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https://www.readbyqxmd.com/read/27857679/bold-imaging-in-awake-wild-type-and-mu-opioid-receptor-knock-out-mice-reveals-on-target-activation-maps-in-response-to-oxycodone
#1
Kelsey Moore, Dan Madularu, Sade Iriah, Jason R Yee, Praveen Kulkarni, Emmanuel Darcq, Brigitte L Kieffer, Craig F Ferris
Blood oxygen level dependent (BOLD) imaging in awake mice was used to identify differences in brain activity between wild-type, and Mu (μ) opioid receptor knock-outs (MuKO) in response to oxycodone (OXY). Using a segmented, annotated MRI mouse atlas and computational analysis, patterns of integrated positive and negative BOLD activity were identified across 122 brain areas. The pattern of positive BOLD showed enhanced activation across the brain in WT mice within 15 min of intraperitoneal administration of 2...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27843694/grey-matter-abnormalities-in-methcathinone-abusers-with-a-parkinsonian-syndrome
#2
Julius Juurmaa, Ricarda A L Menke, Pierre Vila, Andreas Müürsepp, Tiiu Tomberg, Pilvi Ilves, Mait Nigul, Heidi Johansen-Berg, Michael Donaghy, Charlotte J Stagg, Ainārs Stepens, Pille Taba
BACKGROUND: A permanent Parkinsonian syndrome occurs in intravenous abusers of the designer psychostimulant methcathinone (ephedrone). It is attributed to deposition of contaminant manganese, as reflected by characteristic globus pallidus hyperintensity on T1-weighted MRI. METHODS: We have investigated brain structure and function in methcathinone abusers (n = 12) compared to matched control subjects (n = 12) using T1-weighted structural and resting-state functional MRI...
November 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27818626/arousal-rather-than-basic-emotions-influence-long-term-recognition-memory-in-humans
#3
Artur Marchewka, Marek Wypych, Abnoos Moslehi, Monika Riegel, Jarosław M Michałowski, Katarzyna Jednoróg
Emotion can influence various cognitive processes, however its impact on memory has been traditionally studied over relatively short retention periods and in line with dimensional models of affect. The present study aimed to investigate emotional effects on long-term recognition memory according to a combined framework of affective dimensions and basic emotions. Images selected from the Nencki Affective Picture System were rated on the scale of affective dimensions and basic emotions. After 6 months, subjects took part in a surprise recognition test during an fMRI session...
2016: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/27761236/utility-of-susceptibility-weighted-imaging-in-parkinson-s-disease-and-atypical-parkinsonian-disorders
#4
Zhibin Wang, Xiao-Guang Luo, Chao Gao
In the clinic, the diagnosis of Parkinson's disease (PD) largely depends on clinicians' experience. When the diagnosis is made, approximately 80% of dopaminergic cells in the substantia nigra (SN) have been lost. Additionally, it is rather challenging to differentiate PD from atypical parkinsonian disorders (APD). Clinially-available 3T conventional MRI contributes little to solve these problems. The pathologic alterations of parkinsonism show abnormal brain iron deposition, and therefore susceptibility-weighted imaging (SWI), which is sensitive to iron concentration, has been applied to find iron-related lesions for the diagnosis and differentiation of PD in recent decades...
2016: Translational Neurodegeneration
https://www.readbyqxmd.com/read/27752803/nigella-sativa-oil-reduces-extrapyramidal-symptoms-eps-like-behavior-in-haloperidol-treated-rats
#5
Tafheem Malik, Sheema Hasan, Shahid Pervez, Tasneem Fatima, Darakhshan Jabeen Haleem
The symptoms of Parkinsonism and oral dyskinesia have been showing to be induced by neuroleptics that significantly affect its clinical use. In this study, we investigate whether Nigella sativa-oil (NS) (black cumin seeds)-a traditional medicine used for the seizure treatment in eastern country-may reduce the haloperidol (HAL)-induced extrapyramidal symptoms (EPS)-like behavior in rats. After combine treatment with HAL (1 mg/kg) on NS (0.2 ml/rat), rats displayed a significant decreased EPS-like behavior including movement disorders and oral dyskinesia as compared to controls...
December 2016: Neurochemical Research
https://www.readbyqxmd.com/read/27723878/subregional-pattern-of-striatal-dopamine-transporter-loss-on-18f-fp-cit-positron-emission-tomography-in-patients-with-pure-akinesia-with-gait-freezing
#6
Sangwon Han, Minyoung Oh, Jungsu S Oh, Sang Ju Lee, Seung Jun Oh, Sun Ju Chung, Hee Kyung Park, Jae Seung Kim
Importance: Pure akinesia with gait freezing (PAGF) is a clinical syndrome characterized by freezing of gait, handwriting, and speech without abnormal eye movement or cognitive impairment. Several studies have suggested that PAGF may be a variant of progressive supranuclear palsy (PSP). However, the characteristics of striatal dopamine transporter loss in PAGF are unknown. Objective: To investigate the subregional pattern of striatal dopamine transporter loss in patients with PAGF in comparison with patients with PSP and those with Parkinson disease (PD)...
October 10, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27717189/degenerative-encephalopathy-in-nova-scotia-duck-tolling-retrievers-presenting-with-a-rapid-eye-movement-sleep-behavior-disorder
#7
E N Barker, L J Dawson, J H Rose, S Van Meervenne, O Frykman, C Rohdin, A Leijon, K E Soerensen, J Järnegren, G C Johnson, D P O'Brien, N Granger
BACKGROUND: Neurodegenerative diseases are a heterogeneous group of disorders characterized by loss of neurons and are commonly associated with a genetic mutation. HYPOTHESIS/OBJECTIVES: To characterize the clinical and histopathological features of a novel degenerative neurological disease affecting the brain of young adult Nova Scotia Duck Tolling Retrievers (NSDTRs). ANIMALS: Nine, young adult, related NSDTRs were evaluated for neurological dysfunction and rapid eye movement sleep behavior disorder...
September 2016: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/27704219/abundant-collateralization-of-temporal-lobe-projections-to-the-accumbens-bed-nucleus-of-stria-terminalis-central-amygdala-and-lateral-septum
#8
Rhett A Reichard, Suriya Subramanian, Mikiyas T Desta, Tej Sura, Mary L Becker, Comeron W Ghobadi, Kenneth P Parsley, Daniel S Zahm
Behavioral flexibility is subserved in part by outputs from the cerebral cortex to telencephalic subcortical structures. In our earlier evaluation of the organization of the cortical-subcortical output system (Reynolds and Zahm, J Neurosci 25:11757-11767, 2005), retrograde double-labeling was evaluated in the prefrontal cortex following tracer injections into pairs of the following subcortical telencephalic structures: caudate-putamen, core and shell of the accumbens (Acb), bed nucleus of stria terminalis (BST) and central nucleus of the amygdala (CeA)...
October 4, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/27688202/cerebral-neural-correlates-of-differential-melanopic-photic-stimulation-in-humans
#9
Shao-Min Hung, Dan Milea, Annadata Venkata Rukmini, Raymond P Najjar, Joo Huang Tan, Françoise Viénot, Marie Dubail, Sharon Lee Choon Tow, Tin Aung, Joshua J Gooley, Po-Jang Hsieh
Photic stimulation of rods, cones and intrinsically photosensitive melanopsin-containing retinal ganglion cells (ipRGCs) mediates non-visual light responses, including entrainment of circadian rhythms and pupillary light reflex. Unlike visual responses to photic stimulation, the cerebral correlates of non-visual light responses in humans remains elusive. In this study, we used functional magnetic resonance imaging (fMRI) in 14 healthy young participants, to localize cerebral regions which are differentially activated by metameric light that gave rise to different levels of melanopic excitation...
September 26, 2016: NeuroImage
https://www.readbyqxmd.com/read/27642106/transcranial-sonography-of-subcortical-structures-in-patients-with-multiple-sclerosis
#10
P Puz, A Lasek-Bal, P Radecka
BACKGROUND: Transcranial sonography may be applied to assess the basal ganglia nuclei and brain atrophy by the measurement of the width of the third ventricle. The aim of this study was to assess usefulness of transcranial sonography (TCS) in patients with multiple sclerosis (MS) by examining the echogenicity of subcortical structures and the width of the third ventricle. METHOD: Transcranial sonography evaluation of substantia nigra, brain stem raphe nuclei, diameter of the third ventricle, width of the anterior horn of the lateral ventricle, thalamus, lenticular nucleus, and head of the caudate nucleus in 41 patients with relapsing-remitting MS (RRMS), 23 with secondary progressive MS (SPMS), and 20 healthy controls was compared...
September 18, 2016: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/27625015/the-role-of-diffusion-weighted-imaging-in-the-evaluation-of-the-whole-brain-in-isolated-unilateral-polymicrogyria
#11
Sureyya Burcu Görkem, Selim Doganay, Kazim Gumus, Ayse Bayram, Sefer Kumandas, Abdulhakim Coskun
The aim is to evaluate normal-appearing brain regions in isolated unilateral polymicrogyria patients and compare them with controls by using diffusion-weighted imaging and apparent diffusion coefficient. The diffusion-weighted images (b = 0-1000 s/mm(2)) of 10 pediatric patients (7 boys, 3 girls; mean age = 5.8 ± 4.3 years) with isolated unilateral polymicrogyria and age-sex matched 10 control patients were assessed retrospectively. There was a significant increase in apparent diffusion coefficient values of white matter underlying polymicrogyria, uninvolved white matter, deep gray matter (thalami, lentiform nuclei, caudate nuclei) and corpus callosum in polymicrogyria patients compared to control group (P < ...
September 12, 2016: Journal of Child Neurology
https://www.readbyqxmd.com/read/27618763/metabolic-activation-of-amygdala-lateral-septum-and-accumbens-circuits-during-food-anticipatory-behavior
#12
Diana Olivo, Mario Caba, Francisco Gonzalez-Lima, Juan F Rodríguez-Landa, Aleph A Corona-Morales
When food is restricted to a brief fixed period every day, animals show an increase in temperature, corticosterone concentration and locomotor activity for 2-3h before feeding time, termed food anticipatory activity. Mechanisms and neuroanatomical circuits responsible for food anticipatory activity remain unclear, and may involve both oscillators and networks related to temporal conditioning. Rabbit pups are nursed once-a-day so they represent a natural model of circadian food anticipatory activity. Food anticipatory behavior in pups may be associated with neural circuits that temporally anticipate feeding, while the nursing event may produce consummatory effects...
January 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/27580184/magnetic-resonance-imaging-and-clinical-findings-in-carbon-monoxide-intoxication-in-dogs-a-case-report
#13
Malgorzata Kolecka, Kerstin von Pückler, Steven De Decker, Stefano Cortellini, Gabriel Wurtinger, Martin J Schmidt
This paper presents magnetic resonance imaging (MRI) findings of three dogs after carbon monoxide intoxication. In the first and second cases, MRI changes were confined to both caudate nuclei and in the first case also to the putamen as bilaterally symmetric diffuse homogenous T2 and FLAIR hyperintense, T1 hypointense lesions. No contrast enhancement was seen. In the third case MRI revealed multiple areas of hyperintensity bilaterally on T2 and FLAIR as well as ill-defined areas within the frontal, parietal and occipital grey matter...
August 31, 2016: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/27578570/-brain-gray-matter-abnormalities-revealed-by-voxel-based-morphometry-in-patients-with-chronic-low-back-pain
#14
Cui-Ping Mao, Quan-Xin Yang, Jian Tang, Hua-Juan Yang, Zhi-Lan Bai, Qiu-Juan Zhang, Nadeem Zahid
OBJECTIVE: To explore the morphometric abnormalities of brain gray matter (GM) in patients with chronic low back pain (CLBP). METHODS: Thirty patients with CLBP and 30 healthy individuals were enrolled and examined with a 3.0 T magnetic resonance (MR) scanner. High-resolution T1 structural MR data were acquired and data analysis was performed using voxel-based morphometry (VBM) in FMRIB Software Library. The morphological differences were compared between the two groups...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27545971/influence-of-regional-iron-on-the-motor-impairments-of-parkinson-s-disease-a-quantitative-susceptibility-mapping-study
#15
Xiaojun Guan, Min Xuan, Quanquan Gu, Xiaojun Xu, Peiyu Huang, Nian Wang, Zhujing Shen, Jingjing Xu, Wei Luo, Minming Zhang
PURPOSE: Because the roles of striatal-thalamo-cortical and cerebello-thalamo-cortical circuits in the heterogeneous motor impairments of Parkinson's disease (PD) are becoming recognized, this study was designed to investigate the relationships between regional iron in the cardinal subcortical nuclei in these circuits and the different motor impairments. MATERIALS AND METHODS: Sixty-two PD patients and 40 normal subjects were included and accepted for Enhanced T2 -Star Weighted Angiography Scanning (3...
August 22, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27538418/the-prominent-role-of-serotonergic-degeneration-in-apathy-anxiety-and-depression-in-de-novo-parkinson-s-disease
#16
Audrey Maillet, Paul Krack, Eugénie Lhommée, Elise Météreau, Hélène Klinger, Emilie Favre, Didier Le Bars, Emmanuelle Schmitt, Amélie Bichon, Pierre Pelissier, Valérie Fraix, Anna Castrioto, Véronique Sgambato-Faure, Emmanuel Broussolle, Léon Tremblay, Stéphane Thobois
SEE SCHRAG AND POLITIS DOI101093/AWW190 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Apathy, which can occur separately or in combination with depression and anxiety, is one of the most frequently encountered neuropsychiatric symptoms in Parkinson's disease. Pathophysiological evidence suggests that parkinsonian apathy is primarily due to a mesolimbic dopaminergic denervation, but the role of the serotonergic alteration has never been examined, despite its well-known involvement in the pathogenesis of depression and anxiety...
September 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27489078/a-proactive-task-set-influences-how-response-inhibition-is-implemented-in-the-basal-ganglia
#17
Inge Leunissen, James P Coxon, Stephan P Swinnen
Increasing a participant's ability to prepare for response inhibition is known to result in longer Go response times and is thought to engage a "top-down fronto-striatal inhibitory task set." This premise is supported by the observation of anterior striatum activation in functional magnetic resonance imaging (fMRI) analyses that focus on uncertain versus certain Go trials. It is assumed that setting up a proactive inhibitory task set also influences how participants subsequently implement stopping. To assess this assumption, we aimed to manipulate the degree of proactive inhibition in a modified stop-signal task to see how this manipulation influences activation when reacting to the Stop cue...
December 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27468040/hydrocephalus-in-three-juvenile-north-american-black-bears-ursus-americanus
#18
Sylvia H Ferguson, Janelle Novak, Silke Hecht, Linden E Craig
Hydrocephalus has been reported in a variety of species, including the North American black bear ( Ursus americanus ). This report describes three cases of hydrocephalus in this species from wild bears aged 3-4 mo considered retrospectively from necropsy records of one institution. Clinical signs included cortical blindness and ataxia. Primary gross findings were doming of the skull, gyri compression and flattening, and lateral ventricle dilation. Two cases had severe bilateral ventricular dilation with loss of the septum pellucidum; atrophy of the surrounding corpus callosum; and bilateral periventricular tears involving the caudate nuclei, internal capsule, and adjacent cerebrum...
June 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27453637/distributions-of-oxytocin-and-vasopressin-1a-receptors-in-the-taiwan-vole-and-their-role-in-social-monogamy
#19
A R Chappell, S M Freeman, Y K Lin, J L LaPrairie, K Inoue, L J Young, L D Hayes
Social monogamy is a mating strategy rarely employed by mammalian species. Laboratory studies in socially monogamous prairie voles (Microtus ochrogaster) demonstrate that oxytocin and vasopressin act within the mesolimbic dopamine pathway to facilitate pair-bond formation. Species differences in oxytocin receptor (OTR) and vasopressin 1a receptor (V1aR) distribution in this pathway are associated with species differences in mating strategy. Here we characterize the neuroanatomical distribution of OTR and V1aR binding sites in naturally occurring populations of Taiwan voles (M...
June 2016: Journal of Zoology: Proceedings of the Zoological Society of London
https://www.readbyqxmd.com/read/27452602/amyloid-%C3%AE-deposition-and-regional-grey-matter-atrophy-rates-in-dementia-with-lewy-bodies
#20
Lidia Sarro, Matthew L Senjem, Emily S Lundt, Scott A Przybelski, Timothy G Lesnick, Jonathan Graff-Radford, Bradley F Boeve, Val J Lowe, Tanis J Ferman, David S Knopman, Giancarlo Comi, Massimo Filippi, Ronald C Petersen, Clifford R Jack, Kejal Kantarci
Alzheimer's disease pathology frequently coexists with Lewy body disease at autopsy in patients with probable dementia with Lewy bodies. More than half of patients with probable dementia with Lewy bodies have high amyloid-β deposition as measured with (11)C-Pittsburgh compound B binding on positron emission tomography. Biomarkers of amyloid-β deposition precede neurodegeneration on magnetic resonance imaging during the progression of Alzheimer's disease, but little is known about how amyloid-β deposition relates to longitudinal progression of atrophy in patients with probable dementia with Lewy bodies...
July 24, 2016: Brain: a Journal of Neurology
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