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hpv squamous cell carcinoma

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https://www.readbyqxmd.com/read/29788963/cervical-small-cell-carcinoma-frequently-presented-in-multiple-high-risk-hpv-infection-and-often-associated-with-other-type-of-epithelial-tumors
#1
Peifeng Li, Jing Ma, Xiumin Zhang, Yong Guo, Yixiong Liu, Xia Li, Danhui Zhao, Zhe Wang
BACKGROUND: Small cell carcinoma of the uterine cervix is a rare and highly malignant tumor, and its etiopathogenesis is strongly related to high-risk HPV infections. METHODS: The clinicopathological data of 30 cases of cervical primary small cell carcinoma were retrospectively analyzed. In situ hybridization, polymerase chain reaction and reverse dot-blot hybridization were employed to detect HPV DNA in both small cell carcinoma and other coexisting epithelial tumors...
May 22, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29779759/correlation-of-human-papilloma-virus-status-with-quantitative-perfusion-diffusion-metabolic-imaging-parameters-in-the-oral-cavity-and-oropharyngeal-squamous-cell-carcinoma-comparison-of-primary-tumour-sites-and-metastatic-lymph-nodes
#2
M Han, S J Lee, D Lee, S Y Kim, J W Choi
AIM: To investigate the differences in perfusion/diffusion/metabolic imaging parameters according to human papilloma virus (HPV) status in the oral cavity and oropharyngeal squamous cell carcinoma (OC-OPSCC), separately in primary tumour sites and metastatic lymph nodes. MATERIALS AND METHODS: This retrospective study comprised 41 patients with primary OC-OPSCCs and 29 patients with metastatic lymph nodes. The perfusion/diffusion/metabolic imaging parameters were measured at the primary tumour and the largest ipsilateral metastatic lymph node...
May 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29775416/downregulation-of-the-%C3%AE-1-and-%C3%AE-1-subunit-of-sgc-in-arterial-smooth-muscle-cells-of-opscc-is-hpv-independent
#3
Y Korkmaz, H C Roggendorf, O G Siefer, J Seehawer, T Imhof, M Plomann, W Bloch, A Friebe, C U Huebbers
The nitric oxide (NO)-sensitive soluble guanylyl cyclase (sGC) is a heterodimeric enzyme with an α and β subunit. NO binds to heme of the β1 -subunit of sGC, activates the enzyme in the reduced heme iron state in vascular smooth muscle cells (VSMCs), and generates cGMP-inducing vasodilatation and suppression of VSMC proliferation. In the complex tumor milieu with higher levels of reactive oxygen species (ROS), sGC heme iron may become oxidized and insensitive to NO. To change sGC from an NO-insensitive to NO-sensitive state or NO-independent manner, protein expression of sGC in VSMC is required...
May 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29774396/tumor-volume-as-a-prognostic-marker-in-p16-positive-and-p16-negative-oropharyngeal-cancer-patients-treated-with-definitive-intensity-modulated-radiotherapy
#4
Timo Carpén, Kauko Saarilahti, Caj Haglund, Antti Markkola, Jussi Tarkkanen, Jaana Hagström, Petri Mattila, Antti Mäkitie
PURPOSE: To investigate the impact of primary gross tumor volume (pGTV) and nodal gross tumor volume (nGTV) in oropharyngeal squamous cell carcinoma (OPSCC) and the difference in their role between human papillomavirus (HPV)-positive and HPV-negative patients. METHODS: The patient cohort consists of 91 OPSCC patients treated with definitive radiochemotherapy or radiotherapy using intensity-modulated radiotherapy (IMRT). All patients had a minimum follow-up of 31 months...
May 17, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29774090/strong-sod2-expression-and-hpv-16-18-positivity-are-independent-events-in-cervical-cancer
#5
Silvia Helena Rabelo-Santos, Lara Termini, Enrique Boccardo, Sophie Derchain, Adhemar Longatto-Filho, Maria Antonieta Andreoli, Maria Cecília Costa, Rafaella Almeida Lima Nunes, Liliana Aparecida Lucci Ângelo-Andrade, Luisa Lina Villa, Luiz Carlos Zeferino
It is well known that persistent infection with high-risk HPV (hr-HPV), mostly HPV-16 and 18, is the main cause of cervical cancer development. Manganese superoxide dismutase (MnSOD or SOD2) are highly expressed in different neoplasia. The present study investigated SOD2 protein expression and the presence of hr-HPV types in 297 cervical samples including non-neoplastic tissue, cervical intraepithelial neoplasia grade 3 (CIN3), squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Strong SOD2 expression was significantly higher in ADC (82%) than CIN3 (52%) or SCC (64%)...
April 24, 2018: Oncotarget
https://www.readbyqxmd.com/read/29770611/the-changing-aetiology-of-head-and-neck-squamous-cell-cancer-a-tale-of-three-cancers
#6
Steven J Thomas, Chris M Penfold, Andrea Waylen, Andrew R Ness
Head and neck cancers are the sixth most common cancers worldwide and an important cause of ill health.(1) Each year about 9000 cases are reported in the UK.(2) Survival is poor and despite advances in treatment, has not improved until recently.(3) The majority of head and neck cancers are squamous cell carcinomas, affecting the larynx, oropharynx and oral cavity. The aetiology is changing and this has implications for prevention and treatment. Twenty years ago, tobacco and alcohol consumption were considered to be the established risk factors and it was estimated that these risk factors accounted for about 75% of cases...
May 16, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29764277/human-papillomavirus-hpv-is-absent-in-branchial-cleft-cysts-of-the-neck-distinguishing-them-from-hpv-positive-cystic-metastasis
#7
Lars Sivars, David Landin, Marzia Rizzo, Linnea Haeggblom, Cinzia Bersani, Eva Munck-Wikland, Anders Näsman, Tina Dalianis, Linda Marklund
BACKGROUND: Distinguishing branchial cleft cysts (BCCs) from cystic metastases of a human papillomavirus (HPV) positive oropharyngeal squamous cell carcinoma (OPSCC) is challenging. Fine needle aspirates (FNAs) from cystic metastasis may be non-representative, while reactive squamous cells from BCC can be atypic. Based on cytology and with the support of HPV DNA positivity many centers treat cystic metastasis oncological and thus patients are spared neck dissection. To do so safely, one must investigate whether HPV DNA and p16INK4a overexpression is found exclusively in cystic metastases and not in BCC...
May 15, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29764025/-research-progress-in-pathogenesis-treatment-and-prognosis-of-hpv-positive-head-and-neck-squamous-cell-carcinoma
#8
C Y Shui, C Li, W Liu, Y C Cai, J Jiang, R H Sun, Y Q Zhou, G Qin
Head and neck squamous cell carcinoma (HNSCC) is the sixth common malignant tumors of whole body with a high incidence, which accounts for 90% of the head and neck malignant tumors. Previous studies have shown the risk factors, such as tobacco and alcohol, are related to the occurrence and development of HNSCC. However, recent studies have shown that the non-tobacco and non-alcohol related HNSCC increased year by year. At the same time, more and more studies have shown that HNSCC is related to the infection with human papilloma virus (HPV), and the occurrence and development of HPV-positive HNSCC has own characteristics in epidemiology, pathogenesis, treatment and prognosis...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29763978/circulating-human-papillomavirus-dna-as-a-surveillance-tool-in-head-and-neck-squamous-cell-carcinoma-a-systematic-review-and-meta-analysis
#9
Kristina Kvist Jensen, Christian Grønhøj, David H Jensen, Christian von Buchwald
BACKGROUND: The incidence of human papillomavirus-induced (HPV+) head and neck squamous cell carcinoma (HNSCC) i.e. especially oropharyngeal cancers (OPSCC) is increasing and a significant proportion of patients encounter disease progression. A simple and sensitive test to identify patients with progression is an unmet need. OBJECTIVE OF REVIEW: To systematically review the literature and carry out a meta-analysis of studies, investigated circulating HPV-DNA as a biomarker for disease progression in patients with HNSCC...
May 15, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29760583/lncrna-pvt1-promotes-the-growth-of-hpv-positive-and-negative-cervical-squamous-cell-carcinoma-by-inhibiting-tgf-%C3%AE-1
#10
Xiuli Wang, Guichan Wang, Lijuan Zhang, Jianglin Cong, Jianqing Hou, Chunyan Liu
Background: Our study aimed to investigate the role of lncRNA PVT1 in cervical squamous cell carcinoma. Materials and methods: A total of 156 patients with cervical squamous cell carcinoma were enrolled in this study and human papillomavirus (HPV) infection was detected by highly sensitive PCR techniques. Serum levels of PVT1 in patients infected with different HPVs and healthy controls was detected by qRT-PCR and compared. Serum levels of PVT1 were also compared among patients with different sizes of tumor...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29759330/-who-classification-of-head-and-neck-tumours-2017-main-novelties-and-update-of-diagnostic-methods
#11
REVIEW
Victor Sarradin, Aurore Siegfried, Emmanuelle Uro-Coste, Jean-Pierre Delord
The publication of the new WHO classification of head and neck tumours in 2017 brought major modifications. Especially, a new chapter is dedicated to the oropharynx, focusing on the description of squamous cell carcinoma induced by the virus Human Papilloma Virus (HPV), and new entities of tumors are described in nasal cavities and sinuses. In this article are presented the novelties and main changes of this new classification, as well as the updates of the diagnostic methods (immunohistochemistry, cytogenetics or molecular biology)...
May 11, 2018: Bulletin du Cancer
https://www.readbyqxmd.com/read/29756301/oligometastatic-status-as-predictor-of-survival-in-metastatic-human-papillomavirus-positive-oropharyngeal-carcinoma
#12
William G Albergotti, Shira Abberbock, Fasil Mathews, Robert L Ferris, Jonas T Johnson, Umamaheswar Duvvuri, Seungwon Kim
BACKGROUND: Oligometastasis is a good prognostic indicator when compared to widely metastatic disease in malignancies of other organ systems. We hypothesized that oligometastasis in human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (SCC) would be associated with better overall survival. METHODS: This is a retrospective review of all HPV-positive oropharyngeal SCC treated at one center with at least 1-year of follow-up. Patients were stratified into 2 cohorts: oligometastasis (1-2 metastases, confined to 1 organ system) or polymetastasis (>2 metastases or multiple organ involvement) with cohorts compared for time to distant metastasis and overall survival after metastasis...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29754260/robotic-lateral-oropharyngectomy-following-diagnostic-tonsillectomy-is-oncologically-safe-in-patients-with-high-risk-human-papillomavirus-related-squamous-cell-cancer
#13
Somiah Siddiq, David Cartlidge, Sarah Stephen, Hans P Sathasivam, Hannah Fox, James O'Hara, David Meikle, Muhammad Shahid Iqbal, Charles G Kelly, Max Robinson, Vinidh Paleri
PURPOSE: Diagnostic tonsillectomy is rarely an oncologic operation owing to close or positive margins. The standard of care is for further treatment to the primary site, typically with adjuvant radiotherapy. METHODS: 14 patients with close or positive margins following a diagnostic tonsillectomy underwent transoral robotic surgery (TORS) and lateral oropharyngectomy; five patients with the longest follow-up had their excision specimens examined with a step serial sectioning technique (SSS)...
May 12, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/29750853/depth-of-invasion-on-pathological-outcomes-in-clinical-low-stage-oral-tongue-cancer-patients
#14
Maheer M Masood, Douglas R Farquhar, Jessica P Vanleer, Samip N Patel, Trevor G Hackman
OBJECTIVES: Depth of invasion was added to the 8th edition American Joint Committee on Cancer guidelines for T staging of HPV-negative oral cavity squamous cell carcinoma. Our aim is to determine the impact of depth of invasion on pathological variables and outcomes in low-stage tongue cancer patients. We also examine the impact of tumor thickness and tumor clinical staging for comparison. SUBJECTS AND METHODS: All clinical T1/T2 N0 HPV negative tongue squamous cell carcinoma patients who received elective neck dissections at our institution between 2000 and 2015 were included...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29750709/classic-vulvar-intraepithelial-neoplasia-with-superimposed-lichen-simplex-chronicus-a-unique-variant-mimicking-differentiated-vulvar-intraepithelial-neoplasia
#15
Jaclyn C Watkins, Eric Yang, Christopher P Crum, Michael Herfs, Tarik Gheit, Massimo Tommasino, Marisa R Nucci
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC)...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29749321/prevalence-of-the-integration-status-for-human-papillomavirus-16-in-esophageal-carcinoma-samples
#16
Shuying Li, Haie Shen, Ji Li, Xiaoli Hou, Ke Zhang, Jintao Li
BACKGROUND/AIMS: To investigate the etiology of esophageal cancer (EC) related with human papillomavirus (HPV) infection. MATERIALS AND METHODS: Fresh surgically resected tissue samples and clinical information were obtained from 189 patients. Genomic DNA was extracted, and HPV was detected using polymerase chain reaction (PCR) with HPV L1 gene primers of MY09/11; HPV16 was detected using HPV16 E6 type-specific primer sets. Copies of HPV16 E2, E6, and the human housekeeping gene β-actin were tested using quantitative PCR to analyze the relationship between HPV16 integration and esophageal squamous cell carcinoma and the relationship between the HPV16 integration status and clinical information of patients...
March 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29747488/investigating-the-feasibility-of-targeted-next-generation-sequencing-to-guide-the-treatment-of-head-and-neck-squamous-cell-carcinoma
#17
Sun Min Lim, Sang Hee Cho, In Gyu Hwang, Jae Woo Choi, Hyun Chang, Myung-Ju Ahn, Keon Uk Park, Ji-Won Kim, Yoon Ho Ko, Hee Kyung Ahn, Byoung Chul Cho, Byung-Ho Nam, Sang Hoon Chun, Ji Hyung Hong, Jung Hye Kwon, Jong Gwon Choi, Eun Joo Kang, Tak Yun, Keun-Wook Lee, Joo-Hang Kim, Jin Soo Kim, Hyun Woo Lee, Min Kyoung Kim, Dongmin Jung, Ji Eun Kim, Bhumsuk Keam, Hwan Jung Yun, Sangwoo Kim, Hye Ryun Kim
Purpose: Head and neck squamous cell carcinoma (HNSCC) is a deadly disease in which precision medicine needs to be incorporated. We aimed to implement next-generation sequencing (NGS) in determining actionable targets to guide appropriate molecular targeted therapy in HNSCC patients. Materials and Methods: Ninety-three tumors and matched blood samples underwent targeted sequencing of 244 genes using the Illumina HiSeq 2500 platform with an average depth of coverage of greater than 1,000×...
May 9, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29745107/hpv-mrna-expression-profiling-in-head-and-neck-squamous-cell-carcinomas
#18
Vasileios Ragos, Nicholas S Mastronikolis, Evangelos Tsiambas, Panagiotis P Fotiades
No abstract text is available yet for this article.
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29745089/hpv-infection-in-oropharyngeal-squamous-cell-carcinomas-correlation-with-tumor-size
#19
Eleftheria Gletsou, Theodoros A Papadas, Evangelia Baliou, Evangelos Tsiambas, Vasileios Ragos, Ilianna E Armata, George E Metaxas, Panagiotis P Fotiades
PURPOSE: Human papillomavirus (HPV) is implicated in carcinogenesis of a variety of epithelia, including oropharyngeal and laryngeal. High risk (HR) HPV persistent infection in head and neck squamous cell carcinomas (HNSCC) is a significant event, but its influence regarding the prognosis and survival in these patients remains under consideration. Our aim was to analyze a series of oropharyngeal (OP) SCCs at the HPV DNA level, correlating them to the survival status of the corresponding patients...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29744680/association-of-antibody-to-e2-protein-of-human-papillomavirus-and-p16-ink4a-with-progression-of-hpv-infected-cervical-lesions
#20
Jureeporn Chuerduangphui, Chamsai Pientong, Piyawut Swangphon, Sanguanchoke Luanratanakorn, Ussanee Sangkomkamhang, Thumwadee Tungsiriwattana, Pilaiwan Kleebkaow, Ati Burassakarn, Tipaya Ekalaksananan
Human papillomavirus (HPV) E2 and L1 proteins are expressed in cervical cells during the lytic stage of infection. Overexpression of p16INK4A is a biomarker of HPV-associated cervical neoplasia. This study investigated antibodies to HPV16 E2, HPV16 L1, and p16INK4A in sera from women with no squamous intraepithelial lesion (No-SIL) of the cervix, low-grade SIL, high-grade SIL, and cervical squamous cell carcinoma (SCC). HPV DNA was detected by polymerase chain reaction. Anti-E2, -L1, and -p16INK4A antibodies in sera were determined by western blot...
May 9, 2018: Medical Oncology
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