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Bidisha Bhaduri, P L Abhilash, Phalguni Anand Alladi
Epidemiological studies reveal an ethnicity-based bias in prevalence of Parkinson's disease (PD), deriving from the differences that exist between Caucasians and African or Asian populations. Experimental mice models provide a scope to analyse the cellular mechanisms of differential susceptibility to PD. C57BL/6J mice, for instance, are more susceptible to MPTP-induced Parkinsonism whereas CD-1 mice are resistant. In PD-pathogenesis, interneuronal contribution is also likely, although they comprise only 5-10% of the striatal cells...
April 22, 2018: Journal of Chemical Neuroanatomy
Vijayalakshmi Bolla, P Santha Kumari, Surendra Reddy Munnangi, D Sunil Kumar, Y Durgabai, Pradeep Koppolu
AIM: Evaluation and comparison of serum C-reactive protein (CRP) levels in subjects with chronic and aggressive periodontitis. MATERIALS AND METHODS: Based on the periodontal status, 45 subjects were selected and divided into three groups. Group I - subjects with clinically healthy periodontium, Group II - generalized aggressive periodontitis (GAP), and Group III - chronic periodontitis (CP). Blood samples were collected from subjects for measurement of CRP. Periodontal parameters include plaque index (PI), gingival index, bleeding index (BI), probing pocket depth (PPD), and clinical attachment loss (CAL) were assessed...
April 2017: International Journal of Applied and Basic Medical Research
Rafal Panek, Liam Welsh, Lauren C J Baker, Maria A Schmidt, Kee H Wong, Angela M Riddell, Dow-Mu Koh, Alex Dunlop, Dualta Mcquaid, James A d'Arcy, Shreerang A Bhide, Kevin J Harrington, Christopher M Nutting, Georgina Hopkinson, Cheryl Richardson, Carol Box, Suzanne A Eccles, Martin O Leach, Simon P Robinson, Kate L Newbold
Purpose: To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and patients. Experimental Design: Quantitation of the transverse relaxation rate, R2 *, which is sensitive to paramagnetic deoxyhemoglobin, using serial IS-MRI acquisitions, was used to monitor temporal oscillations in levels of paramagnetic deoxyhemoglobin in human CALR xenografts and patients with HNSCC at 3T...
August 1, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Dorcas Lamounier Costa, Regina Lunardi Rocha, Eldo de Brito Ferreira Chaves, Vivianny Gonçalves de Vasconcelos Batista, Henrique Lamounier Costa, Carlos Henrique Nery Costa
INTRODUCTION: Early identification of patients at higher risk of progressing to severe disease and death is crucial for implementing therapeutic and preventive measures; this could reduce the morbidity and mortality from kala-azar. We describe a score set composed of four scales in addition to software for quick assessment of the probability of death from kala-azar at the point of care. METHODS: Data from 883 patients diagnosed between September 2005 and August 2008 were used to derive the score set, and data from 1,031 patients diagnosed between September 2008 and November 2013 were used to validate the models...
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
Nives Rinčić, Darko Božić, Goran Rinčić, Petar Gaćina, Darije Plančak
OBJECTIVE: To assess periodontal conditions in patients with early stage CLL and to compare it with the periodontal status of age matched healthy controls and to analyze the relationship between periodontal and hematological parameters in CLL patients. MATERIALS AND METHODS: 60 subjects were examined: 30 patients with CLL Rai 0 (test group) and 30 age-matching healthy individuals (control group). The exclusion criteria were: presence of other systemic disease or condition (e...
March 2016: Acta Stomatologica Croatica
Supaporn Klangprapan, Ponlatham Chaiyarit, Doosadee Hormdee, Amonrujee Kampichai, Tueanjit Khampitak, Jureerut Daduang, Ratree Tavichakorntrakool, Bhinyo Panijpan, Patcharee Boonsiri
Periodontal diseases, which result from inflammation of tooth supporting tissues, are highly prevalent worldwide. Myeloperoxidase (MPO), from certain white blood cells in saliva, is a biomarker for inflammation. We report our study on the salivary MPO activity and its association with severity of periodontal diseases among Thai patients. Periodontally healthy subjects (n = 11) and gingivitis (n = 32) and periodontitis patients (n = 19) were enrolled. Assessments of clinically periodontal parameters were reported as percentages for gingival bleeding index (GI) and bleeding on probing (BOP), whereas pocket depth (PD) and clinical attachment loss (CAL) were measured in millimeters and then made to index scores...
2016: Enzyme Research
Hengameh Chloé Mirsepasi-Lauridsen, Ulla Bachmann Holmetoft, Sofie Ingdam Halkjær, Karen Angeliki Krogfelt, Andreas Munk Petersen
OBJECTIVE: Fecal calprotectin is a noninvasive marker of intestinal inflammation used to distinguish between functional and organic bowel diseases and to evaluate disease activity among patients with Inflammatory Bowel Disease (IBD). The goal of this study was to compare three different ELISA tests measuring calprotectin in their accuracy to detect IBD and to distinguish between IBD patients with active or inactive disease. MATERIAL AND METHODS: This study includes in total 148 fecal samples, 96 from patients with a previously confirmed IBD diagnosis and 52 from healthy controls, aged from 25 to 86 and 18 to 67 years, respectively...
2016: Scandinavian Journal of Gastroenterology
Saulo Gil, Irineu Loturco, Valmor Tricoli, Carlos Ugrinowitsch, Ronaldo Kobal, Cesar Cavinato Cal Abad, Hamilton Roschel
Tensiomyography has been suggested as an indirect marker of muscle stiffness, which is associated with strength/power performance. Therefore, it is reasonable to suggest that tensiomyography parameters could be associated with power-related motor tasks. The purpose of this study was to investigate the association between tensiomyography parameters (from rectus and biceps femoris) and jumping and sprinting abilities in elite soccer players. In addition, we used tensiomyography parameters to compare the lateral symmetry between dominant and non-dominant legs...
September 2015: Sports Biomechanics
Joo Youn Lee, In Ah Choi, Jin-Hee Kim, Kyoung-Hwa Kim, Eun Young Lee, Eun Bong Lee, Yong-Moo Lee, Yeong Wook Song
BACKGROUND: Periodontitis (PD) has been reported to be associated with rheumatoid arthritis (RA). Porphyromonas gingivalis (P. gingivalis) is a gram-negative anaerobic bacterium that is recognized as one of the major pathogenic organisms in PD and is the only bacterium known to express peptidylarginine deiminase (PAD). Antibody against human α-enolase (ENO1) is one of the autoantibodies in RA. ENO1 is a highly conserved protein, and could be a candidate molecule for molecular mimicry between bacterial and human proteins...
2015: BMC Musculoskeletal Disorders
N Priyanka, Nitish Kalra, Shahab Saquib, Shahabe Saquib, Nikhil Malgaonkar, Malgaonkar Nikhil, Bassel Tarakji, Jadhav Varsha, Davangere Umashree, A R Pradeep
BACKGROUND: The present clinical trial was designed to investigate the effectiveness of subgingivally delivered satranidazole (SZ) gel as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis. METHODS: Sixty-four subjects with probing depth (PD) ≥ 5 mm and who were diagnosed with type 2 diabetes were selected. Thirty-two subjects each were randomly assigned to SRP + placebo (Group 1) and SRP + SZ (Group 2). The clinical outcomes evaluated were plaque index (PI), gingival index (GI), clinical attachment level (CAL) and PD at baseline, 1 month, 3-months and 6 months...
April 2015: Journal of the International Academy of Periodontology
Kaushik Patnaik, A R Pradeep, Kanika Nagpal, Shruti Karvekar, Priyanka Singh, Arjun Raju
AIM: The aim of the present study was to evaluate the levels and correlation of human chemerin in gingival crevicular fluid (GCF) and tear fluid in chronic periodontitis (CP) subjects with and without type-2 diabetes mellitus (DM). MATERIALS AND METHODS: A total of 40 subjects were divided into three groups: group 1 had 10 periodontally healthy subjects; group 2 consisted of 15 CP subjects and group 3 had 15 type-2 DM subjects with CP. The GCF and tear fluid levels of human chemerin were quantified using enzyme linked immunosorbent assay (ELISA)...
February 2017: Journal of Investigative and Clinical Dentistry
E W Kaiser, David S Pierce
The equilibrium constants for the Z to E isomerizations of CF3CF═CHF (K1) and CF3CH═CHCF3 (K2) have been measured using GC/FID analysis over the temperature ranges 360–850 and 297–850 K, respectively. At lower temperature, K was determined using Cl atom catalysis. At higher temperature, K was measured without a catalyst. The temperature-dependent expressions are K1 (Z to E) = 1.45(±0.15)e(–[2845(±100)/RT]) and K2 (Z to E) = 1.9(±0.22)e(+[4330(±120)/RT]) (where the gas constant R ≡ 1.986 cal mol(–1) K(–1))...
August 27, 2015: Journal of Physical Chemistry. A
James P Kennett, Douglas J Kennett, Brendan J Culleton, J Emili Aura Tortosa, James L Bischoff, Ted E Bunch, I Randolph Daniel, Jon M Erlandson, David Ferraro, Richard B Firestone, Albert C Goodyear, Isabel Israde-Alcántara, John R Johnson, Jesús F Jordá Pardo, David R Kimbel, Malcolm A LeCompte, Neal H Lopinot, William C Mahaney, Andrew M T Moore, Christopher R Moore, Jack H Ray, Thomas W Stafford, Kenneth Barnett Tankersley, James H Wittke, Wendy S Wolbach, Allen West
The Younger Dryas impact hypothesis posits that a cosmic impact across much of the Northern Hemisphere deposited the Younger Dryas boundary (YDB) layer, containing peak abundances in a variable assemblage of proxies, including magnetic and glassy impact-related spherules, high-temperature minerals and melt glass, nanodiamonds, carbon spherules, aciniform carbon, platinum, and osmium. Bayesian chronological modeling was applied to 354 dates from 23 stratigraphic sections in 12 countries on four continents to establish a modeled YDB age range for this event of 12,835-12,735 Cal B...
August 11, 2015: Proceedings of the National Academy of Sciences of the United States of America
Santosh S Martande, Avani R Pradeep, Minal Kumari, Ningappa Priyanka, Sonender P Singh, Savitha B Naik, Swati Pradeep Patel, Paulami Bagchi
PURPOSE: The objective of this randomized clinical trial was to evaluate the clinical and microbiological effects of systemic administration of roxithromycin (RXM) as an adjunct to non-surgical periodontal therapy (NSPT) in the treatment of individuals with moderate to severe chronic periodontitis (CP). METHODS: 70 individuals (38 males and 32 females, aged 25 to 60 years) with moderate to severe CP were randomly allocated into two groups. 35 individuals were allocated to full mouth SRP+RXM while 35 individuals were allocated to SRP+ Placebo group...
June 2015: American Journal of Dentistry
Lu Huiling, Liu Yaping, Hu Xiufen
OBJECTIVE: To detect plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) in acute Kawasaki disease (KD) and analyze the relationship between NT-proBNP and other bio-markers in order to evaluate if NT-proBNP could be as a useful diagnostic marker to predict the risk of coronary arterial lesions in acute KD. METHOD: Totally 106 patients with KD were recruited from January 2012 to April 2014 at Department of Pediatrics of Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology,64 were boys and 42 were girls, their age ranged from 2 months to 8 years and 4 months...
April 2015: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Yanan Chen, Fei Zhu, Nan Yang, Pingping Zuo, Ruisheng Li, Senyang Lang, Xiangqing Wang
OBJECTIVE: To explore the changes over time of cannabinoid receptor 1 (CB1R) in hippocampus of status epilepticus (SE) rats. METHODS: A rat model of SE was established by an intraperitoneal injection of kainic acid (KA). The animals were scarified 30 minutes later. And the changes of CB1lR were detected by immunohistochemistry and Western blot at 4 hours, 1 day, 1 week, 1 month and 2 months post-SE. RESULTS: CB1R in CAl area of hippocampus of SE rats increased gradually at 1 week and then decreased to normal afterward (KA vs NS: 5...
February 3, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Angel M R Schols, Femke Stevens, Camiel G I P Zeijen, Geert-Jan Dinant, Christel van Vugt, Jochen W L Cals
OBJECTIVE: To determine GPs' access to diagnostic tests (medical imaging, laboratory tests, and point-of-care tests) during GP out-of-hours care in the Netherlands and to assess whether access differs between services located adjacent to or separate from an Accident and Emergency (A&E) department. DESIGN: Cross-sectional survey. METHOD: In 2014 we invited all GP out-of-hours services in the Netherlands to participate in a survey on GPs' access to diagnostic tests in Dutch GP out-of-hours services...
2015: Nederlands Tijdschrift Voor Geneeskunde
Zhengzong Wu, Enbo Xu, Jie Long, Fang Wang, Xueming Xu, Zhengyu Jin, Aiquan Jiao
The high content of amino acids of Chinese rice wine (CRW), especially essential amino acids makes it a food increasingly demanded by consumers. Rapid detection technique of amino acid content, which is an important quality and function index of CRW, is highly desirable for consumers, producers as well as administrative authorities. In this study, the potential of Fourier transform infrared spectroscopy (FT-IR) as a novel and rapid analytical technique to determine 17 free amino acids in CRW were investigated...
August 2015: Journal of Food Science
L Zhang, X Q Guo, J F Chu, X Zhang, Z R Yan, Y Z Li
Alzheimer's disease (AD) is a neurodegenerative disor-der and the most common cause of dementia in elderly people. Nu-merous studies have focused on the dysregulated genes in AD, but the pathogenesis is still unknown. In this study, we explored critical hippocampal genes and pathways that might potentially be involved in the pathogenesis of AD. Four transcriptome datasets for the hip-pocampus of patients with AD were downloaded from ArrayExpress, and the gene signature was identified by integrated analysis of mul-tiple transcriptomes using novel genome-wide relative significance and genome-wide global significance models...
2015: Genetics and Molecular Research: GMR
R J Barranco, F Gomez-Peralta, C Abreu, M Delgado, R Palomares, F Romero, C Morales, M A de la Cal, J M Garcia-Almeida, F Pasquel, G E Umpierrez
AIMS: Hypoglycaemia is a serious medical emergency. The need for emergency medical service care and the costs of hypoglycaemic emergencies are not completely known. METHODS: This was a retrospective observational study using Public Company for Health Emergencies (EPES) data for hypoglycaemia in 2012. The EPES provides emergency medical services to the entire population of Andalusia, Spain (8.5 million people). Data on event type, onsite treatments, emergency room visits or hospitalization were collected...
November 2015: Diabetic Medicine: a Journal of the British Diabetic Association
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