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Mark Topazian

Ju Dong Yang, Essa A Mohamed, Ashraf O Abdel Aziz, Hend I Shousha, Mohamed B Hashem, Mohamed M Nabeel, Ahmed H Abdelmaksoud, Tamer M Elbaz, Mary Y Afihene, Babatunde M Duduyemi, Joshua P Ayawin, Adam Gyedu, Marie-Jeanne Lohouès-Kouacou, Antonin W Ndjitoyap Ndam, Ehab F Moustafa, Sahar M Hassany, Abdelmajeed M Moussa, Rose A Ugiagbe, Casimir E Omuemu, Richard Anthony, Dennis Palmer, Albert F Nyanga, Abraham O Malu, Solomon Obekpa, Abdelmounem E Abdo, Awatif I Siddig, Hatim M Y Mudawi, Uchenna Okonkwo, Mbang Kooffreh-Ada, Yaw A Awuku, Yvonne A Nartey, Elizabeth T Abbew, Nana A Awuku, Jesse A Otegbayo, Kolawole O Akande, Hailemichael M Desalegn, Abidemi E Omonisi, Akande O Ajayi, Edith N Okeke, Mary J Duguru, Pantong M Davwar, Michael C Okorie, Shettima Mustapha, Jose D Debes, Ponsiano Ocama, Olufunmilayo A Lesi, Emuobor Odeghe, Ruth Bello, Charles Onyekwere, Francis Ekere, Rufina Igetei, Mitchell A Mah'moud, Benyam Addissie, Hawa M Ali, Gregory J Gores, Mark D Topazian, Lewis R Roberts
BACKGROUND: Hepatocellular carcinoma is a leading cause of cancer-related death in Africa, but there is still no comprehensive description of the current status of its epidemiology in Africa. We therefore initiated an African hepatocellular carcinoma consortium aiming to describe the clinical presentation, management, and outcomes of patients with hepatocellular carcinoma in Africa. METHODS: We did a multicentre, multicountry, retrospective observational cohort study, inviting investigators from the African Network for Gastrointestinal and Liver Diseases to participate in the consortium to develop hepatocellular carcinoma research databases and biospecimen repositories...
February 2017: Lancet. Gastroenterology & Hepatology
Kavel Visrodia, Yuri Hanada, Kelly M Pennington, Pritish K Tosh, Mark D Topazian, Bret T Petersen
BACKGROUND & AIMS: Recent reports of infectious outbreaks linked to duodenoscopes have led to proposals for duodenoscope surveillance culturing, which has inherent limitations. We aimed to assess the feasibility of real-time adenosine triphosphate (ATP) testing after manual cleaning, and its ability to predict reprocessing adequacy, as determined by terminal duodenoscope cultures. METHODS: Clinically used duodenoscopes underwent reprocessing per current guidelines...
April 7, 2017: Gastrointestinal Endoscopy
Sinkeet Rankeeti, Michael Mwachiro, Mark Topazian, Stephen Burgert
No abstract text is available yet for this article.
March 22, 2017: Gastrointestinal Endoscopy
Tarun Rustagi, Ferga C Gleeson, Barham K Abu Dayyeh, Mark D Topazian, Michael J Levy
BACKGROUND AND STUDY AIMS: Percutaneous and intraoperative radiofrequency ablation (RFA) has become a valued tool in the management of primary and secondary hepatic lesions. A recent FDA-approved endoscopic ultrasound (EUS)-guided RFA probe now offers promise to help manage such lesions. However, there are no data to determine the ideal power setting and duration of ablation needed to effectively treat hepatic masses. The aim of the study was to evaluate the macroscopic zone of hepatic injury for EUS-RFA using a variety of settings within a fresh porcine hepatic specimen...
March 3, 2017: Journal of Clinical Gastroenterology
Shayan Irani, Saowanee Ngamruengphong, Anthony Teoh, Uwe Will, Jose Nieto, Barham K Abu Dayyeh, S Ian Gan, Michael Larsen, Hon Chi Yip, Mark D Topazian, Michael J Levy, Christopher C Thompson, Andrew C Storm, Gulara Hajiyeva, Amr Ismail, Yen-I Chen, Majidah Bukhari, Yamile Haito Chavez, Vivek Kumbhari, Mouen A Khashab
BACKGROUND & AIMS: Acute cholecystitis in patients who are not candidates for surgery is often managed with percutaneous transhepatic gallbladder drainage (PT-GBD). Endoscopic ultrasound-guided gallbladder drainage (EUS-GBD) with a lumen-apposing metal stent (LAMS) is an effective alternative to PT-GBD. We compared the technical success of EUS-GBD versus PT-GBD, and patient outcomes, numbers of adverse events (AEs), length of hospital stay, pain scores, and repeat interventions. METHODS: We performed a retrospective study to compare EUS-GBD versus PT-GBD at 7 centers (5 in the United States, 1 in Europe, and 1 in Asia), from 2013 through 2015, in management of acute cholecystitis in patients who are not candidates for surgery...
May 2017: Clinical Gastroenterology and Hepatology
Tarun Rustagi, Shayan Irani, D Nageshwar Reddy, Barham K Abu Dayyeh, Todd H Baron, Christopher J Gostout, Michael J Levy, John Martin, Bret T Petersen, Andrew Ross, Mark D Topazian
BACKGROUND AND AIMS: Extension of ampullary adenomas into the common bile duct (CBD) or pancreatic duct (PD) may be difficult to treat endoscopically. We evaluated the feasibility, safety, and efficacy of endoscopic radiofrequency ablation (RFA) in the management of ampullary neoplasms with intraductal extension. METHODS: This was a multicenter, retrospective analysis of all patients with intraductal extension of ampullary neoplasms treated with endoscopic RFA between February 2012 and June 2015...
November 17, 2016: Gastrointestinal Endoscopy
Charles J Lenz, Benjamin L Bick, David Katzka, Francis C Nichols, Zachary S Depew, Louis M Wong Kee Song, Todd H Baron, Navtej S Buttar, Fabien Maldonado, Felicity T Enders, William S Harmsen, Ross A Dierkhising, Mark D Topazian
GOAL: The purpose of this study was to characterize outcomes of esophagorespiratory fistulas (ERF) by etiology and initial treatment strategy. BACKGROUND: ERF is a morbid condition for which optimal treatment strategies and outcomes are still in evolution. STUDY: Medical records and images were reviewed for all patients diagnosed with ERF at Mayo Clinic in Rochester, MN, between September 1, 2001 and January 1, 2012. Fistulas were classified as malignant or benign...
November 7, 2016: Journal of Clinical Gastroenterology
Abdul Haseeb, Barham K Abu Dayyeh, Michael J Levy, Larissa L Fujii, Randall K Pearson, Suresh T Chari, Ferga C Gleeson, Bret T Peterson, Santhi Swaroop Vege, Mark Topazian
Pancreaticocutaneous fistulas (PCFs) may be refractory to medical therapy or endoscopic retrograde cholangopancreaticography. Four patients underwent endoscopic ultrasound-guided management of refractory PCFs, which were internalized by endoscopic ultrasound-guided transmural puncture of the pancreatic duct (n = 2), fistula tract (n = 1), or both (n = 1), with placement of transmural stents providing internal drainage to the stomach (n = 3) or duodenum (n = 1). Drainage from PCFs ceased in all patients, and all percutaneous drains were removed; internal stents were left in place indefinitely...
August 2016: ACG Case Reports Journal
Tarun Rustagi, Ferga C Gleeson, Suresh T Chari, Barham K Abu Dayyeh, Michael B Farnell, Prasad G Iyer, Michael L Kendrick, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Mark D Topazian, Mark J Truty, Santhi S Vege, Kenneth K Wang, Michael J Levy
BACKGROUND AND AIMS: Malignant vascular invasion usually results from gross direct infiltration from a primary tumor and impacts cancer staging, prognosis, and therapy. However, patients may also develop a remote malignant thrombi (RMT), defined as a malignant intravascular thrombus located remote and noncontiguous to the primary tumor. Our aim was to compare EUS, CT, and magnetic resonance imaging (MRI) findings of RMT and to explore the potential impact on cancer staging. METHODS: Patients with RMT were identified from a prospectively maintained EUS database...
October 20, 2016: Gastrointestinal Endoscopy
Philip Blasto Ooko, Patricia Wambua, Mark Oloo, Agneta Odera, Hillary Mariko Topazian, Russell White
INTRODUCTION: Intestinal obstruction (IO) occurs when there is impedance to the flow of intestinal contents due to a congenital or acquired pathology, and is a common paediatric surgical emergency. This study aimed to assess the pattern and outcome of paediatric IO in western Kenya. METHODS: A retrospective review of all recorded cases of mechanical IO in patients aged 15 years or below admitted at Tenwek Hospital between January 2009 and December 2013. RESULTS: The cohort included a total of 217 children (130 boys and 87 girls)...
2016: Pan African Medical Journal
Tarun Rustagi, Ferga C Gleeson, Suresh T Chari, Barham K Abu Dayyeh, Michael B Farnell, Prasad G Iyer, Michael L Kendrick, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Mark D Topazian, Mark J Truty, Santhi S Vege, Kenneth K Wang, Michael J Levy
Synchronous primary pancreatic adenocarcinoma, defined as the simultaneous presence of 2 or more newly identified and anatomically separate primary adenocarcinomas within the pancreas, is reported rarely. We compared endoscopic ultrasound (EUS) and computed tomography (CT) and magnetic resonance imaging (MRI) findings from patients with synchronous primary pancreatic adenocarcinoma and their effects on cancer staging and treatment. We performed a retrospective analysis of the EUS database at the Mayo Clinic, from September 2008 through May 2016, to collect EUS, CT, MRI, and clinical data from patients with synchronous primary pancreatic adenocarcinoma...
August 15, 2016: Clinical Gastroenterology and Hepatology
Yen-I Chen, Michael J Levy, Tom G Moreels, Gulara Hajijeva, Uwe Will, Everson L Artifon, Kazuo Hara, Masayuki Kitano, Mark Topazian, Barham Abu Dayyeh, Andreas Reichel, Tiago Vilela, Saowanee Ngamruengphong, Yamile Haito-Chavez, Majidah Bukhari, Patrick Okolo, Vivek Kumbhari, Amr Ismail, Mouen A Khashab
BACKGROUND AND AIMS: Endoscopic management of post-Whipple pancreatic adverse events (AEs) with enteroscopy-assisted endoscopic retrograde pancreatography (e-ERP) is associated with high failure rates. EUS-guided pancreatic duct drainage (EUS-PDD) has shown promising results; however, no comparative data have been done for these 2 modalities. The goal of this study is to compare EUS-PDD with e-ERP in terms of technical success (PDD through dilation/stent), clinical success (improvement/resolution of pancreatic-type symptoms), and AE rates in patients with post-Whipple anatomy...
January 2017: Gastrointestinal Endoscopy
Saurabh Mukewar, Nicolo de Pretis, Anupama Aryal-Khanal, Nazir Ahmed, Raghuwansh Sah, Felicity Enders, Joseph J Larson, Michael J Levy, Naoki Takahashi, Mark Topazian, Randall Pearson, Santhi S Vege, Suresh T Chari
OBJECTIVE: Fukuoka consensus guidelines classify pancreatic cystic lesions (PCLs) presumed to be intraductal papillary mucinous neoplasms (IPMNs) into Fukuoka positive (FP) (subgroups of high-risk (HR) and worrisome features (WFs)) and Fukuoka negative (FN) (non-HR feature/WF cysts). We retrospectively estimated 5-year risk of pancreatic cancer (PC) in FN, WF and HR cysts of patients with PCL-IPMN. DESIGN: From Mayo Clinic databases, we randomly selected 2000 patients reported to have a PCL; we excluded inflammatory or suspected non-IPMN cysts and those without imaging follow-up...
July 7, 2016: Gut
Philip Blasto Ooko, Seno Saruni, Mark Oloo, Hillary Mariko Topazian, Russell White
INTRODUCTION: Ileo-sigmoid knotting (ISK) is a rare cause of bowel obstruction in which the ileum twists around the sigmoid colon. It is associated with rapid bowel gangrene and a high mortality rate. Little has been published about this condition in Kenya. The objective was to determine the presentation, management, and outcome of patients with ISK. METHODS: A seven year (January 2008-December 2014) retrospective chart review of patients managed for ISK at Tenwek Hospital in Bomet, Kenya...
2016: Pan African Medical Journal
Cornelius A Thiels, Kristine T Hanson, Kashmira S Chawla, Mark D Topazian, Keith H Paley, Elizabeth B Habermann, Juliane Bingener
BACKGROUND: Due to increasing rates of functional gallbladder disease (FGBD), we used national data to compare rates, patient characteristics, and outcomes of cholecystectomy for FGBD with the more defined diagnosis of biliary colic. METHODS: The American College of Surgeons National Surgical Quality Improvement Program was reviewed for elective cholecystectomies from 2005-2013. The proportion of cholecystectomies performed for FGBD was assessed over time using a 2-sided Cochran-Armitage test for trend...
July 2016: Surgery
Yan Bi, Phil A Hart, Ryan Law, Jonathan E Clain, Michael B Farnell, Ferga C Gleeson, Michael L Kendrick, Mike J Levy, Randall K Pearson, Bret T Petersen, Lisa D Pisney, Thomas C Smyrk, Naoki Takahashi, Mark D Topazian, Santhi Swaroop Vege, Suresh T Chari
OBJECTIVE: Autoimmune pancreatitis (AIP) responds dramatically to corticosteroids treatment. We reviewed our experience to determine the safety and effectiveness of treating obstructive jaundice in definitive AIP with corticosteroids alone without biliary stenting. METHODS: From our AIP database, we retrospectively identified type 1 AIP subjects whose jaundice was treated with corticosteroids alone without biliary stenting. Their medical records were reviewed and clinical data were evaluated to determine the outcomes...
May 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Victoria Gómez, Shounak Majumder, Thomas C Smyrk, Mark D Topazian, Suresh T Chari, Ferga C Gleeson, William S Harmsen, Felicity T Enders, Barham K Abu Dayyeh, Prasad G Iyer, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Naoki Takahashi, Santhi S Vege, Kenneth K Wang, Michael J Levy
BACKGROUND AND AIMS: The presence and significance of epithelial denudation among treatment-naïve pancreatic cystic lesions (PCLs) remain undetermined. The aims of this study were to determine the prevalence, extent, and predictors of epithelial denudation in treatment-naïve PCLs. METHODS: Single-center retrospective study including patients who underwent EUS preceded by cross-sectional imaging and who subsequently underwent surgical resection of treatment-naïve PCLs...
November 2016: Gastrointestinal Endoscopy
Elsie T Mensah, John Martin, Mark Topazian
PURPOSE OF REVIEW: Intraductal biliary radiofrequency ablation (RFA) is an emerging therapeutic modality that directly targets malignant biliary strictures during endoscopic retrograde cholangiopancreatography. This article reviews the technology, endoscopic technique, and reported outcomes of endoscopic RFA in the management of malignant biliary strictures. RECENT FINDINGS: Biliary RFA is feasible and has a high technical success rate. Infectious complications and major hemobilia are the main adverse events requiring intervention...
May 2016: Current Opinion in Gastroenterology
Michael M Mwachiro, Stephen L Burgert, Justus Lando, Robert Chepkwony, Collins Bett, Claire Bosire, Christian C Abnet, Jessie Githanga, Wairimu Waweru, Carol A Giffen, Gwen Murphy, Russell E White, Mark D Topazian, Sanford M Dawsey
OBJECTIVES: Esophageal squamous cell carcinoma (ESCC) is endemic in east Africa and is a leading cause of cancer death among Kenyans. The asymptomatic precursor lesion of ESCC is esophageal squamous dysplasia (ESD). We aimed to determine the prevalence of ESD in asymptomatic adult residents of southwestern Kenya. METHODS: In this prospective, community-based, cross-sectional study, 305 asymptomatic adult residents completed questionnaires and underwent video endoscopy with Lugol's iodine chromoendoscopy and mucosal biopsy for detection of ESD...
April 2016: American Journal of Gastroenterology
Shounak Majumder, Navtej S Buttar, Christopher Gostout, Michael J Levy, John Martin, Bret Petersen, Mark Topazian, Louis M Wong Kee Song, Barham K Abu Dayyeh
BACKGROUND AND AIMS: Self-expanding metal stents (SEMS) are safe and effective for endoscopic management of malignant gastrointestinal strictures, but there is limited experience with their use in refractory benign strictures. We assessed the use of a new lumen-apposing covered SEMS for the management of benign gastrointestinal strictures. METHODS: A single-center case-series of five patients who underwent lumen-apposing covered SEMS placement for benign gastrointestinal strictures...
January 2016: Endoscopy International Open
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