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https://www.readbyqxmd.com/read/29036013/patient-experience-based-value-sets-are-they-stable
#1
A Simon Pickard, Yu-Ting Hung, Fang-Ju Lin, Todd A Lee
BACKGROUND: Although societal preference weights are desirable to inform resource-allocation decision-making, patient experienced health state-based value sets can be useful for clinical decision-making, but context may matter. OBJECTIVE: To estimate EQ-5D value sets using visual analog scale (VAS) ratings for patients undergoing knee replacement surgery and compare the estimates before and after surgery. METHODS: We used the Patient Reported Outcome Measures data collected by the UK National Health Service on patients undergoing knee replacement from 2009 to 2012...
October 13, 2017: Medical Care
https://www.readbyqxmd.com/read/29033885/emotions-and-steroid-secretion-in-aging-men-a-multi-study-report
#2
Andreas Walther, Patricia Waldvogel, Emilou Noser, Jessica Ruppen, Ulrike Ehlert
Although aging increases the risk of cognitive and socioemotional deterioration, it has also been shown to be accompanied by an increase in experienced positive emotions and a decrease in negative emotions. Steroid hormones and age-related alterations in secretion patterns have been suggested to play a crucial role in these age-related changes in emotional experience. Importantly, previous studies identified effects of neuroactive hormones on age-related alterations in emotional experience, which vary by sex and depression levels...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29031183/childhood-hunger-and-depressive-symptoms-in-adulthood-findings-from-a-population-based-study
#3
Andrew Stickley, Mall Leinsalu
BACKGROUND: Several studies have linked childhood hunger to an increased risk for later depression. However, as yet, there has been little research on this relation in adults of all ages or whether there are sex differences in this association. The current study examined these issues using data from a national population-based sample. METHODS: Data were analyzed from 5095 adults aged 25-84 collected during the Estonian Health Interview Survey 2006. Information was obtained on the frequency of going to bed hungry in childhood and on depressive symptoms using the Emotional State Questionnaire (EST-Q)...
September 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29030287/inhibition-of-pain-and-pain-related-brain-activity-by-heterotopic-noxious-counter-stimulation-and-selective-attention-in-chronic-non-specific-low-back-pain
#4
Alexandra Ladouceur, Nabi Rustamov, Jean-Daniel Dubois, Jessica Tessier, Alexandre Lehmann, Martin Descarreaux, Pierre Rainville, Mathieu Piché
The aim of the present study was to assess inhibition of pain and somatosensory-evoked potentials (SEP) by heterotopic noxious counter-stimulation (HNCS) and by selective attention in patients with chronic non-specific LBP. Seventeen patients and age/sex matched controls were recruited (10 men, 7 women; mean age ± SD: 43.3 ± 10.4 and 42.7 ± 11.1, respectively). On average, patients with LBP reported pain duration of 7.6 ± 6.5 years, light to moderate disability (19.3 ± 5.7/100) and low clinical pain intensity (21...
October 10, 2017: Neuroscience
https://www.readbyqxmd.com/read/29030008/assessment-of-leukocyte-activity-in-mice-devoid-of-the-glucocorticoid-receptor-in-the-noradrenergic-system-gr-dbhcre
#5
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Disturbances in brain monoamines, overactivity of the hypothalamo-pituitary adrenal (HPA) axis and pro-inflammatory tendency in the immune system are the key features of depressive disorders. Recently, several murine lines with mutations in glucocorticoid receptors (GRs) have been generated and these animals may be utilized for study depressive-like disorders. In the present study, we have investigated whether selective ablation of GRs in noradrenergic neurons affects functional properties of leukocytes and redirects them towards pro-inflammatory activity...
October 8, 2017: Immunobiology
https://www.readbyqxmd.com/read/29029561/women-with-psvt-are-often-misdiagnosed-referred-later-than-men-and-have-more-symptoms-after-ablation
#6
Carina Carnlöf, Marie Iwarzon, Mats Jensen-Urstad, Fredrik Gadler, Per Insulander
OBJECTIVES: Using a patient and gender perspective, this study evaluates the experiences and perspectives of referral for paroxysmal supraventricular tachycardia (PSVT), and symptoms, Health-Related Quality of Life (HRQOL) and functional impairment before and six months after ablation. DESIGN: This prospective study includes 214 (109 women) patients with PSVT who completed questionnaires before and after ablation addressing referral patterns, duration of arrhythmia, socioeconomic status, symptoms, HRQOL, and functional impairment...
October 13, 2017: Scandinavian Cardiovascular Journal: SCJ
https://www.readbyqxmd.com/read/29028757/patient-experience-based-value-sets-are-they-stable
#7
A Simon Pickard, Yu-Ting Hung, Fang-Ju Lin, Todd A Lee
BACKGROUND: Although societal preference weights are desirable to inform resource-allocation decision-making, patient experienced health state-based value sets can be useful for clinical decision-making, but context may matter. OBJECTIVE: To estimate EQ-5D value sets using visual analog scale (VAS) ratings for patients undergoing knee replacement surgery and compare the estimates before and after surgery. METHODS: We used the Patient Reported Outcome Measures data collected by the UK National Health Service on patients undergoing knee replacement from 2009 to 2012...
November 2017: Medical Care
https://www.readbyqxmd.com/read/29022872/arterial-stiffness-is-associated-with-depression-in-middle-aged-men-the-maastricht-study
#8
Veronica Onete, Ronald M Henry, Simone J S Sep, Annemarie Koster, Carla J van der Kallen, Pieter C Dagnelie, Nicolaas Schaper, Sebastian Köhler, Koen Reesink, Coen D A Stehouwer, Miranda T Schram
BACKGROUND: Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. METHODS: We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study...
October 12, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29021442/the-relationship-between-the-serum-oxytocin-levels-disease-activity-the-adls-and-the-qol-in-patients-with-rheumatoid-arthritis
#9
Yusuke Miwa, Hidekazu Furuya, Ryo Yanai, Tsuyoshi Kasama, Kenji Sanada
Objective To investigate the factors associated with depression, including the serum oxytocin (OXT) levels, disease activity, activities of daily living (ADLs) and quality of life (QOL), and their effects on rheumatoid arthritis (RA). Methods This study included 42-RA-patients. We measured the following variables before and after 6 months of treatment with biological disease-modifying anti rheumatic drugs (bDMARDs): the baseline characteristics (including age, sex, disease duration, smoking, and body mass index), the doses of prednisolone and methotrexate, the serum level of matrix metalloprotease-3, the erythrocyte sedimentation rate and the C-reactive protein level...
October 11, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29020525/social-determinants-of-adherence-to-pulmonary-rehabilitation-for-chronic-obstructive-pulmonary-disease
#10
Gabriela R Oates, Bryant W Hamby, Irena Stepanikova, Sara J Knight, Surya P Bhatt, Jason Hitchcock, Christopher Schumann, Mark T Dransfield
Adherence to pulmonary rehabilitation (PR) is low. Previous studies have focused on clinical predictors of PR completion. We aimed to identify social determinants of adherence to PR. A cross-sectional analysis of a database of COPD patients (N = 455) in an outpatient PR program was performed. Adherence, a ratio of attended-to-prescribed sessions, was coded as low (<35%), moderate (35-85%), and high (>85%). Individual-level measures included age, sex, race, BMI, smoking status, pack-years, baseline 6-minute walk distance (6MWD: <150, 150-249, ≥250), co-morbidities, depression, and prescribed PR sessions (≤20, 21-30, >30)...
October 11, 2017: COPD
https://www.readbyqxmd.com/read/28993631/establishment-of-a-repeated-social-defeat-stress-model-in-female-mice
#11
Aki Takahashi, Jia-Ru Chung, Song Zhang, Hongxing Zhang, Yael Grossman, Hossein Aleyasin, Meghan E Flanigan, Madeline L Pfau, Caroline Menard, Dani Dumitriu, Georgia E Hodes, Bruce S McEwen, Eric J Nestler, Ming-Hu Han, Scott J Russo
Numerous studies have employed repeated social defeat stress (RSDS) to study the neurobiological mechanisms of depression in rodents. An important limitation of RSDS studies to date is that they have been conducted exclusively in male mice due to the difficulty of initiating attack behavior directed toward female mice. Here, we establish a female mouse model of RSDS by inducing male aggression toward females through chemogenetic activation of the ventrolateral subdivision of the ventromedial hypothalamus (VMHvl)...
October 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28992584/ogt-related-mitochondrial-motility-is-associated-with-sex-differences-and-exercise-effects-in-depression-induced-by-prenatal-exposure-to-glucocorticoids
#12
Weina Liu, Hongmei Wang, Xiangli Xue, Jie Xia, Jiatong Liu, Zhengtang Qi, Liu Ji
BACKGROUND: Prenatal exposure to glucocorticoids (GCs) has been found to trigger abnormal behaviors and deleterious neurological effects on offspring both in animals and in humans. The sex differences in depression have been replicated in numerous studies across cultures, persisting throughout the reproductive years. As an X-linked gene in rodents and in humans, O-GlcNAc transferase (OGT) may provide a novel perspective for the sex differences in depression. METHODS: In the last third of pregnancy (gestational day 14-21), rats were subcutaneously administered either 0...
September 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28992527/sex-differences-in-the-mediators-of-functional-disability-in-major-depressive-disorder
#13
Nicole E Carmona, Mehala Subramaniapillai, Rodrigo B Mansur, Danielle S Cha, Yena Lee, Dominika Fus, Roger S McIntyre
The aim of this study was to investigate sex differences in discrete domains of psychopathology as mediators of functional disability among individuals with Major Depressive Disorder (MDD). Adults (ages 18-65) with moderate-to-severe MDD (n = 100) and age-, sex-, and education-matched healthy controls (HC; n = 100) participated in a clinical trial validating the THINC-integrated tool, a newly developed cognitive assessment tool for patients with MDD. Variables assessed as possible mediators included depression symptom severity, anxiety symptoms, sleep disturbance, perceived cognitive deficits, and objective cognitive performance...
September 30, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28990447/psychotic-like-experiences-in-help-seeking-adolescents-dimensional-exploration-and-association-with-different-forms-of-bullying-victimization-a-developmental-social-psychiatry-perspective
#14
Gennaro Catone, Roberta Marotta, Simone Pisano, Belinda Lennox, Marco Carotenuto, Antonella Gritti, Antonio Pascotto, Matthew R Broome
BACKGROUND: Psychotic-like experiences (PLEs) are common in the general population and increase the risk of psychotic disorders. Adolescents are a high-risk group of this condition. Stressful events, such as bullying, have a role in the onset of PLEs. This study has several aims: (1) to assess PLEs in adolescents seeking help from a Child and Adolescent Mental Health Service, (2) to assess the association of PLEs with specific bullying victimization and (3) to assess difference in PLEs and victimizations by sex and age...
October 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28985587/cerebrospinal-fluid-d-serine-concentrations-in-major-depressive-disorder-negatively-correlate-with-depression-severity
#15
Sayuri Ishiwata, Kotaro Hattori, Daimei Sasayama, Toshiya Teraishi, Tomoko Miyakawa, Yuuki Yokota, Ryo Matsumura, Toru Nishikawa, Hiroshi Kunugi
BACKGROUND: D-serine is an endogenous co-agonist of N-methyl-D-aspartate receptor (NMDAR) and plays an important role in glutamate neurotransmission. Several studies suggested the possible involvement of D-serine related in the pathophysiology of psychiatric disorders including major depression disorders (MDD). We tried to examine whether cerebrospinal fluid (CSF) or plasma D-serine concentrations are altered in MDD and whether D-serine concentrations correlated with disease severity...
September 27, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28983772/the-impact-of-comorbid-mental-health-symptoms-and-sex-on-sleep-functioning-in-children-with-adhd
#16
Stephen P Becker, Caroline N Cusick, Craig A Sidol, Jeffery N Epstein, Leanne Tamm
Children with attention-deficit/hyperactivity disorder (ADHD) display more sleep problems than their peers, but it remains unclear whether comorbid mental health symptoms [i.e., anxiety, depression, oppositional-defiant disorder (ODD)] are uniquely related to sleep functioning. It is also largely unknown whether boys and girls with ADHD differ in their sleep functioning. This study (1) examined whether boys or girls with ADHD differ in their sleep functioning, (2) evaluated comorbid symptoms as uniquely related to sleep functioning domains, and (3) explored whether sex moderated associations between comorbid symptoms and sleep...
October 5, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/28983413/correlations-between-ultrasonographic-findings-clinical-scores-and-depression-in-patients-with-knee-osteoarthritis
#17
Samia M Abd El Monaem, Nashwa Ismail Hashaad, Noha Hosni Ibrahim
OBJECTIVE: This study aimed to explore correlations between the presence of depression, clinical scores, and ultrasonographic (US) grading in osteoarthritis (OA) patients and to clarify if depressive symptoms might cause a discrepancy between US findings and clinical scores. MATERIAL AND METHODS: Two hundred patients with primary knee OA and 100 healthy hospital volunteers of the same age and sex not complaining of knee troubles participated in this study. We evaluated depressive symptoms in all participants using the Beck Depression Inventory (BDI) scale...
September 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28981913/olfactory-functioning-in-first-episode-psychosis
#18
Vidyulata Kamath, Patricia Lasutschinkow, Koko Ishizuka, Akira Sawa
BACKGROUND: Though olfactory deficits are well-documented in schizophrenia, fewer studies have examined olfactory performance profiles across the psychosis spectrum. The current study examined odor identification, discrimination, and detection threshold performance in first-episode psychosis (FEP) patients diagnosed with schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depression with psychotic features, and other psychotic conditions. METHOD: FEP patients (n = 97) and healthy adults (n = 98) completed birhinal assessments of odor identification, discrimination, and detection threshold sensitivity for lyral and citralva...
August 31, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28978356/is-the-hospital-anxiety-and-depression-scale-hads-a-valid-measure-in-a-general-population-65-80%C3%A2-years-old-a-psychometric-evaluation-study
#19
Ingrid Djukanovic, Jörg Carlsson, Kristofer Årestedt
BACKGROUND: The HADS (Hospital Anxiety and Depression Scale) aims to measure symptoms of anxiety (HADS Anxiety) and depression (HADS Depression). The HADS is widely used but has shown ambiguous results both regarding the factor structure and sex differences in the prevalence of depressive symptoms. There is also a lack of psychometric evaluations of the HADS in non-clinical samples of older people. The aim of the study was to evaluate the factor structure of the HADS in a general population 65-80 years old and to exam possible presence of differential item functioning (DIF) with respect to sex...
October 4, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28978328/anxiety-and-depression-in-older-patients-the-role-of-culture-and-acculturation
#20
Anna Zisberg
BACKGROUND: Anxiety and depression are major health concerns in general among older adults and especially during hospitalization, as they lead to numerous negative outcomes. There is currently no sufficient body of research examining the role of cultural background in patients' experience of these conditions. Better identifying patients at risk may help reduce inequity and provide patient-centered, culturally sensitive care. The current study explores the roles of culture and acculturation in anxiety and depression levels in recent and veteran Russian immigrants compared with native Israelis and veteran immigrants from Middle Eastern countries...
October 4, 2017: International Journal for Equity in Health
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