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hypertension during pregnancy

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https://www.readbyqxmd.com/read/29789348/gestational-low-protein-intake-enhances-whole-kidney-mir-192-and-mir-200-family-expression-and-epithelial-to-mesenchymal-transition-in-rat-adult-male-offspring
#1
Letícia B Sene, Victor Hugo Gonçalves Rizzi, José A R Gontijo, Patricia A Boer
Studies have shown that adult offspring of mothers fed a protein-restricted diet during pregnancy present a pronounced reduction of nephron number associated with decreased fractional urinary sodium excretion and arterial hypertension. Additionally, recent advances in our understanding of the molecular pathways that govern the association of gestational nutritional restriction, intrauterine growth retardation and inflammation with impaired nephrogenesis, nephron underdosing and kidney fibrosis point to the epithelial to mesenchymal transition (EMT) as a common factor...
May 22, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29758115/antepartum-care-of-women-who-are-obese-during-pregnancy-systematic-review-of-the-current-evidence
#2
REVIEW
Nicole S Carlson, Sharon Lynn Leslie, Alexis Dunn
INTRODUCTION: Nearly 40% of US women of childbearing age are obese. Obesity during pregnancy is associated with multiple risks for both the woman and fetus, yet clinicians often feel unprepared to provide optimal antepartum care for this group of women. We collected and reviewed current evidence concerning antepartum care of women who are obese during pregnancy. METHODS: We conducted a systematic review using PRISMA guidelines. Current evidence relating to the pregnancy care of women with a prepregnancy body mass index of 30kg/m2 or higher was identified using MEDLINE databases via PubMed, Embase, and Web of Science Core Collection between January 2012 and February 2018...
May 14, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29755034/association-between-gestational-hypertension-and-risk-of-cardiovascular-disease-among-617-589-norwegian-women
#3
Hilde Kristin Refvik Riise, Gerhard Sulo, Grethe S Tell, Jannicke Igland, Ottar Nygård, Ann-Charlotte Iversen, Anne Kjersti Daltveit
BACKGROUND: Preeclampsia and gestational hypertension (GH) are the most common hypertensive pregnancy disorders. Preeclampsia has been linked to increased risk of cardiovascular disease (CVD), but a similar association for GH has not been established. We aimed to determine the association between GH and subsequent CVD, and explore the additional role of small-for-gestational-age infants, preterm delivery, and parity. METHODS AND RESULTS: Data from the Medical Birth Registry of Norway were linked to the Cardiovascular Disease in Norway project and the Norwegian Cause of Death Registry...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29755033/impact-of-a-history-of-hypertension-in-pregnancy-on-later-diagnosis-of-atrial-fibrillation
#4
Dawn C Scantlebury, Andrea G Kattah, Tracey L Weissgerber, Sanket Agarwal, Michelle M Mielke, Amy L Weaver, Lisa E Vaughan, Stanislav Henkin, Katherine Zimmerman, Virginia M Miller, Wendy M White, Sharonne N Hayes, Vesna D Garovic
BACKGROUND: Atrial fibrillation/flutter (AF) produces significant morbidity in women and is typically attributed to cardiac remodeling from multiple causes, particularly hypertension. Hypertensive pregnancy disorders (HPDs) are associated with future hypertension and adverse cardiac remodeling. We evaluated whether women with AF were more likely to have experienced a HPD compared with those without. METHODS AND RESULTS: A nested case-control study was conducted within a cohort of 7566 women who had a live or stillbirth delivery in Olmsted County, Minnesota between 1976 and 1982...
May 13, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29752724/pregnancy-complications-and-subsequent-breast-cancer-risk-in-the-mother-a-nordic-population-based-case-control-study
#5
Rebecca Troisi, Anne Gulbech Ording, Tom Grotmol, Ingrid Glimelius, Anders Engeland, Mika Gissler, Britton Trabert, Anders Ekbom, Laura Madanat-Harjuoja, Henrik Toft Sørensen, Steinar Tretli, Tone Bjørge
Certain features of pregnancy are important risk factors for breast cancer, such as protection afforded by young age at first birth. Preeclampsia, a pregnancy complication, is associated with reduced maternal breast cancer risk. However, questions remain regarding causality, biological mechanisms and the relation of other hypertensive conditions to risk. We conducted a population-based case-control study of breast cancer cases (n=116,196) in parous women identified through linkage of birth and cancer registries in Denmark, Finland, Norway and Sweden (1967-2013), including up to 10 matched controls per case (n=1,147,192) sampled from the birth registries (complete data were not available on all variables)...
May 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29747733/pregestational-diabetes-in-pregnancy
#6
REVIEW
Ronan Sugrue, Chloe Zera
Diabetes is a common chronic condition in women of reproductive age. Preconception care is crucial to reducing the risk of adverse maternal and fetal outcomes, such as hypertensive disorders, abnormal fetal growth, traumatic delivery and stillbirth, associated with poor glycemic control. Insulin is the preferred medication to optimize glucose control in women with pregestational diabetes. Frequent dose adjustments are needed during pregnancy to achieve glycemic goals, and team-based multidisciplinary care may help...
June 2018: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/29745623/the-role-of-intraoperative-stroke-volume-variation-on-bleeding-during-functional-endoscopic-sinus-surgery
#7
Roberta Di Mauro, Fabiana Lucci, Federica Martino, Maria B Silvi, Eleonora Gidaro, Santo Di Lorenzo, Nicola Toschi, Stefano Di Girolamo, Mario Dauri
BACKGROUNDː Functional Endoscopic Sinus Surgery (FESS) is a minimally-invasive surgical technique for patients with paranasal sinus pathology. Surgical bleeding reduces operative field visibility and increases the incidence of serious complications. Epinephrine injection into the nasal mucosa and controlled hypotension are used to minimise bleeding. Hypotension carries risks and sometimes does not reduce surgical bleeding. The goal of this study is to discover which haemodynamic parameter better correlates with surgical bleeding...
May 9, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29737808/effect-of-individualised-dietary-education-at-medical-check-ups-on-maternal-and-fetal-outcomes-in-pregnant-japanese-women
#8
Reiko Tajirika-Shirai, Hidemi Takimoto, Tetsuji Yokoyama, Hitoshi Kaneko, Toshiro Kubota, Naoyuki Miyasaka
BACKGROUND AND OBJECTIVES: An increased prevalence of low maternal weight and insufficient pregnancy weight gain may be responsible for an increase in low birthweight infants in Japan. We aimed to examine the effects of individualised dietary education at medical check-ups on maternal/fetal outcomes in Japanese women. METHODS AND STUDY DESIGN: Four hundred and six underweight and normal weight singleton pregnant women, who attended check-ups at an obstetric facility until ≥30 weeks gestation and delivered at 36-41 weeks gestation, were selected for analyses...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29730389/mothers-with-hip-the-short-term-and-long-term-impact-what-is-new
#9
REVIEW
Federico Mecacci, Serena Ottanelli, Felice Petraglia
Hyperglycemia is one of the most common medical conditions that women encounter during pregnancy and it is due to gestational diabetes (GDM) in the majority of cases [1]. GDM is associated with a higher incidence of maternal morbidity in pregnancy in term of hypertensive disorders/preclampsia and higher rate of cesarean delivery but also with long-term risk of type 2 diabetes and cardiovascular disease. Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk...
May 3, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29729681/up-regulation-of-renal-renin-angiotensin-system-and-inflammatory-mechanisms-in-the-prenatal-programming-by-low-protein-diet-beneficial-effect-of-the-post-weaning-losartan-treatment
#10
I K M Watanabe, Z P Jara, R A Volpini, M D C Franco, F F Jung, D E Casarini
Previous studies have shown that the renin-angiotensin system (RAS) is affected by adverse maternal nutrition during pregnancy. The aim of this study was to investigate the effects of a maternal low-protein diet on proinflammatory cytokines, reactive oxygen species and RAS components in kidney samples isolated from adult male offspring. We hypothesized that post-weaning losartan treatment would have beneficial effects on RAS activity and inflammatory and oxidative stress markers in these animals. Pregnant Sprague-Dawley rats were fed with a control (20% casein) or low-protein diet (LP) (6% casein) throughout gestation...
May 6, 2018: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/29725630/glomerular-disease-in-women
#11
REVIEW
Kate Wiles, Liz Lightstone
Gender differences exist in the prevalence of glomerular diseases. Data based on histological diagnosis underestimate the prevalence of preeclampsia, which is almost certainly the commonest glomerular disease in the world, and uniquely gender-specific. Glomerular disease affects fertility via disease activity, the therapeutic use of cyclophosphamide, and underlying chronic kidney disease. Techniques to preserve fertility during chemotherapy and risk minimization of artificial reproductive techniques are considered...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29723385/prepregnancy-body-mass-index-gestational-weight-gain-and-birth-weight-in-the-brisa-cohort
#12
Raina Jansen Cutrim Propp Lima, Rosângela Fernandes Lucena Batista, Marizélia Rodrigues Costa Ribeiro, Cecília Cláudia Costa Ribeiro, Vanda Maria Ferreira Simões, Pedro Martins Lima Neto, Antônio Augusto Moura da Silva, Heloisa Bettiol
OBJECTIVE To analyze the effects of maternal pre-pregnancy body mass index and weight gain during pregnancy on the baby's birth weight. METHODS We conducted a cross-sectional study with 5,024 mothers and their newborns using a Brazilian birth cohort study. In the proposed model, estimated by structural equation modeling, we tested socioeconomic status, age, marital status, pre-pregnancy body mass index, smoking habit and alcohol consumption during pregnancy, hypertension and gestational diabetes, gestational weight gain, and type of delivery as determinants of the baby's birth weight...
2018: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29720114/adverse-obstetric-and-neonatal-outcomes-complicated-by-psychosis-among-pregnant-women-in-the-united-states
#13
Qiu-Yue Zhong, Bizu Gelaye, Gregory L Fricchione, Paul Avillach, Elizabeth W Karlson, Michelle A Williams
BACKGROUND: Adverse obstetric and neonatal outcomes among women with psychosis, particularly affective psychosis, has rarely been studied at the population level. We aimed to assess the risk of adverse obstetric and neonatal outcomes among women with psychosis (schizophrenia, affective psychosis, and other psychoses). METHODS: From the 2007 - 2012 National (Nationwide) Inpatient Sample, 23,507,597 delivery hospitalizations were identified. From the same hospitalization, International Classification of Diseases diagnosis codes were used to identify maternal psychosis and outcomes...
May 2, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29719109/belatacept-during-pregnancy-in-renal-transplant-recipients-two-case-reports
#14
Jenna Combs, Anna Kagan, Mark Boelkins, Lisa Coscia, Michael Moritz, R Michael Hofmann
Impaired fertility is common among patients with chronic organ failure, including end stage renal disease (ESRD). Women of child-bearing age undergoing transplantation may experience rapid return of fertility. Pregnancy post-transplant presents numerous risks for the patient, fetus, and allograft. Maternal risks include hypertension and preeclampsia. Allograft risks include acute rejection and failure of the organ, and fetal risks include miscarriage, birth defects from immunosuppressants, premature delivery, and low birth weight...
May 2, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29715049/pregnancy-achieved-using-donor-eggs-in-cancer-survivors-with-treatment-induced-ovarian-failure-obstetric-and-perinatal-outcome
#15
Anna Marklund, Josefine Nasiell, Ann-Sofie Berger, Antonia Fagerberg, Kenny A Rodriguez-Wallberg
BACKGROUND: Egg donation is a common fertility treatment in female cancer survivors with reproductive wish and iatrogenic ovarian failure. We examined whether women previously treated for cancer have a higher risk of pregnancy complications after egg donation treatments when compared to women without cancer history. METHODS: In this prospective cohort treated during 2003-2015 at a single center, 31 women with previous history of cancer achieved 25 deliveries and 212 women without cancer history achieved 244 deliveries...
May 1, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29712720/metabolic-disorders-during-pregnancy-and-postpartum-cardiometabolic-risk
#16
Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, Manfredi Rizzo
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter lead to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia...
April 30, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29707923/hypertensive-disorders-in-pregnant-women-receiving-fertility-treatments
#17
Maryam Barekat, Shahnaz Ahmadi
Hypertensive disorders (HDs) as the most prevalent medical problem during pregnancy, predispose the patient to a lot of comorbidities and may even cause maternal or fetal death. The rate of infertility has been increasing in recent decades. So, we collected and summarized data about the co-existence of these two entities and found that HDs are somewhat more common in women receiving fertility treatments regardless of pathophysiologic correlation of infertility and hypertension or older age and chance of multiple pregnancies...
July 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29705580/impaired-function-of-cerebral-parenchymal-arterioles-in-experimental-preeclampsia
#18
Abbie C Johnson, Marilyn J Cipolla
Preeclampsia (PE), a dangerous hypertensive complication of pregnancy, is associated with widespread maternal vascular dysfunction. However, the effect of PE on the cerebral vasculature that can lead to stroke and cognitive decline is not well understood. We hypothesized that function of cortical parenchymal arterioles (PAs) would be impaired during PE. Using a high cholesterol diet to induce experimental PE in rats (ePE), we studied the function and structure of isolated and pressurized PAs supplying frontoparietal WM tracts and cortex and compared to normal pregnant (Preg) and nonpregnant (Nonpreg) Sprague Dawley rats (n = 8/group)...
April 26, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29704672/environmental-noise-pollution-and-risk-of-preeclampsia
#19
Nathalie Auger, Mathilde Duplaix, Marianne Bilodeau-Bertrand, Ernest Lo, Audrey Smargiassi
BACKGROUND: Environmental noise exposure is associated with a greater risk of hypertension, but the link with preeclampsia, a hypertensive disorder of pregnancy, is unclear. OBJECTIVES: We sought to determine the relationship between environmental noise pollution and risk of preeclampsia during pregnancy. METHODS: We analyzed a population-based cohort comprising 269,263 deliveries on the island of Montreal, Canada between 2000 and 2013. We obtained total environmental noise pollution measurements (LAeq24 , Lden , Lnight ) from land use regression models, and assigned noise levels to each woman based on the residential postal code...
April 25, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29703800/comparing-standard-office-based-follow-up-with-text-based-remote-monitoring-in-the-management-of-postpartum-hypertension-a-randomised-clinical-trial
#20
Adi Hirshberg, Katheryne Downes, Sindhu Srinivas
BACKGROUND: Monitoring blood pressure at 72 hours and 7-10 days post partum in women with hypertensive disorders is recommended to decrease morbidity. However, there are no recommendations as to how to achieve this. OBJECTIVE: To compare the effectiveness of text-based blood pressure monitoring to in-person visits for women with hypertensive disorders of pregnancy in the immediate postpartum period. METHODS: Randomised clinical trial among 206 postpartum women with pregnancy-related hypertension diagnosed during the delivery admission between August 2016 and January 2017...
April 27, 2018: BMJ Quality & Safety
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