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https://www.readbyqxmd.com/read/27735800/the-relation-between-mean-platelet-volume-and-mortality-in-critical-pediatric-patients
#1
Seher Erdoğan, Arzu Oto, Mehmet Boşnak
Mean platelet volume (MPV) is a simple and economical test that is easy to interpret and is routinely measured with automatic cell counters. It indicates platelet volume and platelet function and activation. Variations in platelet volume may occur more as a result of varying differentiation of megakaryocytes in association with production agents in bone marrow rather than of ageing of platelets in circulation. The purpose of this study was to evaluate the relation between mortality and changes in MPV values in patients hospitalized in the pediatric intensive care unit...
November 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27714707/performance-of-the-pediatric-logistic-organ-dysfunction-2-score-in-critically-ill-children-requiring-plasma-transfusions
#2
Oliver Karam, Pierre Demaret, Alain Duhamel, Alison Shefler, Philip C Spinella, Simon J Stanworth, Marisa Tucci, Stéphane Leteurtre
BACKGROUND: Organ dysfunction scores, based on physiological parameters, have been created to describe organ failure. In a general pediatric intensive care unit (PICU) population, the PEdiatric Logistic Organ Dysfunction-2 score (PELOD-2) score had both a good discrimination and calibration, allowing to describe the clinical outcome of critically ill children throughout their stay. This score is increasingly used in clinical trials in specific subpopulation. Our objective was to assess the performance of the PELOD-2 score in a subpopulation of critically ill children requiring plasma transfusions...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27381433/-vitamin-d-deficiency-in-children-admitted-to-the-paediatric-intensive-care-unit
#3
Raúl Bustos B, Iván Rodríguez-Nuñez, Rubén Peña Zavala, Gonzalo Soto Germani
INTRODUCTION: Vitamin D is essential for bone health, as well as for cardiovascular and immune function. In critically ill adults vitamin D deficiency (VDD) is common, and is associated with sepsis and higher critical illness severity. OBJECTIVES: To establish the prevalence of VDD and its association with clinically relevant outcomes in children admitted to a Paediatric Intensive Care Unit (PICU) in Concepcion, Chile. PATIENTS AND METHOD: Prospective observational cohort study in 90 consecutive children admitted to the PICU in a university general hospital...
July 2, 2016: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/27272692/predictors-of-early-extubation-after-pediatric-cardiac-surgery-a-single-center-prospective-observational-study
#4
Çağlar Ödek, Tanıl Kendirli, Tayfun Uçar, Ayhan Yaman, Ercan Tutar, Zeynep Eyileten, Mehmet Taşar, Mehmet Ramoğlu, Can Ateş, Adnan Uysalel, Erdal İnce, Semra Atalay
This prospective, observational, single-center study aimed to determine the perioperative predictors of early extubation (<24 h after cardiac surgery) in a cohort of children undergoing cardiac surgery. Children aged between 1 month and 18 years who were consecutively admitted to pediatric intensive care unit after cardiac surgery for congenital heart disease between January 2012 and June 2014. Ninety-nine patients were qualified for inclusion during the study period. The median duration of mechanical ventilation was 20 h (range 1-480), and 64 patients were extubated within 24 h...
October 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27089280/evaluation-of-new-diagnostic-biomarkers-in-pediatric-sepsis-matrix-metalloproteinase-9-tissue-inhibitor-of-metalloproteinase-1-mid-regional-pro-atrial-natriuretic-peptide-and-adipocyte-fatty-acid-binding-protein
#5
COMPARATIVE STUDY
Mashael F Alqahtani, Craig M Smith, Scott L Weiss, Susan Dawson, Hantamalala Ralay Ranaivo, Mark S Wainwright
Elevated plasma concentrations of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), mid-regional pro-atrial natriuretic peptide (mrProANP), and adipocyte fatty-acid-binding proteins (A-FaBPs) have been investigated as biomarkers for sepsis or detection of acute neurological injuries in adults, but not children. We carried out a single-center, prospective observational study to determine if these measures could serve as biomarkers to identify children with sepsis. A secondary aim was to determine if these biomarkers could identify children with neurologic complications of sepsis...
2016: PloS One
https://www.readbyqxmd.com/read/26953897/to-explore-the-characteristics-of-fatality-in-children-poisoned-by-paraquat-with-analysis-of-146-cases
#6
YingYing Duan, Zheng Wang
PURPOSE: The incidence of paraquat (PQ) poisoning in China is increasing, so it is important to identify the characteristics of fatalities in children with acute PQ poisoning in order to prevent and treat future cases. METHODS: A prospective study that enrolled 146 children with PQ poisoning was performed. A novel evaluation system called the score of lethal factors for PQ poisoning (SLFPP) was established, including 1 contributing factor and 4 weakening factors...
February 2016: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/26369662/daily-estimation-of-the-severity-of-organ-dysfunctions-in-critically-ill-children-by-using-the-pelod-2-score
#7
Stéphane Leteurtre, Alain Duhamel, Valérie Deken, Jacques Lacroix, Francis Leclerc
INTRODUCTION: Daily or serial evaluation of multiple organ dysfunction syndrome (MODS) scores may provide useful information. We aimed to validate the daily (d) PELOD-2 score using the set of seven days proposed with the previous version of the score. METHODS: In all consecutive patients admitted to nine pediatric intensive care units (PICUs) we prospectively measured the dPELOD-2 score at day 1, 2, 5, 8, 12, 16, and 18. PICU mortality was used as the outcome dependent variable...
2015: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/25875250/performance-of-prism-iii-and-pelod-2-scores-in-a-pediatric-intensive-care-unit
#8
Jean-Pierre Gonçalves, Milton Severo, Carla Rocha, Joana Jardim, Teresa Mota, Augusto Ribeiro
UNLABELLED: The study aims were to compare two models (The Pediatric Risk of Mortality III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD-2)) for prediction of mortality in a pediatric intensive care unit (PICU) and recalibrate PELOD-2 in a Portuguese population. To achieve the previous goal, a prospective cohort study to evaluate score performance (standardized mortality ratio, discrimination, and calibration) for both models was performed. A total of 556 patients consecutively admitted to our PICU between January 2011 and December 2012 were included in the analysis...
October 2015: European Journal of Pediatrics
https://www.readbyqxmd.com/read/24628829/relationship-between-hyperglycemia-hormone-disturbances-and-clinical-evolution-in-severely-hyperglycemic-post-surgery-critically-ill-children-an-observational-study
#9
Yolanda Ballestero, Jesús López-Herce, Rafael González, Maria José Solana, Jimena Del Castillo, Javier Urbano, Marta Botran, Ana García, Nieves López, Jose María Bellón
BACKGROUND: To study hormonal changes associated with severe hyperglycemia in critically ill children and the relationship with prognosis and length of stay in intensive care. METHODS: Observational study in twenty-nine critically ill children with severe hyperglycemia defined as 2 blood glucose measurements greater than 180 mg/dL. Severity of illness was assessed using pediatric index of mortality (PIM2), pediatric risk of mortality (PRISM) score, and pediatric logistic organ dysfunction (PELOD) scales...
2014: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/23685639/pelod-2-an-update-of-the-pediatric-logistic-organ-dysfunction-score
#10
MULTICENTER STUDY
Stéphane Leteurtre, Alain Duhamel, Julia Salleron, Bruno Grandbastien, Jacques Lacroix, Francis Leclerc
OBJECTIVE: Multiple organ dysfunction syndrome is the main cause of death in adult ICUs and in PICUs. The PEdiatric Logistic Organ Dysfunction score developed in 1999 was primarily designed to describe the severity of organ dysfunction. This study was undertaken to update and improve the PEdiatric Logistic Organ Dysfunction score, using a larger and more recent dataset. DESIGN: Prospective multicenter cohort study. SETTING: Nine multidisciplinary, tertiary-care PICUs of university-affiliated hospitals in France and Belgium...
July 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/23628371/trefoil-factor-2-expression-and-its-significance-as-a-predictor-of-severity-of-sepsis-in-children
#11
Jiří Zurek, Michal Kýr, Martin Vavřina, Michal Fedora
Intestinal injury significantly contributes to critical illness, sepsis and multiorgan failure. TFF2 (Trefoil Factor 2) is expressed and secreted preferentially by gastric mucous neck cells. TFF2 gene expression is promptly increased after gut injury, and its expression profile broadens to include the regenerative epithelia of virtually the entire gastrointestinal tract. The first objective of our study was an analysis of TFF2 levels dynamics in patients with Systemic Inflammatory Response Syndrome (SIRS) or septic condition during a 5-day period after admission...
August 2013: Peptides
https://www.readbyqxmd.com/read/23509619/anemia-among-pediatric-critical-care-survivors-prevalence-and-resolution
#12
Quang N Ngo, Doreen M Matsui, Ram N Singh, Shayna Zelcer, Alik Kornecki
To determine the incidence of anemia among pediatric critical care survivors and to determine whether it resolves within 6 months of discharge. Design. A prospective observational study. Patients with anemia upon discharge from the pediatric critical care unit (PCCU) underwent in hospital and post hospital discharge followup (4-6 months) for hemoglobin (Hb) levels. Setting. A medical-surgical PCCU in a tertiary care center. Patients. Patients aged 28 days to 18 years who were treated in the PCCU for over 24 hours...
2013: Critical Care Research and Practice
https://www.readbyqxmd.com/read/22273753/kawasaki-disease-an-unexpected-etiology-of-shock-and-multiple-organ-dysfunction-syndrome
#13
Pauline Gatterre, Mehdi Oualha, Laurent Dupic, Franck Iserin, Christine Bodemer, Fabrice Lesage, Philippe Hubert
OBJECTIVE: Severe forms of Kawasaki disease (KD) associated with shock have recently been reported in which a greater number of coronary artery abnormalities (CAA) were observed. In this study, we analyzed organ involvement not restricted to cardiovascular aspects in severe KD and assessed whether their outcome is different than in common forms. DESIGN: Retrospective study. SETTING: A 12-bed pediatric intensive care unit (PICU) in a university hospital setting...
May 2012: Intensive Care Medicine
https://www.readbyqxmd.com/read/21651808/endotoxemia-in-pediatric-critical-illness-a-pilot-study
#14
Shamik Dholakia, David Inwald, Helen Betts, Simon Nadel
INTRODUCTION: The aim was to investigate the prevalence of endotoxemia in children admitted to pediatric intensive care unit (PICU), and its association with disease severity and outcome. METHODS: We conducted a prospective, observational cohort study of children admitted to PICU at St. Mary's Hospital, London over a 6-month period. One hundred consecutive patients were recruited. Demographic and clinical data were collected. Severity of illness was assessed by the pediatric index of mortality 2 (PIM2) score...
2011: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/20549410/noninvasive-ventilation-in-pediatric-acute-respiratory-failure-by-means-of-a-conventional-volumetric-ventilator
#15
Juan I Muñoz-Bonet, Eva M Flor-Macián, Patricia M Roselló, Mari C Llopis, Alicia Lizondo, José L López-Prats, Juan Brines
BACKGROUND: Acute respiratory failure (ARF) is one of the main causes for admission to pediatric intensive care unit (PICU). This study aimed to evaluate the feasibility and outcome of noninvasive ventilation (NIV) by a volumetric ventilator with a specific mode in pediatric acute respiratory failure. METHODS: A three-year prospective non-controlled study was undertaken in children with ARF who had received NIV delivered by Evita 2 Dura with NIV mode through a nonvented oronasal mask...
November 2010: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/20547715/daily-estimation-of-the-severity-of-multiple-organ-dysfunction-syndrome-in-critically-ill-children
#16
Stéphane Leteurtre, Alain Duhamel, Bruno Grandbastien, François Proulx, Jacques Cotting, Ronald Gottesman, Ari Joffe, Bendicht Wagner, Philippe Hubert, Alain Martinot, Jacques Lacroix, Francis Leclerc
BACKGROUND: Daily evaluation of multiple organ dysfunction syndrome has been performed in critically ill adults. We evaluated the clinical course of multiple organ dysfunction over time in critically ill children using the Pediatric Logistic Organ Dysfunction (PELOD) score and determined the optimal days for measuring scores. METHODS: We prospectively measured daily PELOD scores and calculated the change in scores over time for 1806 consecutive patients admitted to seven pediatric intensive care units (PICUs) between September 1998 and February 2000...
August 10, 2010: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/20456697/association-between-length-of-storage-of-transfused-red-blood-cells-and-multiple-organ-dysfunction-syndrome-in-pediatric-intensive-care-patients
#17
RANDOMIZED CONTROLLED TRIAL
France Gauvin, Philip C Spinella, Jacques Lacroix, Ghassan Choker, Thierry Ducruet, Oliver Karam, Paul C Hébert, James S Hutchison, Heather A Hume, Marisa Tucci
BACKGROUND: The objective was to determine if there is an association between red blood cell (RBC) storage time and development of new or progressive multiple organ dysfunction syndrome (MODS) in critically ill children. STUDY DESIGN AND METHODS: This was an analytic cohort analysis of patients enrolled in a randomized controlled trial, TRIPICU (Transfusion Requirements in Pediatric Intensive Care Units; ISRCTN37246456), in which stable critically ill children were randomly assigned to a restrictive or liberal strategy...
September 2010: Transfusion
https://www.readbyqxmd.com/read/19830720/early-elevations-in-b-type-natriuretic-peptide-levels-are-associated-with-poor-clinical-outcomes-in-pediatric-acute-lung-injury
#18
Bhupinder Reel, Peter E Oishi, Jong-Hau Hsu, Ginny Gildengorin, Michael A Matthay, Jeffrey R Fineman, Heidi Flori
OBJECTIVES: To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome. DESIGN: Prospective observational study. SUBJECTS: After informed consent, plasma was collected from 48 pediatric patients on day 1 of ALI. METHODOLOGY: Plasma BNP levels were measured by immunoassay on day 1 of ALI in 48 pediatric patients...
November 2009: Pediatric Pulmonology
https://www.readbyqxmd.com/read/19586569/clinical-severity-scores-do-not-predict-tolerance-to-enteral-nutrition-in-critically-ill-children
#19
César Sánchez, Jesús López-Herce, Santiago Mencía, Javier Urbano, Angel Carrillo, José María Bellón
The objective of the present study was to analyse whether there is a relationship between the clinical severity at the time of starting transpyloric enteral nutrition (TEN) and the onset of digestive tract complications in critically ill children. Between May 2005 and December 2007, we performed a prospective, observational study with the participation of 209 critically ill children aged between 3 d and 17 years and who received TEN. The characteristics of the nutrition and its tolerance were compared with the paediatric risk of mortality (PRISM), the paediatric index of mortality (PIM) and the paediatric logistic organ dysfunction index (PELOD) at the time of starting the nutrition...
July 2009: British Journal of Nutrition
https://www.readbyqxmd.com/read/18477927/glucose-control-organ-failure-and-mortality-in-pediatric-intensive-care
#20
Michael Yung, Barry Wilkins, Lynda Norton, Anthony Slater, et al.
OBJECTIVE: In ventilated children, to determine the prevalence of hyperglycemia, establish whether it is associated with organ failure, and document glycemic control practices in Australasian pediatric intensive care units (PICUs). DESIGN: Prospective inception cohort study. SETTING: All nine specialist PICUs in Australia and New Zealand. PATIENTS: Children ventilated > 12 hrs excluding those with diabetic ketoacidosis, on home ventilation, undergoing active cardiopulmonary resuscitation on admission, or with do-not-resuscitate orders...
March 2008: Pediatric Critical Care Medicine
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