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Thyroid cancer or carcinoma

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https://www.readbyqxmd.com/read/28087965/hypopharyngeal-cancer-masquerading-as-a-thyroid-mass
#1
P S Heng, M Irfan
Hypopharyngeal cancer (HPC) is generally a rare head and neck malignancy. There are differing clinical presentations depending on the subsite location of primary tumour. Advanced HPC will have neck node metastasis particularly upper jugulodigastric nodes. We report a patient with postcricoid tumour who presented with anterior huge neck swelling mimic thyroid mass. The patient first presented to the General Surgical Unit for management of presumed thyroid lesion. She was diagnosed post-cricoid squamous cell carcinoma when further assessed by otorhinolaryngologist...
December 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28087101/current-management-of-low-risk-differentiated-thyroid-cancer-and-papillary-microcarcinoma
#2
V D Tarasova, R M Tuttle
Each year, the proportion of thyroid cancer patients presenting with low risk disease is increasing. Moreover, the definition of low risk thyroid cancer is expanding and several histological subtypes beyond papillary microcarcinomas are now classified as low risk disease. This shift in the landscape of thyroid cancer presentation is forcing clinicians to critically re-evaluate whether or not traditional management paradigms that were effective in treating intermediate and high risk disease are applicable to these low risk patients...
January 10, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28086986/radioiodine-sinus-uptake-related-to-mucosal-thickening-or-aspergilloma-a-case-series-of-an-unrecognized-event-well-evidenced-by-spect-ct
#3
Renaud Ciappuccini, David Blanchard, Jean-Pierre Rame, Dominique de Raucourt, Emmanuel Babin, Stéphane Bardet
BACKGROUND: False-positive radioiodine (RAI) uptake related to chronic sinusitis and mucocele has only rarely been reported in patients with differentiated thyroid cancer (DTC) even with the recent use of single photon emission tomography with computed tomography (SPECT/CT) acquisition. No other etiology of sinus RAI uptake has been mentioned to date. OBJECTIVES: We report five cases of DTC patients with sinus RAI uptake on post-RAI scintigraphy. SPECT/CT clearly localized RAI uptake either in the sphenoid, the maxillary or the frontal sinus and highly suspected mucosal thickening in four patients and sinus aspergilloma in one patient...
January 13, 2017: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/28081573/-prostate-carcinoma-mimics-lung-carcinoma-a-case-report
#4
Konstantinos Drosos, Klaus Höfner
A PSA-negative, advanced adenocarcinoma of the prostate is a rare finding. Expression of thyroid transcription factor-1 (TTF-1) in the tumour in combination with a previous medical history of lung adenocarcinoma could complicate the final diagnosis. To the best of our knowledge, we present the second case of a TTF-1-positive, acinar adenocarcinoma of the prostate.We present the case of a 65-year-old male with surgically treated lung adenocarcinoma; 3 years later we diagnosed adenocarcinoma of the bladder and prostate...
January 12, 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28081315/the-association-of-papillary-thyroid-cancer-with-microcalcification-in-thyroidnodules-with-indeterminate-cytology-based-on-fine-needle-aspiration-biopsy
#5
İbrahim Ali Özemir, Barış Bayraktar, Ender Anılır, Kıvılcım Orhun, Tunç Eren, Jülide Sağıroğlu, Ayşe Bahar Ceyran, Rafet Yiğitbaşı, Orhan Alimoğlu
BACKGROUND/AIM: Microcalcifications are generally accepted as highly specific for thyroid malignancy, especially for papillary thyroid carcinoma (PTC). The aim of this study was to determine the significance of microcalcification within nodules that were classified as being of “indeterminate cytology” (IC) according to fine-needle aspiration biopsy. MATERIALS AND METHODS: Patients who underwent thyroidectomy between January 2010 and 2013 were included in the study...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28081173/effect-of-rifampin-on-thyroid-function-test-in-patients-on-levothyroxine-medication
#6
Hye In Kim, Tae Hyuk Kim, Hosu Kim, Young Nam Kim, Hye Won Jang, Jae Hoon Chung, Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Won-Jung Koh, Sun Wook Kim
BACKGROUND: Levothyroxine (LT4) and rifampin (RIF) are sometimes used together; however, no clinical studies have assessed the effects of these drugs on thyroid function or the need to adjust LT4 dose. METHODS: We retrospectively reviewed the records of 71 Korean patients who started RIF during LT4 treatment. Clinically relevant cases that required dose adjustment according to the American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) guidelines were identified, and risk factors of increased LT4 dose were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28079945/systematic-review-of-site-distribution-of-bone-metastases-in-differentiated-thyroid-cancer
#7
REVIEW
Marcela Osorio, Sami P Moubayed, Henry Su, Mark L Urken
BACKGROUND: Thyroid cancer is the fastest growing cancer in the United States. A small portion of differentiated thyroid cancers (DTCs; 2% to 13%) develop bone metastases, which can decrease a patient's survival rate by more than 60%. METHODS: A systematic literature search of studies, including patients with DTC with bone metastases, was conducted by following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A case series of patients with DTC diagnosed with bone metastases seen at our institution was also included...
January 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28078873/fine-needle-aspiration-cytology-of-650-thyroid-nodules-operated-for-multinodular-goiter-a-cyto-histological-correlation-based-on-the-new-italian-cytological-classification-siapec-2014
#8
F Tartaglia, A Giuliani, L Tromba, S Carbotta, M Karpathiotakis, G Tortorelli, F Pelle, R Merola, C Donello, G Carbotta, L De Anna, G Conzo, S Sorrenti, S Ulisse
The new Italian cytological classification (SIAPEC 2014) of thyroid nodules, in line with those of Bethesda and BTA-RCPath, replaces the previous TIR3 class with two new classes (TIR3A and TIR3B), which correspond to different risks of malignancy and clinical actions required. The present study was conducted to evaluate the diagnostic accuracy of the new SIAPEC classification as opposed to its previous version (SIAPEC 2007). Preoperative cytology was compared with the final histology obtained from 650 consecutive patients who underwent total thyroidectomy for multinodular goiter...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078727/second-cancer-incidence-in-primary-mediastinal-b-cell-lymphoma-treated-with-methotrexate-with-leucovorin-rescue-doxorubicin-cyclophosphamide-vincristine-prednisone-and-bleomycin-regimen-with-or-without-rituximab-and-mediastinal-radiotherapy-results-from-a-monoinstitutional
#9
Vitaliana De Sanctis, Marco Alfò, Alice Di Rocco, Michela Ansuinelli, Eleonora Russo, Mattia F Osti, Maurizio Valeriani, Giuseppe Minniti, Lavinia Grapulin, Daniela Musio, Stefano Bracci, Alessandra Spagnoli, Maria Luisa Moleti, Vincenzo Tombolini, Maurizio Martelli
Our aim is to assess the incidence of second cancer in long-time surviving primary mediastinal B-cell lymphoma (PMBCL) patients treated with combined radiochemoimmunotherapy (standard methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin with rituximab and mediastinal radiation therapy at a dose of 30 to 36 Gy). For this purpose, 92 points were evaluated. After a median overall survival of 137 months (range 76-212), we recorded second cancer in 3 of 80 long-surviving patients (3...
January 12, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28078619/pancreatic-struma-with-papillary-thyroid-carcinoma-a-diagnostic-dilemma
#10
Jerry Liu, Michael J Marcaccio, J E M Young, Tariq Aziz, Josephine Wat, Sylvia L Asa
No abstract text is available yet for this article.
January 11, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28078481/defining-a-new-tumor-dimension-in-staging-of-papillary-thyroid-carcinoma
#11
Ping Wang, Yong Wang, Chundi Miao, Xing Yu, Haichao Yan, Qiuping Xie, Jaiswal Sanjay, Qunzi Zhao
BACKGROUND: Cervical lymph node metastasis is a vital factor associated with local recurrence in papillary thyroid carcinoma (PTC). Tumor size is used in the staging of PTC because it represents the tumor load. This study compared two methods of tumor size assessment to predict tumor behavior in the relationship between size and cervical node involvement for patients with PTC. METHODS: The study enrolled 1084 patients who underwent initial thyroid surgery and had a pathologic diagnosis of PTC between 2012 and 2014 at The Second Affiliated Hospital Zhejiang University School of Medicine...
January 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28077340/clinicopathological-characteristics-of-papillary-thyroid-cancer-in-children-with-emphasis-on-the-pubertal-status-and-association-with-brafv600e-mutation
#12
Şükran Poyrazoğlu, Rüveyde Bundak, Firdevs Baş, Gülçin Yeğen, Yasemin Şanlı, Feyza Darendeliler
OBJECTIVE: Papillary thyroid cancer (PTC) could behave differently in prepubertal than in pubertal children and between children and adults. BRAF gene activating mutations may associate with PTC by creating aberrant activation. We aimed to evaluate clinicopathological characteristics of PTC patients with emphasis on the pubertal status and investigate the association of BRAFV600E mutation with disease characteristics. METHODS: Medical records of 75 patients with PTC were reviewed retrospectively...
January 12, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28076008/pictorial-review-of-false-positive-results-on-radioiodine-scintigrams-of-patients-with-differentiated-thyroid-cancer
#13
Amy V Chudgar, Jagruti C Shah
Radioiodine has served an important role in the diagnostic workup and treatment of patients with differentiated thyroid cancer for more than 6 decades. The interpretation of radioiodine scintigraphic studies should be performed in conjunction with a comprehensive history, histopathologic correlation, and pertinent laboratory values, as well as correlation with available anatomic images and the findings from physical examination. A thorough understanding of the physiology and biodistribution of radioiodine is critical when interpreting radioiodine scintigraphic studies to avoid misinterpretation of physiologic and nonthyroid pathologic variants as thyroid cancer metastases...
January 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28074747/liraglutide-a-glucagon-like-peptide-1-agonist-for-chronic-weight-management
#14
Kendra R Manigault, Maria Miller Thurston
OBJECTIVE: To review the efficacy and safety of liraglutide 3.0 mg for weight loss. DATA SOURCE: A literature search was performed using PubMed and MEDLINE from 2000 to 2016. The following key terms were used alone or in combination: glucagon-like peptide-1 agonist, liraglutide, obesity, overweight, and weight loss. Additional supporting literature was identified utilizing the reference lists of the preceding articles. STUDY SELECTION: Analyzed studies were published in English and investigated use of liraglutide and its impact on weight loss...
December 1, 2016: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
https://www.readbyqxmd.com/read/28073132/hypothyroidism-in-cancer-patients-on-immune-checkpoint-inhibitors-with-anti-pd1-agents-insights-on-underlying-mechanisms
#15
M Alhusseini, J Samantray
Background: Immune therapy using monoclonal antibodies against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programmed cell death 1 receptor (PD-1) for various cancers have been reported to cause thyroid dysfunction. Little is known, however, about the underlying pathogenic mechanisms and the course of hypothyroidism that subsequently develops. In this report, we use the change in thyroglobulin and thyroid antibody levels in patients on immune therapy who develop hypothyroidism to better understand its pathogenesis as well as examine the status of hypothyroidism in the long term...
January 10, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28072974/-clinicopathologic-features-of-mammary-analogue-secretory-carcinoma-of-salivary-glands
#16
X P Zhang, H Ni, X Wang, H Chen, S S Shi, B Yu, X J Zhou, Q Rao
Objective: To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion...
January 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28072581/-131-i-activity-quantification-of-gamma-camera-planar-images
#17
Raquel Barquero, Hugo P Garcia, Monica G Incio, Pablo Minguez, Alexander Cardenas, Daniel Martínez, Michael Lassmann
A procedure to estimate the activity in target tissues in patients during the therapeutic administration of (131)I radiopharmaceutical treatment for thyroid conditions (hyperthyroidism and differentiated thyroid cancer) using a gamma camera (GC) with a high energy (HE) collimator, is proposed. Planar images are acquired for lesions of different sizes r, and at different distances d, in two HE GC systems. Defining a region of interest (ROI) on the image of size r, total counts n g are measured. Sensitivity S (cps MBq(-1)) in each acquisition is estimated as the product of the geometric G and the intrinsic efficiency η 0...
January 10, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28071986/evaluation-of-a-two-year-routine-application-of-molecular-testing-of-thyroid-fine-needle-aspirations-fna-using-a-7-gene-panel-in-a-primary-referral-setting-in-germany
#18
Markus Eszlinger, Katharina Böhme, Maha Ullmann, Fabian Görke, Udo Siebolts, Anna Neumann, Christiane Franzius, Sabine Adam, Thomas Molwitz, Christian Landvogt, Bassam Amro, Anja Hach, Berit Feldmann, Dieter Graf, Antje Wefer, Rainer Niemann, Catharina Bullmann, Günther Klaushenke, Reinhard Santen, Gregor Tönshoff, Velimir Ivancevic, Andreas Kögler, Eberhard Bell, Bernd Lorenz, Gerald Kluge, Christoph Hartenstein, Ilka Ruschenburg, Ralf Paschke
BACKGROUND: Major differences with respect to the diagnostic performance of a "ruling in" approach in the pre-surgical diagnosis of indeterminate thyroid fine needle aspirations (FNAs) have been reported. Therefore, the aim of this prospective multicenter study was to investigate the specific diagnostic impact of mutation testing using a 7-gene-panel in a routine primary referral setting analyzing FNAs from endocrinology and nuclear medicine practices in Germany. METHODS: RNA and DNA was extracted from 564 routine air-dried FNA smears obtained from 64 physicians and cytologically graded by one experienced cytopathologist...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28071623/differentiated-thyroid-cancer-in-iran-initial-observations-histological-features-management-of-the-disease-and-tumor-recurrence-a-review-of-1689-cases
#19
M Moslehi, Z Shahi, S Badihian, P Jalalpour, M Sedghian, G Motamedi, G Tavakol
AIM: The main objective of this study was to define some histopathological aspects of differentiated thyroid cancer (DTC), describe the disease management, and evaluate potential predicting factors for tumor recurrence in Iran. MATERIALS AND METHODS: Medical records of 1689 patients of DTC treated over a 15-year period at a referral hospital located in the central region of Iran were reviewed retrospectively. RESULTS: The female/male ratio was 3...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28070798/does-vitamin-d-play-a-role-in-autoimmune-endocrine-disorders-a-proof-of-concept
#20
REVIEW
Barbara Altieri, Giovanna Muscogiuri, Luigi Barrea, Chantal Mathieu, Carla V Vallone, Luca Mascitelli, Giorgia Bizzaro, Vincenzo M Altieri, Giacomo Tirabassi, Giancarlo Balercia, Silvia Savastano, Nicola Bizzaro, Cristina L Ronchi, Annamaria Colao, Alfredo Pontecorvi, Silvia Della Casa
In the last few years, more attention has been given to the "non-calcemic" effect of vitamin D. Several observational studies and meta-analyses demonstrated an association between circulating levels of vitamin D and outcome of many common diseases, including endocrine diseases, chronic diseases, cancer progression, and autoimmune diseases. In particular, cells of the immune system (B cells, T cells, and antigen presenting cells), due to the expression of 1α-hydroxylase (CYP27B1), are able to synthesize the active metabolite of vitamin D, which shows immunomodulatory properties...
January 9, 2017: Reviews in Endocrine & Metabolic Disorders
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