keyword
MENU ▼
Read by QxMD icon Read
search

Sex differences, depression

keyword
https://www.readbyqxmd.com/read/27922568/sex-differences-in-the-relationship-between-depressive-symptoms-and-actigraphic-assessments-of-sleep-and-rest-activity-rhythms-in-a-population-based-sample
#1
Kaitlin Hanley White, Meredith E Rumble, Ruth M Benca
OBJECTIVE: Depression is often associated with disruptions in sleep and circadian rhythms. We aimed to confirm these relationships via actigraphic assessment in a large, population-based sample, and test whether sex moderates these relationships. METHODS: 418 participants (age 35-85, mean 57.04, SD = 11.47) completed questionnaires and one week of actigraphy, used to calculate sleep and rest-activity statistics including mesor (mean activity level), amplitude (height of rhythm), and acrophase (time of day that rhythm peaks)...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27920723/sex-dependent-anti-stress-effect-of-an-%C3%AE-5-subunit-containing-gabaa-receptor-positive-allosteric-modulator
#2
Sean C Piantadosi, Beverly J French, Michael M Poe, Tamara Timić, Bojan D Marković, Mohan Pabba, Marianne L Seney, Hyunjung Oh, Beverley A Orser, Miroslav M Savić, James M Cook, Etienne Sibille
Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has implicated the GABAergic system in the pathophysiology of depression, including deficits in interneurons targeting the dendritic compartment of cortical pyramidal cells. Objectives: The present study evaluates whether SH-053-2'F-R-CH3 (denoted "α5-PAM"), a positive allosteric modulator selective for α5-subunit containing GABAA receptors found predominantly on cortical pyramidal cell dendrites, has anti-stress effects...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27918926/childhood-adversity-impacts-on-brain-subcortical-structures-relevant-to-depression
#3
Thomas Frodl, Deborah Janowitz, Lianne Schmaal, Leonardo Tozzi, Henrik Dobrowolny, Dan J Stein, Dick J Veltman, Katharina Wittfeld, Theo G M van Erp, Neda Jahanshad, Andrea Block, Katrin Hegenscheid, Henry Völzke, Jim Lagopoulos, Sean N Hatton, Ian B Hickie, Eva Maria Frey, Angela Carballedo, Samantha J Brooks, Daniella Vuletic, Anne Uhlmann, Ilya M Veer, Henrik Walter, Knut Schnell, Dominik Grotegerd, Volker Arolt, Harald Kugel, Elisabeth Schramm, Carsten Konrad, Bartosz Zurowski, Bernhard T Baune, Nic J A van der Wee, Marie-Jose van Tol, Brenda W J H Penninx, Paul M Thompson, Derrek P Hibar, Udo Dannlowski, Hans J Grabe
Childhood adversity plays an important role for development of major depressive disorder (MDD). There are differences in subcortical brain structures between patients with MDD and healthy controls, but the specific impact of childhood adversity on such structures in MDD remains unclear. Thus, aim of the present study was to investigate whether childhood adversity is associated with subcortical volumes and how it interacts with a diagnosis of MDD and sex. Within the ENIGMA-MDD network, nine university partner sites, which assessed childhood adversity and magnetic resonance imaging in patients with MDD and controls, took part in the current joint mega-analysis...
November 19, 2016: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/27917785/dipyrone-ameliorates-behavioural-changes-induced-by-unpredictable-chronic-mild-stress-gender-differences
#4
Olcay E Kiroğlu, Kübra E Demirkol, Fatih Berktaş, Arash A Yegani, Ayşegül Kirpik, Erkan Maytalman, Mahmut Ünverdi, Fazilet Aksu
PURPOSE: Antidepressant effects of analgesics have been investigate in both clinical and experimental studies. The purpose of this study was to investigate if the analgesic-antipyretic drug, dipyrone, also had antidepressant-like effects. METHODS: Depression-like effects were investigated in an unpredictable chronic mild stress (UCMS) model in both male and female mice. Cage changes, light-dark cycle reversal, cage tilting, wet floor, empty cage, foreign material on the floor and predator sounds were used to induce light stress at different times for six weeks...
December 1, 2016: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/27916659/stronger-hypothalamus-pituitary-adrenal-axis-habituation-predicts-lesser-sensitization-of-inflammatory-response-to-repeated-acute-stress-exposures-in-healthy-young-adults
#5
Myriam V Thoma, Danielle Gianferante, Luke Hanlin, Alexander Fiksdal, Chen Xuejie, Nicolas Rohleder
Effective adjustment of the stress systems to repeated stress is regarded as an adaptive response of the organism facing environmental threats. Given the intertwined relationship between the stress systems and the inflammatory system, it could be expected that inflammatory processes should adapt to repeated stress as well. However, only little is known about adaptational processes of the different components of the immune system in response to repeated stress, and how these might be related to adaptational processes of the hypothalamus-pituitary-adrenal (HPA) axis...
December 1, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27914903/cognitive-behavioural-therapy-and-short-term-psychoanalytical-psychotherapy-versus-a-brief-psychosocial-intervention-in-adolescents-with-unipolar-major-depressive-disorder-impact-a-multicentre-pragmatic-observer-blind-randomised-controlled-superiority-trial
#6
Ian M Goodyer, Shirley Reynolds, Barbara Barrett, Sarah Byford, Bernadka Dubicka, Jonathan Hill, Fiona Holland, Raphael Kelvin, Nick Midgley, Chris Roberts, Rob Senior, Mary Target, Barry Widmer, Paul Wilkinson, Peter Fonagy
BACKGROUND: Psychological treatments for adolescents with unipolar major depressive disorder are associated with diagnostic remission within 28 weeks in 65-70% of patients. We aimed to assess the medium-term effects and costs of psychological therapies on maintenance of reduced depression symptoms 12 months after treatment. METHODS: We did this multicentre, pragmatic, observer-blind, randomised controlled superiority trial (IMPACT) at 15 National Health Service child and adolescent mental health service (CAMHS) clinics in three regions in England...
November 30, 2016: Lancet Psychiatry
https://www.readbyqxmd.com/read/27913877/oxidative-stress-in-drug-na%C3%A3-ve-first-episode-patients-with-schizophrenia-and-major-depression-effects-of-disease-acuity-and-potential-confounders
#7
Wolfgang Jordan, Henrik Dobrowolny, Sabine Bahn, Hans-Gert Bernstein, Tanja Brigadski, Thomas Frodl, Berend Isermann, Volkmar Lessmann, Jürgen Pilz, Andrea Rodenbeck, Kolja Schiltz, Edzard Schwedhelm, Hayrettin Tumani, Jens Wiltfang, Paul C Guest, Johann Steiner
Oxidative stress and immune dysregulation have been linked to schizophrenia and depression. However, it is unknown whether these factors are related to the pathophysiology or whether they are an epiphenomenon. Inconsistent oxidative stress-related findings in previous studies may have resulted from the use of different biomarkers which show disparate aspects of oxidative stress. Additionally, disease severity, medication, smoking, endocrine stress axis activation and obesity are potential confounders. In order to address some of these shortcomings, we have analyzed a broader set of oxidative stress biomarkers in our exploratory study, including urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), 8-OH-2-deoyxguanosine (8-OH-2-dG), and blood levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione S-transferase (GST) in acutely ill drug-naïve first episode patients with schizophrenia (n = 22), major depression (n = 18), and controls (n = 43)...
December 2, 2016: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27912908/childhood-sexual-abuse-and-substance-abuse-a-gender-paradox
#8
Lil Tonmyr, Margot Shields
We examine associations between childhood sexual abuse (CSA) and substance abuse, the role of mental health indicators as mediators in these associations and whether or not associations differ by gender. Data are from 14,063 respondents aged 18-76 years from the 2004-2005 Canadian Gender, Alcohol, and Culture: An International Study (GENACIS). Multiple logistic regression models were used to examine associations between CSA and substance abuse variables, controlling for socio-demographic factors. Odds were adjusted by indicators of mental health to assess if these variables mediated associations between CSA and substance abuse...
November 29, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27909451/gender-differences-in-somatic-symptoms-and-current-suicidal-risk-in-outpatients-with-major-depressive-disorder
#9
Hong Jin Jeon, Jong-Min Woo, Hyo-Jin Kim, Maurizio Fava, David Mischoulon, Seong Jin Cho, Sung Man Chang, Doo-Heum Park, Jong Woo Kim, Ikki Yoo, Jung-Yoon Heo, Jin Pyo Hong
OBJECTIVE: Although somatic symptoms are common complaints of patients with major depressive disorder (MDD), their associations with suicide are still unclear. METHODS: A total of 811 MDD outpatients of aged between 18 to 64 years were enrolled nationwide in Korea with the suicidality module of the Mini-International Neuropsychiatric Interview (MINI) and the Depression and Somatic Symptom Scale (DSSS). RESULTS: On stepwise regression analysis, current suicidality scores were most strongly associated with chest pain in men, and neck or shoulder pain in women...
November 2016: Psychiatry Investigation
https://www.readbyqxmd.com/read/27901518/life-events-substance-use-psychological-distress-and-quality-of-life-in-male-and-female-french-gamblers
#10
Ce Line Bonnaire, Vivianne Kovess, Romain Guignard, Jean-Baptiste Richard, Enguerrand Du-Roscoat, Franc Ois Beck
BACKGROUND: Most studies on substance use, psychological distress, quality of life (QoL), and life events among gamblers are carried out on pathological gamblers seeking treatment, and sex differences are rarely investigated. The aim of this study was to explore the potential male-female differences in the relationship between these variables in a nationally representative French sample. METHODS: Three hundred thirty-two problem gamblers (PGs) and 25,314 non-problem gamblers or non-gamblers (NPGs) were evaluated for sociodemographic variables, gambling behavior, substance use, QoL, and life events...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27900526/the-prospective-associations-between-self-efficacy-and-depressive-symptoms-from-early-to-middle-adolescence-a-cross-lagged-model
#11
Yuli R Tak, Steven M Brunwasser, Anna Lichtwarck-Aschoff, Rutger C M E Engels
Over the course of adolescence, an increasing number of adolescents experience depression. In order to effectively target depression, identifying risk factors for depressive symptoms is pivotal. Since low levels of self-efficacy were associated with higher levels of depressive symptoms in previous studies, the current study investigated the bidirectional and prospective associations between depressive symptoms and academic, social and emotional self-efficacy from early to mid adolescence in a cross-lagged path model...
November 29, 2016: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/27900437/bdnf-and-ltp-ltd-like-plasticity-of-the-primary-motor-cortex-in-gilles-de-la-tourette-syndrome
#12
L Marsili, A Suppa, F Di Stasio, D Belvisi, N Upadhyay, I Berardelli, M Pasquini, S Petrucci, M Ginevrino, G Fabbrini, F Cardona, G Defazio, A Berardelli
Gilles de la Tourette syndrome (GTS) is characterized by motor and vocal tics and often associated with obsessive-compulsive disorder (OCD). Responses to intermittent/continuous theta-burst stimulation (iTBS/cTBS), which probe long-term potentiation (LTP)-/depression (LTD)-like plasticity in the primary motor cortex (M1), are reduced in GTS. ITBS-/cTBS-induced M1 plasticity can be affected by brain-derived neurotrophic factor (BDNF) polymorphism. We investigated whether the BDNF polymorphism influences iTBS-/cTBS-induced LTP-/LTD-like M1 plasticity in 50 GTS patients and in 50 age- and sex-matched healthy subjects...
November 30, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27898709/individual-differences-in-emotion-regulation-childhood-trauma-and-proneness-to-shame-and-guilt-in-adolescence
#13
Aurora Szentágotai-Tătar, Andrei C Miu
Dispositional shame and guilt have been associated with psychopathology and an increasing number of studies have traced this relation back to adolescence. This developmental period is thought to be characterized by maturational changes in emotion regulation, which also play an important role in vulnerability to psychopathology, but little is known about the links between emotion regulation and dispositional shame and guilt. The current study investigated the relations between individual differences in the habitual use of a wide range of emotion regulation strategies and proneness to shame and guilt in a large sample of adolescents (N = 706), aged 13 to 17 years...
2016: PloS One
https://www.readbyqxmd.com/read/27896803/the-effect-of-craniokinesis-on-the-middle-ear-of-domestic-chickens-gallus-gallus-domesticus
#14
Raf Claes, Pieter G G Muyshondt, Luc Van Hoorebeke, Jelle Dhaene, Joris J J Dirckx, Peter Aerts
The avian middle ear differs from that of mammalians and contains a tympanic membrane, one ossicle (bony columella and cartilaginous extra-columella), some ligaments and one muscle. The rim of the eardrum (closing the middle ear cavity) is connected to the neurocranium and, by means of a broad ligament, to the otic process of the quadrate. Due to the limited number of components in the avian middle ear, the possibilities of attenuating the conduction of sound seem to be limited to activity of the stapedius muscle...
November 29, 2016: Journal of Anatomy
https://www.readbyqxmd.com/read/27894930/sex-dependent-influence-of-chronic-mild-stress-cms-on-voluntary-alcohol-consumption-study-of-neurobiological-consequences
#15
Eva M Marco, Javier Antonio Ballesta, Carlos Irala, María-Donina Hernández, María Elisa Serrano, Virginia Mela, Meritxell López-Gallardo, María-Paz Viveros
Alcohol use disorder and depression are highly comorbid, and both conditions exhibit important sexual dimorphisms. Here, we aimed to investigate voluntary alcohol consumption after 6weeks of chronic mild stress (CMS) in Wistar rats - employed as an animal model of depression. Male and female rats were investigated, and changes in several molecular markers were analysed in frontal cortex (FCx) and hippocampal formation (HF). CMS induced depressive-like responses in the forced swimming test - increased immobility time - in male and female animals, without affecting anhedonia (sucrose preference test) nor motor activity (holeboard); body weight gain and food intake were diminished only among CMS males...
November 25, 2016: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/27894461/does-mindfulness-based-cognitive-therapy-benefit-all-people-with-diabetes-and-comorbid-emotional-complaints-equally-moderators-in-the-diamind-trial
#16
Ivan Nyklíček, Jenny van Son, Victor J Pop, Johan Denollet, François Pouwer
OBJECTIVES: Research has shown the effectiveness of mindfulness-based interventions for a variety of emotional problems in different samples, but it is unknown which factors influence this effectiveness. Therefore, the aim of the current study was: which factors (demographic, personality, and baseline levels of mindfulness skills) moderate the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT)? METHODS: Outpatients with diabetes (type 1 or type 2; N=139) and an elevated level of emotional distress participated in the Diabetes and Mindfulness (DiaMind) trial...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27891676/sex-dependent-independent-prediction-of-incident-diabetes-by-depressive-symptoms
#17
Tuğba Akbaş-Şimşek, Altan Onat, Adnan Kaya, Eyyup Tusun, Hüsniye Yüksel, Günay Can
OBJECTIVE: To study the predictive value of depressive symptoms (DeprSs) in a general population of Turkey for type 2 diabetes. METHODS: Responses to three questions served to assess the sense of depression. Cox regression analyses were used regarding risk estimates for incident diabetes, after exclusion of prevalent cases of diabetes. Mean follow-up consisted of 5.15 (±1.4) years. RESULTS: Depressive symptoms were present at baseline in 16...
November 28, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27887649/postpartum-depression-in-the-occupied-palestinian-territory-a-longitudinal-study-in-bethlehem
#18
Sara Qandil, Samah Jabr, Stefan Wagler, Simon M Collin
BACKGROUND: Postpartum depression (PPD) affects women from different cultures around the world. No previous studies have investigated PPD among women in Palestine. Fertility rates in Palestine are among the highest in the world, hence even low rates of PPD could have considerable national impact. The aim of this study was to determine the prevalence of, and risk factors for, PPD among Palestinian mothers. METHODS: 101 mothers were recruited during the registration of their child's birth (within 1 week) at the Bethlehem branch of the Ministry of Interior...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27882830/adherence-to-disease-modifying-therapies-for-multiple-sclerosis
#19
Lucas Higuera, Caroline S Carlin, Sarah Anderson
BACKGROUND: Multiple sclerosis (MS) is a neurological degenerative chronic condition without cure. However, long-term disease-modifying therapies (DMTs) help reduce the severity of MS symptoms. Adherence to DMTs is key to their success. Several studies have analyzed what makes patients adherent to their DMTs. As new DMTs have entered the market, few studies have analyzed factors of adherence using all currently available DMTs. OBJECTIVE: To analyze different factors of adherence to DMTs for MS, in particular how the type of DMT affects adherence...
December 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27878639/association-between-depression-and-condom-use-differs-by-sexual-behavior-group-in-patients-with-hiv
#20
Cristina Brickman, Kathleen J Propert, Chelsea Voytek, David Metzger, Robert Gross
Identifying a relationship between depression and sexual risk behavior in HIV-infected patients could establish a mechanism to enhance prevention efforts. We conducted a cross-sectional analysis using data from the University of Pennsylvania Center for AIDS Research and used ordinal logistic regression to measure the association between depression and non-condom use. 716 men who have sex with men (MSM), 262 heterosexual men and 277 heterosexual women were included. The association between depression and non-condom use was strongest in heterosexual men with and without HIV-infected regular partners (OR 8...
November 23, 2016: AIDS and Behavior
keyword
keyword
72019
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"