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diagnosis of cryptococcosis

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https://www.readbyqxmd.com/read/29762761/burden-of-acute-kidney-injury-in-hiv-patients-under-deoxycholate-amphotericin-b-therapy-for-cryptococcal-meningitis-and-cost-minimization-analysis-of-amphotericin-b-lipid-complex
#1
Felipe Francisco Tuon, Khaiany Lino Florencio, Jaime L Rocha
Deoxycholate amphotericin B (d-AMB) has a higher rate of acute kidney injury (AKI) in comparison of lipid formulations. However, lipid amphotericin B has high costs in developing countries. The aim of this study is to assemble a model of cost-minimization of amphotericin B lipid complex (ABLC) in patients with cryptococcal meningitis. This is a retrospective study done in a cohort of patients with cryptococcal meningitis to study the economic impact of its use in developing countries. Cost analysis were based on direct cost of different antifungal therapies, chronic dialysis after discharge, and survival of patients based on a retrospective cohort of 102 patients infected with human immunodeficiency virus with confirmed diagnosis of cryptococcal meningitis...
May 14, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29756504/tuberculous-peritonitis-and-pleurisy-accompanied-by-pulmonary-cryptococcosis-a-case-report
#2
Jian-Kun Chen, Shu-Bin Cai, Qian Cai, Hang Qi, Ji-Qiang Li
Although the infectious diseases tuberculosis (TB) and cryptococcosis both cause formation of single or multiple nodules in immunodeficient hosts, cases of co-infection of these diseases are rarely seen. We report a patient who was co-infected with TB and cryptococcosis. A male patient with no clinical evidence of immunodeficiency presented with a 3-week history of abdominal distension accompanied by oedema of recurring lower extremities. The patient was diagnosed with tuberculous peritonitis and tuberculous pleurisy by an abdominal puncture biopsy...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29742199/diagnostic-and-therapeutic-strategies-in-cryptococcosis-impact-on-outcome
#3
Timothée Boyer Chammard, Elvis Temfack, Olivier Lortholary, Alexandre Alanio
Cryptococcosis diagnosis has been recently improved by the use of rapid cryptococcal antigen testing with lateral flow assays, which have proved sensitive and specific. Using "test and treat" screening strategies for cryptococcal disease with these tests has been showed effective in reducing cryptococcal meningitis (CM) in HIV-infected patients. Recommended induction, consolidation, and maintenance therapeutic strategy for CM is widely unavailable and/or expensive in low and middle-income settings...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29663539/cryptococcal-infections-over-a-15-year-period-at-a-tertiary-facility-impact-of-guideline-management
#4
Ian Gassiep, Joel Douglas, Theophilus I Emeto, Katherine Crawley, Elliott G Playford
BACKGROUND: Cryptococcosis is an invasive fungal infection caused primarily by Cryptococcus neoformans and Cryptococcus gattii species, presenting predominantly as meningoencephalitis. The aim of this study is to assess all cryptococcal infections managed at our facility from 2001-2015 to determine incidence, risk factors, and comparison of outcomes prior to and following introduction of the 2010 Infectious Disease Society of America (IDSA) guidelines. METHODS: Retrospective analysis of all patients diagnosed and treated for cryptococcal infection occurring between January 2001 and December 2015...
April 17, 2018: Mycoses
https://www.readbyqxmd.com/read/29562641/estimating-the-burden-of-serious-fungal-infections-in-uruguay
#5
Marina Macedo-Viñas, David W Denning
We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400...
March 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29538024/duodenum-cryptococcosis-mimicking-primary-duodenum-cancer-on-pet-ct-imaging
#6
Yan Xiu, Jie Zhang, Hongcheng Shi
A 73-year-old man presented with fatigue and anorexia and underwent FDG PET/CT scan to evaluate a right lung nodule revealed by a chest CT. The FDG PET/CT not only showed that the lung nodule was hypermetabolic but also revealed that there was significantly increased activity in the region of the duodenum. The findings were suspected as primary duodenal malignancy with metastases. However, an upper gastrointestinal tract endoscopic examination with further culture led to a diagnosis of duodenal cryptococcosis...
May 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29516271/antibody-conjugated-silica-modified-gold-nanorods-for-the-diagnosis-and-photo-thermal-therapy-of-cryptococcus-neoformans-an-experiment-in-vitro
#7
Qin Xiao, Yongzhou Lu, Min Chen, Bo Chen, Yuming Yang, Daxiang Cui, Bo Pan, Nan Xu
BACKGROUND: Cryptococcus neoformans is an encapsulated yeast. There is still little quick and effective solution for the diagnosis or treatment of C. neoformans infection at an early stage in clinical. Antibody-conjugated silica-modified gold nanorods (GNR-SiO2 -Ab) can conjugate C. neoformans selectively. It may provide a possibility for treatment of cryptococcosis safely and effectively. METHODS: Gold nanorods (GNRs) were synthesized according to the seed-mediated template-assisted protocol...
March 7, 2018: Nanoscale Research Letters
https://www.readbyqxmd.com/read/29494502/cryptococcosis-in-colombia-compilation-and-analysis-of-data-from-laboratory-based-surveillance
#8
Patricia Escandón, Jairo Lizarazo, Clara Inés Agudelo, Elizabeth Castañeda
The passive and voluntary surveillance of cryptococcosis in Colombia since 1997 has seen an increasing participating rate, revealing its importance to both in immunosuppressed and immunocompetent people. The present work details the national data gathered in 1997-2016, through a retrospective analysis of the information collected in the survey. From a total of 1974 cases reported, an overall incidence of 0.23 cases per 100,000 people was found. This incidence rose to 1.1 cases per 1000 people in the Acquired Immunodeficiency Syndrome (AIDS) population...
March 1, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29454844/the-epidemiology-of-febrile-illness-in-sub-saharan-africa-implications-for-diagnosis-and-management
#9
REVIEW
M J Maze, Q Bassat, N A Feasey, I Mandomando, P Musicha, J A Crump
BACKGROUND: Fever is among the most common symptoms of people living in Africa, and clinicians are challenged by the similar clinical features of a wide spectrum of potential aetiologies. AIM: To summarize recent studies of fever aetiology in sub-Saharan Africa focusing on causes other than malaria. SOURCES: A narrative literature review by searching the MEDLINE database, and recent conference abstracts. CONTENT: Studies of multiple potential causes of fever are scarce, and for many participants the infecting organism remains unidentified, or multiple co-infecting microorganisms are identified, and establishing causation is challenging...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29449166/clinical-characteristics-and-treatment-outcomes-of-pulmonary-invasive-fungal-infection-among-adult-patients-with-hematological-malignancy-in-a-medical-centre-in-taiwan-2008-2013
#10
Chien-Yuan Chen, Wang-Huei Sheng, Feng-Ming Tien, Po-Chu Lee, Shang-Yi Huang, Jih-Luh Tang, Woei Tsay, Hwei-Fang Tien, Po-Ren Hsueh
BACKGROUND/PURPOSE: This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy. METHODS: All patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus. RESULTS: During the study period, 236 (11...
January 31, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29372886/the-outcome-of-hiv-positive-late-presenters-according-to-detectable-cmv-dna-and-anti-cmv-treatment
#11
Paolo Bigliano, Andrea Calcagno, Anna Lucchini, Sabrina Audagnotto, Chiara Montrucchio, Letizia Marinaro, Chiara Alcantarini, Valeria Ghisetti, Giovanni Di Perri, Stefano Bonora
BACKGROUND: HIV late presenters are at high risk of Cytomegalovirus reactivation and end-organ disease. CMV viremia has been associated with poor survival but the effect of anti-CMV treatment has not been studied in this setting. METHODS: HIV-positive patients were included in a retrospective study if presenting with <350 CD4/uL and starting an antiretroviral treatment within 3 months of the diagnosis. Primary endpoint was 5-year survival according to the presence of CMV viremia (CMV-V), CMV end-organ disease (CMV-EOD) and anti-CMV treatment...
January 26, 2018: Antiviral Therapy
https://www.readbyqxmd.com/read/29359837/a-cluster-of-donor-derived-cryptococcus-neoformans-infection-affecting-lung-liver-and-kidney-transplant-recipients-case-report-and-review-of-literature
#12
Jose F Camargo, Jacques Simkins, Denise C Schain, A Adrian Gonzalez, Maria L Alcaide, Shweta Anjan, Giselle Guerra, David Roth, Warren L Kupin, Adela Mattiazzi, Yaohong Tan, Clara Milikowski, Michele I Morris, Lilian M Abbo
Donor-derived infections (DDIs) are a very rare but potentially devastating complication of solid organ transplantation. Here we present a cluster of proven donor-derived cryptococcal infection in the kidney, liver, and lung recipients from a single donor. Remarkably, the onset of illness in the kidney and liver recipients occurred more than 8-12 weeks after transplantation, which is beyond the incubation period previously reported for donor-derived cryptococcosis. DDI should always be considered in the differential diagnosis of transplant recipients admitted with febrile illness, even when presenting beyond the first month post-transplant...
April 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29327953/multicentric-cryptococcosis-in-a-congo-african-grey-parrot-psittacus-erithacus-erithacus
#13
Raina S K Schunk, Nicholas E Sitinas, Katherine E Quesenberry, Jessica L Grodio
An approximately 10-year-old, female Congo African grey parrot ( Psittacus erithacus erithacus) developed progressive, unilateral exophthalmos and buphthalmos. Survey radiographs revealed a large, coelomic, soft tissue mass, which was confirmed on computed tomography scan. Aspirates of both the contents of the buphthalmic globe and coelomic mass were consistent with Cryptococcus species. Initial results were later confirmed with serum antigen latex agglutination and polymerase chain reaction testing, and the organism was then identified as Cryptococcus neoformans with DNA sequencing...
December 2017: Journal of Avian Medicine and Surgery
https://www.readbyqxmd.com/read/29320833/-analysis-of-9-cases-of-nodular-type-of-pulmonary-cryptococcosis-with-coexisting-lung-cancer-confirmed-by-pathological-examinations
#14
H Y Li, C Q Lan, H Weng, S X Chen, Q H Lin, J B Huang
Objective: To describe the characteristics of the nodular type of pulmonary cryptococcosis (PC) with coexisting lung cancer. Methods: A total of 9 cases of PC with coexisting lung cancer, admitted to Fuzhou Pulmonary Hospital of Fujian from 1st January 2009 to 31th December 2016, and confirmed by pathological examinations, were studied and the related literature were reviewed. Results: The patients consisted of 1 male and 8 females, with a mean age of (53±10) years (range, 38 to 68 years). Four patients (44...
November 12, 2017: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29284182/cryptococcosis-and-cryptococcal-meningitis-new-predictors-and-clinical-outcomes-at-a-united-states-academic-medical-centre
#15
Bahar H Kashef Hamadani, Carlos Franco-Paredes, Bruce McCollister, Leland Shapiro, J David Beckham, Andrés F Henao-Martínez
As the diagnosis of cryptococcosis is challenging in low-prevalence settings, uncovering predictive factors can improve early diagnosis and timely treatment. The aim of the study was to relate clinical outcomes to predictive variables for the presence of cryptococcosis. A retrospective case-control study matched by collection date, age and gender at a 1:2 ratio (55 cases and 112 controls) was performed in case patients diagnosed with Cryptococcus infection at the University of Colorado Hospital between 2000 and 2017 (n = 167)...
December 28, 2017: Mycoses
https://www.readbyqxmd.com/read/29185961/recommendations-for-the-management-of-pulmonary-fungal-infections-in-patients-with-rheumatoid-arthritis
#16
REVIEW
Massimo Galli, Spinello Antinori, Fabiola Atzeni, Luca Meroni, Agostino Riva, Carlo Scirè, Fulvio Adorni, Luca Quartuccio, Marco Sebastiani, Paolo Airò, Laura Bazzichi, Francesco Cristini, Valerio Del Bono, Andreina Manfredi, Ombretta Viapiana, Francesco De Rosa, Ennio Favalli, Enzo Petrelli, Carlo Salvarani, Marcello Govoni, Silvia Corcione, Rossana Scrivo, Loredana Sarmati, Adriano Lazzarin, Walter Grassi, Claudio Mastroianni, Giovanni Battista Gaeta, Gianfranco Ferraccioli, Maurizio Cutolo, Salvatore De Vita, Giovanni Lapadula, Marco Matucci-Cerinic, Orlando Armignacco, Piercarlo Sarzi-Puttini
Often life-threatening pulmonary fungal infections (PFIs) can occur in patients with rheumatoid arthritis (RA) receiving disease-modifying anti-rheumatic drugs (DMARDs). Most of the data concerning PFIs in RA patients come from case reports and retrospective case series. Of the ve most widely described PFIs, Pneumocystis jirovecii pneumonia (PJP) has rarely been seen outside Japan, pulmonary cryptococcosis has been diagnosed in only a small number of patients worldwide, pulmonary coccidioidomycosis has almost only been observed in endemic areas, the limited number of cases of pulmonary histoplasmosis have mainly occurred in the USA, and the rare cases of invasive pulmonary aspergillosis have only been encountered in leukopenic patients...
November 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29177510/disseminated-cryptococcosis-presenting-as-miliary-lung-shadows-in-an-immunocompetent-child
#17
Javed Ismail, Muthu Chidambaram, Jhuma Sankar, Shipra Agarwal, Rakesh Lodha
Disseminated cryptococcosis is infrequent in immunocompetent children. Pulmonary and central nervous system are the commonly involved sites of infection in an immunocompromised host. We report a fatal case of disseminated cryptococcosis in an immunocompetent host presenting as fever of unknown origin with miliary shadows on chest radiograph, mimicking tuberculosis. In countries with the heavy burden of tuberculosis, a high index of suspicion is needed for early diagnosis of its close mimics like disseminated cryptococcosis...
November 21, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29150356/cryptococcosis-manifesting-as-isolated-biliary-infection-case-report-and-brief-review-of-literature
#18
Hua-Ying Zhou, Xiao-Bo Zeng, Sheng-Long Shi, Min Wang, Da-Min Li
BACKGROUND: Biliary cryptococci infection is rare, which is frequently diagnosed by exploratory laparotomy, preoperative diagnosis is difficult. CASE PRESENTATION: A 14-year-old girl presented with intermittent jaundice for 6 years. She had no pruritus, anorexia, nausea or vomiting, fever, abdominal pain, or clay stools. Laboratory tests showed obstructive jaundice, eosinophilia, and increased IgE levels. The patient was ultimately diagnosed as Cryptococcal infection by bone marrow culture...
November 14, 2017: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29132792/-neuromeningeal-cryptococcosis-in-patients-infected-with-hiv-at-agadir-regional-hospital-souss-massa-morocco
#19
S Chadli, M Aghrouch, N Taqarort, M Malmoussi, Z Ouagari, F Moustaoui, M Bourouache, S Oulkheir
INTRODUCTION: Neuromeningeal cryptococcosis (NMC) is a severe and fatal opportunistic infection. Lethality is frequent in the absence of treatment, especially in the presence of HIV co-infection. OBJECTIVE: To determine the prevalence, epidemiological, clinical, biological and therapeutic aspects as well as the evolution of NMC for patients infected with HIV. PATIENTS AND METHODS: This is a retrospective study of 40 cases of neuromeningeal cryptococcosis diagnosed in HIV-infected patients...
November 10, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29129578/cryptococcosis-in-an-infectious-diseases-hospital-of-buenos-aires-argentina-revision-of-2041-cases-diagnosis-clinical-features-and-therapeutics
#20
Alicia Arechavala, Ricardo Negroni, Fernando Messina, Mercedes Romero, Emmanuel Marín, Roxana Depardo, Laura Walker, Gabriela Santiso
BACKGROUND: Cryptococcosis is still a life-threatening mycosis that continues to be of serious concern in Latin American countries, especially among HIV+positive population. However, there is not any reliable information about the prevalence of this disease in this region. AIMS: The aim of this study is to report data of 2041 patients with cryptococcosis that were attended at the Infectious Diseases Hospital F. J. Muñiz over a 30 year-period. METHODS: Information about demographic and clinical data, survival time and the applied treatment, was taken from the Mycology Unit database...
January 2018: Revista Iberoamericana de Micología
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