Matthew L Baum, Daniel K Wilton, Rachel G Fox, Alanna Carey, Yu-Han H Hsu, Ruilong Hu, Henna J Jäntti, Jaclyn B Fahey, Allie K Muthukumar, Nikkita Salla, William Crotty, Nicole Scott-Hewitt, Elizabeth Bien, David A Sabatini, Toby B Lanser, Arnaud Frouin, Frederick Gergits, Bjarte Håvik, Chrysostomi Gialeli, Eugene Nacu, Kasper Lage, Anna M Blom, Kevin Eggan, Steven A McCarroll, Matthew B Johnson, Beth Stevens
Complement proteins facilitate synaptic elimination during neurodevelopmental pruning, but neural complement regulation is not well understood. CUB and Sushi Multiple Domains 1 (CSMD1) can regulate complement activity in vitro, is expressed in the brain, and is associated with increased schizophrenia risk. Beyond this, little is known about CSMD1 including whether it regulates complement activity in the brain or otherwise plays a role in neurodevelopment. We used biochemical, immunohistochemical, and proteomic techniques to examine the regional, cellular, and subcellular distribution as well as protein interactions of CSMD1 in the brain...
March 27, 2024: Brain, Behavior, and Immunity