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IP-10 and pediatric TB diagnosis

S Dhanasekaran, S Jenum, R Stavrum, C Ritz, J Kenneth, M Vaz, T M Doherty, H M S Grewal
The tuberculin skin test (TST) and QuantiFERON-TB-Gold-In-tube (QFTGIT) are adjunctive tests used in the diagnosis of pediatric tuberculosis (TB). Neither test can rule out TB; however, a positive test usually triggers preventive treatment in TB contacts aged <5 years. TST and QFTGIT can give divergent results and it is unclear how discordant results should be interpreted in terms of TB risk and preventive treatment. To understand the immune processes underlying concordant or discordant TST and QFTGIT results, we analyzed immune responses in children from Palamaner Taluk in India (a TB-endemic region with routine neonatal BCG vaccination) who were referred to a TB case verification ward on suspicion of TB...
July 2014: Genes and Immunity
Marine Armand, Vibol Chhor, Agathe de Lauzanne, Valérie Guérin-El Khourouj, Béatrice Pédron, Mohamed Jeljeli, Pierre Gressens, Albert Faye, Ghislaine Sterkers
OBJECTIVES: Detailed understanding of tuberculosis (TB) immunopathology and cytokine/chemokine responses can ultimately lead to the development of new diagnostic tools, especially useful in children where TB diagnosis remains challenging. METHODS: Nineteen cytokine/chemokine responses to Mycobacterium tuberculosis (M.tb) antigens were analyzed in 47 children distributed as follow: 28 with TB-disease (TD), 12 with latent TB and 7 uninfected controls. All the cytokines and chemokines were quantified in a multiplexed microsphere-based assay by using residual plasma from the quantiFERON kit (IFNγ release assay)...
January 2014: Journal of Infection
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