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Radial acces

Elodie Perdreau, Pierre-Emmanuel Séguéla, Zakaria Jalal, Adrien Perdreau, Jean-Baptiste Mouton, Marie Nelson-Veniard, Elodie Guillet, Xavier Iriart, Alexandre Ouattara, François Roubertie, Philippe Mauriat, Jean-Benoit Thambo
BACKGROUND: Left ventricular (LV) dysfunction may complicate paediatric cardiac surgery with cardiopulmonary bypass, notably after long aortic cross-clamping (ACC). Assessment of occult myocardial injury by conventional echocardiographic variables may be difficult in the postoperative period. AIMS: To evaluate the feasibility of two-dimensional (2D) strain in the postoperative period, and to assess the effect of ACC duration on this variable. METHODS: Thirty-three paediatric patients (age<18years) with congenital heart disease undergoing cardiac surgery with cardiopulmonary bypass were included in this prospective single-centre study...
September 28, 2016: Archives of Cardiovascular Diseases
Fatima Rodriguez, Kenneth W Mahaffey
Non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are the leading cause of morbidity and mortality from cardiovascular disease worldwide. The American Heart Association/American College of Cardiology and the European Society of Cardiology periodically release practice guidelines to guide clinicians in the management of NSTE-ACS, most recently in in 2014 and 2015, respectively. The present review compares and contrasts the 2 guidelines, with a focus on the strength of recommendation and level of evidence in the approach to initial presentation and diagnosis of NSTE-ACS, risk assessment, treatments, and systems of care...
July 19, 2016: Journal of the American College of Cardiology
Jessica Pepe, Daniele Diacinti, Emanuela Fratini, Italo Nofroni, Antonella D'Angelo, Roberta Pilotto, Claudio Savoriti, Luciano Colangelo, Orlando Raimo, Mirella Cilli, Cristiana Cipriani, Salvatore Minisola
OBJECTIVE: The prevalence of abdominal aortic calcification (AAC) in primary hyperparathyroidism (PHPT) is unknown. We assessed both prevalence and severity of AAC in PHPT postmenopausal women. METHODS: In this study 70 PHPT postmenopausal women and 70 age- and sex-matched controls were enrolled. Each participant underwent biochemical evaluation, lateral spine radiograph, bone mineral density (BMD) measurement (lumbar, femoral, radial sites), and kidney ultrasound...
August 2016: European Journal of Endocrinology
N S Hari Narayana Moorthy, Sergio F Sousa, Maria J Ramos, Pedro A Fernandes
Farnesyltransferase is one of the enzyme targets for the development of drugs for diseases, including cancer, malaria, progeria, etc. In the present study, the structure-based pharmacophore models have been developed from five complex structures (1LD7, 1NI1, 2IEJ, 2ZIR and 2ZIS) obtained from the protein data bank. Initially, molecular dynamic (MD) simulations were performed for the complexes for 10 ns using AMBER 12 software. The conformers of the complexes (75) generated from the equilibrated protein were undergone protein-ligand interaction fingerprint (PLIF) analysis...
December 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
Altuğ Cincin, Kürşat Tigen, Tansu Karaahmet, Cihan Dündar, Emre Gürel, Mustafa Bulut, Murat Sünbül, Yelda Başaran
OBJECTIVE: The aim of this study was to explore right ventricular (RV) mechanical function in patients with hypertrophic cardiomyopathy (HCM) by 2-D speckle tracking echocardiography (2-D-STE). METHODS: Forty-three patients with HCM (mean age 48, 17 females) and 40 healthy subjects were consecutively included in this cross-sectional study. The diagnosis of HCM was based on the presence of typical clinical, electrocardiographic (ECG), and echocardiographic features...
July 2015: Anatolian Journal of Cardiology
Brianne C Wartman, Jennifer Gabel, Matthew R Holahan
One system consolidation model suggests that as time passes, ensembles of cortical neurons form strong connections to represent remote memories. In this model, the anterior cingulate cortex (ACC) serves as a cortical region that represents remote memories. However, there is debate as to whether remote spatial memories go through this systems consolidation process and come to rely on the ACC. The present experiment examined whether increasing the processing demand on the hippocampus, by sequential training on two spatial tasks, would more fully engage the ACC during retrieval of a remote spatial memory...
2014: PloS One
Brianne C Wartman, Matthew R Holahan
Consolidation processes, involving synaptic and systems level changes, are suggested to stabilize memories once they are formed. At the synaptic level, dendritic structural changes are associated with long-term memory storage. At the systems level, memory storage dynamics between the hippocampus and anterior cingulate cortex (ACC) may be influenced by the number of sequentially encoded memories. The present experiment utilized Golgi-Cox staining and neuron reconstruction to examine recent and remote structural changes in the hippocampus and ACC following training on three different behavioral procedures...
2014: Frontiers in Behavioral Neuroscience
Gregory A Chinn, Karla E Hirokawa, Tony M Chuang, Cecilia Urbina, Fenil Patel, Jeanette Fong, Nobuo Funatsu, Edwin S Monuki
Establishment of the corpus callosum involves coordination between callosal projection neurons and multiple midline structures, including the glial wedge (GW) rostrally and hippocampal commissure caudally. GW defects have been associated with agenesis of the corpus callosum (ACC). Here we show that conditional Lhx2 inactivation in cortical radial glia using Emx1-Cre or Nestin-Cre drivers results in ACC. The ACC phenotype was characterized by aberrant ventrally projecting callosal axons rather than Probst bundles, and was 100% penetrant on 2 different mouse strain backgrounds...
September 2015: Cerebral Cortex
Austin Chiang, Hemal Gada, Susheel K Kodali, Michael S Lee, Allen Jeremias, Duane S Pinto, Sripal Bangalore, Robert W Yeh, Timothy D Henry, Georgina Lopez-Cruz, Roxana Mehran, Ajay J Kirtane
BACKGROUND: Great strides have been made in improving outcomes for patients with ST-elevation myocardial infarction (STEMI), predominately through initiatives focusing upon improving clinical processes "upstream" of percutaneous coronary intervention (PCI). The actual step-by-step mechanics of diagnostic angiography during STEMI and other aspects of the PCI procedure itself have received relatively little attention. OBJECTIVES AND METHODS: We hypothesized that there would be significant variation in how primary PCI for STEMI is performed in the United States...
April 1, 2014: Catheterization and Cardiovascular Interventions
Y Derraz, H Benamer, T Lefèvre, B Chevalier, T Hovasse, R Chaito, P Garot, M-C Morice, Y Louvard
BACKGROUND: The mother and child "5-in-6" technique using the Heartrail II catheter is a novel tool allowing stent delivery in challenging lesions, when conventional techniques have failed. METHODS: A total of 147 consecutive patients underwent percutaneous coronary intervention (PCI) using the "5-in-6" Heartrail II catheter was restrospectively identified in the Institut Cardiovasculaire Paris Sud, (Jacques-cartier hospital), Institut hospitalier Claude-Galien (Claude-Galien hospital) and European hospital of Paris between July 2009 and September 2012...
December 2013: Annales de Cardiologie et D'angéiologie
Emily C Hodkinson, Adesh Ramsewak, John Conleth Murphy, James A Shand, Anthony J McClelland, Ian B A Menown, Colm G Hanratty, Mark S Spence, Simon J Walsh
OBJECTIVES: To investigate the outcomes of a cohort of acute and elective percutaneous coronary intervention (PCI) patients who were discharged home 6 hours postprocedure. BACKGROUND: Contemporary PCI is safe with a low rate of acute complications. It is well established as a day procedure in elective cases; however, data are lacking in acute cases. METHODS: We describe a prospective observational audit of routine clinical practice in the 3 PCI centers in Northern Ireland...
December 2013: Journal of Interventional Cardiology
Keun-Ho Park, Myung Ho Jeong, Youngkeun Ahn, Sang Sik Jung, Moo Hyun Kim, Hyoung-Mo Yang, Junghan Yoon, Seung Woon Rha, Keum Soo Park, Kyoo Rok Han, Byung Ryul Cho, Kwang Soo Cha, Byung Ok Kim, Min Soo Hyon, Won-Yong Shin, Hyunmin Choe, Jang-Whan Bae, Hee Yeol Kim
The aim of our study was to determine the impact of vascular access on in-hospital major bleeding (IHMB) in acute coronary syndrome (ACS). We analyzed 995 patients with non-ST elevation myocardial infarction and unstable angina at the Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines (CRUSADE) moderate- to very high-bleeding risk scores in trans-radial intervention (TRI) retrospective registry from 16 centers in Korea. A total of 402 patients received TRI and 593 patients did trans-femoral intervention (TFI)...
September 2013: Journal of Korean Medical Science
Dominique Fabre, Frederic Kolb, Elie Fadel, Olaf Mercier, Sacha Mussot, Thierry Le Chevalier, Philippe Dartevelle
BACKGROUND: Fifty years of surgical research using synthetic materials and heterologous tissues failed to find a good, durable replacement for the trachea. We investigated autologous tracheal substitution (ATS) without synthetic material or immunosuppression. METHODS: For ATS, we used a single-stage operation to construct a tube from a forearm free fasciocutaneous flap vascularized by radial vessels that was reanastomosed to internal mammary vessels and reinforced by rib cartilages interposed transversally in the subcutaneous tissue...
October 2013: Annals of Thoracic Surgery
Dominique Fabre, Frédéric Kolb, Elie Fadel, Nicolas Leymarie, Sacha Mussot, Thierry Le Chevalier, Philippe Dartevelle
BACKGROUND: Despite numerous attempts, synthetic materials and heterologous tissues failed to replace durably the trachea. Autologous tracheal substitution (ATS) without synthetic material or immunosuppression was investigated to replace extended tracheal defect. We present our experience regards to this innovative challenge. METHOD: After a previous research study, we developed a novel reconstruction technique for extended tracheal defects on animals. Through a single stage operation, a tube from a forearm free fascio-cutaneous flap vascularized by radial vessels is re-anastomosed to cervical vessels...
September 2013: La Presse Médicale
Alexander Frizell Santillo, Johanna Mårtensson, Olof Lindberg, Markus Nilsson, Amir Manzouri, Maria Landqvist Waldö, Danielle van Westen, Lars-Olof Wahlund, Jimmy Lätt, Christer Nilsson
MRI diffusion tensor imaging (DTI) studies of white matter integrity in behavioral variant frontotemporal dementia have consistently shown involvement of frontal and temporal white matter, corresponding to regional loss of cortical volume. Volumetric imaging has a suboptimal sensitivity as a diagnostic tool and thus we wanted to explore if DTI is a better method to discriminate patients and controls than volumetric imaging. We examined the anterior cingulum bundle in 14 patients with behavioral variant frontotemporal dementia and 22 healthy controls using deterministic manual diffusion tensor tractography, and compared DTI parameters with two measures of cortical atrophy, VBM and cortical thickness, of the anterior cingulate cortex (ACC)...
2013: PloS One
Michael Connolly, Ian B A Menown
Multiple key cardiology trials with the potential to change practice or advance understanding have been presented over the past 12 months at international meetings, including the American College of Cardiology (ACC, Chicago, USA, March 2012), European Association for Percutaneous Cardiovascular Interventions (EuroPCR, Paris, France, May 2012), European Society of Cardiology (ESC, Munich, Germany, August 2012), Transcatheter Cardiovascular Therapeutics (TCT, Miami, USA, October 2012), and the American Heart Association (AHA, Los Angeles, USA, November 2012)...
April 2013: Advances in Therapy
Diana Droubi, Ilene L Rothman
Aplasia cutis congenita (ACC), congenital absence of skin, is most common on the scalp but may rarely occur on the trunk and limbs. It is a physical finding that can occur in isolation or as part of a heterogeneous group of syndromes. It can affect localized to widespread areas of absent or atrophic, scarred skin at birth. We report a case of ACC of the distal right forearm associated with radial dysplasia in a newborn boy. According to the Frieden classification of ACC, this case, along with other similar reported cases, highlights the need to adjust the classification scheme commonly used for ACC so that it reflects the associated limb abnormalities with ACC of the extremities...
May 2014: Pediatric Dermatology
Seppo K Koskinen, Ville V Haapamäki, Jari Salo, Nina C Lindfors, Mika Kortesniemi, Lauri Seppälä, Kimmo T Mattila
PURPOSE: To evaluate the feasibility and intra- and interobserver agreement of CBCT arthrography of wrist ligaments, triangular fibrocartilaginous complex (TFCC), and to assess the sensitivity (SE), specificity (SP), accuracy (ACC), and positive and negative predictive value (PPV, NPV) of CBCT arthrography in the diagnosis of scapholunate (SLL) and lunotriquetral (LTL) ligament tears, TFCC, and cartilage abnormalities of the scaphoid and lunate with their corresponding radial surfaces (scaphoid and lunate fossa) using a novel, mobile, dedicated extremity CBCT scanner...
May 2013: Skeletal Radiology
Aliki K Tzima, Epaminondas J Paplomatas, Dimitrios I Tsitsigiannis, Seogchan Kang
To gain insight into the role of G protein-mediated signaling in virulence and development of the soilborne, wilt causing fungus Verticillium dahliae, the G protein β subunit gene (named as VGB) was disrupted in tomato race 1 strain of V. dahliae. A resulting mutant strain, 70ΔGb15, displayed drastic reduction in virulence, increased microsclerotia formation and conidiation, and decreased ethylene production compared to the corresponding wild type (wt) strain 70wt-r1. Moreover, 70ΔGb15 exhibited an elongated rather than radial growth pattern on agar media...
April 2012: Fungal Genetics and Biology: FG & B
Egidio Imbalzano, Concetta Zito, Scipione Carerj, Giuseppe Oreto, Giuseppe Mandraffino, Maurizio Cusmà-Piccione, Gianluca Di Bella, Carlo Saitta, Antonino Saitta
BACKGROUND: Conventional transthoracic echocardiography (TTE) and tissue Doppler imaging (TDI) are usually unable to reveal very early subtle abnormalities in left ventricular (LV) systolic function caused by hypertension, prior to manifestation of hypertrophy (LVH). This study was undertaken to assess whether speckle tracking echocardiography (STE) provides more insight into early hypertension-induced LV systolic dysfunction, with the purpose of identifying patients at higher risk for heart failure (HF)...
July 2011: Echocardiography
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