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Oral agentes antidiabetes

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https://www.readbyqxmd.com/read/27866701/place-of-sodium-glucose-cotransporter-2-inhibitors-in-east-asian-subjects-with-type-2-diabetes-mellitus-insights-into-the-management-of-asian-phenotype
#1
REVIEW
Lee Ling Lim, Alexander Tong Boon Tan, Kevin Moses, Viraj Rajadhyaksha, Siew Pheng Chan
The burden of type 2 diabetes (T2DM) in East Asia is alarming. Rapid modernization and urbanization have led to major lifestyle changes and a tremendous increase in the prevalence of obesity, metabolic syndrome, and diabetes mellitus. The development of T2DM at a younger age, with lower body mass index, higher visceral adiposity, and more significant pancreatic beta-cell dysfunction compared to Caucasians are factors responsible for the increased prevalence of T2DM in East Asians. Sodium-glucose Cotransporter-2 (SGLT2) inhibitors (canagliflozin, dapaglifozin, empagliflozin, etc...
October 15, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27853981/intensification-of-idegasp-twice-daily-adding-insulin-aspart-vs-switching-to-basal-bolus-exploratory-randomized-trial-in-type-2-diabetes
#2
Wan Mohamaed Wan Bebakar, Louis Chaykin, Malene Lundgren Hersløv, Søren Rasmussen
INTRODUCTION: In a preceding trial comparing two different titration schemes, insulin degludec/insulin aspart (IDegAsp) showed good efficacy for achieving HbA1c <7% when administered twice daily (BID) in patients with uncontrolled type 2 diabetes (T2D). However, poor glycemic control persisted in a minority of patients. The current exploratory trial investigated the efficacy and safety of intensifying IDegAsp BID treatment in these patients by either adding a once-daily (OD) bolus injection of insulin aspart (IAsp) or by switching to a basal-bolus regimen of insulin degludec (IDeg) plus IAsp taken three times a day (TID)...
November 16, 2016: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/27832382/diabetes-diabetes-treatment-and-mammographic-density-in-danish-diet-cancer-and-health-cohort
#3
Karsten Buschard, Katrin Thomassen, Elsebeth Lynge, Ilse Vejborg, Anne Tjønneland, My von Euler-Chelpin, Zorana Jovanovic Andersen
PURPOSE: We examined whether diabetes and diabetes treatment are associated with MD in a cohort study of Danish women above age of 50 years. METHODS: Study cohort consisted of 5,644 women (4,500 postmenopausal) who participated in the Danish Diet, Cancer, and Health cohort (1993-1997) and subsequently attended mammographic screening in Copenhagen (1993-2001). We used MD assessed at the first screening after the cohort entry, defined as mixed/dense or fatty. Diabetes diagnoses and diabetes treatments (diet, insulin, or oral antidiabetic agents) were self-reported at the time of recruitment (1993-1997)...
November 10, 2016: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/27824405/antidiabetic-and-antihyperalgesic-effects-of-a-decoction-and-compounds-from-acourtia-thurberi
#4
Ana Laura Martínez, Abraham Madariaga-Mazón, Isabel Rivero-Cruz, Robert Bye, Rachel Mata
The purpose of this research was to examine the preclinical efficacy of a decoction from the roots of Acourtia thurberi as a hypoglycemic, antihyperglycemic, and antihyperalgesic agent using well-known experimental models in mice. Acute oral administration of A. thurberi decoction did not produce toxic effects in mice, according to the Lorke procedure. A. thurberi decoction (31.6-316.2 mg/kg, p. o.) decreased blood glucose levels during acute hypoglycemic and the oral glucose tolerance and oral sucrose tolerance tests, both in normoglycemic and hyperglycemic animals...
November 4, 2016: Planta Medica
https://www.readbyqxmd.com/read/27766241/gemigliptin-an-update-of-its-clinical-use-in-the-management-of-type-2-diabetes-mellitus
#5
Sung-Ho Kim, Jung-Hwa Yoo, Woo Je Lee, Cheol-Young Park
Dipeptidyl peptidase-4 (DPP-4) inhibitors are a new class of oral antidiabetic agent for the treatment of type 2 diabetes mellitus. They increase endogenous levels of incretin hormones, which stimulate glucose-dependent insulin secretion, decrease glucagon secretion, and contribute to reducing postprandial hyperglycemia. Although DPP-4 inhibitors have similar benefits, they can be differentiated in terms of their chemical structure, pharmacology, efficacy and safety profiles, and clinical considerations. Gemigliptin (brand name: Zemiglo), developed by LG Life Sciences, is a potent, selective, competitive, and long acting DPP-4 inhibitor...
October 2016: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/27751591/selective-speciation-improves-efficacy-and-lowers-toxicity-of-platinum-anticancer-and-vanadium-antidiabetic-drugs
#6
Kaitlin A Doucette, Kelly N Hassell, Debbie C Crans
Improving efficacy and lowering resistance to metal-based drugs can be addressed by consideration of the coordination complex speciation and key reactions important to vanadium antidiabetic drugs or platinum anticancer drugs under biological conditions. The methods of analyses vary depending on the specific metal ion chemistry. The vanadium compounds interconvert readily, whereas the reactions of the platinum compounds are much slower and thus much easier to study. However, the vanadium species are readily differentiated due to vanadium complexes differing in color...
October 3, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27738482/comparison-of-combined-tofogliflozin-and-glargine-tofogliflozin-added-to-insulin-and-insulin-dose-increase-therapy-in-uncontrolled-type-2-diabetes
#7
Katsunori Suzuki, Yurie Mitsuma, Takaaki Sato, Takumi Anraku, Mariko Hatta
BACKGROUND: Some patients with type 2 diabetes mellitus (T2DM) on insulin have poor glycemic control and require add-on therapy to reach target glucose values. Increased insulin doses or the addition of an oral antidiabetic drug (OAD) may improve glycemic control, but many patients fail to achieve target values. The aim of this study was to compare the treatment efficacy and safety of three different therapies in such patients. METHODS: T2DM outpatients with poor glycemic control (HbA1c ≥ 7...
November 2016: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/27731814/ameliorative-potential-of-solanum-trilobatum-leaf-extract-and-fractions-on-lipid-profile-and-oxidative-stress-in-experimental-diabetes
#8
KhaderSyed Zameer Ahmed, Syed Zameer Ahmed Sidhra, Ponnusamy Ponmurugan, Balasubramanian Senthil Kumar
Solanum trilobatum Linn is a medicinal plants used in India from many centuries to cure various diseases. The purpose of the study is to evaluate the ameliorative potential of the ethanolic leaf extract and fractions of Solanum trilobatum (St) against alloxan induced diabetic rats. Solanum trilobatum leaf extract and fractions were administered orally at two different concentration (100-200mg/kg body weight) to alloxan induced diabetic rats. The antidiabetic efficacy was validated through various biochemical parameters, enzyme assays, renal markers and antioxidant properties were also determined...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27676771/bilateral-proximal-femoral-agenesis-case-report
#9
Mouna Sghir, Mohamed Guedria, Marwa Maraoui, Wafa Haj Hamad, Wafa Said, Saida Jerbi, Wassia Kessomtini
OBJECTIVE: The femur aplasia is a congenital developmental defect of the femur often associated with malformations of the pelvis and lower limb. There are all intermediaries between the short femur and vestigial femoral. The total femur absence (agenesis) is rare. We report a case of a child followed in our Physical Medicine Department for proximal bilateral femoral agenesis. OBSERVATIONS: This is M.S., a 5 years old child, addressed for a waddling gait and a deformation of the trunk...
September 2016: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27650977/efficacy-and-safety-of-lixilan-a-titratable-fixed-ratio-combination-of-insulin-glargine-plus-lixisenatide-in-type-2-diabetes-inadequately-controlled-on-basal-insulin-and-metformin-the-lixilan-l-randomized-trial
#10
Vanita R Aroda, Julio Rosenstock, Carol Wysham, Jeffrey Unger, Diego Bellido, Guillermo González-Gálvez, Akane Takami, Hailing Guo, Elisabeth Niemoeller, Elisabeth Souhami, Richard M Bergenstal
OBJECTIVE: This study was conducted to demonstrate the efficacy and safety of LixiLan (iGlarLixi), a novel, titratable, fixed-ratio combination of insulin glargine (iGlar) (100 units) and lixisenatide, compared with iGlar in patients with type 2 diabetes inadequately controlled on basal insulin with or without up to two oral glucose-lowering agents. RESEARCH DESIGN AND METHODS: After a 6-week run-in when iGlar was introduced and/or further titrated, and oral antidiabetic drugs other than metformin were stopped, 736 basal insulin-treated patients (mean diabetes duration 12 years, BMI 31 kg/m(2)) were randomized 1:1 to open-label, once-daily iGlarLixi or iGlar, both titrated to fasting plasma glucose <100 mg/dL (<5...
September 20, 2016: Diabetes Care
https://www.readbyqxmd.com/read/27643646/metformin-increases-e-cadherin-in-tumors-of-diabetic-patients-with-endometrial-cancer-and-suppresses-epithelial-mesenchymal-transition-in-endometrial-cancer-cell-lines
#11
Ido Laskov, Paul Abou-Nader, Oreekha Amin, Charles-Andre Philip, Marie-Claude Beauchamp, Amber Yasmeen, Walter H Gotlieb
PURPOSE: Epithelial-mesenchymal transition (EMT) is a critical process for cancer metastasis and recurrence. Metformin, an effective oral antidiabetic drug, has been associated with decreased cancer risk and mortality. In this pilot study, we started to evaluate the effect of metformin on EMT in vivo and in vitro in endometrial cancer (EC). METHODS: Endometrial cancer cell lines and freshly isolated EC tumor specimens were used to assess EMT after metformin treatment...
September 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27642282/polyphenol-rich-extract-of-garcinia-pedunculata-fruit-attenuates-the-hyperlipidemia-induced-by-high-fat-diet
#12
Rahul Sarma, Sima Kumari, Ramakrishnan Elancheran, Meetali Deori, Rajlakshmi Devi
Fatty foods, the most common diet today are the crux of many metabolic disorders which need urgent attention. Garcinia pedunculata Roxb. (GP, Clusiaceae) is a plant found available in Northeast (NE) region of India, is considered to have versatile therapeutic properties. The people of this region has been using dried pulp of GP fruit for the treatment of different stomach related diseases traditionally. This study aimed at evaluating the potential therapeutic action of the polyphenol-rich methanolic extract of the fruit in experimental induced obese rats...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27623396/a-newly-developed-silymarin-nanoformulation-as-a-potential-antidiabetic-agent-in-experimental-diabetes
#13
Yousra M El-Far, Mahmoud M Zakaria, Mahmoud M Gabr, Amal M El Gayar, Ibrahim M El-Sherbiny, Laila A Eissa
AIM: This study aimed to develop a new stable nanoformulation of silymarin (SM) with optimum enhanced oral bioavailability and to evaluate its effect as well as mechanism of action as a superior antidiabetic agent over native SM using streptozotocin-induced diabetic rats. MATERIALS AND METHODS: SM-loaded pluronic nanomicelles (SMnp) were prepared and fully characterized. Biochemical parameters were performed as well as histological, confocal and reverse-transcription polymerase chain reaction studies on pancreatic target tissues...
October 2016: Nanomedicine
https://www.readbyqxmd.com/read/27621520/ulcer-healing-potential-of-ethanolic-extract-of-caralluma-attenuata-on-experimental-diabetic-rats
#14
Sunil Garg, Sajal Srivastava, Kisanpal Singh, Alok Sharma, Kavita Garg
INTRODUCTION: Available data indicated that diabetes mellitus (DM) increases the vulnerability of the gastric ulcers and the need of the hour is to develop effective agents to treat ulcer with diabetes for better patient compliance and cost effectiveness. The ulcer-healing properties of ethanolic extract of Caralluma attenuata (CAEt) against both chemically- and physically induced gastric ulcers in experimental rats are recently studied. AIM: To assess the ulcer healing potential of Ethanolic Extract of Caralluma attenuata on Experimental Diabetic Rats...
April 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/27618891/sodium-glucose-cotransporter-2-sglt2-inhibitors-from-natural-products-discovery-of-next-generation-antihyperglycemic-agents
#15
REVIEW
Chang-Ik Choi
Diabetes mellitus is a chronic condition associated with the metabolic impairment of insulin actions, leading to the development of life-threatening complications. Although many kinds of oral antihyperglycemic agents with different therapeutic mechanisms have been marketed, their undesirable adverse effects, such as hypoglycemia, weight gain, and hepato-renal toxicity, have increased demand for the discovery of novel, safer antidiabetic drugs. Since the important roles of the sodium-glucose cotransporter 2 (SGLT2) for glucose homeostasis in the kidney were recently elucidated, pharmacological inhibition of SGLT2 has been considered a promising therapeutic target for the treatment of type 2 diabetes...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27602537/dietary-supplementation-with-myo-inositol-in-women-during-pregnancy-for-treating-gestational-diabetes
#16
Julie Brown, Tineke J Crawford, Jane Alsweiler, Caroline A Crowther
BACKGROUND: Gestational diabetes mellitus (GDM) is any degree of glucose intolerance that first presents and is recognised during pregnancy and usually resolves after the birth of the baby. GDM is associated with increased short- and long-term morbidity for the mother and her baby. Treatment usually includes lifestyle modification and/or pharmacological therapy (oral antidiabetic agents or insulin) with the aim to maintain treatment targets for blood glucose concentrations. Finding novel treatment agents which are effective, acceptable and safe for the mother and her baby are important...
September 7, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27585542/association-between-use-of-oral-antidiabetic-drugs-and-the-risk-of-aortic-aneurysm-a-nested-case-control-analysis
#17
Chien-Yi Hsu, Yu-Wen Su, Yung-Tai Chen, Shih-Hung Tsai, Chun-Chin Chang, Szu-Yuan Li, Po-Hsun Huang, Jaw-Wen Chen, Shing-Jong Lin
BACKGROUND: Pleiotropic effects on cardiovascular protection have been suggested in several oral antidiabetic drugs (OAD). The impacts of OADs on aortic aneurysm (AA) growth have been found in animal studies, but the evidence of their beneficial effects for AA protection in human are lacking. We investigated the relationship between OAD therapy and the risk of developing AA. METHODS: We conducted a nested case-control analysis using the database extracted from Taiwan's National Health Insurance Research Database...
2016: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/27578618/controversy-of-oral-hypoglycemic-agents-in-type-2-diabetes-mellitus-novel-move-towards-combination-therapies
#18
Abhijit A Ghadge, Aniket A Kuvalekar
AIM: As diabetes mellitus is multi-factorial disease, use of several oral hypoglycemic agents (OHAs) is the main stay of pharmacological treatment. The treatment has become more challenging and controversial as OHAs are heterogeneous in their mode of action that causes unwanted side effects. Complementary approaches such as use of medicinal plants and dietary polyunsaturated fatty acids (PUFA) with hypoglycemic and hypolipidemic activities are therefore imperative. A vast literature has independently documented the effects of OHAs, medicinal plants and PUFA for management of diabetes...
August 22, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27552342/effects-of-lactobacillus-plantarum-ccfm0236-on-hyperglycaemia-and-insulin-resistance-in-high-fat-and-streptozotocin-induced-type-2-diabetic-mice
#19
X Li, N Wang, B Yin, D Fang, T Jiang, S Fang, J Zhao, H Zhang, G Wang, W Chen
AIMS: The aim of this study was to rapidly screen potential hypoglycaemic strain by α-glucosidase inhibitory activity in vitro, then explored the antidiabetic effect of Lactobacillus plantarum CCFM0236 in vivo. METHODS AND RESULTS: The cell-free supernatant of Lact. plantarum CCFM0236 significantly inhibited α-glucosidase activity in vitro. Therefore, the effects of Lact. plantarum CCFM0236, with potential hypoglycaemia activity, on insulin resistance and hyperglycaemia were explored in high-fat and streptozotocin-induced type 2 diabetes mice...
December 2016: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/27538464/antidiabetic-antihyperlipidemic-and-antioxidant-properties-of-ethanol-extract-of-grewia-asiatica-linn-bark-in-alloxan-induced-diabetic-rats
#20
Naznin Ara Khatune, Bytul Mokaddesur Rahman, Ranjan Kumar Barman, Mir Imam Ibne Wahed
BACKGROUND: Inspite of introduction of oral hypoglycemic agents, diabetes and its related complications remains to be a major clinical problem. The aim of this study was to investigate the antidiabetic, antihyperlipidemic and antioxidant activities of Grewia asiatica (Linn) stem bark in alloxan induced diabetic rats. METHODS: Diabetes was induced by a single dose of intraperitoneal injection of alloxan (110 mg/kg) in Norwegian Long Evans rats. Ethanol extract of barks from Grewia asiatica (GAE 200 and 400 mg/kg) and metformin (150 mg/kg) were orally administered once daily for 15 days...
2016: BMC Complementary and Alternative Medicine
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