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Shayan Irani, Sujai Jalaj, Andrew Ross, Michael Larsen, Ian S Grimm, Todd H Baron
BACKGROUND AND AIMS: Benign gastrointestinal strictures occur typically in the esophagus and pyloric channel, but can occur anywhere in the GI tract and at anastomotic sites. Such strictures can be treated with dilation, incisional therapy, steroid injection and stents. Our aim was to describe the use of a lumen-apposing metal stent (LAMS) to treat short, benign gastrointestinal strictures. PATIENTS AND METHODS: Retrospective review of consecutive patients who underwent LAMS placement for various benign strictures at 2 tertiary care centers from August 2014 to November 2015...
September 12, 2016: Gastrointestinal Endoscopy
Manon C W Spaander, Todd H Baron, Peter D Siersema, Lorenzo Fuccio, Brigitte Schumacher, Àngels Escorsell, Juan-Carlos Garcia-Pagán, Jean-Marc Dumonceau, Massimo Conio, Antonella de Ceglie, Janusz Skowronek, Marianne Nordsmark, Thomas Seufferlein, André Van Gossum, Cesare Hassan, Alessandro Repici, Marco J Bruno
This Guideline is an official statement of the European Society of Gastrointestinal Endoscopy (ESGE), endorsed by the European Society for Radiotherapy and Oncology (ESTRO), the European Society of Digestive Endoscopy (ESDO), and the European Society for Clinical Nutrition and Metabolism (ESPEN). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was adopted to define the strength of recommendations and the quality of evidence. Main recommendations for malignant disease 1 ESGE recommends placement of partially or fully covered self-expandable metal stents (SEMSs) for palliative treatment of malignant dysphagia over laser therapy, photodynamic therapy, and esophageal bypass (strong recommendation, high quality evidence)...
October 2016: Endoscopy
Eduardo Rodrigues-Pinto, Todd H Baron
INTRODUCTION: Endoscopic ultrasound guided translumenal drainage of pancreatic fluid collections (PFCs) has been widely practiced for over a decade, using conventional plastic and self-expandable metal stents. The use of such stents for transmural drainage is off-label and limited by the lack of lumen-to-lumen anchorage, which can lead to leakage, migration and tissue trauma. AREAS COVERED: Novel stent designs dedicated to applications of translumenal drainage have recently emerged and promise to make transmural drainage quicker, safer, and more effective...
September 2016: Expert Review of Medical Devices
Karina V Grooteman, Louis M Wong Kee Song, Frank P Vleggaar, Peter D Siersema, Todd H Baron
BACKGROUND AND AIMS: Although the rule of 3 is recommended to minimize the risk of perforation when esophageal dilation is performed using bougie dilators, there are no data to validate its use. Our aim was to investigate the association between the rule of 3 and adverse events (AEs) in esophageal dilation. METHODS: A retrospective chart review in patients who underwent esophageal bougie or balloon dilation between December 1991 and February 2013 at a tertiary hospital was performed...
August 6, 2016: Gastrointestinal Endoscopy
Eduardo Rodrigues-Pinto, Todd Huntley Baron
No abstract text is available yet for this article.
July 2016: Endoscopic Ultrasound
Eduardo Rodrigues-Pinto, Sujai Jalaj, Ian S Grimm, Todd H Baron
BACKGROUND AND AIMS: FNA is the primary method of EUS tissue acquisition. In an attempt to improve our yield of EUS-guided tissue acquisition, we compared fine-needle biopsy (FNB) sampling without rapid onsite evaluation (ROSE) with FNA with ROSE and assessed the concordance of FNA and FNB sampling. METHODS: This was a retrospective review of prospectively collected data from consecutive patients. Patients underwent FNB sampling and FNA of the same single lesion, with the same needle gauge and number of passes...
June 23, 2016: Gastrointestinal Endoscopy
Muhammad Ali Khan, Omair Atiq, Nisa Kubiliun, Bilal Ali, Faisal Kamal, Richard Nollan, Mohammad Kashif Ismail, Claudio Tombazzi, Michel Kahaleh, Todd H Baron
BACKGROUND AND AIMS: The efficacy and safety of endoscopic gallbladder drainage (EGBD) performed via endoscopic retrograde cholangiography (ERC) based transpapillary stenting or endoscopic ultrasound (EUS) based transmural stenting are unknown. We aimed to conduct a proportion meta-analysis to evaluate the cumulative efficacy and safety of these procedures and to compare them with percutaneous gallbladder drainage (PGBD). METHODS: We searched several databases from inception through December 10, 2015, to identify studies (with 10 or more patients) reporting technical success and post-procedure adverse events of EGBD...
June 22, 2016: Gastrointestinal Endoscopy
Ryan Law, Ian S Grimm, Todd H Baron
No abstract text is available yet for this article.
2016: Endoscopy
Andrew C Storm, Christopher C Thompson, Todd H Baron, Anna S Griffith
No abstract text is available yet for this article.
May 31, 2016: Gastrointestinal Endoscopy
Eduardo Rodrigues-Pinto, Ian S Grimm, Todd H Baron
No abstract text is available yet for this article.
May 2016: Endoscopy International Open
Eduardo Rodrigues-Pinto, Todd H Baron
No abstract text is available yet for this article.
July 2016: Gastroenterology
Anne Sinning, Nikita Radionov, Francesco Trepiccione, Karen I López-Cayuqueo, Maximilien Jayat, Stéphanie Baron, Nicolas Cornière, R Todd Alexander, Juliette Hadchouel, Dominique Eladari, Christian A Hübner, Régine Chambrey
We recently described a novel thiazide-sensitive electroneutral NaCl transport mechanism resulting from the parallel operation of the Cl(-)/HCO3 (-) exchanger pendrin and the Na(+)-driven Cl(-)/2HCO3 (-) exchanger (NDCBE) in β-intercalated cells of the collecting duct. Although a role for pendrin in maintaining Na(+) balance, intravascular volume, and BP is well supported, there is no in vivo evidence for the role of NDCBE in maintaining Na(+) balance. Here, we show that deletion of NDCBE in mice caused only subtle perturbations of Na(+) homeostasis and provide evidence that the Na(+)/Cl(-) cotransporter (NCC) compensated for the inactivation of NDCBE...
May 5, 2016: Journal of the American Society of Nephrology: JASN
Jose Francisco Nunes Pereira das Neves, Mariana Moraes Pereira das Neves Araújo, Fernando de Paiva Araújo, Clarice Martins Ferreira, Fabiana Baeta Neves Duarte, Fabio Heleno Pace, Laura Cotta Ornellas, Todd H Baron, Lincoln Eduardo Villela Vieira de Castro Ferreira
Colonoscopy is one of the most common procedures. Sedation and analgesia decrease anxiety and discomfort and minimize risks. Therefore, patients prefer to be sedated when undergoing examination, although the best combination of drugs has not been determined. The combination of opioids and benzodiazepines is used to relieve the patient's pain and discomfort. More recently, propofol has assumed a prominent position. This randomized prospective study is unique in medical literature that specifically compared the use of propofol and fentanyl with or without midazolam for colonoscopy sedation performed by anesthesiologists...
May 2016: Brazilian Journal of Anesthesiology
Amy Tyberg, Manuel Perez-Miranda, Ramon Sanchez-Ocaña, Irene Peñas, Carlos de la Serna, Janak Shah, Kenneth Binmoeller, Monica Gaidhane, Ian Grimm, Todd Baron, Michel Kahaleh
BACKGROUND: Surgical gastrojejunostomy and enteral self-expanding metal stents are efficacious for the management of gastric outlet obstruction but limited by high complication rates and short-term efficacy. Endoscopic ultrasound-guided gastrojejunostomy (EUS-GJ) is a novel alternative option. PATIENTS AND METHODS: Patients who underwent EUS-GJ between March 2014 and September 2015 as part of a prospective multicenter registry at four academic centers in two countries were included...
March 2016: Endoscopy International Open
Todd H Baron, Ian S Grimm
No abstract text is available yet for this article.
July 2016: Clinical Gastroenterology and Hepatology
Enrique Vazquez-Sequeiros, Todd H Baron, Manuel Pérez-Miranda, Andres Sánchez-Yagüe, Joan Gornals, Ferran Gonzalez-Huix, Carlos de la Serna, Juan Angel Gonzalez Martin, Antonio Z Gimeno-Garcia, Carlos Marra-Lopez, Ana Castellot, Fernando Alberca, Ignacio Fernandez-Urien, Jose Ramon Aparicio, Maria Luisa Legaz, Oriol Sendino, Carmen Loras, Jose Carlos Subtil, Juan Nerin, Mercedes Perez-Carreras, Jose Diaz-Tasende, Gustavo Perez, Alejandro Repiso, Angels Vilella, Carlos Dolz, Alberto Alvarez, Santiago Rodriguez, Jose Miguel Esteban, Diego Juzgado, Agustin Albillos
BACKGROUND AND AIMS: Initial reports suggest that fully covered self-expandable metal stents (FCSEMSs) may be better suited for drainage of dense pancreatic fluid collections (PFCs), such as walled-off pancreatic necrosis. The primary aim was to analyze the effectiveness and safety of FCSEMSs for drainage of different types of PFCs in a large cohort. The secondary aim was to investigate which type of FCSEMS is superior. METHODS: This was a retrospective, noncomparative review of a nationwide database involving all hospitals in Spain performing EUS-guided PFC drainage...
September 2016: Gastrointestinal Endoscopy
Ryan Law, Todd H Baron
PURPOSE OF REVIEW: Endoscopic ultrasound (EUS)-guided biliary drainage procedures can be utilized in patients with biliary obstruction and incomplete drainage with prior interventions, in those whose ampulla is inaccessible (i.e. from surgically altered anatomy and malignant luminal obstruction), or in those who failed bile duct cannulation during endoscopic retrograde cholangiopancreatography. Improved techniques and accessories have streamlined these procedures; however, further investigation is required...
May 2016: Current Opinion in Gastroenterology
B Joseph Elmunzer, Jose Serrano, Amitabh Chak, Steven A Edmundowicz, Georgios I Papachristou, James M Scheiman, Vikesh K Singh, Shyam Varadurajulu, John J Vargo, Field F Willingham, Todd H Baron, Gregory A Coté, Joseph Romagnuolo, April Wood-Williams, Emily K Depue, Rebecca L Spitzer, Cathie Spino, Lydia D Foster, Valerie Durkalski
BACKGROUND: The combination of prophylactic pancreatic stent placement (PSP) - a temporary plastic stent placed in the pancreatic duct - and rectal non-steroidal anti-inflammatory drugs (NSAIDs) is recommended for preventing post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) in high-risk cases. Preliminary data, however, suggest that PSP may be unnecessary if rectal NSAIDs are administered. Given the costs and potential risks of PSP, we aim to determine whether rectal indomethacin obviates the need for pancreatic stent placement in patients undergoing high-risk ERCP...
2016: Trials
Michelle Goldsworthy, Ying Bai, Chi-Ming Li, Huanying Ge, Edwin Lamas, Helen Hilton, Christopher T Esapa, Dan Baker, Will Baron, Todd Juan, Murielle M Véniant, David J Lloyd, Roger D Cox
Insulin resistance in mice typically does not manifest as diabetes due to multiple compensatory mechanisms. Here, we present a novel digenic model of type 2 diabetes in mice heterozygous for a null allele of the insulin receptor and an N-ethyl-N-nitrosourea-induced alternative splice mutation in the regulatory protein phosphatase 2A (PP2A) subunit PPP2R2A. Inheritance of either allele independently results in insulin resistance but not overt diabetes. Doubly heterozygous mice exhibit progressive hyperglycemia, hyperinsulinemia, and impaired glucose tolerance from 12 weeks of age without significant increase in body weight...
May 2016: Diabetes
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