Jérôme Granel, Helder Fernandes, Brigitte Bader-Meunier, Amandine Guth, Olivier Richer, Pascal Pillet, Guy Leverger, Stéphane Ducassou, Mony Fahd, Marlène Pasquet, Nathalie Garnier, Vincent Barlogis, Corinne Guitton, Eric Jeziorski, Caroline Thomas, Sophie Bayart, Nathalie Cheikh, Catherine Paillard, Wadih Abou Chahla, Pascal Chastagner, Bénédicte Neven, Frédéric Millot, Julien Lejeune, Valérie Li-Thiao Te, Corinne Armari-Alla, Claire Briandet, Liana Carausu, Marianna Deparis, Christophe Piguet, Joy Benadiba, Aude Marie-Cardine, Jean-Louis Stephan, Isabelle Pellier, Claire Pluchart, Eric Doré, Katell Michaux, Sébastien Héritier, Thierry Leblanc, Nathalie Aladjidi
Autoimmune cytopenia (AIC) in children may be associated with positive antinuclear antibodies (ANA) and may progress to systemic lupus erythematosus (SLE). We evaluated the risk of progression to SLE of childhood-onset ANA-associated AIC. In the French national prospective OBS'CEREVANCE cohort, the long-term outcome of children with ANA-associated AIC (ANA titer ≥1/160) and a subgroup of children who developed SLE were described. ANA were positive in 355 of 1803 (20%) children with AIC. With a median follow-up of 5...
April 18, 2024: Blood