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https://www.readbyqxmd.com/read/28110352/effects-of-methylphenidate-on-attention-in-wistar-rats-treated-with-the-neurotoxin-n-2-chloroethyl-n-ethyl-2-bromobenzylamine-dsp4
#1
Joachim Hauser, Andreas Reissmann, Thomas-A Sontag, Oliver Tucha, Klaus W Lange
The aim of this study was to assess the effects of the neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4) on attention in rats as measured using the 5-choice-serial-reaction-time task (5CSRTT) and to investigate whether methylphenidate has effects on DSP4-treated rats. Methylphenidate is a noradrenaline and dopamine reuptake inhibitor and commonly used in the pharmacological treatment of individuals with attention deficit/hyperactivity disorder (ADHD). Wistar rats were trained in the 5CSRTT and treated with one of three doses of DSP4 or saline...
January 21, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28110257/acidification-with-nitric-acid-improves-chemical-characteristics-and-reduces-phytotoxicity-of-alkaline-chars
#2
Fernando Fornes, Rosa Maria Belda
Charred organic matter is recently receiving attention for its potential use as soilless growth medium. However, depending on its origin and on the manufacturing technology, it can result toxic for plants. This fact implies that a detoxifying treatment ought to be devised in order to reclaim char in this way. We have studied three materials which combine these factors: two pyrolyzed biochars, one from forest waste (BCH-FW) and another from olive mill waste (BCH-OMW), and one hydrothermally carbonized hydrochar from forest waste (HYD-FW)...
January 19, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28109725/6q12-and-11p14-variants-are-associated-with-postnatal-exhaled-nitric-oxide-and-respiratory-symptoms
#3
Oliver Fuchs, Olga Gorlanova, Philipp Latzin, Anne Schmidt, Maximilian Schieck, Antoaneta A Toncheva, Sven Michel, Vincent D Gaertner, Michael Kabesch, Urs Frey
BACKGROUND: Exhaled nitric oxide (eNO) is a biomarker of airway inflammation and seems to precede respiratory symptoms, such as asthma in childhood. Identifying genetic determinants of postnatal eNO may aid in unraveling the role of eNO in epithelial function or airway inflammation and disease. OBJECTIVE: To identify genetic determinants of early postnatal eNO and subsequent respiratory symptoms during the first year of life. METHODS: Within a population-based birth cohort, eNO was measured in healthy term infants aged 5 weeks during quiet tidal breathing in unsedated sleep...
January 18, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28109033/a-quality-improvement-initiative-to-decrease-the-rate-of-solitary-blood-cultures-in-the-emergency-department
#4
Joseph Choi, Sahand Ensafi, Lucas Brien Chartier, Oliver Van Praet
OBJECTIVES: Best practice guidelines recommend that at least two sets of blood cultures (BCs) be sent when blood cultures are required. However, high rates of solitary BCs are still common in the emergency department (ED). The aim of this study was to evaluate the efficacy of different quality improvement initiatives aimed at reducing the rate of solitary blood cultures being sent to the lab on patients ultimately discharged from our ED. METHODS: This was a multi-centre, multi-phase, prospective study evaluating a comprehensive education-based intervention and a second intervention that combined a computerized forcing function along with a brief education-based intervention...
January 20, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28108836/smad-dependent-signaling-plays-a-detrimental-role-in-a-fly-model-of-smarcb1-deficiency-and-the-biology-of-atypical-teratoid-rhabdoid-tumors
#5
Astrid Jeibmann, Jacqueline Schulz, Kristin Eikmeier, Pascal D Johann, Katharina Thiel, Isabel Tegeder, Oliver Ambrée, Michael C Frühwald, Stefan M Pfister, Marcel Kool, Werner Paulus, Martin Hasselblatt
Atypical teratoid/rhabdoid tumors (ATRT) are highly malignant brain tumors arising in young children. The majority of ATRT is characterized by inactivation of the chromatin remodeling complex member SMARCB1 (INI1/hSNF5). Little is known, however, on downstream pathways involved in the detrimental effects of SMARCB1 deficiency which might also represent targets for treatment. Using Drosophila melanogaster and the Gal4-UAS system, modifier screens were performed in order to identify the role of SMAD dependent signaling in the lethal phenotype associated with knockdown of snr1, the fly homolog of SMARCB1...
January 20, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28108814/the-small-neurotoxin-apamin-blocks-not-only-small-conductance-ca-2-activated-k-channels-sk-type-but-also-the-voltage-dependent-kv1-3-channel
#6
Patrick Voos, Mehtap Yazar, René Lautenschläger, Oliver Rauh, Anna Moroni, Gerhard Thiel
Apamin is frequently used as a specific blocker of small-conductance Ca(2+)-activated (SK type) K(+) channels. Here we show that the small neurotoxin is not as specific as anticipated. It is also a high-affinity inhibitor with an IC50 of 13 nM of the Kv1.3 channel; it blocks the latter with potency similar to the Kv1.3 blocker PAP-1. Since SK type channels and Kv1.3 channels are frequently coexpressed in different tissues such as cells of the immune system, apamin must be used with caution as a pharmacological tool...
January 20, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28108340/rna-seq-transcriptome-analysis-of-the-olive-flounder-paralichthys-olivaceus-kidney-response-to-vaccination-with-heat-inactivated-viral-hemorrhagic-septicemia-virus
#7
Jee Youn Hwang, Mun Gyeoung Kwon, Sung-Hee Jung, Myoung Ae Park, Dong-Wook Kim, Wang Sik Cho, Jeong Woo Park, Maeng-Hyun Son
Viral hemorrhagic septicemia (VHS) is a highly contagious disease of cultured flounder caused by VHS virus (VHSV). To develop effective VHSV vaccines, it is essential to understand the molecular mechanisms underlying the host's protective response against VHSV. The purpose of this study is to clarify which genes are involved in the protective response of olive flounder after VHSV vaccination. We first injected olive flounder intraperitoneally with 10(7) TCID50 heat-inactivated VHSV vaccine and evaluated the vaccine efficacy at 20 °C...
January 17, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28107970/a-new-analytical-method-for-quantification-of-olive-and-palm-oil-in-blends-with-other-vegetable-edible-oils-based-on-the-chromatographic-fingerprints-from-the-methyl-transesterified-fraction
#8
Ana M Jiménez-Carvelo, Antonio González-Casado, Luis Cuadros-Rodríguez
A new analytical method for the quantification of olive oil and palm oil in blends with other vegetable edible oils (canola, safflower, corn, peanut, seeds, grapeseed, linseed, sesame and soybean) using normal phase liquid chromatography, and applying chemometric tools was developed. The procedure for obtaining of chromatographic fingerprint from the methyl-transesterified fraction from each blend is described. The multivariate quantification methods used were Partial Least Square-Regression (PLS-R) and Support Vector Regression (SVR)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28107410/prognostic-impact-of-ct-quantified-muscle-and-fat-distribution-before-and-after-first-line-chemotherapy-in-lung-cancer-patients
#9
Johanna Nattenmüller, Raoul Wochner, Thomas Muley, Martin Steins, Simone Hummler, Birgit Teucher, Joachim Wiskemann, Hans-Ulrich Kauczor, Mark Oliver Wielpütz, Claus Peter Heussel
INTRODUCTION: Cachexia and sarcopenia are associated with poor outcome and increased chemotherapy-induced toxicity in lung cancer patients. However, the complex interplay of obesity, sarcopenia and cachexia, and its impact on survival in the context of first-line-chemotherapy is not yet understood. METHODS: In 200 consecutively recruited lung cancer patients (70 female, mean age 62y; mean BMI 25 kg/m2; median follow-up 15.97 months) with routine staging-CT before and after chemotherapy (CTX, mean interval: 4...
2017: PloS One
https://www.readbyqxmd.com/read/28107097/comparison-of-systemic-and-topical-hypericum-perforatum-on-diabetic-surgical-wounds
#10
Mehmet Altıparmak, Teoman Eskitaşçıoğlu
BACKGROUND: Surgical wounds in diabetic patients still remain a problem till the present day. As a common plant found around the world, Hypericum perforatum L. (Hypericaceae) is traditionally prepared as an oily extract and used as a folk remedy for various diseases such as wounds, burns, cuts, etc. This study aims to evaluate the effect of St. John's wort (Hypericum perforatum) on problematic wounds while comparing oral and topical applications. METHODS: Incisional and excisional wound models were made on the dorsal regions of 54 diabetic Spraque-Dawley rats...
January 20, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28106939/maximizing-output-in-rna-programmed-peptidyl-transfer-reactions
#11
Margherita Di Pisa, Anett Hauser, Oliver Seitz
A chemical reaction that is triggered by specific RNA molecules may provide opportunities for the design of artificial feedback loops. We envision a peptidyl transfer reaction, in which mRNA encoding for antiapoptotic protein would instruct the synthesis of apoptosis-inducing peptides. In this study, we tackled the RNA-programmed synthesis of a 16mer peptide derived from the Bak-BH3 protein which inhibits the antiapoptotic protein Bcl-xL. The reaction involves the transfer of a thioester-linked donor peptide fragment from one PNA conjugate onto an acceptor peptide-PNA conjugate...
January 20, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28106624/intraoperative-electrocochleography-a-window-into-endolymphatic-hydrops-in-a-patient-with-an-endolymphatic-sac-tumor
#12
William J Riggs, Dominic J Catalano, Michael S Harris, Oliver F Adunka, Aaron C Moberly
OBJECTIVES: Intraoperative electrocochleography (ECochG) provides valuable information regarding inner ear function during surgical procedures. Here, we report findings from ECochG collected at three time intervals during the management of a patient with symptoms of inner ear hydrops. PATIENTS: A 38-year-old man with an endolymphatic sac tumor who demonstrated classic Ménière's symptoms. INTERVENTIONS: Endolymphatic shunt, tumor biopsy, and definitive resection of an endolymphatic sac tumor...
January 18, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28106611/time-course-of-copeptin-during-a-model-of-experimental-pain-and-hyperalgesia-a-randomised-volunteer-crossover-trial
#13
Eckhard Mauermann, Claudine A Blum, Giovanna Lurati Buse, Oliver Bandschapp, Wilhelm Ruppen
BACKGROUND: A reliable biomarker for quantifying pain or hyperalgesia has yet to be found. A surrogate marker of arginine vasopressin, copeptin, is elevated in a number of states of physiological and psychological stress and may have a role in quantifying pain and/or hyperalgesia. OBJECTIVES: To evaluate copeptin as a biomarker for pain or hyperalgesia developing after 120 min of sustained electrical stimulation. DESIGN: Secondary analysis of a randomised, double-blinded, crossover trial...
January 19, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28106272/health-claims-and-methodological-controversy-in-nutrition-science
#14
Oliver Todt, José Luis Luján
This article analyzes the debate about data acquisition and assessment in health claims regulation by identifying the underlying controversies on methodological choice. Regulation in the European Union imposes the need for a scientific substantiation of all health claims (claims about a relationship between consumption of certain food ingredients and positive health effects). Randomized controlled trials (RCTs) are the method that generally is considered to provide the highest quality data for decision making in claims regulation because they allow for establishing cause-effect relationships...
January 20, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/28106250/assessment-of-biochar-and-hydrochar-as-minor-to-major-constituents-of-growing-media-for-containerized-tomato-production
#15
Fernando Fornes, Rosa M Belda, Pascual Fernández de Córdova, Jaime Cebolla-Cornejo
BACKGROUND: Chars are emerging materials as constituents of growth media. However, chars of different origin differ in their characteristics and more studies are needed to ratify them for such role. The characteristics of coir mixed with 0, 10, 25, 50, 75, and 100 (% v:v) of two biochars, from forest waste (BCH-FW) and from olive mill waste (BCH-OMW), and one hydrochar, from forest waste (HYD-FW), and their effects on growth, yield and fruit quality of two tomato cultivars (Gransol RZ and Cuarenteno) were assessed...
January 20, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28105952/movement-visualisation-in-virtual-reality-rehabilitation-of-the-lower-limb-a-systematic-review
#16
REVIEW
Luara Ferreira Dos Santos, Oliver Christ, Kedar Mate, Henning Schmidt, Jörg Krüger, Christian Dohle
BACKGROUND: Virtual reality (VR) based applications play an increasing role in motor rehabilitation. They provide an interactive and individualized environment in addition to increased motivation during motor tasks as well as facilitating motor learning through multimodal sensory information. Several previous studies have shown positive effect of VR-based treatments for lower extremity motor rehabilitation in neurological conditions, but the characteristics of these VR applications have not been systematically investigated...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105951/theoretical-implementation-of-prior-knowledge-in-the-design-of-a-multi-scale-prosthesis-satisfaction-questionnaire
#17
Tim Schürmann, Philipp Beckerle, Julia Preller, Joachim Vogt, Oliver Christ
BACKGROUND: In product development for lower limb prosthetic devices, a set of special criteria needs to be met. Prosthetic devices have a direct impact on the rehabilitation process after an amputation with both perceived technological and psychological aspects playing an important role. However, available psychometric questionnaires fail to consider the important links between these two dimensions. In this article a probabilistic latent trait model is proposed with seven technical and psychological factors which measure satisfaction with the prosthesis...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105949/towards-active-lower-limb-prosthetic-systems-design-issues-and-solutions
#18
EDITORIAL
Oliver Christ, Philipp Beckerle
No abstract text is available yet for this article.
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105948/active-lower-limb-prosthetics-a-systematic-review-of-design-issues-and-solutions
#19
REVIEW
Michael Windrich, Martin Grimmer, Oliver Christ, Stephan Rinderknecht, Philipp Beckerle
This paper presents a review on design issues and solutions found in active lower limb prostheses. This review is based on a systematic literature search with a methodical search strategy. The search was carried out across four major technical databases and the retrieved records were screened for their relevance. A total of 21 different active prostheses, including 8 above-knee, 9 below-knee and 4 combined knee-ankle prostheses were identified. While an active prosthesis may help to restore the functional performance of an amputee, the requirements regarding the actuation unit as well as for the control system are high and the development becomes a challenging task...
December 19, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28105567/effects-of-oleuropein-on-pentylenetetrazol-induced-seizures-in-mice-involvement-of-opioidergic-and-nitrergic-systems
#20
Nastaran Rahimi, Bahram Delfan, Nazgol Motamed-Gorji, Ahmad R Dehpour
Oleuropein, a well-known olive polyphenol, has been shown to mediate neuroprotection in Alzheimer's disease and cerebral ischemia. We investigated the effects of oleuropein on pentylenetetrazole (PTZ)-induced seizures in male NMRI mice, with diazepam as the standard drug. We also examined the possible involvement of opioidergic/nitrergic pathways in the probable effects of oleuropein. Intraperitoneal (i.p.) administration of different doses of oleuropein (10, 20 and 30 mg/kg) significantly increased the seizure threshold 60 min prior to induction of seizure, in a dose-dependent manner...
January 19, 2017: Journal of Natural Medicines
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