Rafal Panek, Liam Welsh, Lauren C J Baker, Maria A Schmidt, Kee H Wong, Angela M Riddell, Dow-Mu Koh, Alex Dunlop, Dualta Mcquaid, James A d'Arcy, Shreerang A Bhide, Kevin J Harrington, Christopher M Nutting, Georgina Hopkinson, Cheryl Richardson, Carol Box, Suzanne A Eccles, Martin O Leach, Simon P Robinson, Kate L Newbold
Purpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and patients. Experimental Design: Quantitation of the transverse relaxation rate, R2 *, which is sensitive to paramagnetic deoxyhemoglobin, using serial IS-MRI acquisitions, was used to monitor temporal oscillations in levels of paramagnetic deoxyhemoglobin in human CALR xenografts and patients with HNSCC at 3T...
August 1, 2017: Clinical Cancer Research