Hui Yang, Jinghui Cheng, Hao Zhuang, Hongchuang Xu, Yinuo Wang, Tingting Zhang, Yinmo Yang, Honggang Qian, Yinying Lu, Feng Han, Lihua Cao, Nanmu Yang, Rong Liu, Xing Yang, Jiangong Zhang, Jianmin Wu, Ning Zhang
Inter- and intra-tumor heterogeneity is a major hurdle in primary liver cancer (PLC) precision therapy. Here, we establish a PLC biobank, consisting of 399 tumor organoids derived from 144 patients, which recapitulates histopathology and genomic landscape of parental tumors, and is reliable for drug sensitivity screening, as evidenced by both in vivo models and patient response. Integrative analysis dissects PLC heterogeneity, regarding genomic/transcriptomic characteristics and sensitivity to seven clinically relevant drugs, as well as clinical associations...
April 8, 2024: Cancer Cell