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proteomics and hippocampus

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https://www.readbyqxmd.com/read/29064675/age-dependent-effects-of-acute-alcohol-administration-in-the-hippocampal-phosphoproteome
#1
Ana Contreras, Lidia Morales, Ali Tebourbi, Miguel Miguéns, Nuria Del Olmo, Carmen Pérez-García
Alcohol consumption during adolescence is deleterious to the developing brain and leads to persistent deficits in adulthood. Several results provide strong evidence for ethanol-associated alterations in glutamatergic signaling and impaired synaptic plasticity in the hippocampus. Protein phosphorylation is a well-known and well-documented mechanism in memory processes, but information on phosphoprotein alterations in hippocampus after ethanol exposure is limited. This study focuses on age-related changes in the hippocampal phosphoproteome after acute alcohol administration...
November 3, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29043558/enriched-expression-of-neutral-sphingomyelinase-2-in-the-striatum-is-essential-for-regulation-of-lipid-raft-content-and-motor-coordination
#2
Laura Hui-Ru Tan, Angela Jin-Rong Tan, Yu-Ying Ng, John Jia-En Chua, Wee-Siong Chew, Sneha Muralidharan, Federico Torta, Bamaprasad Dutta, Siu Kwan Sze, Deron R Herr, Wei-Yi Ong
Sphingomyelinases are a family of enzymes that hydrolyze sphingomyelin to generate phosphocholine and ceramide. The brain distribution and function of neutral sphingomyelinase 2 (nSMase2) were elucidated in this study. nSMase2 mRNA expression was greatest in the striatum, followed by the prefrontal cortex, hippocampus, cerebellum, thalamus, brainstem, and olfactory bulb. The striatum had the highest level of nSMase2 protein expression, followed by the prefrontal cortex, thalamus, hippocampus, brainstem, and cerebellum...
October 17, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/29034205/kaempferia-parviflora-rhizome-extract-and-myristica-fragrans-volatile-oil-increase-the-levels-of-monoamine-neurotransmitters-and-impact-the-proteomic-profiles-in-the-rat-hippocampus-mechanistic-insights-into-their-neuroprotective-effects
#3
Waluga Plaingam, Siriporn Sangsuthum, Wannee Angkhasirisap, Tewin Tencomnao
Potentially useful in the treatment of neurodegenerative disorders, Kaempferia parviflora and Myristica fragrans have been shown to possess a wide spectrum of neuropharmacological activities and neuroprotective effects in vivo and in vitro. In this study, we determined whether and how K. parviflora ethanolic extract and M. fragrans volatile oil could influence the levels of neurotransmitters and the whole proteomic profile in the hippocampus of Sprague Dawley (SD) rats. The effects of K. parviflora and M...
October 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29032200/sez6l2-regulates-phosphorylation-of-add-and-neuritogenesis
#4
Hiroaki Yaguchi, Ichiro Yabe, Hidehisa Takahashi, Masashi Watanabe, Taichi Nomura, Takahiro Kano, Masaki Matsumoto, Keiichi I Nakayama, Masahiko Watanabe, Shigetsugu Hatakeyama
Increasing evidence shows that immune-mediated mechanisms may contribute to the pathogenesis of central nervous system disorders including cerebellar ataxias, as indicated by the aberrant production of neuronal surface antibodies. We previously reported a patient with cerebellar ataxia associated with production of a new anti-neuronal antibody, anti-seizure-related 6 homolog like 2 (Sez6l2). Sez6l2 is a type 1 membrane protein that is highly expressed in the hippocampus and cerebellar cortex and mice lacking Sez6l2 protein family members develop ataxia...
October 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28970065/valosin-containing-protein-vcp-is-a-novel-iq-motif-containing-gtpase-activating-protein-1-iqgap1-interacting-protein
#5
Norimichi Itoh, Taku Nagai, Takashi Watanabe, Kentaro Taki, Toshitaka Nabeshima, Kozo Kaibuchi, Kiyofumi Yamada
Scaffold proteins play a pivotal role in making protein complexes, and organize binding partners into a functional unit to enhance specific signaling pathways. IQ motif-containing GTPase activating protein 1 (IQGAP1) is an essential protein for spine formation due to its role in scaffolding multiple signal complexes. However, it remains unclear how IQGAP1 interacts within the brain. In the present study, we screened novel IQGAP1-interacting proteins by a proteomic approach. As a novel IQGAP1-interacting protein, we identified valosin-containing protein (VCP) which is a causative gene in patients with inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD)...
December 2, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28965411/next-generation-proteomic-pipeline-for-chromosome-based-proteomic-research-using-nextprot-and-gencode-databases
#6
Heeyoun Hwang, Gun Wook Park, Ji Yeong Park, Hyun Kyoung Lee, Ju Yeon Lee, Ji Eun Jeong, Sung-Kyu Robin Park, John R Yates, Kyung-Hoon Kwon, Young Mok Park, Hyoung-Joo Lee, Young-Ki Paik, Jin Young Kim, Jong Shin Yoo
Human Proteome Project aims to map all human proteins including missing proteins as well as proteoforms with post translational modifications, alternative splicing variants (ASVs), and single amino acid variants (SAAVs). neXtProt and Ensemble databases are usually used to provide curated information of human coding genes. However, in order to find these proteoforms, we (Chr #11 team) first introduce a streamlined pipeline using customized and concatenated neXtProt and GENCODE originated from Ensemble, with controlled false discovery rate (FDR)...
October 1, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28946568/protein-expression-profiling-in-the-hippocampus-after-focal-cerebral-ischemia-injury-in-rats
#7
Lichan He, Rui He, Ruihua Liang, Yi Li, Xiaoqiang Li, Chuqiao Li, Suping Zhang
In this study, we aimed to explore protein expression profiles in the hippocampus of rats after the induction of focal ischemia injury. Forty SD male rats were randomly divided into 4 groups, with ten rats per group: the control, Day 3, Day 7, and Day 14 after the ischemia injury surgery. Focal cortical ischemia was induced in thirty rats by photothrombosis of the cortical microvessels. After surgery, the induction of ischemia was confirmed by the measurement of infarct size using 2,3,5-triphenyltetrazolium chloride (TTC) staining...
September 20, 2017: Journal of Integrative Neuroscience
https://www.readbyqxmd.com/read/28935861/correlation-profiling-of-brain-sub-cellular-proteomes-reveals-co-assembly-of-synaptic-proteins-and-subcellular-distribution
#8
Nikhil J Pandya, Frank Koopmans, Johan A Slotman, Iryna Paliukhovich, Adriaan B Houtsmuller, August B Smit, Ka Wan Li
Protein correlation profiling might assist in defining co-assembled proteins and subcellular distribution. Here, we quantified the proteomes of five biochemically isolated mouse brain cellular sub-fractions, with emphasis on synaptic compartments, from three brain regions, hippocampus, cortex and cerebellum. We demonstrated the expected co-fractionation of canonical synaptic proteins belonging to the same functional groups. The enrichment profiles also suggested the presence of many novel pre- and post-synaptic proteins...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935605/pyridoxine-improves-hippocampal-cognitive-function-via-increases-of-serotonin-turnover-and-tyrosine-hydroxylase-and-its-association-with-cb1-cannabinoid-receptor-interacting-protein-and-the-cb1-cannabinoid-receptor-pathway
#9
Hyo Young Jung, Dae Won Kim, Sung Min Nam, Jong Whi Kim, Jin Young Chung, Moo-Ho Won, Je Kyung Seong, Yeo Sung Yoon, Dae Young Yoo, In Koo Hwang
BACKGROUND: In the present study, we investigated the effects of pyridoxine on hippocampal functions and changes in protein profiles based on the proteomic approach. METHODS: Eight-week-old mice received intraperitoneal injections of physiological saline (vehicle) or 350mg/kg pyridoxine twice a day for 21days. RESULTS: Phosphoglycerate mutase 1 was up-regulated, while CB1 cannabinoid receptor-interacting protein 1 (CRIP1) was down-regulated, in the pyridoxine-treated group...
December 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28852399/effect-of-glycosides-of-cistanche-on-the-expression-of-mitochondrial-precursor-protein-and-keratin-type-ii-cytoskeletal-6a-in-a-rat-model-of-vascular-dementia
#10
Yan-Mei Zhang, Wei Wu, Wei Ma, Fang Wang, Jun Yuan
Glycosides of Cistanche (GC) is a preparation used extensively for its neuroprotective effect against neurological diseases, but its mechanisms of action remains incompletely understood. Here, we established a bilateral common carotid artery occlusion model of vascular dementia in rats and injected the model rats with a suspension of GC (10 mg/kg/day, intraperitoneally) for 14 consecutive days. Immunohistochemistry showed that GC significantly reduced p-tau and amyloid beta (Aβ) immunoreactivity in the hippocampus of the model rats...
July 2017: Neural Regeneration Research
https://www.readbyqxmd.com/read/28758946/hippocampal-proteome-of-rats-subjected-to-the-li-pilocarpine-epilepsy-model-and-the-effect-of-carisbamate-treatment
#11
José Eduardo Marques-Carneiro, Daniele Suzete Persike, Julia Julie Litzahn, Jean-Christophe Cassel, Astrid Nehlig, Maria José da Silva Fernandes
In adult rats, the administration of lithium-pilocarpine (LiPilo) reproduces most clinical and neuropathological features of human temporal lobe epilepsy (TLE). Carisbamate (CRS) possesses the property of modifying epileptogenesis in this model. Indeed, about 50% of rats subjected to LiPilo status epilepticus (SE) develop non-convulsive seizures (NCS) instead of motor seizures when treated with CRS. However, the mechanisms underlying these effects remain unknown. The aim of this study was to perform a proteomic analysis in the hippocampus of rats receiving LiPilo and developing motor seizures or NCS following CRS treatment...
July 30, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/28730955/itraq-based-proteomic-analysis-of-appsw-ind-mice-provides-insights-into-the-early-changes-in-alzheimer-s-disease
#12
Nan Li, Pinghong Hu, Tiantian Xu, Huan Chen, Xiaoying Chen, Jianwen Hu, Xifei Yang, Lei Shi, Jian-Hong Luo, Junyu Xu
BACKGROUND: Several proteins have been identified as potential diagnostic biomarkers in imaging, genetic, or proteomic studies in Alzheimer disease (AD) patients and mouse models. However, biomarkers for presymptom diagnosis of AD are still under investigation, as are the presymptom molecular changes in AD pathogenesis. OBJECTIVE: In this study, we aim to analyzed the early proteomic changes in APPSw,Ind mice and to conduct further functional studies on interesting proteins...
July 19, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28672812/in-depth-proteomic-analysis-of-the-hippocampus-in-a-rat-model-after-cerebral-ischaemic-injury-and-repair-by-danhong-injection-dhi
#13
Yiran Cui, Xin Liu, Xianyu Li, Hongjun Yang
Stroke is the second most common cause of death worldwide. A systematic description and characterization of the strokes and the effects induced in the hippocampus have not been performed so far. Here, we analysed the protein expression in the hippocampus 24 h after cerebral ischaemic injury and repair. Drug intervention using Danhong injection (DHI), which has been reported to have good therapeutic effects in a clinical setting, was selected for our study of cerebral ischaemia repair in rat models. A larger proteome dataset and total 4091 unique proteins were confidently identified in three biological replicates by combining tissue extraction for rat hippocampus and LC-MS/MS analysis...
June 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28633005/autophagy-impairment-mediated-by-s-nitrosation-of-atg4b-leads-to-neurotoxicity-in-response-to-hyperglycemia
#14
Yazi Li, Yuying Zhang, Lei Wang, Ping Wang, Yanhong Xue, Xiaopeng Li, Xinhua Qiao, Xu Zhang, Tao Xu, Guanghui Liu, Peng Li, Chang Chen
The majority of diabetic patients develop neuropathy and there is an increasing prevalence of neurodegeneration in the central nervous system (CNS). However, the mechanism behind this is poorly understood. Here we first observed that macroautophagy/autophagy was suppressed in the hippocampus of diabetic GK rats with hyperglycemia, whereas it was unchanged in ob/ob mice without hyperglycemia. Autophagy could be directly inhibited by high glucose in mouse primary hippocampal neurons. Moreover, autophagy was protective in high-glucose-induced neurotoxicity...
July 3, 2017: Autophagy
https://www.readbyqxmd.com/read/28627465/differential-proteome-analysis-of-hippocampus-and-temporal-cortex-using-label-free-based-2d-lc-ms-ms
#15
Xiaoyan Liu, Zhengguang Guo, Wei Liu, Wei Sun, Chao Ma
Hippocampus and temporal cortex are important brain regions, which play distinct, but complimentary roles in mediating learning and memory. Herein, we utilized label-free differential proteome strategy to explore function of normal human hippocampus and temporal cortex in learning and memory. As a result, a total of 5529 and 5702 proteins were identified in hippocampus and temporal cortex, respectively, 516 of which were significantly differential expressed, with abundance span 5 orders of magnitudes. Pathways analysis showed that temporal cortex was involved in growth of axons growth and synapse density regulation, through which could regulate long-term potentiation and long-term retention of trace memory...
June 13, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28608594/melatonin-ameliorates-anxiety-and-depression-like-behaviors-and-modulates-proteomic-changes-in-triple-transgenic-mice-of-alzheimer-s-disease
#16
Lulin Nie, Gang Wei, Shengming Peng, Zhongsen Qu, Ying Yang, Qian Yang, Xinfeng Huang, Jianjun Liu, Zhixiong Zhuang, Xifei Yang
Alzheimer's disease (AD) is a devastating neurodegenerative disease accompanied by neuropsychiatric symptoms, such as anxiety and depression. The levels of melatonin decrease in brains of AD patients. The potential effect of melatonin on anxiety and depression behaviors in AD and the underlying mechanisms remain unclear. In this study, we treated 10-month-old triple transgenic mice of AD (3xTg-AD) with melatonin (10 mg/kg body weight/day) for 1 month and explored the effects of melatonin on anxiety and depression-like behaviors in 3xTg-AD mice and the protein expression of hippocampal tissues...
June 13, 2017: BioFactors
https://www.readbyqxmd.com/read/28576708/a-systems-level-analysis-of-epileptogenesis-associated-proteome-alterations
#17
Michael Keck, Ganna Androsova, Fabio Gualtieri, Andreas Walker, Eva-Lotta von Rüden, Vera Russmann, Cornelia A Deeg, Stefanie M Hauck, Roland Krause, Heidrun Potschka
Despite intense research efforts, the knowledge about the mechanisms of epileptogenesis and epilepsy is still considered incomplete and limited. However, an in-depth understanding of molecular pathophysiological processes is crucial for the rational selection of innovative biomarkers and target candidates. Here, we subjected proteomic data from different phases of a chronic rat epileptogenesis model to a comprehensive systems level analysis. Weighted Gene Co-expression Network analysis identified several modules of interconnected protein groups reflecting distinct molecular aspects of epileptogenesis in the hippocampus and the parahippocampal cortex...
September 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28526399/evaluation-of-the-effectiveness-of-chronic-antidepressant-drug-treatments-in-the-hippocampal-mitochondria-a-proteomic-study-in-an-animal-model-of-depression
#18
Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Rafał Olszanecki, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
Several lines of evidence indicate that adverse experience in early life may be a triggering factor for disturbances in the brain mitochondrial proteins and lead to the development of depression in adulthood. On the other hand, little is known about the impact of chronic administration of various antidepressant drugs on the brain mitochondria, as a target for the pharmacotherapy of depression. The purpose of our study was to compare the impact of chronic treatment with two antidepressant drugs with different mechanisms of action, a tricyclic antidepressant (TCA), imipramine, and an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class, fluoxetine, on the mitochondria-enriched subproteome profile in the hippocampus of 3-month-old male rats following a prenatal stress procedure (an animal model of depression)...
August 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28522608/altered-learning-memory-and-social-behavior-in-type-1-taste-receptor-subunit-3-knock-out-mice-are-associated-with-neuronal-dysfunction
#19
Bronwen Martin, Rui Wang, Wei-Na Cong, Caitlin M Daimon, Wells W Wu, Bin Ni, Kevin G Becker, Elin Lehrmann, William H Wood, Yongqing Zhang, Harmonie Etienne, Jaana van Gastel, Abdelkrim Azmi, Jonathan Janssens, Stuart Maudsley
The type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perception. Besides the tongue, the T1R3 receptor is highly expressed in brain areas implicated in cognition, including the hippocampus and cortex. As cognitive decline is often preceded by significant metabolic or endocrinological dysfunctions regulated by the sweet-taste perception system, we hypothesized that a disruption of the sweet-taste perception in the brain could have a key role in the development of cognitive dysfunction...
July 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28504966/functional-characterization-of-the-lysosomal-membrane-protein-tmem192-in-mice
#20
Thuy Linh Nguyen, Janna Schneppenheim, Sönke Rudnik, Renate Lüllmann-Rauch, Christian Bernreuther, Irm Hermans-Borgmeyer, Markus Glatzel, Paul Saftig, Bernd Schröder
The Transmembrane protein 192 (TMEM192) is a lysosomal/late endosomal protein initially discovered by organellar proteomics. TMEM192 exhibits four transmembrane segments with cytosolic N- and C-termini and forms homodimers. Devoid of significant homologies, the molecular function of TMEM192 is currently unknown. Upon TMEM192 knockdown in hepatoma cells, a dysregulation of autophagy and increased apoptosis were reported. Here, we aimed to define the physiological role of TMEM192 by analysing consequences of TMEM192 ablation in mice...
July 4, 2017: Oncotarget
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