis or tortuosity of vascular anatomy appears to be the probable contributor to catheter breakage by anchoring the catheter with resultant fracture at the constraint point from catheter withdrawal tensile stress...
April 2018: Interventional Neurology
https://www.readbyqxmd.com/read/29718541/differential-cell-surface-recruitment-of-the-superoxide-producing-nadph-oxidases-nox1-nox2-and-nox5-the-role-of-the-small-gtpase-sar1
#17
Takuya Kiyohara, Kei Miyano, Sachiko Kamakura, Junya Hayase, Kanako Chishiki, Akira Kohda, Hideki Sumimoto
Transmembrane glycoproteins, synthesized at the endoplasmic reticulum (ER), generally reach the Golgi apparatus in COPII-coated vesicles en route to the cell surface. Here, we show that the bona fide nonglycoprotein Nox5, a transmembrane superoxide-producing NADPH oxidase, is transported to the cell surface in a manner resistant to co-expression of Sar1 (H79G), a GTP-fixed mutant of the small GTPase Sar1, which blocks COPII vesicle fission from the ER. In contrast, Sar1 (H79G) effectively inhibits ER-to-Golgi transport of glycoproteins including the Nox5-related oxidase Nox2...
May 2, 2018: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/29706534/ca-2-triggered-synaptic-vesicle-fusion-initiated-by-release-of-inhibition
#18
REVIEW
Axel T Brunger, Jeremy Leitz, Qiangjun Zhou, Ucheor B Choi, Ying Lai
Recent structural and functional studies of the synaptic vesicle fusion machinery suggest an inhibited tripartite complex consisting of neuronal soluble N-ethylmaleimide sensitive factor attachment protein receptors (SNAREs), synaptotagmin, and complexin prior to Ca2+ -triggered synaptic vesicle fusion. We speculate that Ca2+ -triggered fusion commences with the release of inhibition by Ca2+ binding to synaptotagmin C2 domains. Subsequently, fusion is assisted by SNARE complex zippering and by active membrane remodeling properties of synaptotagmin...
April 26, 2018: Trends in Cell Biology
https://www.readbyqxmd.com/read/29705273/cold-snare-protrusion
#19
V Zimmer
No abstract text is available yet for this article.
April 25, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29701342/endovascular-removal-of-foreign-bodies
#20
Roger Rodrigues, Alfredo Agostinho, Gabriel Anacleto, Paula Branco, Óscar Gonçalves
INTRODUCTION: Intravascular or catheter embolization of a foreign body, either by fracture or migration, is a rare condition, occurring in approximately 1%. This study is focused on the migration of catheters since they represent the majority of cases of embolization. We present one of the largest published series of removal of foreign bodies with endovascular techniques. The objective of the present study is to demonstrate the different locations where foreign bodies, in most cases catheters, can reach, the technique used to remove them and the affected population...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
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