Marc Oliva, Alya Heirali, Geoffrey Watson, Ashley M Rooney, Kyla Cochrane, Sarah Jennings, Rachel Taylor, Minge Xu, Ali Hosni, Andrew Hope, Scott V Bratman, Douglas Chepeha, Ilan Weinreb, Bayardo Perez-Ordonez, Ricard Mesia Nin, John Waldron, Wei Xu, Aaron R Hansen, Lillian L Siu, Bryan Coburn, Anna Spreafico
BACKGROUND: Gut microbiome modulation to boost antitumor immune responses is under investigation. METHODS: ROMA-2 evaluated the microbial ecosystem therapeutic (MET)-4 oral consortia, a mixture of cultured human stool-derived immune-responsiveness associated bacteria, given with chemoradiation (CRT) in HPV-related oropharyngeal cancer patients. Co-primary endpoints were safety and changes in stool cumulative MET-4 taxa relative abundance (RA) by 16SRNA sequencing...
May 7, 2024: British Journal of Cancer