Eloïse Baudou, Patrice Peran, Fatima Tensaouti, Germain Arribarat, Jérémie Pariente, Nicolas Courbieres, Lisa Pollidoro, Anne-Isabelle Bertozzi, Marion Gambart, Annick Sevely, Margaux Roques, Anne Ducassou, Jérémy Danna, Jessica Tallet, Christelle Dufour, Yves Chaix, Anne Laprie
PURPOSE: Memory is one of the main specific cognitive domains impaired with attention and processing speed after a pediatric brain tumor. This work explored the long-term impact of radiotherapy in children with posterior fossa tumor (PFT) on brain connectivity in neural circuits involved in memory using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: A total of 20 irradiated and 15 non-irradiated PFT survivors, and 21 healthy controls, prospectively included in the IMPALA study (NCT04324450), performed memory tests assessing episodic, procedural, and working memories and were subjected to an rs-fMRI...
December 23, 2023: Radiotherapy and Oncology