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https://www.readbyqxmd.com/read/28926626/do-privacy-and-security-regulations-need-a-status-update-perspectives-from-an-intergenerational-survey
#1
Stacey Pereira, Jill Oliver Robinson, Hayley A Peoples, Amanda M Gutierrez, Mary A Majumder, Amy L McGuire, Mark A Rothstein
BACKGROUND: The importance of health privacy protections in the era of the "Facebook Generation" has been called into question. The ease with which younger people share personal information about themselves has led to the assumption that they are less concerned than older generations about the privacy of their information, including health information. We explored whether survey respondents' views toward health privacy suggest that efforts to strengthen privacy protections as health information is moved online are unnecessary...
2017: PloS One
https://www.readbyqxmd.com/read/28926259/dual-photochemical-reaction-pathway-in-flavin-based-photoreceptor-lov-domain-a-combined-quantum-mechanics-molecular-mechanics-investigation
#2
Setsuko Nakagawa, Oliver Weingart, Christel M Marian
The primary photochemical reaction of the light, oxygen, and voltage (LOV) domain of the blue-light photo-sensor YtvA of Bacillus subtilis were investigated using high-level QM(DFT/MRCI)/MM methods. After blue-light excitation, the Sγ atom of the reactive cysteine forms a covalent bond with the C4a of the flavin mononucleotide (FMN) ring. Two conformations for the side chain of reactive cysteine with occupancies of 70% (conf A) and 30% (conf B) are observed in the X-ray crystallographic structures of the YtvA-LOV (Möglich, A...
September 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28926179/abstracts
#3
Jocelyn Rinne, Oliver Norah Nabacwa, Rose Chalo Nabirye, Allison Shorten
No abstract text is available yet for this article.
September 19, 2017: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/28925570/first-trimester-screening-based-on-ultrasound-and-cfdna-vs-first-trimester-combined-screening-a-randomized-controlled-study
#4
Karl Oliver Kagan, Fabrina Sroka, Jiri Sonek, Harald Abele, Kai Lüthgens, Maximilian Schmid, Philipp Wagner, Sara Brucker, Diethelm Wallwiener, Markus Hoopmann
OBJECTIVE: Prospective randomized trial to compare the performance of first trimester combined screening (FTCS) with an approach that uses the combination of a detailed ultrasound examination and cfDNA analysis. METHODS: Pregnant women with a normal first-trimester ultrasound examination at 11 to 13 weeks' gestation (fetal NT ≤3.5 mm and no fetal defects) were randomized into two groups. In the first group, the risk of aneuploidy was assessed using FTCS based on the most recent FMF UK algorithm...
September 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28925339/improving-the-artificial-diet-for-adult-of-seven-spotted-ladybird-beetle-coccinella-septempunctata-l-coleoptera-coccinellidae-with-orthogonal-design
#5
Y Cheng, J R Zhi, F L Li, W H Li, Y H Zhou
In this study, an orthogonal array design with 16 factors at two levels (216) was performed to develop an artificial diet rearing the adults of seven spotted ladybird beetle Coccinella septempunctata. The parameters of weight gain and survival rate of adults, preoviposition period, fecundity and hatching rate of diet-fed adults were monitored. The 16 factors were included: pork liver, infant formula, sucrose, olive oil, yolk, corn oil, yeast powder, cholesterol, casein, casein hydrolysate, vitamin powder, 65% juvenile hormone III, protein powder, vitamin E, honey and pumpkin...
September 19, 2017: Bulletin of Entomological Research
https://www.readbyqxmd.com/read/28925102/continued-alcohol-misuse-in-human-cirrhosis-is-associated-with-an-impaired-gut-liver-axis
#6
Jasmohan S Bajaj, Genta Kakiyama, Derrick Zhao, Hajime Takei, Andrew Fagan, Phillip Hylemon, Huiping Zhou, William M Pandak, Hiroshi Nittono, Oliver Fiehn, Nita Salzman, Mary Holtz, Pippa Simpson, Edith A Gavis, Douglas M Heuman, Runping Liu, Dae Joong Kang, Masoumeh Sikaroodi, Patrick M Gillevet
BACKGROUND: Cirrhosis and alcohol can independently affect the gut-liver axis with systemic inflammation. However their concurrent impact in humans is unclear. AIM: Determine the effect of continued alcohol misuse on the gut-liver axis in cirrhotic patients. METHODS: Age and MELD-balanced cirrhotic patients who were currently drinking (Alc) or abstinent (NAlc), and healthy controls underwent serum and stool collection. A subset underwent upper endoscopy and colonoscopy for biopsies and duodenal fluid collection...
September 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28925082/prospective-evaluation-of-the-septifast-multiplex-real-time-pcr-assay-for-surveillance-and-diagnosis-of-infections-in-haematological-patients-after-allogeneic-stem-cell-transplantation-compared-to-routine-microbiological-assays-and-an-in-house-real-time-pcr
#7
Sandra Elges, Renate Arnold, Oliver Liesenfeld, Grzegorz Kofla, Agata Mikolajewska, Stefan Schwartz, Lutz Uharek, Markus Ruhnke
We prospectively evaluated a multiplex real-time PCR assay (SeptiFast, SF) in a cohort of patients undergoing allo-BMT in comparison to an in-house PCR method (IH-PCR). Overall 847 blood samples (mean 8 samples/patient) from 104 patients with haematological malignancies were analysed. The majority of patients had acute leukaemia (62%) with a mean age of 52 years (54% female). Pathogens could be detected in 91 of 847 (11%) samples by SF compared to 38 of 205 (18.5%) samples by BC, and 57 of 847 (6.7%) samples by IH-PCR...
September 19, 2017: Mycoses
https://www.readbyqxmd.com/read/28924704/-anaphylaxis-caused-by-hymenoptera-stings-importance-of-instructions-and-training-for-emergency-treatment-by-non-medical-personnel
#8
REVIEW
Nils Welchering, Erika von Mutius, Oliver Fuchs
No abstract text is available yet for this article.
September 2017: MMW Fortschritte der Medizin
https://www.readbyqxmd.com/read/28924533/thoracoscopic-tracheoesophageal-n-fistula-repair-using-a-5-8-mm-miniature-stapler-for-fistula-division
#9
Anne-Sophie Holler, Martin Schwind, Krystyna Poplawska, Oliver J Muensterer
No abstract text is available yet for this article.
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/28924196/rapid-alignment-of-nanotomography-data-using-joint-iterative-reconstruction-and-reprojection
#10
Doğa Gürsoy, Young P Hong, Kuan He, Karl Hujsak, Seunghwan Yoo, Si Chen, Yue Li, Mingyuan Ge, Lisa M Miller, Yong S Chu, Vincent De Andrade, Kai He, Oliver Cossairt, Aggelos K Katsaggelos, Chris Jacobsen
As x-ray and electron tomography is pushed further into the nanoscale, the limitations of rotation stages become more apparent, leading to challenges in the alignment of the acquired projection images. Here we present an approach for rapid post-acquisition alignment of these projections to obtain high quality three-dimensional images. Our approach is based on a joint estimation of alignment errors, and the object, using an iterative refinement procedure. With simulated data where we know the alignment error of each projection image, our approach shows a residual alignment error that is a factor of a thousand smaller, and it reaches the same error level in the reconstructed image in less than half the number of iterations...
September 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923877/interplay-among-resistance-profiles-high-risk-clones-and-virulence-in-the-caenorhabditis-elegans-pseudomonas-aeruginosa-infection-model
#11
Irina Sánchez-Diener, Laura Zamorano, Carla López-Causapé, Gabriel Cabot, Xavier Mulet, Carmen Peña, Rosa Del Campo, Rafael Cantón, Antonio Doménech-Sánchez, Luis Martínez-Martínez, Susana C Arcos, Alfonso Navas, Antonio Oliver
The increasing prevalence of nosocomial infections produced by multidrug-resistant (MDR) or extensively drug-resistant (XDR) Pseudomonas aeruginosa is frequently linked to widespread international strains designated as high-risk clones. In this work we attempted to decipher the interplay between resistance profiles, high-risk clones and virulence, testing a large (n=140) collection of well characterized P. aeruginosa isolates from different sources (bloodstream infections, nosocomial outbreaks, cystic fibrosis and environment) in a Caenorhabditis elegans infection model...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28923828/attenuated-pdgf-signaling-drives-alveolar-and-microvascular-defects-in-neonatal-chronic-lung%C3%A2-disease
#12
Prajakta Oak, Tina Pritzke, Isabella Thiel, Markus Koschlig, Daphne S Mous, Anita Windhorst, Noopur Jain, Oliver Eickelberg, Kai Foerster, Andreas Schulze, Wolfgang Goepel, Tobias Reicherzer, Harald Ehrhardt, Robbert J Rottier, Peter Ahnert, Ludwig Gortner, Tushar J Desai, Anne Hilgendorff
Neonatal chronic lung disease (nCLD) affects a significant number of neonates receiving mechanical ventilation with oxygen-rich gas (MV-O2). Regardless, the primary molecular driver of the disease remains elusive. We discover significant enrichment for SNPs in the PDGF-Rα gene in preterms with nCLD and directly test the effect of PDGF-Rα haploinsufficiency on the development of nCLD using a preclinical mouse model of MV-O2 In the context of MV-O2, attenuated PDGF signaling independently contributes to defective septation and endothelial cell apoptosis stemming from a PDGF-Rα-dependent reduction in lung VEGF-A...
September 18, 2017: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/28922994/two-attributes-of-number-meaning
#13
Michael Wiemers, Harold Bekkering, Oliver Lindemann
Many studies demonstrated interactions between number processing and either spatial codes (effects of spatial-numerical associations) or visual size-related codes (size-congruity effect). However, the interrelatedness of these two number couplings is still unclear. The present study examines the simultaneous occurrence of space- and size-numerical congruency effects and their interactions both within and across trials. In a magnitude judgment task physically small or large digits were presented left or right from screen center...
July 2017: Experimental Psychology
https://www.readbyqxmd.com/read/28922980/a-genome-wide-association-study-of-early-gamma-band-response-in-a-schizophrenia-case-control-sample
#14
Bettina Konte, Gregor Leicht, Ina Giegling, Oliver Pogarell, Susanne Karch, Annette M Hartmann, Marion Friedl, Ulrich Hegerl, Dan Rujescu, Christoph Mulert
OBJECTIVES: Disturbances in the gamma-frequency band of electroencephalography (EEG) measures are among the most consistently observed intermediate phenotypes in schizophrenia. We assessed whether genetic variations are associated with gamma-band activity. METHODS: We performed a genome-wide association analysis of the early auditory evoked gamma-band response in schizophrenia affected subjects and healthy control individuals (in total N = 315). RESULTS: No marker surpassed the threshold for genome-wide significant association...
September 19, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28922519/a-cost-minimisation-analysis-of-olive-oil-versus-hyperoxygenated-fatty-acid-treatment-for-the-prevention-of-pressure-ulcers-in-primary-health-care-a-randomised-controlled-trial
#15
Inmaculada Lupiañez-Pérez, Juan Carlos Morilla-Herrera, Shakira Kaknani-Uttumchanchandani, Yolanda Lupiañez-Perez, Magdalena Cuevas-Fernandez-Gallego, Francisco Martin-Santos, Jorge Caro-Bautista, Jose Miguel Morales-Asencio
Pressure ulcers represent a major current health problem and cause an important economic impact on the health care system. Most studies on the prevention of pressure ulcers have been carried out in hospital contexts, with respect to the use of hyperoxygenated fatty acids, and to date no studies have specifically examined the use of olive oil-based treatments. AIM: To evaluate the cost of using extra virgin olive oil, rather than hyperoxygenated fatty acids, in the prevention of pressure ulcers among persons with impaired mobility and receiving home care...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28922490/risk-factors-for-football-injuries-in-young-players-aged-7-to-12-years
#16
Roland Rössler, Astrid Junge, Jiri Chomiak, Karel Němec, Jiri Dvorak, Eric Lichtenstein, Oliver Faude
OBJECTIVES: Football (soccer) is very popular amongst children. Little is known about risk factors for football injuries in children. The aim was to analyse potential injury risk factors in 7 to 12 year old players. DESIGN: Prospective epidemiological study. METHODS: We collected prospective data in Switzerland and the Czech Republic over two seasons. Coaches reported exposure of players (in hours), absence, and injury data via an internet-based registration system...
September 18, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28922417/lingering-single-strand-breaks-trigger-rad51-independent-homology-directed-repair-of-collapsed-replication-forks-in-the-polynucleotide-kinase-phosphatase-mutant-of-fission-yeast
#17
Arancha Sanchez, Mariana C Gadaleta, Oliver Limbo, Paul Russell
The DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) protects genome integrity by restoring ligatable 5'-phosphate and 3'-hydroxyl termini at single-strand breaks (SSBs). In humans, PNKP mutations underlie the neurological disease known as MCSZ, but these individuals are not predisposed for cancer, implying effective alternative repair pathways in dividing cells. Homology-directed repair (HDR) of collapsed replication forks was proposed to repair SSBs in PNKP-deficient cells, but the critical HDR protein Rad51 is not required in PNKP-null (pnk1Δ) cells of Schizosaccharomyces pombe...
September 18, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28922331/descemet-membrane-thickening-as-a-sign-for-the-diagnosis-of-corneal-graft-rejection-an-ex-vivo-study
#18
Ryan VanDenBerg, Vasilios F Diakonis, Alison Bozung, Gustavo Rosa Gameiro, Oliver Fischer, Ahmed El Dakkak, Jan Paul Ulloa-Padilla, Apostolos Anagnostopoulos, Sander Dubovy, Mohamed Abou Shousha
PURPOSE: To disclose, using an ex vivo study, the histopathological mechanism behind in vivo thickening of the endothelium/Descemet membrane complex (En/DM) observed in rejected corneal grafts (RCGs). METHODS: Descemet membrane (DM), endothelium, and retrocorneal membranes make up the total En/DM thickness. These layers are not differentiable by high-definition optical coherence tomography; therefore, the source of thickening is unclear from an in vivo perspective...
September 14, 2017: Cornea
https://www.readbyqxmd.com/read/28921501/immunological-tolerance-to-lcmv-antigens-differently-affects-control-of-acute-and-chronic-virus-infection-in-mice
#19
Christina Woopen, Tobias Straub, Oliver Schweier, Ulrike Aichele, Katharina Düker, Thomas Boehm, Hanspeter Pircher
Cytotoxic T lymphocytes (CTLs) play a key role in the control of lymphocytic choriomeningitis virus (LCMV) infection. In C57BL/6 mice (H-2(b) ), the CTL response is mainly directed against epitopes from the LCMV glycoprotein (GP) and the nucleoprotein (NP) which represent the two major viral proteins. The role of GP- versus NP-derived epitopes for viral clearance was examined using transgenic (tg) mice ubiquitously expressing LCMV GP and NP, respectively. These mice lack GP- or NP-specific CTLs and show decreased levels of GP- or NP-specific antibodies as a result of tolerance induction...
August 11, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28921017/the-german-arthroscopy-registry-dart
#20
Ralf Mueller-Rath, Oliver Miltner, Alfred Hochrein, Philipp Niemeyer
In Germany, more than 400,000 arthroscopic procedures are performed each year. The DART registry is designed to study the outcome of arthroscopic procedures of the shoulder, hip, knee and ankle joint under everyday clinical circumstances using patient-reported outcome measures (PROMs). DART aims at identifying patient-specific factors correlated with therapy-associated complications and treatment failure and will help study the influence of concurrent joint diseases and procedures. To achieve these tasks, a Web-based remote data entry system will be applied and adapted to the needs of DART...
September 18, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
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