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hypertension during pregnancy

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https://www.readbyqxmd.com/read/28230268/potential-climate-change-health-risks-from-increases-in-heat-waves-abnormal-birth-outcomes-and-adverse-maternal-health-conditions
#1
Gulcan Cil, Trudy Ann Cameron
We investigate the risks presented by heat waves for adverse health conditions for babies and expectant mothers when these mothers have been exposed to heat waves during gestation or during the period just prior to conception. Rather than just birth weight and gestational age, we focus on less common metrics such as abnormal conditions in the newborn (fetal distress, reliance on a ventilator, and meconium aspiration) and adverse health conditions in the mother (pregnancy-related hypertension, uterine bleeding during pregnancy, eclampsia, and incompetent cervix)...
February 23, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28229431/hypertensive-disorders-of-pregnancy
#2
REVIEW
Sahar Naderi, Sandra A Tsai, Abha Khandelwal
PURPOSE OF REVIEW: Although pregnancy-related deaths are rare in the USA, they are on the rise and have more than doubled in the last 20 years. A substantial portion of these deaths are related to cardiovascular disease, specifically hypertensive disorders of pregnancy (HDP). In this review, we will discuss the definitions and proposed pathophysiology of HDP as well as its potential role in cardiovascular morbidity and mortality. RECENT FINDINGS: Placental hypoperfusion may lead to an imbalance in proangiogenic and antiangiogenic factors, notably an increase in soluble fms-like tyrosine kinsase-1 (sFlt-1), thereby leading to endothelial dysfunction...
March 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28223469/maternal-gestational-hypertension-induced-sensitization-of-angiotensin-ii-hypertension-is-reversed-by-renal-denervation-or-angiotensin-converting-enzyme-inhibition-in-rat-offspring
#3
Baojian Xue, Haifeng Yin, Fang Guo, Terry G Beltz, Robert L Thunhorst, Alan Kim Johnson
Numerous findings demonstrate that there is a strong association between maternal health during pregnancy and cardiovascular disease in adult offspring. The purpose of the present study was to test whether maternal gestational hypertension modulates brain renin-angiotensin-aldosterone system (RAAS) and proinflammatory cytokines that sensitizes angiotensin II-elicited hypertensive response in adult offspring. In addition, the role of renal nerves and the RAAS in the sensitization process was investigated. Reverse transcription polymerase chain reaction analyses of structures of the lamina terminalis and paraventricular nucleus indicated upregulation of mRNA expression of several RAAS components and proinflammatory cytokines in 10-week-old male offspring of hypertensive dams...
February 21, 2017: Hypertension
https://www.readbyqxmd.com/read/28218407/chronic-hypertension-in-women-after-perinatal-exposure-to-preeclampsia-being-born-small-for-gestational-age-or-preterm
#4
Linda Lindström, Rolv Skjaerven, Eva Bergman, Maria Lundgren, Kari Klungsøyr, Sven Cnattingius, Anna-Karin Wikström
BACKGROUND: There is an established association between adverse events during perinatal life and chronic hypertension in adult life. However, disadvantageous conditions often co-exist in the same pregnancy. We investigated single and joint perinatal exposure to preeclampsia, being born small for gestational age (SGA) or preterm and subsequent risk of chronic hypertension. METHODS: The study population consisted of 731 008 primiparous women from Norway and Sweden registered in the Medical Birth Registers, both as infants and as first time mothers between 1967-2009 (Norway) and 1973-2010 (Sweden)...
March 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28217686/pregnancy-related-osteoporosis-and-spinal-fractures
#5
Ka Yeong Yun, Si Eun Han, Seung Chul Kim, Jong Kil Joo, Kyu Sup Lee
Pregnancy-related osteoporosis is a very rare condition characterized by the occurrence of fracture during pregnancy or the puerperium. Despite its relative rarity, it can be a dangerous condition that causes severe back pain, height loss and disability. Normal physiologic changes during pregnancy, genetic or racial difference, obstetrical history and obstetrical disease, such as preterm labor or pregnancy-induced hypertension, are presumed risk factors of pregnancy-related osteooporosis. However, exact etiology and pathogenesis are uncertain...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28208948/abducens-nerve-palsy-in-pregnancy-a-case-report
#6
Sayedeh Reyhaneh Yousefi, Shokrollah Zandi
Headache, blurring of vision and confusion are neurologic symptoms of preeclampsia. Whereas abducens nerve palsy during pregnancy is an extremely rare condition, we report here a 40-year-old patient with diplopia, blurring of vision and abducens nerve palsy in the 39(th) week of pregnancy with history of hypertension (HTN). No specific pathology was found. Symptoms of abducens nerve palsy were resolved spontaneously by controlling blood pressure after delivery.
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28197344/from-bad-to-worse-paraganglioma-diagnosis-during-induction-of-labor-for-coexisting-preeclampsia
#7
Sasima Dusitkasem, Blair H Herndon, Dalton Paluzzi, Joseph Kuhn, Robert H Small, John C Coffman
Pheochromocytomas and extra-adrenal paragangliomas are catecholamine-secreting tumors that rarely occur in pregnancy. The diagnosis of these tumors in pregnancy can be challenging given that many of the signs and symptoms are commonly attributed to preeclampsia or other more common diagnoses. Early diagnosis and appropriate management are essential in optimizing maternal and fetal outcomes. We report a rare case of a catecholamine-secreting tumor in which diagnosis occurring at the time labor was being induced for concomitant preeclampsia with severe features...
2017: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/28195885/eisenmenger-syndrome-and-pregnancy-novel-ecmo-configuration-as-a-bridge-to-delivery-and-recovery-utilizing-a-multidisciplinary-team
#8
Erika B Rosenzweig, Darryl Abrams, Mauer Biscotti, Diane Kerstein, Daphnie Drassinower, Daniel Brodie, Matthew Bacchetta
Pregnancy is typically contraindicated in Eisenmenger syndrome because of its association with excessively high maternal and fetal morbidity and mortality. We report on our novel approach to successfully managing a 29 year-old pregnant woman with an unrepaired patent ductus arteriosus (PDA) with Eisenmenger syndrome through delivery and recovery. Venovenous ECMO was utilized during induction of labor to stabilize maternal hemodynamics and optimize fetal oxygenation by creating an oxygenated right-to-left shunt through the PDA...
February 9, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28195551/b-type-natriuretic-peptide-and-echocardiography-reflect-volume-changes-during-pregnancy
#9
Janet M Burlingame, Kelly Yamasato, Hyeong Jun Ahn, Todd Seto, W H Wilson Tang
OBJECTIVE: To evaluate B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac structure and function in normal women through pregnancy and the postpartum. METHODS: In this prospective observational study, we obtained serial transthoracic echocardiograms, BNP, and NT-proBNP at seven intervals from 6 weeks' gestation through 12 months postpartum. Women with hypertension or cardiac disease were excluded. Using 6-12 months postpartum as reference for non-pregnant levels, echocardiogram measurements and BNP/NT-proBNP were compared over time using linear mixed models with Tukey-Kramer adjustment for multiple comparisons...
February 14, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28194919/management-of-pulmonary-vasodilator-therapy-in-three-pregnancies-with-pulmonary-arterial-hypertension
#10
Atsushi Daimon, Chizuko A Kamiya, Naoko Iwanaga, Tomoaki Ikeda, Norifumi Nakanishi, Jun Yoshimatsu
Pregnancy with pulmonary arterial hypertension (PAH) has a significantly high risk of maternal death and women with PAH are basically advised to avoid pregnancy. Recently, several reports have described pregnant women with PAH who were treated with pulmonary vasodilators during pregnancy and delivered safely. However, the efficacy of this treatment during pregnancy is still not clear. Here we report on the short-term outcomes of three primiparous women with PAH who were prescribed pulmonary vasodilator therapy during their pregnancies...
February 14, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28181996/blood-pressure-during-pregnancy-neonatal-size-and-altered-body-composition-the-healthy-start-study
#11
A P Starling, A L B Shapiro, K A Sauder, J L Kaar, B M Ringham, D H Glueck, H L Galan, D Dabelea
OBJECTIVE: The objective of this study is to estimate associations between changes in maternal arterial pressure during normotensive pregnancies and offspring birth weight and body composition at birth. STUDY DESIGN: Prospective study of 762 pregnant normotensive Colorado women, recruited from outpatient obstetrics clinics. Repeated arterial pressure measurements during pregnancy were averaged within the second and third trimesters, respectively. Multivariable regression models estimated associations between second to third trimester changes in arterial pressure and small-for-gestational-age birth weight, fat mass, fat-free mass and percent body fat...
February 9, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28178739/methamphetamine-consumption-during-pregnancy-effects-on-child-health
#12
Jürgen Dinger, Patricia Hinner, Jörg Reichert, Mario Rüdiger
Methamphetamine abuse during pregnancy represents an emerging health care problem. The consequences are not only of relevance to the pregnant women, but also their unborn child. It is associated with an increased risk of preeclampsia and hypertension, fetal demise, preterm delivery, and intrauterine growth restriction. The deleterious effects of prenatal methamphetamine exposure on the developing fetal brain may lead to long-term neuro-developmental and behavioral problems.Given the current evidence, abuse of methamphetamine during pregnancy must be of utmost concern to health care professionals and to policy-makers...
February 8, 2017: Pharmacopsychiatry
https://www.readbyqxmd.com/read/28178057/recurrent-placenta-mediated-complications-in-women-with-three-consecutive-deliveries
#13
Liran Hiersch, Shiri Shinar, Nir Melamed, Amir Aviram, Eran Hadar, Yariv Yogev, Eran Ashwal
OBJECTIVE: To estimate the risk of placenta-mediated complications in women in their third delivery according to their obstetric history in the first and second deliveries. METHODS: A retrospective cohort study of all women with singleton pregnancies who delivered their first three consecutive deliveries in a single medical center over a 20-year period (1994-2013). The risk of placenta-mediated complications in the third delivery, that is, hypertensive disorders such as preeclampsia or gestational hypertension, placental abruption, and small for gestational age (SGA less than the 10th percentile), was assessed according to the presence or absence of complications in previous deliveries...
March 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28176447/statins-during-pregnancy-a-cohort-study-using-the-general-practice-research-database-to-investigate-pregnancy-loss
#14
Anita McGrogan, Julia Snowball, Rachel A Charlton
PURPOSE: The aim of this study was to determine if there are any differences between the types of pregnancy loss experienced by women who have been prescribed a statin just before or early in pregnancy compared with those who have not. METHODS: A retrospective cohort study using the General Practice Research Database was carried out. Women aged 10-49 years at pregnancy start who received a prescription for a statin in the 3 months before and/or during the first trimester of pregnancy were matched to up to 10 pregnancies on age at start date, diabetes and hypertension status before pregnancy...
February 8, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/28169502/physiological-adaptation-of-maternal-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#15
REVIEW
S de Haas, C Ghossein-Doha, S M J van Kuijk, J van Drongelen, M E A Spaanderman
OBJECTIVE: To describe the physiological pattern of gestational plasma volume adjustments in normal singleton pregnancy and compare this with the pattern in pregnancies complicated by pregnancy-induced hypertension, pre-eclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases...
February 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28165570/effect-of-serum-high-molecular-weight-adiponectin-level-on-the-occurrence-of-eclampsia-during-subsequent-pregnancy-in-patients-with-primary-pregnancy-induced-hypertension
#16
Y Zhou, Z-H Chen, X-L Zhao, Y-H Qiao, R-X Guo
OBJECTIVE: To analyze the effect of serum levels of high molecular weight adiponectin (HMWA) on the occurrence of eclampsia during subsequent pregnancy in patients with primary pregnancy-induced hypertension (PIH). PATIENTS AND METHODS: Thirty patients with primary PIH (observation group) and sixty patients without primary PIH (control group) were consecutively selected. ELISA was used to measure the serum levels of HMWA. The differences in the occurrence of eclampsia during subsequent pregnancy between the two groups were compared...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28164084/comparison-of-phenylephrine-and-ephedrine-in-treatment-of-spinal-induced-hypotension-in-high-risk-pregnancies-a-narrative-review
#17
REVIEW
Sasima Dusitkasem, Blair H Herndon, Monsicha Somjit, David L Stahl, Emily Bitticker, John C Coffman
PURPOSE: To compare maternal and fetal effects of intravenous phenylephrine and ephedrine administration during spinal anesthesia for cesarean delivery in high-risk pregnancies. SOURCE: An extensive literature search was conducted using the US National Library of Medicine, MEDLINE search engine, Cochrane review, and Google Scholar using search terms "ephedrine and phenylephrine," "preterm and term and spinal hypotension," "preeclampsia and healthy parturients," or "multiple and singleton gestation and vasopressor...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28161306/a-randomized-clinical-trial-of-exercise-during-pregnancy-to-prevent-gestational-diabetes-mellitus-and-improve-pregnancy-outcome-in-overweight-and-obese-pregnant-women
#18
Chen Wang, Yumei Wei, Xiaoming Zhang, Yue Zhang, Qianqian Xu, Yiying Sun, Shiping Su, Li Zhang, Chunhong Liu, Yaru Feng, Chong Shou, Kym J Guelfi, John P Newnham, Huixia Yang
BACKGROUND: Obesity and being overweight are becoming epidemic, and indeed, the proportion of such women of reproductive age has increased in recent times. Being overweight or obese prior to pregnancy is a risk factor for gestational diabetes mellitus (GDM), and increases the risk of adverse pregnancy outcome for both mothers and their offspring. Furthermore, the combination of GDM with obesity/overweight status may increase the risk of adverse pregnancy outcome attributable to either factor alone...
February 1, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28161265/-reasons-for-first-consultation-in-nephrology-in-the-health-area-5-of-britanny-during-the-year-2014
#19
Jeanne Prévot, Sahar Bayat-Makoei, Cécile Vigneau
BACKGROUND: In France, the coordinated healthcare circuit means that patients should be referred to specialists, for example nephrologists, by another physician. However, there are no recommendations concerning the reasons justifying the referral to a nephrologist. The main purpose of our study is to describe the motif of first consultations in nephrology in the health area 5 of Brittany. METHODS: We retrospectively collected medical reports of first consultations by 17 nephrologists in the 4 centers of the study area, during the year 2014...
February 1, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28157249/effect-of-antidepressants-use-in-pregnancy-on-foetus-development-and-adverse-effects-in-newborns
#20
Ewa Bałkowiec-Iskra, Dagmara Maria Mirowska-Guzel, Mirosław Wielgoś
Over the last few years, several reports on the safety of antidepressants use in pregnancy have been published. Studies concerning the adverse effects of exposure to selective serotonin reuptake inhibitors (SSRI) during pregnancy on the developing foetus have indicated an increased risk of various congenital malformations and untoward effects such as poor neonatal adaptation syndrome or persistent pulmonary hypertension, but there still remain inconsistencies between various study results. This paper aims at reviewing the literature on the risks of exposure to antidepressants during pregnancy...
2017: Ginekologia Polska
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