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Mark Topazian

Philip Blasto Ooko, Patricia Wambua, Mark Oloo, Agneta Odera, Hillary Mariko Topazian, Russell White
INTRODUCTION: Intestinal obstruction (IO) occurs when there is impedance to the flow of intestinal contents due to a congenital or acquired pathology, and is a common paediatric surgical emergency. This study aimed to assess the pattern and outcome of paediatric IO in western Kenya. METHODS: A retrospective review of all recorded cases of mechanical IO in patients aged 15 years or below admitted at Tenwek Hospital between January 2009 and December 2013. RESULTS: The cohort included a total of 217 children (130 boys and 87 girls)...
2016: Pan African Medical Journal
Tarun Rustagi, Ferga C Gleeson, Suresh T Chari, Barham K Abu Dayyeh, Michael B Farnell, Prasad G Iyer, Michael L Kendrick, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Mark D Topazian, Mark J Truty, Santhi S Vege, Kenneth K Wang, Michael J Levy
Synchronous primary pancreatic adenocarcinoma, defined as the simultaneous presence of 2 or more newly identified and anatomically separate primary adenocarcinomas within the pancreas, is rarely reported. We compared endoscopic ultrasound (EUS) and computed tomography (CT) and magnetic resonance imaging (MRI) findings from patients with synchronous primary pancreatic adenocarcinoma and their effects on cancer staging and treatment. We performed a retrospective analysis of the EUS database at the Mayo Clinic, from September 2008 through May 2016, to collect EUS, CT, MRI, and clinical data from patients with synchronous primary pancreatic adenocarcinoma...
August 15, 2016: Clinical Gastroenterology and Hepatology
Yen-I Chen, Michael J Levy, Tom G Moreels, Gulara Hajijeva, Uwe Will, Everson L Artifon, Kazuo Hara, Masayuki Kitano, Mark Topazian, Barham Abu Dayyeh, Andreas Reichel, Tiago Vilela, Saowanee Ngamruengphong, Yamile Haito-Chavez, Majidah Bukhari, Patrick Okolo, Vivek Kumbhari, Amr Ismail, Mouen A Khashab
BACKGROUND AND AIMS: Endoscopic management of post-Whipple pancreatic adverse events (AEs) with enteroscopy-assisted endoscopic retrograde pancreatography (e-ERP) is associated with high failure rates. EUS-guided pancreatic duct drainage (EUS-PDD) has shown promising results; however, no comparative data have been done for these 2 modalities. The goal of this study is to compare EUS-PDD with e-ERP in terms of technical success (PDD through dilation/stent), clinical success (improvement/resolution of pancreatic-type symptoms), and AE rates in patients with post-Whipple anatomy...
July 25, 2016: Gastrointestinal Endoscopy
Saurabh Mukewar, Nicolo de Pretis, Anupama Aryal-Khanal, Nazir Ahmed, Raghuwansh Sah, Felicity Enders, Joseph J Larson, Michael J Levy, Naoki Takahashi, Mark Topazian, Randall Pearson, Santhi S Vege, Suresh T Chari
OBJECTIVE: Fukuoka consensus guidelines classify pancreatic cystic lesions (PCLs) presumed to be intraductal papillary mucinous neoplasms (IPMNs) into Fukuoka positive (FP) (subgroups of high-risk (HR) and worrisome features (WFs)) and Fukuoka negative (FN) (non-HR feature/WF cysts). We retrospectively estimated 5-year risk of pancreatic cancer (PC) in FN, WF and HR cysts of patients with PCL-IPMN. DESIGN: From Mayo Clinic databases, we randomly selected 2000 patients reported to have a PCL; we excluded inflammatory or suspected non-IPMN cysts and those without imaging follow-up...
July 7, 2016: Gut
Philip Blasto Ooko, Seno Saruni, Mark Oloo, Hillary Mariko Topazian, Russell White
INTRODUCTION: Ileo-sigmoid knotting (ISK) is a rare cause of bowel obstruction in which the ileum twists around the sigmoid colon. It is associated with rapid bowel gangrene and a high mortality rate. Little has been published about this condition in Kenya. The objective was to determine the presentation, management, and outcome of patients with ISK. METHODS: A seven year (January 2008-December 2014) retrospective chart review of patients managed for ISK at Tenwek Hospital in Bomet, Kenya...
2016: Pan African Medical Journal
Cornelius A Thiels, Kristine T Hanson, Kashmira S Chawla, Mark D Topazian, Keith H Paley, Elizabeth B Habermann, Juliane Bingener
BACKGROUND: Due to increasing rates of functional gallbladder disease (FGBD), we used national data to compare rates, patient characteristics, and outcomes of cholecystectomy for FGBD with the more defined diagnosis of biliary colic. METHODS: The American College of Surgeons National Surgical Quality Improvement Program was reviewed for elective cholecystectomies from 2005-2013. The proportion of cholecystectomies performed for FGBD was assessed over time using a 2-sided Cochran-Armitage test for trend...
July 2016: Surgery
Yan Bi, Phil A Hart, Ryan Law, Jonathan E Clain, Michael B Farnell, Ferga C Gleeson, Michael L Kendrick, Mike J Levy, Randall K Pearson, Bret T Petersen, Lisa D Pisney, Thomas C Smyrk, Naoki Takahashi, Mark D Topazian, Santhi Swaroop Vege, Suresh T Chari
OBJECTIVE: Autoimmune pancreatitis (AIP) responds dramatically to corticosteroids treatment. We reviewed our experience to determine the safety and effectiveness of treating obstructive jaundice in definitive AIP with corticosteroids alone without biliary stenting. METHODS: From our AIP database, we retrospectively identified type 1 AIP subjects whose jaundice was treated with corticosteroids alone without biliary stenting. Their medical records were reviewed and clinical data were evaluated to determine the outcomes...
May 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Victoria Gómez, Shounak Majumder, Thomas C Smyrk, Mark D Topazian, Suresh T Chari, Ferga C Gleeson, William S Harmsen, Felicity T Enders, Barham K Abu Dayyeh, Prasad G Iyer, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Naoki Takahashi, Santhi S Vege, Kenneth K Wang, Michael J Levy
BACKGROUND AND AIMS: The presence and significance of epithelial denudation among treatment-naïve pancreatic cystic lesions (PCLs) remain undetermined. The aims of this study were to determine the prevalence, extent and predictors of epithelial denudation in treatment-naïve PCLs. METHODS: Single-center retrospective study including patients who underwent EUS preceded by cross-sectional imaging and who subsequently underwent surgical resection of treatment-naïve PCLs...
April 6, 2016: Gastrointestinal Endoscopy
Elsie T Mensah, John Martin, Mark Topazian
PURPOSE OF REVIEW: Intraductal biliary radiofrequency ablation (RFA) is an emerging therapeutic modality that directly targets malignant biliary strictures during endoscopic retrograde cholangiopancreatography. This article reviews the technology, endoscopic technique, and reported outcomes of endoscopic RFA in the management of malignant biliary strictures. RECENT FINDINGS: Biliary RFA is feasible and has a high technical success rate. Infectious complications and major hemobilia are the main adverse events requiring intervention...
May 2016: Current Opinion in Gastroenterology
Michael M Mwachiro, Stephen L Burgert, Justus Lando, Robert Chepkwony, Collins Bett, Claire Bosire, Christian C Abnet, Jessie Githanga, Wairimu Waweru, Carol A Giffen, Gwen Murphy, Russell E White, Mark D Topazian, Sanford M Dawsey
OBJECTIVES: Esophageal squamous cell carcinoma (ESCC) is endemic in east Africa and is a leading cause of cancer death among Kenyans. The asymptomatic precursor lesion of ESCC is esophageal squamous dysplasia (ESD). We aimed to determine the prevalence of ESD in asymptomatic adult residents of southwestern Kenya. METHODS: In this prospective, community-based, cross-sectional study, 305 asymptomatic adult residents completed questionnaires and underwent video endoscopy with Lugol's iodine chromoendoscopy and mucosal biopsy for detection of ESD...
April 2016: American Journal of Gastroenterology
Shounak Majumder, Navtej S Buttar, Christopher Gostout, Michael J Levy, John Martin, Bret Petersen, Mark Topazian, Louis M Wong Kee Song, Barham K Abu Dayyeh
BACKGROUND AND AIMS: Self-expanding metal stents (SEMS) are safe and effective for endoscopic management of malignant gastrointestinal strictures, but there is limited experience with their use in refractory benign strictures. We assessed the use of a new lumen-apposing covered SEMS for the management of benign gastrointestinal strictures. METHODS: A single-center case-series of five patients who underwent lumen-apposing covered SEMS placement for benign gastrointestinal strictures...
January 2016: Endoscopy International Open
Barham K Abu Dayyeh, Andres Acosta, Michael Camilleri, Manpreet S Mundi, Elizabeth Rajan, Mark D Topazian, Christopher J Gostout
BACKGROUND & AIMS: Although bariatric surgery is the most effective therapy for obesity, only a small proportion of candidates undergo this surgery. Endoscopic sleeve gastroplasty (ESG) is a minimally invasive procedure that reduces the size of the gastric reservoir. We investigated its durability and effects on body weight and gastrointestinal function in a prospective study of obese individuals. METHODS: Twenty-five obese individuals (21 female; mean body mass index, 35...
December 31, 2015: Clinical Gastroenterology and Hepatology
Victoria Gomez, Mark D Topazian
No abstract text is available yet for this article.
April 2016: Gastrointestinal Endoscopy
Victoria Gómez, Naoki Takahashi, Michael J Levy, Kiaran P McGee, Andrea Jones, Yajue Huang, Suresh T Chari, Jonathan E Clain, Ferga C Gleeson, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Santhi Swaroop Vege, Mark D Topazian
BACKGROUND: The true efficacy of EUS-guided ethanol lavage (EEL) of pancreatic cystic neoplasms is unclear. This study aimed to assess long-term outcomes and adverse events of EEL by using a standardized protocol. METHODS: Single-center, prospective, pilot study in which participants with suspected mucinous cyst neoplasms or branch duct intraductal papillary mucinous neoplasms ≥1 cm in maximum diameter underwent EEL with 80% ethanol. Follow-up cross-sectional imaging was obtained to assess for changes in cyst volume...
May 2016: Gastrointestinal Endoscopy
Mohamed O Othman, Mark D Topazian
No abstract text is available yet for this article.
October 2015: Clinical Gastroenterology and Hepatology
Phil A Hart, Michael J Levy, Thomas C Smyrk, Naoki Takahashi, Barham K Abu Dayyeh, Jonathan E Clain, Ferga C Gleeson, Randall K Pearson, Bret T Petersen, Mark D Topazian, Santhi S Vege, Lizhi Zhang, Suresh T Chari
OBJECTIVE: Idiopathic duct-centric chronic pancreatitis (IDCP), also known as type 2 autoimmune pancreatitis (AIP), is an uncommon subtype of AIP. International Consensus Diagnostic Criteria for IDCP propose that the diagnosis requires pancreatic histology and/or concurrent IBD. We examined our experience with IDCP (type 2 AIP) to assess the appropriateness of these criteria, and identify unique characteristics in patients presenting with acute pancreatitis. DESIGN: We reviewed the Mayo Clinic AIP database through May 2014 to identify subjects with either definitive (n=31) or probable (n=12) IDCP...
October 2016: Gut
Russell E White, Robert Chepkwony, Michael Mwachiro, Stephen L Burgert, Felicity T Enders, Mark Topazian
GOALS: To assess the effect of esophageal stent diameter on outcomes of patients with malignant esophageal obstruction. BACKGROUND: Esophageal self-expandable metal stents (SEMS) effectively palliate dysphagia due to malignancy, but the best stent diameter is unknown. STUDY: A prospective randomized trial was conducted at a regional referral hospital. One hundred persons with unresectable esophageal cancer were enrolled, randomized to receive a SEMS of either 18 or 23 mm shaft diameter but identical design, and followed until death...
September 2015: Journal of Clinical Gastroenterology
Eun Ji Shin, Mark Topazian, Michael G Goggins, Sapna Syngal, John R Saltzman, Jeffrey H Lee, James J Farrell, Marcia I Canto
BACKGROUND: Studies comparing linear and radial EUS for the detection of pancreatic lesions in an asymptomatic population with increased risk for pancreatic cancer are lacking. OBJECTIVES: To compare pancreatic lesion detection rates between radial and linear EUS and to determine the incremental diagnostic yield of a second EUS examination. DESIGN: Randomized controlled tandem study. SETTING: Five academic centers in the United States...
November 2015: Gastrointestinal Endoscopy
Larissa L Fujii-Lau, William R Bamlet, Jason S Eldrige, Suresh T Chari, Ferga C Gleeson, Barham K Abu Dayyeh, Jonathan E Clain, Randall K Pearson, Bret T Petersen, Elizabeth Rajan, Mark D Topazian, Santhi S Vege, Kenneth K Wang, Maurits J Wiersema, Michael J Levy
BACKGROUND: Pancreatic cancer (PC) often produces pain that is difficult to control. Celiac neurolysis (CN) is performed with the goal of improving pain control and quality of life while reducing opioid-related side effects. OBJECTIVE: We aimed to evaluate whether CN provides a survival advantage for PC patients. DESIGN: Retrospective case-control study. SETTING: Single tertiary-care referral center. PATIENTS: Review of a prospectively maintained database identified patients with unresectable PC who underwent CN over a 12-year period...
July 2015: Gastrointestinal Endoscopy
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