keyword
https://read.qxmd.com/read/38522704/in-vitro-digestive-properties-of-dictyophora-indusiata-polysaccharides-by-steam-explosion-pretreatment-methods
#21
JOURNAL ARTICLE
Zihao Zhang, Lin Wang, Baodong Zheng, Yi Zhang, Lei Pan
Dictyophora indusiata is medicinal and edible fungi containing various nutrients. The aim of this study was to investigate the efficient extraction and structural evolution of Dictyophora indusiata polysaccharides during the vitro digestion based on steam explosion pretreatment methods. In this study, the extraction rate of Dictyophora indusiata polysaccharides was optimized by steam explosion pretreatment methods, which was 2.46 folds that of the water extraction method. In addition, the digestion and fermentation properties of Dictyophora indusiata polysaccharides before and after steam explosion were evaluated in vitro by the changes of molecular weights, total and reducing sugars levels, surface morphology and functional groups, which showed that the structure of Dictyophora indusiata polysaccharides remained stable after salivary-gastric digestion, and partially entered the large intestine, where it could be utilized by gut microbiota...
March 22, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38521930/human-derived-bacterial-strains-mitigate-colitis-via-modulating-gut-microbiota-and-repairing-intestinal-barrier-function-in-mice
#22
JOURNAL ARTICLE
Juanjuan Dai, Mingjie Jiang, Xiaoxin Wang, Tao Lang, Leilei Wan, Jingjing Wang
BACKGROUND: Unbalanced gut microbiota is considered as a pivotal etiological factor in colitis. Nevertheless, the precise influence of the endogenous gut microbiota composition on the therapeutic efficacy of probiotics in colitis remains largely unexplored. RESULTS: In this study, we isolated bacteria from fecal samples of a healthy donor and a patient with ulcerative colitis in remission. Subsequently, we identified three bacterial strains that exhibited a notable ability to ameliorate dextran sulfate sodium (DSS)-induced colitis, as evidenced by increased colon length, reduced disease activity index, and improved histological score...
March 23, 2024: BMC Microbiology
https://read.qxmd.com/read/38521894/clostridium-butyricum-inhibits-the-inflammation-in-children-with-primary-nephrotic-syndrome-by-regulating-th17-tregs-balance-via-gut-kidney-axis
#23
JOURNAL ARTICLE
Ting Li, Xiaolong Ma, Ting Wang, Wenyan Tian, Jian Liu, Wenke Shen, Yuanyuan Liu, Yiwei Li, Xiaoxu Zhang, Junbai Ma, Xiaoxia Zhang, Jinhai Ma, Hao Wang
BACKGROUND: Primary nephrotic syndrome (PNS) is a common glomerular disease in children. Clostridium butyricum (C. butyricum), a probiotic producing butyric acid, exerts effective in regulating inflammation. This study was designed to elucidate the effect of C. butyricum on PNS inflammation through the gut-kidney axis. METHOD: BALB/c mice were randomly divided into 4 groups: normal control group (CON), C. butyricum control group (CON+C. butyricum), PNS model group (PNS), and PNS with C...
March 23, 2024: BMC Microbiology
https://read.qxmd.com/read/38521168/poly-d-l-lactide-co-glycolide-particles-are-metabolised-by-the-gut-microbiome-and-elevate-short-chain-fatty-acids
#24
JOURNAL ARTICLE
Laura E McCoubrey, Fabiana Ferraro, Nidhi Seegobin, Jérémy Verin, Haya A Alfassam, Atheer Awad, Massimo Marzorati, Lynn Verstrepen, Jonas Ghyselinck, Julie De Munck, Jelle De Medts, Evi Steppe, Valerie De Vleeschhauwer, Gilles De Rocker, Alexandra Droesbeke, Melanie De Rijck, Sara Vanthoor, Frédéric Moens, Juergen Siepmann, Florence Siepmann, Simon Gaisford, Mine Orlu, Abdul W Basit
The production of short chain fatty acids (SCFAs) by the colonic microbiome has numerous benefits for human health, including maintenance of epithelial barrier function, suppression of colitis, and protection against carcinogenesis. Despite the therapeutic potential, there is currently no optimal approach for elevating the colonic microbiome's synthesis of SCFAs. In this study, poly(D,l-lactide-co-glycolide) (PLGA) was investigated for this application, as it was hypothesised that the colonic microbiota would metabolise PLGA to its lactate monomers, which would promote the resident microbiota's synthesis of SCFAs...
March 21, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38520936/effect-of-replacing-soybean-meal-with-hermetia-illucens-meal-on-cecal-microbiota-liver-transcriptome-and-plasma-metabolome-of-broilers
#25
JOURNAL ARTICLE
Simone Beller, Sarah M Grundmann, Klara Pies, Erika Most, Sven Schuchardt, Waldemar Seel, Marie-Christine Simon, Klaus Eder, Robert Ringseis
Despite the existence of a number of studies investigating the effect of insect meal on the growth performance of broilers, knowledge about the metabolic effects of insect meal in broilers is still scarce. Thus, the present study investigated the effect of partial replacement of soybean meal with Hermetia illucens (HI) larvae meal on the liver transcriptome, the plasma metabolome, and the cecal microbiota in broilers. For the study, 72 male one-day-old Cobb 500 broilers were divided into three groups and fed 3 different diets with either 0% (HI0), 7...
March 8, 2024: Poultry Science
https://read.qxmd.com/read/38520351/exopolysaccharides-produced-by-bifidobacterium-longum-subsp-longum-ys108r-ameliorates-dss-induced-ulcerative-colitis-in-mice-by-improving-the-gut-barrier-and-regulating-the-gut-microbiota
#26
JOURNAL ARTICLE
Huizhen Li, Haitao Li, Catherine Stanton, R Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Ulcerative colitis (UC) is a major disease that has endangered human health. Our previous study demonstrated that Bifidobacterium longum subsp. longum YS108R, a ropy exopolysaccharide (EPS)-producing bacterium, could alleviate UC in mice, but it is unclear whether EPS is the key substance responsible for its action. In this study, we proposed to investigate the remitting effect of EPS from B. longum subsp. longum YS108R on UC in a DSS-induced UC mouse model. Water extraction and alcohol precipitation were applied to extract EPS from the supernatant of B...
March 23, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38519188/wet-type-grinder-treated-okara-modulates-gut-microbiota-composition-and-attenuates-obesity-in-high-fat-fed-mice
#27
JOURNAL ARTICLE
Takao Nagano, Chihiro Watanabe, Eri Oyanagi, Hiromi Yano, Takumi Nishiuchi
Wet-type grinder (WG) is a nanofiber technology used to atomize dietary fiber-rich materials. WG-treated okara (WGO) exhibits high dispersion and viscosity similar to those of viscous soluble dietary fibers. Here, we studied the effect of WGO supplementation on obesity and gut microbiota composition in high-fat diet (HFD)-fed mice. WGO intake suppressed body weight gain and fat accumulation, improved glucose tolerance, lowered cholesterol levels, and prevented HFD-induced decrease in muscle mass. WGO supplementation also led to cecum enlargement, lower pH, and higher butyrate production...
April 2024: Food Research International
https://read.qxmd.com/read/38519184/food-additives-impair-gut-microbiota-from-healthy-individuals-and-ibd-patients-in-a-colonic-in-vitro-fermentation-model
#28
JOURNAL ARTICLE
Irma Gonza, Elizabeth Goya-Jorge, Caroline Douny, Samiha Boutaleb, Bernard Taminiau, Georges Daube, Marie-Louise Scippo, Edouard Louis, Véronique Delcenserie
Intestinal fibrosis is a long-term complication of inflammatory bowel diseases (IBD). Changes in microbial populations have been linked with the onset of fibrosis and some food additives are known to promote intestinal inflammation facilitating fibrosis induction. In this study, we investigated how polysorbate 80, sucralose, titanium dioxide, sodium nitrite and maltodextrin affect the gut microbiota and the metabolic activity in healthy and IBD donors (patients in remission and with a flare of IBD). The Simulator of the Human Intestinal Microbial Ecosystem (SHIME®) with a static (batch) configuration was used to evaluate the effects of food additives on the human intestinal microbiota...
April 2024: Food Research International
https://read.qxmd.com/read/38517358/cms121-a-novel-approach-to-mitigate-aging-related-obesity-and-metabolic-dysfunction
#29
JOURNAL ARTICLE
Alcir L Dafre, Saadia Zahid, Jessica Jorge Probst, Antonio Currais, Jingting Yu, David Schubert, Pamela Maher
BACKGROUND: Modulated by differences in genetic and environmental factors, laboratory mice often show progressive weight gain, eventually leading to obesity and metabolic dyshomeostasis. Since the geroneuroprotector CMS121 has a positive effect on energy metabolism in a mouse model of type 2 diabetes, we investigated the potential of CMS121 to counteract the metabolic changes observed during the ageing process of wild type mice. METHODS: Control or CMS121-containing diets were supplied ad libitum for 6 months, and mice were sacrificed at the age of 7 months...
March 20, 2024: Aging
https://read.qxmd.com/read/38516869/effect-of-lactobacillus-plantarum-bfs1243-on-a-female-frailty-model-induced-by-fecal-microbiota-transplantation-in-germ-free-mice
#30
JOURNAL ARTICLE
Sashuang Dong, Qi Zeng, Weimin He, Wei Cheng, Ling Zhang, Ruimin Zhong, Wen He, Xiang Fang, Hong Wei
Frailty, a complex geriatric syndrome, significantly impedes the goal of achieving 'healthy aging'. Increasing evidence suggests a connection between gut microbiota, systemic inflammation, and disease. However, it remains to be determined whether interventions targeting the intestinal flora can effectively ameliorate frailty. Our research involved fecal microbiota transplantation (FMT) experiments on germ-free (GF) mice, dividing these mice into three groups: a group receiving transplants from healthy elderly individuals (HF group), a group of frailty patients (FF group), and the FF group supplemented with Lactobacillus plantarum BFS1243 (FFL group)...
March 22, 2024: Food & Function
https://read.qxmd.com/read/38516398/exploring-new-strategies-for-optimizing-the-production-of-poly-3-hydroxybutyrate-co-3-hydroxyvalerate-from-methane-and-vfas-in-synthetic-cocultures-and-mixed-methanotrophic-consortia
#31
JOURNAL ARTICLE
Claudia Amabile, Teresa Abate, Enrique Marcos, Simeone Chianese, Dino Musmarra, Raul Muñoz
In this work, the potential of a synthetic coculture and a mixed methanotrophic consortium to synthesize poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) from renewable and waste-based feedstocks was assessed batchwise. Methylocystis parvus cocultivated with Rhodococcus opacus and a Methylocystis -enriched culture previously grown on methane were subjected to nutrient starvation in a medium enriched with valeric acid (30% w w-1 of C tot ) or with a VFAs mixture containing acetic, propionic, butyric, and valeric acids (15% w w-1 of C tot ) under a CH4 :O2 or air atmosphere...
March 18, 2024: ACS Sustainable Chemistry & Engineering
https://read.qxmd.com/read/38515857/total-phenolic-contents-cytotoxic-free-radicals-porcine-pancreatic-%C3%AE-amylase-and-lipase-suppressant-activities-of-artemisia-dracunculus-plant-from-palestine
#32
JOURNAL ARTICLE
Nidal Jaradat, Majdi Dwikat, Johnny Amer, Mustafa Ghanim, Mohammed Hawash, Fatima Hussein, Linda Issa, Salsabeel Ishtawe, Shahd Salah, Sara Nasser
Artemisia dracunculus: L. ( A. dracunculus ) is a popular vegetable and spice cultivated across many Middle Eastern countries. The herb's aqueous extract has significant folkloric medicinal importance for treating various disorders. Hence, the present investigation aimed to investigate A. dracunculus hydrophilic extract phytochemical constituents and pleiotropic biological potentials, as no previous studies have investigated the antilipase and anti-α-amylase effects of the A. dracunculus plant. Total phenol content and phytochemical screening assays were performed utilizing standard analytical methods...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38514462/dual-rna-sequencing-of-helicobacter-pylori-and-host-cell-transcriptomes-reveals-ontologically-distinct-host-pathogen-interaction
#33
JOURNAL ARTICLE
Wei Hu, Zhi Yong Zhai, Zhao Yu Huang, Ze Min Chen, Ping Zhou, Xia Xi Li, Gen Hua Yang, Chong Ju Bao, Li Juan You, Xiao Bing Cui, Gui Li Xia, Mei Ping Ou Yang, Lin Zhang, William Ka Kei Wu, Long Fei Li, Yu Xuan Zhang, Zhan Gang Xiao, Wei Gong
UNLABELLED: Helicobacter pylori is a highly successful pathogen that poses a substantial threat to human health. However, the dynamic interaction between H. pylori and the human gastric epithelium has not been fully investigated. In this study, using dual RNA sequencing technology, we characterized a cytotoxin-associated gene A ( cagA )-modulated bacterial adaption strategy by enhancing the expression of ATP-binding cassette transporter-related genes, metQ and HP_0888 , upon coculturing with human gastric epithelial cells...
March 22, 2024: MSystems
https://read.qxmd.com/read/38513071/improving-feed-intake-and-rumen-fermentation-in-lambs-using-mixed-dimensional-attapulgite-clay-to-adsorb-naturally-occurring-mycotoxins
#34
JOURNAL ARTICLE
Liang Chen, Fei Li, Zhiyuan Ma, Aiqin Wang, Yuru Kang, Baocang Liu, Hui Xu, Jiandong Li, Xinji Wang, Kaidong Li
This experiment was conducted to evaluate the effects of including a mixed-dimensional attapulgite clay (MDA) into a naturally moldly diet for Hu lambs. Fifty male Hu lambs with similar initial body weight (28.24 ± 1.80 kg) were randomly allocated into five dietary treatments: a basal diet containing naturally occurring mycotoxins with 0, 0.5, 1.0, and 2.0 kg/t MDA, and basal diet with a commercial mycotoxin adsorbent SolisTM with montmorillonite as the major component at 1 kg/t. Both MDA and Solis increased average daily gain (ADG) and dry matter intake (DMI) (P ≤ 0...
March 21, 2024: Journal of Animal Science
https://read.qxmd.com/read/38511344/mannan-oligosaccharides-promote-gut-microecological-recovery-after-antibiotic-disturbance
#35
JOURNAL ARTICLE
Jing Chen, Jialin Yin, Heqiang Xie, Wenwei Lu, Hongchao Wang, Jianxin Zhao, Jinlin Zhu
Antibiotic treatment often causes collateral damage to the gut microbiota, including changes in its diversity and composition. Dietary fiber helps maintain intestinal health, regulate short-chain fatty acids, and promote the recovery of the intestinal microbiome. However, it is currently unknown which specific plant-based dietary fiber is optimal as a dietary supplement for restoring the intestinal microbiota after antibiotic disturbance. Previously, we proposed predictive recovery-associated bacterial species (p-RABs) and identified the most important interventions...
March 21, 2024: Food & Function
https://read.qxmd.com/read/38511005/genomic-and-functional-analysis-of-the-mucinolytic-species-clostridium-celatum-clostridium-tertium-and-paraclostridium-bifermentans
#36
JOURNAL ARTICLE
Francesco Candeliere, Eliana Musmeci, Laura Sola, Alberto Amaretti, Stefano Raimondi, Maddalena Rossi
Mucins are large glycoproteins whose degradation requires the expression of several glycosil hydrolases to catalyze the cleavage of the oligosaccharide chains and release monosaccharides that can be assimilated. In this study, we present a characterization on the strains Clostridium celatum WC0700, Clostridium tertium WC0709, and Paraclostridium bifermentans WC0705. These three strains were previously isolated from enrichment cultures on mucin of fecal samples from healthy subjects and can use mucin as sole carbon and nitrogen source...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38509791/design-of-a-cofactor-self-sufficient-whole-cell-biocatalyst-for-enzymatic-asymmetric-reduction-via-engineered-metabolic-pathways-and-multi-enzyme-cascade
#37
JOURNAL ARTICLE
Shuping Zou, Bing Zhang, Yuyue Han, Jinlong Liu, Kuo Zhao, Yaping Xue, Yuguo Zheng
NAD(P)H-dependent oxidoreductases are crucial biocatalysts for synthesizing chiral compounds. Yet, the industrial implementation of enzymatic redox reactions is often hampered by an insufficient supply of expensive nicotinamide cofactors. Here, a cofactor self-sufficient whole-cell biocatalyst was developed for the enzymatic asymmetric reduction of 2-oxo-4-[(hydroxy)(-methyl)phosphinyl] butyric acid (PPO) to L-phosphinothricin (L-PPT). The endogenous NADP+ pool was significantly enhanced by regulating Preiss-Handler pathway toward NAD(H) synthesis and, in the meantime, introducing NAD kinase to phosphorylate NAD(H) toward NADP+ ...
March 2024: Biotechnology Journal
https://read.qxmd.com/read/38508273/novel-oxidising-feed-additives-reduce-in-vitro-methane-emissions-using-the-rumen-simulation-technique
#38
JOURNAL ARTICLE
Caroline O'Donnell, Camilla Thorn, Emily Roskam, Ruairi Friel, Stuart F Kirwan, Sinéad M Waters, Vincent O'Flaherty
Enteric methane (CH4 ) produced by ruminant livestock is a potent greenhouse gas and represents significant energy loss for the animal. The novel application of oxidising compounds as antimethanogenic agents with future potential to be included in ruminant feeds was assessed across two separate experiments in this study. Low concentrations of oxidising agents, namely urea hydrogen peroxide (UHP) with and without potassium iodide (KI), and magnesium peroxide (MgO2 ), were investigated for their effects on CH4 production, total gas production (TGP), volatile fatty acid (VFA) profiles, and nutrient disappearance in vitro using the rumen simulation technique...
March 18, 2024: Science of the Total Environment
https://read.qxmd.com/read/38507924/specific-vaginal-and-gut-microbiome-and-the-anti-tumor-effect-of-butyrate-in-cervical-cancer-women
#39
JOURNAL ARTICLE
Mengzhen Han, Na Wang, Wenjie Han, Xiaolin Liu, Tao Sun, Junnan Xu
OBJECTIVE: To investigate the vaginal and gut microbes changes during the carcinogenesis of cervical and the auxiliary diagnostic value. To investigate the effect of microbiome-specific metabolites butyric on cervical cancer cells. METHODS: We studied 416 vaginal 16S rRNA sequencing data and 116 gut sequencing data. Reads were processed using VSEARCH. We used Shannon index, Chao1 index, Simpson diversity index, β diversity index, Linear discriminant analysis Effect Size (LEfSe), co-abundance network and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis to explore microbiome differences between groups...
March 19, 2024: Translational Oncology
https://read.qxmd.com/read/38507436/integrating-microbial-abundance-time-series-with-fermentation-dynamics-of-the-rumen-microbiome-via-mathematical-modelling
#40
JOURNAL ARTICLE
Mohsen Davoudkhani, Francesco Rubino, Christopher J Creevey, Seppo Ahvenjärvi, Ali R Bayat, Ilma Tapio, Alejandro Belanche, Rafael Muñoz-Tamayo
The rumen represents a dynamic microbial ecosystem where fermentation metabolites and microbial concentrations change over time in response to dietary changes. The integration of microbial genomic knowledge and dynamic modelling can enhance our system-level understanding of rumen ecosystem's function. However, such an integration between dynamic models and rumen microbiota data is lacking. The objective of this work was to integrate rumen microbiota time series determined by 16S rRNA gene amplicon sequencing into a dynamic modelling framework to link microbial data to the dynamics of the volatile fatty acids (VFA) production during fermentation...
2024: PloS One
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