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https://www.readbyqxmd.com/read/29215631/which-patients-with-mild-acute-pancreatitis-require-prolonged-hospitalization
#1
Harkirat Singh, Amir Gougol, Rawad Mounzer, Dhiraj Yadav, Efstratios Koutroumpakis, Adam Slivka, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: In our experience, a subset of mild acute pancreatitis (AP) patients, as defined by the Revised Atlanta Classification, has longer than expected hospitalization. Our aims are to report the prevalence of patients with mild AP who have a prolonged length of stay (LOS), evaluate the etiology, thoroughly phenotype, and finally compare this subset to those with expected LOS. METHODS: Patients admitted with AP from 2003 to 2015 were prospectively enrolled into this cohort study...
December 7, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29215544/the-251-a-t-polymorphism-in-the-il8-promoter-is-a-risk-factor-for-acute-pancreatitis
#2
Shrinivas Bishu, Efstratios Koutroumpakis, Rawad Mounzer, Kimberly Stello, Nijole Pollock, Anna Evans, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: Inflammation in the setting of acute pancreatitis (AP) is partially driven by pathogen recognition receptors that recognize damage-associated molecular patterns. Interleukin (IL)-8 is a chemotactic factor produced by pathogen recognition receptor-expressing cells. A single-nucleotide polymorphism in IL8 promoter region (-251 A/T) has been implicated in inflammatory diseases. We examined whether this IL8 polymorphism confers susceptibility to AP. METHODS: Patients with AP (n = 357) were prospectively recruited...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215538/cortisol-outperforms-novel-cardiovascular-inflammatory-and-neurohumoral-biomarkers-in-the-prediction-of-outcome-in-acute-pancreatitis
#3
Christian A Nebiker, Sebastian Staubli, Juliane Schäfer, Roland Bingisser, Mirjam Christ-Crain, Salome Dell-Kuster, Christian Mueller, Karla Scamardi, Carsten T Viehl, Dieter Kolleth, Urs von Holzen, Daniel Oertli, Rachel Rosenthal
OBJECTIVES: The aims of this study were to assess whether copeptin, pro-atrial natriuretic peptide, proadrenomedullin, and cortisol are associated with disease severity in patients with acute pancreatitis (AP) and to compare their ability in predicting organ failure or death. METHODS: From April 2011 to January 2015, 142 patients with AP were included in this prospective single-center study and observed for 4 days. Disease severity was rated by the Atlanta 1992 and 2012 criteria and organ failure by the modified Marshall score...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29209119/how-severe-is-moderately-severe-acute-pancreatitis-clinical-validation-of-revised-2012-atlanta-classification
#4
Povilas Ignatavicius, Aiste Gulla, Karolis Cernauskis, Giedrius Barauskas, Zilvinas Dambrauskas
AIM: To explore the outcomes and the appropriate treatment for patients with moderately severe acute pancreatitis (AP). METHODS: Statistical analysis was performed on data from the prospectively collected database of 103 AP patients admitted to the Department of Surgery, Hospital of Lithuanian University of Health Sciences in 2008-2013. All patients were confirmed to have the diagnosis of AP during the first 24 h following admission. The severity of pancreatitis was assessed by MODS and APACHE II scale...
November 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29202530/-a-comparison-between-the-revision-of-atlanta-classification-and-determinant-based-classification-in-acute-pancreatitis
#5
D Wu, B Lu, H D Xue, Y M Lai, J M Qian, H Yang
Objective: To compare the performance of the revision of Atlanta classification (RAC) and determinant-based classification (DBC) in acute pancreatitis. Methods: Consecutive patients with acute pancreatitis admitted to a single center from January 2001 to January 2015 were retrospectively analyzed. Patients were classified into mild, moderately severe and severe categories based on RAC and were simultaneously classified into mild, moderate, severe and critical grades according to DBC. Disease severity and clinical outcomes were compared between subgroups...
December 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29201763/role-of-clinical-biochemical-and-imaging-parameters-in-predicting-the-severity-of-acute-pancreatitis
#6
Dina Zerem, Omar Zerem, Enver Zerem
Aim: The assessment of the severity of acute pancreatitis (AP) is important for proper management of the disease and for its prognosis. The aim was to correlate clinical, biochemical, and imaging diagnostic parameters and evaluate their prognostic values in the early assessment of severity of AP. Materials and methods: We prospectively studied 128 consecutive patients with AP. The predictors were clinical, biochemical, and imaging diagnostic parameters. The outcome measure was the occurrence of complications...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29164335/clinical-characteristics-of-acute-pancreatitis-in-pregnancy-experience-based-on-121-cases
#7
Lingyu Luo, Hao Zen, Hongrong Xu, Yin Zhu, Pi Liu, Liang Xia, Wenhua He, Nonghua Lv
PURPOSE: Acute pancreatitis in pregnancy (APIP) is a rare condition; however, it markedly affects maternal and fetal health. This study aimed to describe the types, clinical characteristics, mortality, and the safety and necessity of gestation termination of acute pancreatitis in pregnancy (APIP). METHODS: We retrospectively reviewed 121 APIP cases in the Gastroenterology Department of The First Affiliated Hospital of Nanchang University. APIP diagnosis were based on 2012 Atlanta Criteria...
November 21, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29103188/management-of-inflammatory-fluid-collections-and-walled-off-pancreatic-necrosis
#8
REVIEW
Apeksha Shah, Richard Denicola, Cynthia Edirisuriya, Ali A Siddiqui
Pancreatic fluid collections are a frequent complication of acute pancreatitis. The revised Atlanta criterion classifies chronic fluid collections into pseudocysts and walled-off pancreatic necrosis (WON). Symptomatic PFCs require drainage options that include surgical, percutaneous, or endoscopic approaches. With the advent of newer and more advanced endoscopic tools and expertise, minimally invasive endoscopic drainage has now become the preferred approach. An endoscopic ultrasonography (EUS)-guided approach for pancreatic fluid collection drainage is now the preferred endoscopic approach...
December 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/29095423/association-of-statins-with-decreased-acute-pancreatitis-severity-a-propensity-score-analysis
#9
Peter J Lee, Kunjam Modha, Tiffany Chua, Amitabh Chak, Daniel Jang, Rocio Lopez, Amir Gougol, Georgios I Papachristou, Tyler Stevens
BACKGROUND: Statins possess anti-inflammatory properties and have a protective effect in certain inflammatory conditions; however, their effect on the natural history of pancreatitis is unknown. AIM: The aim of this study is to assess the effect of statin exposure on the severity of pancreatitis and incidence of organ failure using a propensity-matched approach. METHODS: A historical cohort study was conducted of adult patients with acute pancreatitis (AP) admitted in the Cleveland Clinic Health System between 2007 and 2014...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29046745/the-bedside-index-for-severity-in-acute-pancreatitis-a-systematic-review-of-prospective-studies-to-determine-predictive-performance
#10
Subhash Chandra, Arvind Murali, Reena Bansal, Dipti Agarwal, Adrian Holm
Background: predicting the development of severe disease has remained a major challenge in management of acute pancreatitis. The Bedside Index for Severity in Acute Pancreatitis (BISAP) is easy to calculate from the data available in the first 24 hours. Here, we performed a systematic review to determine the prognostic accuracy of the BISAP for severe acute pancreatitis (SAP). Methods: major databases of biomedical publications were searched during the first week of October 2015. Two independent reviewers searched records in two phases...
October 2017: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/29031861/the-benefits-of-early-oral-nutrition-in-mild-acute-pancreatitis
#11
Kate M Ellery, Soma Kumar, Wallace Crandall, Cheryl Gariepy
OBJECTIVE: To determine whether early patient-directed oral nutrition in children with mild acute pancreatitis decreases the length of hospitalization without increasing complications. STUDY DESIGN: Hospitalized patients aged 2-21 years of age who met the criteria for acute pancreatitis based on the Revised Atlanta Classification were enrolled prospectively and allowed to eat by mouth at their discretion (patient-directed nutrition [PDN]). These patients were compared with a retrospective cohort of children who were allowed to eat based on traditional practices (treatment team-directed nutrition [TTDN])...
October 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28990794/value-of-the-revised-atlanta-classification-rac-and-determinant-based-classification-dbc-classification-systems-in-the-evaluation-of-acute-pancreatitis
#12
Xiaolei Wang, Li Qin, Jingli Cao
Objective Since increasing AP severity is significantly associated with mortality, accurate and rapid determination of severity is crucial for effective clinical management of AP. This study investigated the value of the revised Atlanta classification (RAC) and the determinant-based classification (DBC) systems in stratifying severity of acute pancreatitis (AP). Methods This retrospective observational cohort study included 480 AP patients. Patient demographics and clinical characteristics were recorded. The primary outcome was mortality, and secondary outcomes were admission to intensive care unit (ICU), duration of ICU stay, and duration of hospital stay...
October 9, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28944325/comparison-of-contrast-enhanced-ct-with-diffusion-weighted-mri-in-the-evaluation-of-patients-with-acute-biliary-pancreatitis
#13
Mehmet İlhan, Muhammet Üçüncü, Ali Fuat Kaan Gök, Gizem Öner, Elidor Agolli, Bahar Canbay, Barış Bakır, Recep Güloğlu, Cemalettin Ertekin
OBJECTIVE: The aim of this study was to compare contrast-enhanced computed tomography with diffusion-weighted magnetic resonance imaging in the evaluation of patients with acute biliary pancreatitis. MATERIAL AND METHODS: Fifty-three patients diagnosed with acute biliary pancreatitis, between February 2012 and July 2015, were evaluated using diffusion-weighted magnetic resonance imaging and magnetic resonance cholangiopancreatography to explain the elevation of cholestasis enzymes and bilirubin levels at "stanbul University...
2017: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/28902793/the-risk-factors-for-moderately-severe-and-severe-post-endoscopic-retrograde-cholangiopancreatography-pancreatitis-according-to-the-revised-atlanta-classification
#14
Eui Joo Kim, Jae Hee Cho, Kyong Yong Oh, Su Young Kim, Yeon Suk Kim
OBJECTIVES: The aim of this study was to confirm the value of the revised Atlanta classification for predicting the severity of post-endoscopic retrograde choloangiopancreatography pancreatitis (PEP) and to validate the risk factors for moderately severe and severe PEP. METHODS: Among 2672 patients, 86 with PEP and 172 randomly selected control patients were included in this study. Post-endoscopic retrograde choloangiopancreatography pancreatitis was evaluated according to Cotton criteria and the revised Atlanta classification...
October 2017: Pancreas
https://www.readbyqxmd.com/read/28876645/is-hiv-status-relevant-in-acute-pancreatitis
#15
L A Prodehl, M B Brand, M Mauser
BACKGROUND: HIV positivity and antiretroviral (ARV) treatment have been described as significant causes of acute pancreatitis prevalence and predictors of poor outcomes. Most data are from the late 1990s and early 2000s, prior to widespread roll out of ARVs and newer agents. This study assessed if there is still a significant difference between HIV positive (HIV+) and negative(HIV-) patients in acute pancreatitis in the presentation and outcomes of acute pancreatitis. METHOD: A retrospective review of a prospectively collected database of patient admission data...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28839444/clinical-outcomes-of-isolated-renal-failure-compared-to-other-forms-of-organ-failure-in-patients-with-severe-acute-pancreatitis
#16
Amir Gougol, Mohannad Dugum, Anwar Dudekula, Phil Greer, Adam Slivka, David C Whitcomb, Dhiraj Yadav, Georgios I Papachristou
AIM: To assess differences in clinical outcomes of isolated renal failure (RF) compared to other forms of organ failure (OF) in patients with severe acute pancreatitis (SAP). METHODS: Using a prospectively maintained database of patients with acute pancreatitis admitted to a tertiary medical center between 2003 and 2016, those with evidence of persistent OF were classified to renal, respiratory, cardiovascular, or multi-organ (2 or more organs). Data regarding demographics, comorbidities, etiology of acute pancreatitis, and clinical outcomes were prospectively recorded...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28815220/severity-and-outcomes-of-acute-alcoholic-pancreatitis-in-cannabis-users
#17
Hemant Goyal, Kelsey Guerreso, Betsy Smith, Kaitlin Harper, Sheetal Patel, Akash Patel, Puja Parikh
BACKGROUND: Cannabis is the most commonly and widely used illicit drug in the world and is also the most commonly used drug of abuse in alcohol drinkers. Experimental studies have shown conflicting results of the effects of cannabis on the severity of acute pancreatitis (AP). The purpose of this study is to ascertain the clinical effects of simultaneous alcohol and cannabis use on severity at presentation and outcomes of acute alcoholic pancreatitis (AAP). METHODS: A retrospective review was conducted on the patients discharged with principle or secondary diagnosis of AP using ICD-9 & ICD-10 codes during the time period from January 2006 to December 2015 at a large community-based hospital in Central Georgia...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28796137/cannabis-induced-acute-pancreatitis-a-systematic-review
#18
Jodie A Barkin, Zsuzsanna Nemeth, Ashok K Saluja, Jamie S Barkin
OBJECTIVES: Cannabis is the most frequently consumed illicit drug in the world, with higher prevalence under the age of 35 years. Cannabis was first reported as a possible cause of acute pancreatitis (AP) in 2004. The aim of this systematic review is to examine cannabis use as an etiology of AP. METHODS: A search using PubMed/Medline, Embase, Scopus, and Cochrane was performed without language or year limitations to May 1, 2016. Search terms were "Cannabis" and "Acute Pancreatitis" with all permutations...
September 2017: Pancreas
https://www.readbyqxmd.com/read/28744075/severity-assessment-of-acute-pancreatitis-using-ct-severity-index-and-modified-ct-severity-index-correlation-with-clinical-outcomes-and-severity-grading-as-per-the-revised-atlanta-classification
#19
Biswanath Sahu, Pooja Abbey, Rama Anand, Ashok Kumar, Shaili Tomer, Ekta Malik
AIMS: To assess the severity of acute pancreatitis (AP) using computed tomography (CT) severity index (CTSI) and modified CT severity index (MCTSI), to correlate with clinical outcome measures, and to assess concordance with severity grading, as per the revised Atlanta classification (RAC). MATERIALS AND METHODS: In this prospective study approved by the Institutional Review Board (November 2014 to March 2016), sixty patients with AP (as per the RAC definition) underwent contrast-enhanced computed tomography (CECT) 5-11 days (median 6 days) after symptom onset...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28700471/plasma-cytokines-can-help-to-identify-the-development-of-severe-acute-pancreatitis-on-admission
#20
Li-Hui Deng, Cheng Hu, Wen-Hao Cai, Wei-Wei Chen, Xiao-Xin Zhang, Na Shi, Wei Huang, Yun Ma, Tao Jin, Zi-Qi Lin, Kun Jiang, Jia Guo, Xiao-Nan Yang, Qing Xia
Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicytokine array, were submitted to quantitative determination using either microparticle-based multiplex immunoassays analyzed on a Luminex 100 platform or enzyme-linked immunosorbent assay kits...
July 2017: Medicine (Baltimore)
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