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Sex differences depression

Kathrin Jobski, Niklas Schmedt, Bianca Kollhorst, Jutta Krappweis, Tania Schink, Edeltraut Garbe
PURPOSE: The purpose of this study was to investigate characteristics, drug use patterns, and predictors for treatment choice in older German patients initiating antidepressant (AD) treatment. METHODS: Using the German Pharmacoepidemiological Research Database, we identified a cohort of AD initiators aged at least 65 years between 2005 and 2011. Potential indications, co-morbidity, and co-medication as well as treatment patterns such as the duration of the first treatment episode were assessed...
October 18, 2016: European Journal of Clinical Pharmacology
Saeid Komasi, Mozhgan Saeidi
BACKGROUND: To investigate the role of sex and age differences in marital conflict and stress of patients who were under cardiac rehabilitation (CR) program. METHODS: The data of this cross-sectional study were collected from the database of the CR Department of Imam Ali Hospital, Kermanshah, Iran. The demographics and medical data of 683 persons were collected from January 2003 and January 2010 using medical records, the Beck Anxiety Inventory, the Beck Depression Inventory, the Hudson's Index of Marital Stress, and the Structured Clinical Interview for axis I disorders...
May 2016: ARYA Atherosclerosis
N Kappelmann, G Lewis, R Dantzer, P B Jones, G M Khandaker
Inflammatory cytokines are commonly elevated in acute depression and are associated with resistance to monoaminergic treatment. To examine the potential role of cytokines in the pathogenesis and treatment of depression, we carried out a systematic review and meta-analysis of antidepressant activity of anti-cytokine treatment using clinical trials of chronic inflammatory conditions where depressive symptoms were measured as a secondary outcome. Systematic search of the PubMed, EMBASE, PsycINFO and Cochrane databases, search of reference lists and conference abstracts, followed by study selection process yielded 20 clinical trials...
October 18, 2016: Molecular Psychiatry
Eralda Hegendörfer, Bert Vaes, Elena Andreeva, Catharina Matheï, Gijs Van Pottelbergh, Jean-Marie Degryse
OBJECTIVES: Forced expiratory volume in 1 second (FEV1) is proposed as a marker of healthy ageing and FEV1 expressions that are independent of reference values have been reported to be better at predicting mortality in older adults. We assess and compare the predictive value of different FEV1 expressions for mortality, hospitalization, and physical and mental decline in adults aged 80 and older. DESIGN: Population-based, prospective, cohort study. SETTING: The BELFRAIL study, Belgium...
October 14, 2016: Journal of the American Medical Directors Association
Heba A Abdel Sadek, Mervat W Abu-Nazel, Zeinab N Shata, Nesrin K Abd El-Fatah
BACKGROUND: Although the relationship between obesity and depression has been researched extensively, the relation of the wide range of body-weight problems, as indicated by the BMI, to emotional health problems has received little attention. OBJECTIVES: To assess the rate of concomitant co-occurrence of emotional health and weight problems in Alexandria University students, and to investigate the relationship between their BMI and emotional status. PARTICIPANTS AND METHODS: A cross-sectional study was carried out on 842 university students (17-27 years), enrolled in four faculties of Alexandria University, Egypt, during the academic year 2012-2013...
September 2016: Journal of the Egyptian Public Health Association
Lauren B Alloy, Jessica L Hamilton, Elissa J Hamlat, Lyn Y Abramson
Adolescence marks the emergence of sex differences in internalizing symptoms and disorders, with girls at increased risk for depression and anxiety during the pubertal transition. However, the mechanisms through which puberty confers risk for internalizing psychopathology for girls, but not boys, remain unclear. We examined two pubertal indicators (pubertal status and timing) as predictors of the development of emotion regulation styles (rumination and emotional clarity) and depressive and anxiety symptoms and disorders in a three-wave study of 314 adolescents...
September 2016: Clinical Psychological Science
Ram Kandasamy, Jonas J Calsbeek, Michael M Morgan
Opioids are effective at inhibiting responses to noxious stimuli in rodents, but have limited efficacy and many side effects in chronic pain patients. One reason for this disconnect is that nociception is typically assessed using withdrawal from noxious stimuli in animals, whereas chronic pain patients suffer from abnormal pain that disrupts normal activity. We hypothesized that assessment of home cage wheel running in rats would provide a much more clinically relevant method to assess opioid efficacy to restore normal behavior...
October 13, 2016: Behavioural Brain Research
Adam L Beckman, Emily M Bucholz, Weiwei Zhang, Xiao Xu, Rachel P Dreyer, Kelly M Strait, John A Spertus, Harlan M Krumholz, Erica S Spatz
BACKGROUND: Financial barriers to health care are associated with worse outcomes following acute myocardial infarction (AMI). Yet, it is unknown whether the prevalence of financial barriers and their relationship with post-AMI outcomes vary by sex among young adults. METHODS AND RESULTS: We assessed sex differences in patient-reported financial barriers among adults aged <55 years with AMI using data from the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients study...
October 14, 2016: Journal of the American Heart Association
Siyang Yan, Amanda C Kentner
Exposure to painful procedures and/or stressors during the early neonatal period can reprogram the underlying neurocircuitry involved in nociception and neuropathic pain perception. The reprogramming of these systems can result in an enduring elevation in sensitivity towards mechanical and thermal stimuli. Recent evidence suggests that exposure to mild inflammatory mediators during the neonatal period can induce similar pain responses in both adolescent and adult rats. Therefore, we sought to profile changes in the expression of several genes across brain areas involved in the active modulation of nociception and neuropathic pain using a well-recognized model of neonatal inflammation...
October 11, 2016: Brain, Behavior, and Immunity
Kelly E Gill, Stephanie A Cardenas, Layla Kassem, Thomas G Schulze, Francis J McMahon
BACKGROUND: Anabaptists comprise large and growing Amish and Mennonite populations with a unique genetic heritage and cultural background. Little is known about the symptoms and course of major mood disorders in Anabaptists. Even less is known about the impact of potential moderators on symptom severity and course. METHODS: A sample of Amish and Mennonite participants with bipolar, recurrent unipolar, or schizoaffective bipolar disorder (n = 155) were systematically evaluated with a well-validated instrument...
December 2016: International Journal of Bipolar Disorders
(no author information available yet)
BACKGROUND: Healthy life expectancy (HALE) and disability-adjusted life-years (DALYs) provide summary measures of health across geographies and time that can inform assessments of epidemiological patterns and health system performance, help to prioritise investments in research and development, and monitor progress toward the Sustainable Development Goals (SDGs). We aimed to provide updated HALE and DALYs for geographies worldwide and evaluate how disease burden changes with development...
October 8, 2016: Lancet
Brielle M Spataro, Sarah A Tilstra, Doris M Rubio, Melissa A McNeil
BACKGROUND: Burnout is a significant problem facing internal medicine residents contributing to increased risk of depression and suicidal ideation. Coping mechanisms and burnout may differ based on sex. METHODS: The study was a retrospective cross-sectional study of reported burnout and coping mechanisms used by internal medicine residents in June 2014 at a large academic center and its community affiliate. Two hundred eighty-five postgraduate year (PGY)-1, 2, 3, and 4 and incoming PGY-1 residents were surveyed...
October 12, 2016: Journal of Women's Health
Richard B Lipton, Sagar Munjal, Dawn C Buse, Kristina M Fanning, Alix Bennett, Michael L Reed
BACKGROUND: Pain freedom at 2 hours and sustained pain response at 24 hours are important outcomes of acute migraine therapy. Some studies have examined rates and predictors of successful treatment outcomes for single attacks in clinical trials. However, little is known about predictors of typical response to acute treatment over multiple attacks in the population. OBJECTIVES: To identify sociodemographic features, headache characteristics, comorbidities and treatment-related factors that predict acute treatment success or failure at 2 hours and 24 hours post dose in a US population sample of persons with episodic migraine...
October 12, 2016: Headache
Kimberly Rose P Singian, Morgan Price, Vicky Bungay, Sabrina T Wong
BACKGROUND: Parkinson disease is a complex neurodegenerative disorder, and a comorbidity of depression is common. We aimed to describe demographic and health characteristics of patients with Parkinson disease and examine sex differences in antidepressant prescriptions for those with comorbid depression using electronic medical records. METHODS: We analyzed Canadian Primary Care Sentinel Surveillance Network data for patients 18 years and older with a diagnosis of Parkinson disease who had at least 1 primary care encounter between Sep...
July 2016: CMAJ Open
Ilaria Galizia, Lucio Oldani, Karine Macritchie, Erica Amari, Dominic Dougall, Tessa N Jones, Raymond W Lam, Guido Jacopo Massei, Lakshmi N Yatham, Allan H Young
BACKGROUND: Depression is a recurrent illness with high rates of chronicity, treatment-resistance and significant economic impact. There is evidence in the literature that S-adenosyl methionine (SAMe), a naturally occurring compound in the human body, has antidepressant efficacy. This product may be an important addition to the armamentarium of antidepressant agents. OBJECTIVES: To assess the effects of SAMe in comparison with placebo or antidepressants for the treatment of depression in adults...
October 10, 2016: Cochrane Database of Systematic Reviews
Peng Liu, Bo Xing, Zheng Chu, Fei Liu, Gang Lei, Li Zhu, Ya Gao, Teng Chen, Yong-Hui Dang
Pain is a complex and subjective experience. Previous studies have shown that mice lacking the dopamine D3 receptor (D3RKO) exhibit hypoalgesia, indicating a role of the D3 receptor in modulation of nociception. Given that there are sex differences in pain perception, there may be differences in responses to nociceptive stimuli between male and female D3RKO mice. In the current study, we examined the role of the D3 receptor in modulating nociception in male and female D3RKO mice. Acute thermal pain was modeled by hot-plate test...
September 26, 2016: Journal of Neuroscience Research
Thaíse Campos Mondin, Taiane de Azevedo Cardoso, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
BACKGROUND: It is known that sleep disturbance has been considered a trait-marker of mood disorders. However, the role of disruptions in biological rhythms, such as eating, activity, and social patterns, needs to be better understood. AIM: To assess the differences in biological rhythms in subjects with bipolar disorder, major depressive disorder, and healthy controls. We also tested the association between disruptions of biological rhythms and circadian preferences...
September 30, 2016: Journal of Psychiatric Research
Jaime Barrientos, Fabiola Gómez, Manuel Cárdenas
This paper examines the levels of subjective well-being (psychological and social well-being, subjective happiness, and satisfaction with life) and clinical symptomatology (anxiety, depression, somatization, hostility, and phobic anxiety) in a transwomen sample (n = 112). The sample was recruited through a snowball procedure in Chile (Santiago, Valparaíso, and Arica). Data obtained are compared to those from a group of Men who have Sex with Men (MSM) (n = 323). Results reveal statistically significant differences in the levels of happiness (t(157) = 2...
August 12, 2016: Journal of Homosexuality
Renata Villoro, María Merino, Alvaro Hidalgo-Vega
PURPOSE: This study estimates the health-related quality of life and the health care resource utilization of patients diagnosed with chronic depression (CD) in Spain. PATIENTS AND METHODS: We used the Spanish National Health Survey 2011-2012, a cross-sectional survey representative at the national level, that selects people aged between 18 and 64 years (n=14,691). We estimated utility indices through the EuroQol five-dimensional descriptive system questionnaire included in the survey...
2016: Patient related Outcome Measures
Sarah J Peterson, Elizabeth A McAninch, Antonio C Bianco
CONTEXT: Levothyroxine (LT4) monotherapy is the standard of care for hypothyroidism. OBJECTIVE: To determine whether LT4 at doses that normalize the serum TSH is associated with normal markers of thyroid status. DESIGN: Cross-sectional data from the US National Health and Nutrition Examination Survey (2001-2012) was used to evaluate 52 clinical parameters. LT4-users were compared to healthy controls and controls matched for age, sex, race, and serum TSH...
October 4, 2016: Journal of Clinical Endocrinology and Metabolism
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