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preeclampsia pregnancy

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https://www.readbyqxmd.com/read/29913544/uterine-artery-doppler-in-screening-for-preeclampsia-and-fetal-growth-restriction
#1
Marianna Amaral Pedroso, Kirsten Rebecca Palmer, Ryan James Hodges, Fabricio da Silva Costa, Daniel Lorber Rolnik
OBJECTIVE:  To perform a comprehensive review of the current evidence on the role of uterine artery Doppler, isolated or in combination with other markers, in screening for preeclampsia (PE) and fetal growth restriction (FGR) in the general population. The review included recently published large cohort studies and randomized trials. METHODS:  A search of the literature was conducted using Medline, PubMed, MeSH and ScienceDirect. Combinations of the search terms "preeclampsia," "screening," "prediction," "Doppler," "Doppler velocimetry," "fetal growth restriction," "small for gestational age" and "uterine artery" were used...
May 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#2
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29912017/hypertensive-disorders-of-pregnancy-and-genital-anomalies-in-boys-a-danish-nationwide-cohort-study
#3
Linn Håkonsen Arendt, Tine Brink Henriksen, Morten Søndergaard Lindhard, Erik T Parner, Jørn Olsen, Cecilia Høst Ramlau-Hansen
BACKGROUND: Although congenital abnormalities in the male reproductive tract are common, their causes remain poorly understood. We studied associations between hypertensive disorders of pregnancy (pre-gestational hypertension, gestational hypertension, and preeclampsia) and the genital anomalies, cryptorchidism (undescended testes), and hypospadias (ventrally displaced urethral meatus). METHODS: We established a population of 1,073,026 Danish boys born alive between 1 January 1978 and 31 December 2012...
June 14, 2018: Epidemiology
https://www.readbyqxmd.com/read/29908013/patient-reported-disease-activity-and-adverse-pregnancy-outcomes-in-systemic-lupus-erythematosus-and-rheumatoid-arthritis
#4
Nathaniel Harris, Amanda Eudy, Megan Clowse
OBJECTIVES: While increased rheumatic disease activity during pregnancy has been associated with adverse pregnancy outcomes, this activity is typically assessed by the physician. Little is known, however, about the association between patient-reported measures of disease activity and pregnancy outcomes. METHODS: Univariate and multivariable regression models were used to assess the relationship between patient and physician-reported measures of disease activity and adverse pregnancy outcomes in 225 patients with lupus or rheumatoid arthritis (RA) enrolled in a prospective registry at a single academic center from 2008-2016...
June 15, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29907450/altered-maternal-and-placental-lipid-metabolism-and-fetal-fat-development-in-obesity-current-knowledge-and-advances-in-non-invasive-assessment
#5
Flavien Delhaes, Stephanie A Giza, Tianna Koreman, Genevieve Eastabrook, Charles A McKenzie, Samantha Bedell, Timothy R H Regnault, Barbra de Vrijer
Abnormal maternal lipid profiles, a hallmark of increased maternal adiposity, are associated with pregnancy complications such as preeclampsia and gestational diabetes, and offspring long-term metabolic health is impacted as the consequence of altered fetal growth, physiology and often iatrogenic prematurity. The metabolic changes associated with maternal obesity and/or the consumption of a high-fat diet effecting maternal lipid profiles and metabolism have also been documented to specifically affect placental function and may underlie changes in fetal development and life course disease risk...
May 26, 2018: Placenta
https://www.readbyqxmd.com/read/29906797/validation-of-the-suntech-medical-advantage-model-2-series-automated-blood-pressure-module-in-pregnancy
#6
Spencer G Kuper, Kristin N Dotson, Sarah B Anderson, Stacy L Harris, Lorie M Harper, Alan T Tita
OBJECTIVE:  We sought to validate the SunTech Medical Advantage Model 2 Series with firmware LX 3.40.8 algorithm noninvasive blood pressure module in a pregnant population, including those with preeclampsia. STUDY DESIGN:  Validation study of an oscillometric noninvasive blood pressure module using the ANSI/AAMI ISO 81060-2:2013 standard guidelines. Pregnant women were enrolled into three subgroups: normotensive, hypertensive without proteinuria, and preeclampsia (hypertensive with random protein-to-creatinine ratio ≥ 0...
June 15, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29899140/-hypertension-editors-picks-preeclampsia-pregnancy-and-hypertension
#7
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
July 2018: Hypertension
https://www.readbyqxmd.com/read/29898711/maternal-cardiovascular-hemodynamics-in-normotensive-versus-preeclamptic-pregnancies-a-prospective-longitudinal-study-using-a-noninvasive-cardiac-system-nicas%C3%A2
#8
Anat Lavie, Maya Ram, Shaul Lev, Yair Blecher, Uri Amikam, Yael Shulman, Tomer Avnon, Eran Weiner, Ariel Many
BACKGROUND: Preeclampsia is among the most common medical complications of pregnancy. The clinical utility of invasive hemodynamic monitoring in preeclampsia (e.g., Swan-Ganz catheter) is controversial. Thoracic impedance cardiography (TIC) and Doppler echocardiography are noninvasive techniques but they both have important limitations. NICaS™ (NI Medical, PetachTikva, Israel) is a noninvasive cardiac system for determining cardiac output (CO) that utilizes regional impedance cardiography (RIC) by noninvasively measuring the impedance signal in the periphery...
June 14, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29898033/interleukin-6-contributes-to-myocardial-damage-in-pregnant-rats-with-reduced-uterine-perfusion-pressure
#9
Lan Ding, Chuanming Bai, Ying Liu
Preeclampsia is one of the most frequent and difficult illnesses in pregnancy, which jeopardizes both mother and fetus. There are several diagnostic criteria for preeclampsia. However, the preeclampsia-associated myocardial damage has not been described. In this study, we employed reduced uterine perfusion pressure (RUPP) to generate a rat model of preeclampsia for the evaluation of myocardial damage in late-gestation rats. The expressions of cardiac injury markers were analyzed by immunohistochemistry and ELISA...
June 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29897824/the-risk-of-cardiovascular-disease-end-stage-renal-disease-and-stroke-in-post-partum-women-and-their-fetuses-after-a-hypertensive-pregnancy
#10
Mark W Cunningham, Babbette D LaMarca
Women with hypertensive pregnancy complications are at greater risk of developing cardiovascular disease (CVD), metabolic diseases, stroke, and end-stage renal disease later in life. Pregnancy complications not only effect the mother's long-term health, but also the health of the fetus immediately after delivery and into adulthood. The health of the fetus until adulthood can be influenced by developmental programming, in which the fetus is exposed to insults that will ultimately affect the growth of the offspring and increase the offspring's risk of developing hypertension, coronary heart disease, metabolic disease, and chronic kidney disease in adulthood...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29897820/time-course-of-changes-in-maternal-left-ventricular-function-during-subsequent-pregnancy-in-women-with-a-history-of-gestational-hypertensive-disorders
#11
Michinari Hieda, Jeung-Ki Yoo, Dan-Dan Sun, Yoshiyuki Okada, Rosemary S Parker, Monique A Roberts-Reeves, Beverley Adams-Huet, David B Nelson, Benjamin D Levine, Qi Fu
Women with a history of gestational hypertensive disorders (GHD) are at increased risk for developing perinatal cardiovascular complications (e.g., gestational hypertension, preeclampsia, etc.) in subsequent pregnancies. The underlying mechanisms remain uncertain, but impaired maternal left ventricular function may be one contributing factor for these complications. We evaluated the time course of changes in left ventricular function before, during and after pregnancy in women with prior GHD. Sixteen women with a history of GHD (the high-risk group), and 25 women without such a history (controls) were enrolled...
June 13, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29896812/screening-for-pre-eclampsia-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
#12
Min Yi Tan, Argyro Syngelaki, Liona C Poon, Daniel L Rolnik, Neil O'Gorman, Juan Luis Delgado, Ranjit Akolekar, Liountmila Konstantinidou, Maria Tsavdaridou, Slavyana Galeva, Ursula Ajdacka, Francisca S Molina, Nicola Persico, Jacques C Jani, Walter Plasencia, Elena Greco, George Papaioannou, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for early-, preterm- and term-preeclampsia (PE) at 11-13 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum pregnancy associated plasma protein-A (PAPP-A). METHODS: The data for this study were derived from three previously reported prospective non-intervention screening studies at 11+0 - 13+6 weeks' gestation in a combined total of 61,174 singleton pregnancies, including 1,770 (2...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29896778/screening-for-pre-eclampsia-at-35-37-weeks-gestation
#13
Anca Panaitescu, Anca Ciobanu, Argyro Syngelaki, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for preeclampsia (PE) at 35-37 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum soluble fms-like tyrosine kinase-1 (sFLT). METHODS: This was a prospective observational study in women with singleton pregnancies attending for an ultrasound scan at 35+0 - 36+6 weeks as part of routine pregnancy care...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29896480/use-of-antihypertensive-drugs-during-preeclampsia
#14
Obinnaya Odigboegwu, Lu J Pan, Piyali Chatterjee
Treatment of pregnancy-related hypertensive disorders, such as preeclampsia (PE), remain a challenging problem in obstetrics. Typically, aggressive antihypertensive drug treatment options are avoided to prevent pharmacological-induced hypotension. Another major concern of administering antihypertensive drugs during pregnancy is possible adverse fetal outcome. In addition, management of hypertension during pregnancy in chronic hypertensive patients or in patients with prior kidney problems are carefully considered...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29895998/first-trimester-uterine-artery-pulsatility-index-and-maternal-serum-papp-a-and-plgf-in-prediction-of-preeclampsia-in-primigravida
#15
Mostafa Abdo Ahmed Salem, Islam Mohamed Magdi Ammar
Background: Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures. Objective: The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29895993/critical-care-in-obstetrics-where-are-we
#16
REVIEW
Sushil Chawla, T Jose, Manish Paul
Maternal mortality is disastrous news for the society, family, newborn, and the obstetrician. Yet, we all who are care providers to these apparently healthy women carrying another life within them are dumbfounded by the clinical conditions arising due to the pregnancy or the effects of the pregnancy, that it becomes difficult to provide an ideal care to them. The rapid uprising of a condition and the worsening of commonly occurring benign conditions-preeclampsia, hemorrhage, etc., necessitates that all obstetricians are well versed with the physiological changes and should be able to not only provide the best of obstetric care to the mother and the newborn but also perform or assist in performance of life-saving procedures...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29895850/longitudinal-measures-of-maternal-vitamin-d-and-neonatal-body-composition
#17
Nansi S Boghossian, Winston Koo, Aiyi Liu, Sunni L Mumford, Michael Y Tsai, Edwina H Yeung
BACKGROUND/OBJECTIVES: Vitamin D status has been associated with fetal growth and offspring's bone mass in some observational studies. We characterize the trajectory of total maternal serum 25-hydroxyvitamin D [25(OH)D] concentration by race and examine whether vitamin D status is associated with neonatal anthropometry and body composition as assessed by dual energy X-ray absorptiometry (DXA). SUBJECTS/METHODS: Three longitudinal pregnancy samples from the Memphis site of the Calcium for Preeclampsia Prevention trial (1992-1995) were used...
June 12, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29895300/papp-a2-deficiency-does-not-exacerbate-the-phenotype-of-a-mouse-model-of-intrauterine-growth-restriction
#18
Julian K Christians, Kendra I Lennie, Maria F Huicochea Munoz, Nimrat Binning
BACKGROUND: Pregnancy-associated plasma protein-A2 (PAPP-A2) is consistently upregulated in the placentae of pregnancies complicated by preeclampsia and fetal growth restriction. The causes and significance of this upregulation remain unknown, but it has been hypothesized that it is a compensatory response to improve placental growth and development. We predicted that, if the upregulation of PAPP-A2 in pregnancy complications reflects a compensatory response, then deletion of Pappa2 in mice would exacerbate the effects of a gene deletion previously reported to impair placental development: deficiency of matrix metalloproteinase-9 (MMP9)...
June 12, 2018: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29894501/early-onset-preeclampsia-predisposes-to-preclinical-diastolic-left-ventricular-dysfunction-in-the-fifth-decade-of-life-an-observational-study
#19
Anouk Bokslag, Constantijn Franssen, Lisa J Alma, Igor Kovacevic, Floortje van Kesteren, Pim W Teunissen, Otto Kamp, Wessel Ganzevoort, Peter L Hordijk, Christianne J M de Groot, Walter J Paulus
BACKGROUND: Systemic inflammation, endothelial dysfunction and deficient vascularization of either uterus or myocardium are mechanistic hallmarks of early-onset preeclampsia and heart failure with preserved ejection fraction (HFpEF). HFpEF is especially prevalent in elderly women and preceded in middle age by preclinical left ventricular (LV) diastolic dysfunction. To detect if preeclampsia predisposes to HFpEF at later age, echocardiographic indices of LV function and of LV structure and biomarkers of systemic inflammation and of endothelial dysfunction were compared in middle-aged women with a history of early-onset preeclampsia or uncomplicated pregnancy...
2018: PloS One
https://www.readbyqxmd.com/read/29892919/resistant-hypertension-in-pregnancy-how-to-manage
#20
REVIEW
Maria Rita Bortolotto, Rossana Pulcineli Vieira Francisco, Marcelo Zugaib
PURPOSE OF REVIEW: The concept of resistant hypertension may be changed during pregnancy by the physiological hemodynamic changes and the particularities of therapy choices in this period. This review discusses the management of pregnant patients with preexisting resistant hypertension and also of those who develop severe hypertension in gestation and puerperium. RECENT FINDINGS: The main cause of severe hypertension in pregnancy is preeclampsia, and differential diagnosis must be done with secondary or primary hypertension...
June 11, 2018: Current Hypertension Reports
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