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Liver chemoembolization

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https://www.readbyqxmd.com/read/28430314/transulnar-approach-as-an-alternative-to-transradial-approach-in-non-coronary-intervention-safety-feasibility-and-technical-factors
#1
Adam Zybulewski, Martin Edwards, Edward Kim, Francis S Nowakowski, Rahul Patel, Nora Tabori, Robert Lookstein, Aaron Fischman
PURPOSE: Transulnar access (TUA) has been shown to be an effective alternative to transradial access (TRA) for coronary intervention. This study evaluates the safety and efficacy of TUA in patients undergoing visceral interventions in the setting of contraindication to TRA. MATERIALS AND METHODS: Patients who underwent visceral interventions via ulnar approach were included in the study. Outcome variables include technical success, access site and bleeding complications...
April 13, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28427829/systematic-review-and-meta-analysis-of-hepatic-resection-versus-transarterial-chemoembolization-for-solitary-large-hepatocellular-carcinoma
#2
REVIEW
Claire L Stevens, Andrew Awad, Saleh M Abbas, David A K Watters
BACKGROUND: Surgical techniques and pre-operative patient evaluation have improved since the initial development of the Barcelona clinic liver cancer staging system. The optimal treatment for solitary hepatocellular carcinoma ≥5 cm remains unclear. The aim of this study was to review the long-term survival outcomes of hepatic resection versus transarterial chemoembolisation (TACE) for solitary large tumours. METHODS: EMBASE, MEDLINE, Pubmed and the Cochrane database were searched for studies comparing resection with TACE for solitary HCC ≥5 cm...
April 17, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28425822/association-of-hepatic-vein-lipiodol-tram-track-sign-during-transcatheter-arterial-chemoembolization-with-perioperative-death
#3
Hongwei Zhao, Fuquan Liu, Zhendong Yue, Lei Wang, Zhenhua Fan, Fuliang He
Objective To assess the relationship between the hepatic vein Lipiodol tram-track sign during transcatheter arterial chemoembolization (TACE) and perioperative death. Methods Patients treated for hepatic carcinoma at the Beijing Shijitan Hospital, Capital Medical University from January 2010 to December 2015 were retrospectively evaluated. The patients underwent hepatic TACE with Lipiodol. The incidence of the hepatic vein Lipiodol tram-track sign, prognosis, and possible risk factors were analyzed. Results A total of 5372 patients underwent hepatic TACE and had complete available intraoperative imaging data...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28422858/350-560%C3%A2-%C3%AE-m-gelatin-sponge-particles-combined-with-transcatheter-arterial-chemoembolization-for-the-treatment-of-elderly-hepatocellular-carcinoma-the-safety-and-efficacy
#4
Guang Sheng Zhao, Chuang Li, Ying Liu, Zhi Zhong Ren, Xiao Lin Yuan, Jun Zhou, Yue Wei Zhang, Ming Zhang
To retrospectively analyze the safety and efficacy of 350-560 μm gelatin sponge particles combined with single-chemotherapy drug transcatheter arterial chemoembolization (Gs-TACE) for the treatment of elderly hepatocellular carcinoma without surgical resection.Thirty elderly hepatocellular carcinoma patients without surgical resection, who received Gs-TACE in our hospital, were selected. Slowly injected gelatin sponge particles (350-560 μm)+ 10 mg lobaplatin injection into the regional embolization tumor target vessel...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28421483/update-on-embolization-therapies-for-hepatocellular-carcinoma
#5
REVIEW
Sirish Kishore, Tamir Friedman, David C Madoff
PURPOSE OF REVIEW: The purpose of the review is to summarize the latest applications for embolotherapy in the management of patients with HCC according to BCLC stage. RECENT FINDINGS: While traditionally reserved for patients with unresectable HCC and stage B disease, there is an important role for embolization therapies in earlier stage patients as an adjunct to ablation, bridging, or downstaging therapy, as a means to improve safety of resection, and potentially as an arterial ablative option in the case of radioembolization...
June 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28407686/tumor-stage-and-primary-treatment-of-hepatocellular-carcinoma-at-a-large-tertiary-hospital-in-china-a-real-world-study
#6
Jian-Hong Zhong, Ning-Fu Peng, Xue-Mei You, Liang Ma, Xiao Xiang, Yan-Yan Wang, Wen-Feng Gong, Fei-Xiang Wu, Bang-De Xiang, Le-Qun Li
The current clinical reality of tumor stages and primary treatments of hepatocellular carcinoma (HCC) is poorly understood. This study reviewed the distribution of tumor stages and primary treatment modalities among a large population of patients with primary HCC. Medical records of patients treated between January 2003 and October 2013 for primary HCC at our tertiary hospital in China were retrospectively reviewed. A total of 6241 patients were analyzed. The distribution of Barcelona Clinic Liver Cancer (BCLC) stages was as follows: stage 0/A, 28...
March 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28406546/role-of-hepatic-resection-in-patients-with-intermediate-stage-hepatocellular-carcinoma-a-multicenter-study-from-japan
#7
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kunihiko Tsuji, Atsushi Hiraoka, Ei Itobayashi, Kazuhiro Nouso, Kazuya Kariyama, Toru Ishikawa, Masashi Hirooka, Yoichi Hiasa
Transarterial chemoembolization (TACE) is recommended for patients with intermediate-stage (Barcelona Clinic Liver Cancer (BCLC) criteria B, BCLC-B) hepatocellular carcinoma (HCC). However, patients with BCLC-B HCC can differ in background factors related to hepatic function as well as tumor size and number. In the present study, we clarified the role of hepatic resection in patients with BCLC-B HCC. A total of 489 BCLC-B HCC patients with Child-Pugh class A disease initially treated with hepatic resection or TACE were included...
April 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28403099/us-guided-percutaneous-laser-ablation-of-refractory-metastatic-retroperitoneal-lesions-a-care-compliant-case-report
#8
Guo Tian, Tian'an Jiang
RATIONALE: Retroperitoneal metastatic lymph node is rare but severe, which has important structures like the gastrointestinal tract and large blood vessels around and may challenge excision, inducing serious complications like hemorrhage, intestinal adhesion, and even death after injury. PATIENT CONCERNS: We described the case of a 60-year-old man with a history of right liver resection in 2010, pulmonary wedge resection in 2012, and transarterial chemoembolization twice in 2014, in which the postoperative pathology suggested the mixed liver cancer, and poorly differentiated lung cancer from liver metastasis...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28402958/thalidomide-combined-with-thanscatheter-artierial-chemoembolzation-for-primary-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#9
REVIEW
De-Dong Cao, Hui-Lin Xu, Liang Liu, Yong-Fa Zheng, Si-Fa Gao, Xi-Ming Xu, Wei Ge
OBJECTIVE: Transcatheter arterial chemoembolization (TACE) and thalidomide have been used for treating primary hepatocellular carcinoma(HCC). This study aims to evaluate the clinical efficacy and safety of thalidomide and TACE in primary HCC. METHODS: Randomized controlled trials(RCTs) about efficacy and safety of thalidomide combined with TACE for primary HCC were identified from the Cochrane Library, Pubmed, Embase, CNKI, and Wan Fang until August, 2016. The retrieved trials were reviewed and the data were extracted by two reviewers, independently...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28396192/safety-and-efficacy-of-irradiation-stent-placement-for-malignant-portal-vein-thrombus-combined-with-transarterial-chemoembolization-for-hepatocellular-carcinoma-a-single-center-experience
#10
Jian Lu, Jin-He Guo, Hai-Dong Zhu, Guang-Yu Zhu, Li Chen, Gao-Jun Teng
PURPOSE: To assess feasibility, safety, and preliminary efficacy of an irradiation portal vein stent for portal vein tumor thrombosis (PVTT) in patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Between October 2012 and September 2015, 25 of 40 patients (mean age of 55.5 y) with PVTT caused by HCC were recruited for treatment with an irradiation portal vein stent (self-expandable stent loaded with iodine-125 seeds) at a single hospital. Liver function was classified as Child-Pugh class A in 15 patients (60%) and class B in 10 patients (40%)...
April 7, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28396005/transradial-access-for-interventional-radiology-single-centre-procedural%C3%A2-and-clinical-outcome-analysis
#11
Avnesh S Thakor, Mohammed T Alshammari, David M Liu, John Chung, Stephen G F Ho, Gerald M Legiehn, Lindsay Machan, Aaron M Fischman, Rahul S Patel, Darren Klass
PURPOSE: The study sought to describe a single centre's technical approach to transradial intervention and report on clinical outcomes and safety. METHODS: A total of 749 transradial access (TRA) procedures were performed at a single hospital in 562 patients (174 women and 388 men). Procedures included 445 bland embolizations or chemoembolizations of the liver, 88 uterine artery embolizations, and 148 procedures for Selective Internal Radiation Therapy (Y90), which included mapping and administration...
April 7, 2017: Canadian Association of Radiologists Journal, Journal L'Association Canadienne des Radiologistes
https://www.readbyqxmd.com/read/28392205/radiofrequency-vs-microwave-ablation-after-neoadjuvant-transarterial-bland-and-drug-eluting-microsphere-chembolization-for-the-treatment-of-hepatocellular-carcinoma
#12
Lindsay M Thornton, Roniel Cabrera, Melissa Kapp, Michael Lazarowicz, Jeffrey D Vogel, Beau B Toskich
AIM: To retrospectively compare the initial response, local recurrence, and complication rates of radiofrequency ablation (RFA) vs microwave ablation (MWA) when combined with neoadjuvant bland transarterial embolization (TAE) or drug-eluting microsphere chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). METHODS: A total of 35 subjects with Barcelona Clinic Liver Cancer (BCLC) very early and early-stage HCC (range: 1.2-4.1cm) underwent TAE (23) or TACE (12) with RFA (15) or microwave ablation (MWA) (20) from January 2009 to June 2015 as either definitive therapy or a bridge to transplant...
February 20, 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/28386283/rare-gingival-metastasis-by-hepatocellular-carcinoma
#13
Li-Jun Xue, Xiao-Bei Mao, Jian Geng, Ya-Nan Chen, Qian Wang, Xiao-Yuan Chu
Hepatocellular carcinoma (HCC) uncommonly metastasizes to the gingiva, which always means a poor outcome. We reported a rare HCC case with multiple metastases to gingiva, lungs, and brain. A 60-year-old man was initially diagnosed as HCC with metastases to double lungs. He was subjected to a transarterial chemoembolization (TACE) (5-fluorouracil, 750 mg) and two cycles of intravenous chemotherapy (gemcitabine 1.8 g at days 1 and 8, oxaliplatin 200 mg at day 2, every 4 weeks). However, the volume of liver tumor still increased...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28382591/erratum-to-third-line-treatment-of-colorectal-liver-metastases-using-debiri-chemoembolization
#14
Germano Scevola, Giorgio Loreni, Marco Rastelli, Stefano Sposato, Sara Ramponi, Vittorio Miele
No abstract text is available yet for this article.
May 2017: Medical Oncology
https://www.readbyqxmd.com/read/28374075/potentiation-of-doxorubicin-efficacy-in-hepatocellular-carcinoma-by-the-dna-repair-inhibitor-dt01-in-preclinical-models
#15
Nirmitha I Herath, Flavien Devun, Aurélie Herbette, Marie-Christine Lienafa, Philippe Chouteau, Jian-Sheng Sun, Marie Dutreix, Alban Denys
OBJECTIVE: This study aimed to explore the antitumour effect of the DNA repair inhibitor, DT01 (the cholesterol conjugated form of Dbait), as an adjunct treatment to enhance the therapeutic efficacy of transarterial chemoembolization (TACE) in pre-clinical models of hepatocellular carcinoma (HCC). METHODS: A rabbit model bearing liver tumours was either left untreated or treated with TACE or with a combination of TACE+DT01. Tumour growth was monitored by ultrasound...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28373752/prognostic-factors-for-transarterial-chemoembolization-combined-with-sustained-oxaliplatin-based-hepatic-arterial-infusion-chemotherapy-of-colorectal-cancer-liver-metastasis
#16
Hangyu Zhang, Jianhai Guo, Song Gao, Pengjun Zhang, Hui Chen, Xiaodong Wang, Xiaoting Li, Xu Zhu
OBJECTIVE: To investigate the prognostic factors in chemorefractory colorectal cancer liver metastasis (CRCLM) patients treated by transarterial chemoembolization (TACE) and sustained hepatic arterial infusion chemotherapy (HAIC). METHODS: Between 2006 and 2015, 162 patients who underwent 763 TACE and HAIC in total were enrolled in this retrospective study, including 110 males and 52 females, with a median age of 60 (range, 26-83) years. Prognostic factors were assessed with Log-rank test, Cox univariate and multivariate analyses...
February 2017: Chinese Journal of Cancer Research, Chung-kuo Yen Cheng Yen Chiu
https://www.readbyqxmd.com/read/28365948/sorafenib-with-tace-improves-the-survival-of-hepatocellular-carcinoma-patients-with-more-than-10-cm-tumor-a-single-center-retrospective-study
#17
Gokmen Aktas, Tulay Kus, Mehmet Emin Kalender, Selim Kervancioglu, Alper Sevinc, Seval Kul, Celaletdin Camci
PURPOSE: Sorafenib, a multikinase inhibitor, is effective in patients with advanced hepatocellular carcinoma (HCC). Transarterial chemoembolization (TACE) is an important palliative treatment for unresectable HCC, but TACE-induced ischemic injury can upregulate angiogenic factors and it might be associated with poor prognosis. The purpose of this study was to evaluate the efficacy of conventional TACE with or without sorafenib in patients with Barcelona Clinic Liver Cancer (BCLC) stage A-B HCC...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28362557/chemoembolization-of-hepatocellular-carcinoma-with-extrahepatic-collateral-blood-supply-anatomic-and-technical-considerations
#18
Amr Soliman Moustafa, Ahmed Kamel Abdel Aal, Nathan Ertel, Nael Saad, Derek DuBay, Souheil Saddekni
Transarterial chemoembolization (TACE) is considered a standard local-regional treatment for intermediate-stage hepatocellular carcinoma (HCC) and the most common bridging therapy. This treatment is offered to more than 70% of patients who are on the waiting list for liver transplantation in the United States. HCC typically receives its blood supply from the hepatic artery; however, it can recruit a parasitic supply from extrahepatic collateral (EHC) arteries. The development of an EHC arterial blood supply can interfere with the therapeutic efficacy of TACE and result in treatment failure and poor outcome...
March 31, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28360525/the-importance-of-a-multidisciplinary-approach-to-hepatocellular-carcinoma
#19
REVIEW
Osama Siddique, Eric R Yoo, Ryan B Perumpail, Brandon J Perumpail, Andy Liu, George Cholankeril, Aijaz Ahmed
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The rising incidence, genetic heterogeneity, multiple etiologies, and concurrent chronic liver diseases make diagnosis, staging, and selection of treatment options challenging in patients with HCC. The best approach to optimize the management of HCC is one that utilizes a core multidisciplinary liver tumor board, consisting of hepatologists, pathologists, interventional radiologists, oncologists, hepatobiliary and transplant surgeons, nurses, and general practitioners...
2017: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/28357816/metastatic-mixed-acinar-endocrine-carcinoma-of-the-pancreas-treated-with-a-multidisciplinary-approach-a-case-report
#20
Takeo Hara, Yoshiyuki Fujiwara, Hidenori Takahashi, Keijiro Sugimura, Jeong-Ho Moon, Takeshi Omori, Norikatsu Miyoshi, Akira Tomokuni, Hirofumi Akita, Shogo Kobayashi, Masayoshi Yasui, Hiroshi Miyata, Masayuki Ohue, Masato Sakon, Yasuhiko Tomita, Masahiko Yano
BACKGROUND: Pancreatic neoplasms are usually characterized by ductal, acinar, or endocrine differentiation. Mixed exocrine and endocrine pancreatic tumours are extremely rare. Here, we report a case of pancreatic mixed acinar-endocrine carcinoma (MAEC) with multiple synchronous liver metastases that were treated with surgery and transcatheter arterial chemoembolization (TACE) that later recurred in the stomach. CASE PRESENTATION: A 45-year-old female with severe anaemia was referred to our hospital...
December 2017: Surgical Case Reports
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