Michael C Saul, Elizabeth M Litkowski, Niran Hadad, Amy R Dunn, Stephanie M Boas, Jon A L Wilcox, Julia E Robbins, Yiyang Wu, Vivek M Philip, Gennifer E Merrihew, Jea Park, Philip L De Jager, Dave E Bridges, Vilas Menon, David A Bennett, Timothy J Hohman, Michael J MacCoss, Catherine C Kaczorowski
Alzheimer's disease (AD) is a prevalent and costly age-related dementia. Heritable factors account for 58-79% of variation in late-onset AD, but substantial variation remains in age-of- onset, disease severity, and whether those with high-risk genotypes acquire AD. To emulate the diversity of human populations, we utilized the AD-BXD mouse panel. This genetically diverse resource combines AD genotypes with multiple BXD strains to discover new genetic drivers of AD resilience. Comparing AD-BXD carriers to noncarrier littermates, we computed a novel quantitative metric for resilience to cognitive decline in the AD-BXDs...
January 11, 2024: bioRxiv