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https://www.readbyqxmd.com/read/29454928/resting-state-functional-connectivity-of-the-amygdala-and-problem-drinking-in-non-dependent-alcohol-drinkers
#1
Sien Hu, Jaime S Ide, Herta H Chao, Simon Zhornitsky, Kimberly A Fischer, Wuyi Wang, Sheng Zhang, Chiang-Shan R Li
Alcohol misuse is associated with dysfunction of the amygdala-prefrontal cortical circuit. The amygdala and its cortical targets show decreased activity during a variety of task challenges in individuals engaged in problem drinking. On the other hand, it is less clear how amygdala resting state functional connectivity (rsFC) may be altered in association with alcohol misuse and whether such changes are restricted to prefrontal cortical structures. Further, the influences of comorbid substance use and depression and potential sex differences have not been assessed in earlier work...
February 7, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29454029/sex-related-differences-in-the-association-between-grip-strength-and-depression-results-from-the-irish-longitudinal-study-on-ageing
#2
Cillian P McDowell, Brett R Gordon, Matthew P Herring
Muscular strength is a modifiable protective factor for mental health across aging populations. Evidence of sex-related differences in its associations with mental health is limited. Therefore, the purpose of this study was to examine sex-related differences in cross-sectional and prospective associations between grip strength and depressive symptoms and status. Participants were community dwelling adults (N = 4505; 56.5% female), aged ≥50 years. As a measure of muscular strength, grip strength (kg) of the dominant hand was assessed using a hand-held dynamometer at baseline...
February 14, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29453441/circulating-cell-free-mitochondrial-dna-but-not-leukocyte-mitochondrial-dna-copy-number-is-elevated-in-major-depressive-disorder
#3
Daniel Lindqvist, Owen M Wolkowitz, Martin Picard, Lars Ohlsson, Francesco S Bersani, Johan Fernström, Åsa Westrin, Christina M Hough, Jue Lin, Victor I Reus, Elissa S Epel, Synthia H Mellon
Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the mitochondrial genome released during cellular stress. Few studies have examined ccf-mtDNA in MDD, and no studies have tested its relationship with intracellular mtDNA-cn or with antidepressant treatment response...
January 30, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29451303/sex-specific-manifestation-of-genetic-risk-for-attention-deficit-hyperactivity-disorder-in-the-general-population
#4
Joanna Martin, Mark J Taylor, Mina Rydell, Lucy Riglin, Olga Eyre, Yi Lu, Sebastian Lundström, Henrik Larsson, Anita Thapar, Paul Lichtenstein
BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is more commonly diagnosed in males than in females. A growing body of research suggests that females with ADHD might be underdiagnosed or receive alternative diagnoses, such as anxiety or depression. Other lines of reasoning suggest that females might be protected from developing ADHD, requiring a higher burden of genetic risk to manifest the disorder. METHODS: We tested these two hypotheses, using common variant genetic data from two population-based cohorts...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29451300/decreased-anterior-cingulate-activation-in-a-motor-task-in-youths-with-bipolar-disorder
#5
Jace B King, Jeffrey S Anderson, Deborah A Yurgelun-Todd, Punitha Subramaniam, Marie R Ehrler, Melissa P Lopez-Larson
BACKGROUND: Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. METHODS: Thirty-five youths with BP and 35 HC (aged 10-19) completed a self-paced sequential bilateral finger-tapping task, consisting of a 4-minute scan block with alternating 20-second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging...
February 16, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29446186/longterm-persistence-and-nonrecurrence-of-depression-treatment-in-germany-a-four-year-retrospective-follow-up-using-linked-claims-data
#6
Christoph J Wagner, Charalabos Markos Dintsios, Florian G Metzger, Helmut L'Hoest, Ursula Marschall, Bjoern Stollenwerk, Stephanie Stock
OBJECTIVES: To measure persistence and nonrecurrence of depression treatment and investigate potential risk factors. METHODS: We retrospectively observed a closed cohort of insurees with new-onset depression treatment in 2007 and without most psychiatric comorbidity for 16 quarters (plus one to ascertain discontinuation). We linked inpatient/outpatient/drug-data per person and quarter. Person-quarters containing specified depression services were classified as depression-treatment-person-quarters (DTPQ)...
February 15, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29445298/presence-of-pain-on-three-or-more-days-of-the-week-is-associated-with-worse-patient-reported-outcomes-in-adults-with-sickle-cell-disease
#7
Nitya Bakshi, Diana Ross, Lakshmanan Krishnamurti
While acute episodic pain is the hallmark of sickle cell disease (SCD), transition to chronic pain is a major cause of morbidity and impaired quality of life. One of the core diagnostic criteria used by Analgesic, Anesthetic, and Addiction Clinical Trial Translations Innovations Opportunities and Networks-American Pain Society Pain Taxonomy (AAPT) to define chronic SCD pain is the presence of pain on a "majority of days" in the past 6 months in one or more locations. The frequency characteristic of "majority of days" is adapted from the criteria of 15 days or more per month, used to define chronic migraine, but there are inadequate data to support this cutoff in SCD...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29441710/olfactory-processing-in-bipolar-disorder-major-depression-and-anxiety
#8
Vidyulata Kamath, Diana Paksarian, Lihong Cui, Paul J Moberg, Bruce I Turetsky, Kathleen R Merikangas
OBJECTIVES: Although olfactory abnormalities are well established in schizophrenia, considerably less work has examined olfactory performance in other neuropsychiatric conditions. In the current study, we examined odor identification, odor discrimination, detection threshold, and odor hedonic processing performance in individuals with bipolar I disorder (n = 43; n = 13 with psychotic features), bipolar II disorder (n = 48), major depressive disorder (MDD) (n = 134), anxiety (n = 48), and no mental disorder (n = 72) who participated in a community-based family study...
February 13, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29439279/-comorbid-mental-disorders-in-gastroenterology-and-hepatology-prevalence-and-psychosocial-needs-in-tertiary-care
#9
Alexander Niecke, Hanna Lemke, Tobias Goeser, Martin Hellmich, Frank Vitinius, Christian Albus
BACKGROUND: In the field of gastroenterology and hepatology, associations and interactions with comorbid mental disorders are often described, but there is currently a lack of methodologically high-quality studies on prevalence and the need for care. The aim of the study was to take account of this shortcoming. METHODS: Prospective, monocentric, cross-sectional study of a representative sample of inpatients at a university hospital. A total of 308 participants were examined for the presence of 8 frequent psychological syndromes with a validated questionnaire (PHQ-D)...
February 13, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29438604/increased-burden-of-psychiatric-disorders-in-rheumatoid-arthritis
#10
Ruth Ann Marrie, Carol A Hitchon, Randy Walld, Scott B Patten, James M Bolton, Jitender Sareen, John R Walker, Alexander Singer, Lisa M Lix, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder and schizophrenia in a population-based cohort with rheumatoid arthritis (RA) as compared to an age-, sex- and geographically matched cohort without RA. METHODS: Using population-based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex and region...
February 13, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29434802/an-investigation-of-the-mechanism-of-dexmedetomidine-in-improving-postoperative-cognitive-dysfunction-from-the-perspectives-of-alleviating-neuronal-mitochondrial-membrane-oxidative-stress-and-electrophysiological-dysfunction
#11
Jie Chen, Na Shen, Xiaohui Duan, Yaning Guo
The aim of this study was to investigate the mechanism of dexmedetomidine in improving postoperative cognitive dysfunction from the perspectives of alleviating neuronal mitochondrial membrane oxidative stress and electrophysiological dysfunction. A total of 120 patients undergoing elective surgery under general anesthesia from June 2013 to May, 2016 were selected as the subjects of the study and randomly divided into the propofol + remifentanil and dexmedetomidine groups. The Rey Auditory Verbal Learning Test (AVLT) and Beck Depression Inventory (BDI) were performed at day 1 before operation and at day 1, 3, 5 and 15 after operation...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434563/determining-factors-for-stress-perception-assessed-with-the-perceived-stress-scale-pss-4-in-spanish-and-other-european-samples
#12
Miguel A Vallejo, Laura Vallejo-Slocker, Enrique G Fernández-Abascal, Guillermo Mañanes
Objective: Stress perception depends on cultural and social aspects that vary from one country to another. One of the most widely disseminated methods of assessing psychological stress is the Perceived Stress Scale (PSS-4). Therefore, in order to identify these factors and their impact on mental health, the present study compares the PSS-4 results among three European countries (Great Britain, France and Spain). This study focuses on PSS-4 results within a Spanish sample to determine: (1) normative data, reliability and validity of PSS-4 in a Spanish sample and (2) how stress perception changes depending on cultural and social factors...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29433843/biological-alterations-affecting-risk-of-adult-psychopathology-following-childhood-trauma-a-review-of-sex-differences
#13
REVIEW
Ashwini Tiwari, Andrea Gonzalez
Childhood trauma exposure is a significant public health problem. While adult mental health consequences of such experiences are well documented, sex differences in both prevalence and severity are less understood. Sex-based differences in biological circuitry and physiological trauma responses are proposed to potentiate the differential risk for pathogenesis of mental health disorders among adults. This paper will provide a contextualized summary of neuroendocrine, neuroimaging, and behavioral epigenetic studies on biological sex differences contributing to internalizing psychopathology, specifically posttraumatic stress disorder and depression, among adults with a history of childhood abuse...
February 2, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29432509/body-image-and-depressive-symptoms-in-person-suffering-from-psoriasis
#14
Monika Rosińska, Teresa Rzepa, Beata Szramka-Pawlak, Ryszard Żaba
OBJECTIVES: The purpose of the research study was specifying the relationship between severity of psoriasis and body image and self-reported depressive symptoms, taking into account the differences between the sexes. METHODS: The research study involved 54 psoriasis patients, including 30 men and 24 women aged from 19 to 82. The level of depressive symptoms was assessed using the Beck Depression Inventory, and body image - using the Multidimensional Body-Self Relations Questionnaire...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29432299/comparative-metaproteomics-analysis-shows-altered-fecal-microbiota-signatures-in-patients-with-major-depressive-disorder
#15
Zhi Chen, Jie Li, Siwen Gui, Chanjuan Zhou, Jianjun Chen, Chuangchuang Yang, Zicheng Hu, Haiyang Wang, Xiaogang Zhong, Li Zeng, Ke Chen, Pengfei Li, Peng Xie
Major depressive disorder (MDD) is a highly prevalent and debilitating mental illness, which is associated with disorder of gut microbiota. However, few studies focusing on detection of the signatures of bacteria in feces of MDD patients using proteomics approach have been carried out. Here, a comparative metaproteomics analysis on the basis of an isobaric tag for relative and absolute quantification coupled with tandem mass spectrometry was carried out to explore the signature of gut microbiota in patients with MDD...
February 9, 2018: Neuroreport
https://www.readbyqxmd.com/read/29431190/-a-joke-a-day-keeps-the-doctor-away-meta-analytical-evidence-of-differential-associations-of-habitual-humor-styles-with-mental-health
#16
Martha Schneider, Martin Voracek, Ulrich S Tran
Humor and mental health are interconnected as is evidenced by a large number of studies. However, associations are only small and inconsistent as the operationalization of humor poses a methodological challenge. The Humor Styles Questionnaire (HSQ) differentiates four humor styles that might be beneficial or harmful to mental health. The aim of the present study was to meta-analytically aggregate studies using the HSQ to assess the associations of different humor styles with four areas of mental health (self-esteem, life satisfaction, optimism, depression)...
February 12, 2018: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29430636/sex-differences-in-life-span-females-homozygous-for-the-x-chromosome-do-not-suffer-the-shorter-life-span-predicted-by-the-unguarded-x-hypothesis
#17
Martin Brengdahl, Christopher M Kimber, Jack Maguire-Baxter, Urban Friberg
Life span differs between the sexes in many species. Three hypotheses to explain this interesting pattern have been proposed, involving different drivers: sexual selection, asymmetrical inheritance of cytoplasmic genomes, and hemizygosity of the X(Z) chromosome (the unguarded X hypothesis). Of these, the unguarded X has received the least experimental attention. This hypothesis suggests that the heterogametic sex suffers a shortened life span because recessive deleterious alleles on its single X(Z) chromosome are expressed unconditionally...
February 12, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29430564/sensory-symptom-profiles-differ-between-trigeminal-and-thoracolumbar-postherpetic-neuralgia
#18
Stefanie Rehm, Moritz Groβkopf, Maria Kabelitz, Thomas Keller, Rainer Freynhagen, Thomas R Tölle, Ralf Baron
Introduction: Animal experimental evidence suggests that mechanisms of pain generation and response to treatment differ between neuropathic pain in the cephalic and the extracephalic innervation territories. Objectives: The objective of the study was to examine whether in humans an identical peripheral painful neuropathy is associated with different pain qualities and sensory abnormalities in the face as compared with the thoracic region. Methods: We retrospectively analysed epidemiological and clinical data of 639 patients with postherpetic neuralgia (PHN) in the face and at the trunk who were collected within a cross-sectional cohort survey and compared the respective sensory symptom profiles captured with the painDETECT questionnaire...
January 2018: Pain Reports (Baltimore, Md.)
https://www.readbyqxmd.com/read/29429384/differences-in-cognitive-performance-in-nondemented-parkinson-s-disease-a-latent-profile-analysis-of-cognitive-subtypes
#19
Laura Alonso-Recio, Pilar Martín-Plasencia, Miguel Ruiz, Juan Manuel Serrano
INTRODUCTION: Cognitive impairments are common in Parkinson's disease (PD) patients without dementia. These deficits are quite heterogeneous, which makes it difficult to recognize and treat them. For this reason, many authors have attempted to classify patients into more homogeneous groups with diverse results. The present study was designed to analyze the cognitive heterogeneity in PD patients using a novel data-driven approach, latent profile analysis (LPA), to classify patients according to cognitive characteristics...
February 12, 2018: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/29428324/pre-and-postnatal-tobacco-and-cannabis-exposure-and-child-behavior-problems-bidirectional-associations-joint-effects-and-sex-differences
#20
Rina D Eiden, Junru Zhao, Meghan Casey, Shannon Shisler, Pamela Schuetze, Craig Colder
AIMS: We examined prospective associations between pre-and-postnatal tobacco and cannabis exposure on child behavior problems from 2 to 3 years of child age, sex differences in these associations, and bidirectional associations between maternal postnatal substance use and child behavior problems across time. METHODS: The sample consisted of 247 primarily young, unmarried, low-income, minority mothers and their children (97 prenatally exposed to tobacco and cannabis, 81 exposed to tobacco only, and 69 non-exposed)...
February 5, 2018: Drug and Alcohol Dependence
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