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cytokines removal by cvvhdf

Jung Tak Park, Hajeong Lee, Youn Kyung Kee, Seokwoo Park, Hyung Jung Oh, Seung Hyeok Han, Kwon Wook Joo, Chun-Soo Lim, Yon Su Kim, Shin-Wook Kang, Tae-Hyun Yoo, Dong Ki Kim
BACKGROUND: Soluble inflammatory mediators are known to exacerbate sepsis-induced acute kidney injury (AKI). Continuous renal replacement therapy (CRRT) has been suggested to play a part in immunomodulation by cytokine removal. However, the effect of continuous venovenous hemodiafiltration (CVVHDF) dose on inflammatory cytokine removal and its influence on patient outcomes are not yet clear. STUDY DESIGN: Prospective, randomized, controlled, open-label trial. SETTING & PARTICIPANTS: Septic patients with AKI receiving CVVHDF for AKI...
October 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Beata Marie R Quinto, Ilson J Iizuka, Julio C M Monte, Bento F Santos, Virgílio Pereira, Marcelino S Durão, Maria A Dalboni, Miguel Cendoroglo, Oscar F P Santos, Marcelo C Batista
INTRODUCTION: Critically ill patients with acute kidney injury (AKI) present high mortality rates. The magnitude of inflammatory response could determine the prognosis of such patients. Continuous renal replacement therapy (CRRT) may play an important role in removing inflammatory mediators in patients with AKI. AIM: To investigate whether the magnitude of inflammatory mediator's removal is associated with mortality among critically ill patients on CVVHDF, a CRRT modality...
February 2015: Cytokine
P Toft, M Felding, E K Tønnesen
The development of computerized machines with a simple user-friendly interface to perform continuous venovenous hemodiafiltration (CVVHDF) has resulted in a break-through of CVVHDF in the treatment of acute renal failure (ARF) in Danish intensive care units. During CVVHDF the blood is submitted to a combination of dialysis and ultrafiltration. In contrast to intermittent haemodialysis (HD), CVVHDF can be used in critically ill patients with unstable circulation. Biocompatible membranes are used. During treatment with CVVHDF, cytokines are removed from the blood partly by ultrafiltration, partly by adsorption to the filter...
May 15, 2000: Ugeskrift for Laeger
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