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https://www.readbyqxmd.com/read/29862466/piperacillin-population-pharmacokinetics-and-dosing-regimen-optimization-in-critically-ill-children-with-normal-and-augmented-renal-clearance
#1
Agathe Béranger, Sihem Benaboud, Saïk Urien, Florence Moulin, Emmanuelle Bille, Fabrice Lesage, Yi Zheng, Mathieu Genuini, Inès Gana, Sylvain Renolleau, Déborah Hirt, Jean-Marc Tréluyer, Mehdi Oualha
BACKGROUND: Critically ill children frequently display observed alterations of pharmacokinetic (PK) parameters, leading to a reduction in β-lactam concentrations. This study aimed to develop a PK population model for piperacillin in order to optimize individual dosing regimens. METHODS: All children aged ≤ 18 years, weighing more than 2.5 kg, and receiving piperacillin infusions were included in this study. Piperacillin was quantified by high-performance liquid chromatography, and PK were described using the non-linear mixed-effect modeling software MONOLIX...
June 4, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29746311/evaluating-mortality-risk-adjustment-among-children-receiving-extracorporeal-support-for-respiratory-failure
#2
Ryan P Barbaro, Philip S Boonstra, Kevin W Kuo, David T Selewski, David K Bailly, Cheryl L Stone, Chin Ying Chow, Gail M Annich, Frank W Moler, Matthew L Paden
This study evaluates whether three commonly used pediatric intensive care unit (PICU) severity of illness scores, pediatric risk of mortality score (PRISM) III, pediatric index of mortality (PIM) 2, and pediatric logistic organ dysfunction (PELOD), are the appropriate tools to discriminate mortality risk in children receiving extracorporeal membrane oxygenation (ECMO) support for respiratory failure. This study also evaluates the ability of the Pediatric Risk Estimate Score for Children Using Extracorporeal Respiratory Support (Ped-RESCUERS) to discriminate mortality risk in the same population, and whether Ped-RESCUERS' discrimination of mortality is improved by additional clinical and laboratory measures of renal, hepatic, neurologic, and hematologic dysfunction...
May 8, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/29566462/safety-profile-of-blind-bronchial-sampling-a-prospective-study-in-pediatric-intensive-care-unit
#3
Neeraj Gupta, Anil Sachdev, Dhiren Gupta, Suresh Gupta
OBJECTIVE: To study the safety profile of blind bronchial sampling in mechanically ventilated children. DESIGN: Prospective interventional study. SETTING: Tertiary level pediatric intensive care unit of a multispecialty hospital. PATIENTS: Children aged 1 month to 16 years on mechanical ventilator for ≥48 h, were assessed by clinical pulmonary infection score for ventilator-associated pneumonia (VAP). INTERVENTIONS: Blind bronchial sampling was performed following standard procedural guidelines...
March 22, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29178963/chloral-hydrate-enteral-infusion-for-sedation-in-ventilated-children-the-chosen-pilot-study
#4
Ari R Joffe, Jessica Hogan, Cathy Sheppard, Gerda Tawfik, Jonathan P Duff, Gonzalo Garcia Guerra
BACKGROUND: We aimed to test a novel method of delivery of chloral hydrate (CH) sedation in ventilated critically ill young children. METHODS: Children < 12 years old, within 72 hours of admission, who were ventilated, receiving enteral tube-feeds, with intermittent CH ordered were enrolled after signed consent. Patients received a CH loading-dose of 10 mg/kg enterally, then a syringe-pump enteral infusion at 5 mg/kg/hour, increasing to a maximum of 9 mg/kg/hour...
November 26, 2017: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29167083/the-effect-of-diagnostic-blood-loss-on-anemia-and-transfusion-among-postoperative-patients-with-congenital-heart-disease-in-a-pediatric-intensive-care-unit
#5
Dan Zhou, Yu-Lan Luo, Shu-Hua Luo, Mei Feng, Meng-Lin Tang
PURPOSE: To evaluate whether diagnostic blood loss can lead to anemia and consequent blood transfusion among postoperative patients with congenital heart disease (CHD) in the pediatric intensive care unit (PICU). DESIGN AND METHODS: This prospective observational study was conducted in a university-affiliated tertiary hospital between January and August 2016. CHD patients aged <12years, undergoing cardiac surgery, with a PICU stay >48h were included (n=205)...
January 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/28771554/increased-serum-thrombomodulin-level-is-associated-with-disease-severity-and-mortality-in-pediatric-sepsis
#6
Jainn-Jim Lin, Hsiang-Ju Hsiao, Oi-Wa Chan, Yu Wang, Shao-Hsuan Hsia, Cheng-Hsun Chiu
BACKGROUND: Endothelial dysfunction plays an important role in the pathophysiology of sepsis. As previously reported, the serum thrombomodulin is elevated in diseases associated with endothelial injury. OBJECTIVE: The aim of this study was to investigate the association of serum thrombomodulin level in different pediatric sepsis syndromes and evaluate the relationship with disease severity and mortality. METHODS: We prospectively collected cases of sepsis treated in a pediatric intensive care unit from June 2012 to July 2015 at Chang Gung Children's Hospital in Taoyuan, Taiwan...
2017: PloS One
https://www.readbyqxmd.com/read/28492972/performance-of-the-pediatric-logistic-organ-dysfunction-pelod-and-pelod-2-scores-in-a-pediatric-intensive-care-unit-of-a-developing-country
#7
COMPARATIVE STUDY
Ahmed El-Nawawy, Aly Abdel Mohsen, Manal Abdel-Malik, Sarah Omar Taman
The study aimed to compare two scores: the pediatric logistic organ dysfunction (PELOD) with its updated version (PELOD-2) in describing the severity of organ dysfunction in pediatric intensive care unit (PICU) and assess the performance of PELOD-2 in the Egyptian population. A prospective cohort study of 200 patients consecutively admitted to PICU between July 2015 and A 2016 was included. The median age was 6 months, and the male to female ratio was 1.04. The median length of PICU stay was 4 days. The overall predicted number of deaths using PELOD was 76 patients whereas, by PELOD-2, it was 50 patients...
July 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/27735800/the-relation-between-mean-platelet-volume-and-mortality-in-critical-pediatric-patients
#8
Seher Erdoğan, Arzu Oto, Mehmet Boşnak
Mean platelet volume (MPV) is a simple and economical test that is easy to interpret and is routinely measured with automatic cell counters. It indicates platelet volume and platelet function and activation. Variations in platelet volume may occur more as a result of varying differentiation of megakaryocytes in association with production agents in bone marrow rather than of ageing of platelets in circulation. The purpose of this study was to evaluate the relation between mortality and changes in MPV values in patients hospitalized in the pediatric intensive care unit...
November 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27714707/performance-of-the-pediatric-logistic-organ-dysfunction-2-score-in-critically-ill-children-requiring-plasma-transfusions
#9
Oliver Karam, Pierre Demaret, Alain Duhamel, Alison Shefler, Philip C Spinella, Simon J Stanworth, Marisa Tucci, Stéphane Leteurtre
BACKGROUND: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27381433/-vitamin-d-deficiency-in-children-admitted-to-the-paediatric-intensive-care-unit
#10
Raúl Bustos B, Iván Rodríguez-Nuñez, Rubén Peña Zavala, Gonzalo Soto Germani
INTRODUCTION: Vitamin D is essential for bone health, as well as for cardiovascular and immune function. In critically ill adults vitamin D deficiency (VDD) is common, and is associated with sepsis and higher critical illness severity. OBJECTIVES: To establish the prevalence of VDD and its association with clinically relevant outcomes in children admitted to a Paediatric Intensive Care Unit (PICU) in Concepcion, Chile. PATIENTS AND METHOD: Prospective observational cohort study in 90 consecutive children admitted to the PICU in a university general hospital...
November 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27272692/predictors-of-early-extubation-after-pediatric-cardiac-surgery-a-single-center-prospective-observational-study
#11
Çağlar Ödek, Tanıl Kendirli, Tayfun Uçar, Ayhan Yaman, Ercan Tutar, Zeynep Eyileten, Mehmet Taşar, Mehmet Ramoğlu, Can Ateş, Adnan Uysalel, Erdal İnce, Semra Atalay
This prospective, observational, single-center study aimed to determine the perioperative predictors of early extubation (<24 h after cardiac surgery) in a cohort of children undergoing cardiac surgery. Children aged between 1 month and 18 years who were consecutively admitted to pediatric intensive care unit after cardiac surgery for congenital heart disease between January 2012 and June 2014. Ninety-nine patients were qualified for inclusion during the study period. The median duration of mechanical ventilation was 20 h (range 1-480), and 64 patients were extubated within 24 h...
October 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27089280/evaluation-of-new-diagnostic-biomarkers-in-pediatric-sepsis-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-mid-regional-pro-atrial-natriuretic-peptide-and-adipocyte-fatty-acid-binding-protein
#12
COMPARATIVE STUDY
Mashael F Alqahtani, Craig M Smith, Scott L Weiss, Susan Dawson, Hantamalala Ralay Ranaivo, Mark S Wainwright
Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic peptide (mrProANP), and adipocyte fatty-acid-binding proteins (A-FaBPs) have been investigated as biomarkers for sepsis or detection of acute neurological injuries in adults, but not children. We carried out a single-center, prospective observational study to determine if these measures could serve as biomarkers to identify children with sepsis. A secondary aim was to determine if these biomarkers could identify children with neurologic complications of sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/26953897/to-explore-the-characteristics-of-fatality-in-children-poisoned-by-paraquat-with-analysis-of-146-cases
#13
YingYing Duan, Zheng Wang
PURPOSE: The incidence of paraquat (PQ) poisoning in China is increasing, so it is important to identify the characteristics of fatalities in children with acute PQ poisoning in order to prevent and treat future cases. METHODS: A prospective study that enrolled 146 children with PQ poisoning was performed. A novel evaluation system called the score of lethal factors for PQ poisoning (SLFPP) was established, including 1 contributing factor and 4 weakening factors...
February 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/26369662/daily-estimation-of-the-severity-of-organ-dysfunctions-in-critically-ill-children-by-using-the-pelod-2-score
#14
Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix, Francis Leclerc
INTRODUCTION: Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the previous version of the score. METHODS: In all consecutive patients admitted to nine pediatric intensive care units (PICUs) we prospectively measured the dPELOD-2 score at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as the outcome dependent variable...
September 15, 2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25875250/performance-of-prism-iii-and-pelod-2-scores-in-a-pediatric-intensive-care-unit
#15
Jean-Pierre Gonçalves, Milton Severo, Carla Rocha, Joana Jardim, Teresa Mota, Augusto Ribeiro
UNLABELLED: The study aims were to compare two models (The Pediatric Risk of Mortality III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD-2)) for prediction of mortality in a pediatric intensive care unit (PICU) and recalibrate PELOD-2 in a Portuguese population. To achieve the previous goal, a prospective cohort study to evaluate score performance (standardized mortality ratio, discrimination, and calibration) for both models was performed. A total of 556 patients consecutively admitted to our PICU between January 2011 and December 2012 were included in the analysis...
October 2015: European Journal of Pediatrics
https://www.readbyqxmd.com/read/24628829/relationship-between-hyperglycemia-hormone-disturbances-and-clinical-evolution-in-severely-hyperglycemic-post-surgery-critically-ill-children-an-observational-study
#16
Yolanda Ballestero, Jesús López-Herce, Rafael González, Maria José Solana, Jimena Del Castillo, Javier Urbano, Marta Botran, Ana García, Nieves López, Jose María Bellón
BACKGROUND: To study hormonal changes associated with severe hyperglycemia in critically ill children and the relationship with prognosis and length of stay in intensive care. METHODS: Observational study in twenty-nine critically ill children with severe hyperglycemia defined as 2 blood glucose measurements greater than 180 mg/dL. Severity of illness was assessed using pediatric index of mortality (PIM2), pediatric risk of mortality (PRISM) score, and pediatric logistic organ dysfunction (PELOD) scales...
2014: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/23685639/pelod-2-an-update-of-the-pediatric-logistic-organ-dysfunction-score
#17
MULTICENTER STUDY
Stéphane Leteurtre, Alain Duhamel, Julia Salleron, Bruno Grandbastien, Jacques Lacroix, Francis Leclerc
OBJECTIVE: Multiple organ dysfunction syndrome is the main cause of death in adult ICUs and in PICUs. The PEdiatric Logistic Organ Dysfunction score developed in 1999 was primarily designed to describe the severity of organ dysfunction. This study was undertaken to update and improve the PEdiatric Logistic Organ Dysfunction score, using a larger and more recent dataset. DESIGN: Prospective multicenter cohort study. SETTING: Nine multidisciplinary, tertiary-care PICUs of university-affiliated hospitals in France and Belgium...
July 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/23628371/trefoil-factor-2-expression-and-its-significance-as-a-predictor-of-severity-of-sepsis-in-children
#18
Jiří Zurek, Michal Kýr, Martin Vavřina, Michal Fedora
Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission...
August 2013: Peptides
https://www.readbyqxmd.com/read/23509619/anemia-among-pediatric-critical-care-survivors-prevalence-and-resolution
#19
Quang N Ngo, Doreen M Matsui, Ram N Singh, Shayna Zelcer, Alik Kornecki
To determine the incidence of anemia among pediatric critical care survivors and to determine whether it resolves within 6 months of discharge. Design. A prospective observational study. Patients with anemia upon discharge from the pediatric critical care unit (PCCU) underwent in hospital and post hospital discharge followup (4-6 months) for hemoglobin (Hb) levels. Setting. A medical-surgical PCCU in a tertiary care center. Patients. Patients aged 28 days to 18 years who were treated in the PCCU for over 24 hours...
2013: Critical Care Research and Practice
https://www.readbyqxmd.com/read/22273753/kawasaki-disease-an-unexpected-etiology-of-shock-and-multiple-organ-dysfunction-syndrome
#20
Pauline Gatterre, Mehdi Oualha, Laurent Dupic, Franck Iserin, Christine Bodemer, Fabrice Lesage, Philippe Hubert
OBJECTIVE: Severe forms of Kawasaki disease (KD) associated with shock have recently been reported in which a greater number of coronary artery abnormalities (CAA) were observed. In this study, we analyzed organ involvement not restricted to cardiovascular aspects in severe KD and assessed whether their outcome is different than in common forms. DESIGN: Retrospective study. SETTING: A 12-bed pediatric intensive care unit (PICU) in a university hospital setting...
May 2012: Intensive Care Medicine
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