Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole McKay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric McDade, Alisha Daniels, Celeste Karch, Gregory S Day, Adam M Brickman, Michael Fulham, Clifford R Jack, Christian la La Fougère, Gerald Reischl, Peter R Schofield, Hwamee Oh, Johannes Levin, Jonathan Vöglein, David M Cash, Igor Yakushev, Takeshi Ikeuchi, William E Klunk, John C Morris, Randall J Bateman, Tammie L S Benzinger
Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1-weighted and Fluid attenuated inversion recovery (FLAIR) MR scans...
October 23, 2023: Human Brain Mapping