keyword
https://read.qxmd.com/read/37353174/metformin-suppresses-cardiac-fibroblast-proliferation-under-high-glucose-conditions-via-regulating-the-mitochondrial-complex-i-protein-grim-19-involved-in-the-sirt1-stat3-signaling-pathway
#21
JOURNAL ARTICLE
Yongguang Li, Xiangdong Liu, Lili Wan, Beibei Han, Shixin Ma, Hongyuan Pan, Junbo Wei, Xiaofang Cui
Hyperglycemia associated with myocardial oxidative stress and fibrosis is the main cause of diabetic cardiomyopathy. Currently, no approved drug is available for preventing or treating diabetes-induced cardiac fibrosis. Metformin has been reported to improve glycemic control and ameliorate diabetic cardiomyopathy. This study aimed to investigate the effects and mechanism of metformin on diabetes-induced cardiac fibrosis and high glucose-induced proliferation of cardiac fibroblasts (CFs). In this study, db/db mice were treated with metformin [250 mg/kg⋅d, gavage]...
June 21, 2023: Free Radical Biology & Medicine
https://read.qxmd.com/read/37255806/evaluation-of-curcumin-effect-on-il6-sirt1-tnf%C3%AE-and-nfkb-expression-of-liver-tissues-in-diabetic-mice-with-stz
#22
JOURNAL ARTICLE
Somayyeh Mojtabavi, Amin Saed, Sajad Aboulfazli, Ali Kheirandish, Mojtaba Najafi, Majid Jafari-Sabet, Ali Ziar, Nima Ebrahimi, Seyedeh Habibeh Mirmajidi, Ramin Ataee
BACKGROUND: Curcumin is active ingredient of turmeric The main purpose of this study is evaluating impact of curcumin on suger, hypoalgesia and inflammatory factors in diabetic mice. MATERIALS AND METHODS: Male mice divided into six groups of 6. One group as a negative and the other five groups injected with Streptozotocin (STZ) (200 mg/kg). Diabetic mice in each group given different treatments for twenty-one days.After that, blood sugar and neuroathy studies have been done and tissue samples the liver were studied for gene expression...
June 2023: Journal of Diabetes and Metabolic Disorders
https://read.qxmd.com/read/37209153/a-novel-combination-of-metformin-and-resveratrol-alleviates-hepatic-steatosis-by-activating-autophagy-through-the-camp-ampk-sirt1-signaling-pathway
#23
JOURNAL ARTICLE
Havva Afshari, Shokoofe Noori, Afshin Zarghi
Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disorder that is associated with the accumulation of triglycerides (TG) in hepatocytes. Resveratrol (RSV), as a natural product, and metformin have been reported to have potential lipid-lowering effects for the treatment of NAFLD via autophagy, but the combined effects of both have not yet been studied. The current study aimed to investigate the role of autophagy in the lipid-lowering effects of RSV, alone and in combination with metformin, on the hepatic steatosis model of HepG2 cells and elucidate the mechanism of action...
May 20, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37038833/jianpi-qinghua-formula-attenuates-nonalcoholic-fatty-liver-disease-by-regulating-the-ampk-sirt1-nf-%C3%AE%C2%BAb-pathway-in-high-fat-diet-fed-c57bl-6-mice
#24
JOURNAL ARTICLE
Jing Tian, Mengjie Cai, Shenyi Jin, Qingguang Chen, Jiahui Xu, Qiuyue Guo, Zihui Yan, Xu Han, Hao Lu
CONTEXT: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, accompanied by liver lipid accumulation and inflammation. JianPi-QingHua formula (JPQH), a Chinese herbal formula, exhibits effects on obesity and T2DM. However, the hepatoprotective effect of JPQH has not been elucidated. OBJECTIVE: To investigate the hepatoprotective effect of JPQH in NAFLD induced by a high-fat diet (HFD) in mice. MATERIALS AND METHODS: C57BL/6J mice were divided into four groups and fed a normal-fat diet (ND), high-fat diet (HFD), HFD + JPQH (2...
December 2023: Pharmaceutical Biology
https://read.qxmd.com/read/36915137/metformin-regulates-chondrocyte-senescence-and-proliferation-through-microrna-34a-sirt1-pathway-in-osteoarthritis
#25
JOURNAL ARTICLE
Shiju Yan, Wenjing Dong, Zhirui Li, Junqiang Wei, Tao Han, Junliang Wang, Feng Lin
BACKGROUND: Osteoarthritis (OA) is the most common degenerative disease in joints among elderly patients. Senescence is deeply involved in the pathogenesis of osteoarthritis. Metformin is widely used as the first-line drug for Type 2 diabetes mellitus (T2DM), and has great potential for the treatment of other aging-related disorders, including OA. However, the role of metformin in OA is not fully elucidated. Therefore, our aim here was to investigate the effects of metformin on human chondrocytes...
March 13, 2023: Journal of Orthopaedic Surgery and Research
https://read.qxmd.com/read/36881661/divergent-roles-of-sirtuin-1-in-human-granulosa-lutein-cells-similarities-to-hcg
#26
JOURNAL ARTICLE
Rina Meidan, Magdalena Szymanska
Sirtuin 1 (SIRT1) is an NAD+ dependent deacetylase that modifies gene expression through histone deacetylation. It also deacetylates non-histone substrates, e.g. tumor suppressor p53, NOS3, HIF1A, NFKB, FOXO3a, PGC-1α, and PPARγ. Consequently, it regulates a wide range of physiological functions including cell cycle control, energy expenditure, oxidative stress response, apoptosis, and aging. SIRT1 is expressed in ovarian granulosa cells (GCs) of various species including humans at different stages of the reproductive cycle...
March 6, 2023: Biology of Reproduction
https://read.qxmd.com/read/36773805/metformin-induced-ttp-mediates-communication-between-kupffer-cells-and-hepatocytes-to-alleviate-hepatic-steatosis-by-regulating-lipophagy-and-necroptosis
#27
JOURNAL ARTICLE
Jeongmin Park, So-Young Rah, Hyeong Seok An, Jong Youl Lee, Gu Seob Roh, Stefan W Ryter, Jeong Woo Park, Chae Ha Yang, Young-Joon Surh, Uh-Hyun Kim, Hun Taeg Chung, Yeonsoo Joe
OBJECTIVE: Emerging evidence suggests that crosstalk between Kupffer cells (KCs) and hepatocytes protects against non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms that lead to the reduction of steatosis in NAFLD remain obscure. METHODS: Ttp+/+ and Ttp-/- mice were fed with a high-fat diet. Hepatic steatosis was analyzed by Nile Red staining and measurement of inflammatory cytokines. Lipid accumulation and cell death were evaluated in co-culture systems with primary hepatocytes and KCs derived from either Ttp+/+ or Ttp-/- mice...
April 2023: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/36726289/ampk-activation-restores-salivary-function-following-radiation-treatment
#28
JOURNAL ARTICLE
R K Meyer, K E Gilman, B A Rheinheimer, L Meeks, K H Limesand
Head and neck cancers represent a significant portion of cancer diagnoses, with head and neck cancer incidence increasing in some parts of the world. Typical treatment of early-stage head and neck cancers includes either surgery or radiotherapy; however, advanced cases often require surgery followed by radiation and chemotherapy. Salivary gland damage following radiotherapy leads to severe and chronic hypofunction with decreased salivary output, xerostomia, impaired ability to chew and swallow, increased risk of developing oral mucositis, and malnutrition...
February 1, 2023: Journal of Dental Research
https://read.qxmd.com/read/36582738/bibliometric-analysis-of-the-inflammation-in-diabetic-cardiomyopathy
#29
JOURNAL ARTICLE
Ning Zhu, Bingwu Huang, Liuyan Zhu
BACKGROUND: Maladaptive inflammation is implicated in the development of diabetic cardiomyopathy (DCM). This study aimed to visually analyze the global scientific output over the past two decades regarding research on inflammation associated with DCM. METHODS: All relevant articles and reviews were retrieved in the Web of Science (WOS) Core Collection (limited to SCIE) using "inflammation" and "diabetic cardiomyopathy" as search terms. Articles and reviews published from 1 January 2001 to 28 February 2021 were collected...
2022: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/36484892/metformin-in-therapeutic-applications-in-human-diseases-its-mechanism-of-action-and-clinical-study
#30
REVIEW
Yang Du, Ya-Juan Zhu, Yi-Xin Zhou, Jing Ding, Ji-Yan Liu
Metformin, a biguanide drug, is the most commonly used first-line medication for type 2 diabetes mellites due to its outstanding glucose-lowering ability. After oral administration of 1 g, metformin peaked plasma concentration of approximately 20-30 μM in 3 h, and then it mainly accumulated in the gastrointestinal tract, liver and kidney. Substantial studies have indicated that metformin exerts its beneficial or deleterious effect by multiple mechanisms, apart from AMPK-dependent mechanism, also including several AMPK-independent mechanisms, such as restoring of redox balance, affecting mitochondrial function, modulating gut microbiome and regulating several other signals, such as FBP1, PP2A, FGF21, SIRT1 and mTOR...
December 9, 2022: Mol Biomed
https://read.qxmd.com/read/36319785/role-of-metformin-in-inflammation
#31
REVIEW
Yu Yue Feng, Zhengjie Wang, Hua Pang
BACKGROUND: Metformin has good anti-hyperglycemic effectiveness, but does not induce hypoglycemia,is very safe, and has become the preferred drug for the treatment of type 2 diabetes. Recently, the other effects of metformin, such as being anti-inflammatory and delaying aging, have also attracted increased attention. METHODS AND RESULTS: The relevant literatures on pubmed and other websites for reading, classification and sorting, and did not involve any animal experiments...
November 1, 2022: Molecular Biology Reports
https://read.qxmd.com/read/36316840/effect-of-metformin-on-nonalcoholic-fatty-liver-based-on-meta-analysis-and-network-pharmacology
#32
JOURNAL ARTICLE
Yuanshe Huang, Xiaodong Wang, Chen Yan, Chen Li, Lidan Zhang, Lai Zhang, E Liang, Tianlei Liu, Jingxin Mao
BACKGROUND: Whether metformin is related to nonalcoholic fatty liver disease (NAFLD) is controversial. Our aim was to investigate the relationship between metformin and NAFLD that may predict the metformin potential of these lesions and new prevention strategies in NAFLD patients. METHODS: The meta-analysis was analyzed by Revman 5.3 softwares systematically searched for works published through July 29, 2022. Network pharmacology research based on databases, Cytoscape 3...
October 28, 2022: Medicine (Baltimore)
https://read.qxmd.com/read/36315407/metformin-alleviates-hfd-induced-oxidative-stress-in-hepatocyte-via-activating-sirt6-pgc-1%C3%AE-endog-signaling
#33
JOURNAL ARTICLE
Shuya Gao, Qingchen Yang, Zekun Liu, Weixian Kong, Jiawen Chen, Xie Li, Yue Peng, Mengmeng Bao, Xiaohong Bian, Yuexin Zhang, Qizhou Jiang, Zhe Li, Yubin Zhang, Fangrong Yan, Junmei Ye
Metformin is accepted as a first-line drug for the therapy of type 2 diabetes (T2D), while its mechanism is still controversial. In this study, by taking advantage of mouse model of high-fat-diet (HFD)-induced obesity and primary mouse hepatocytes (PMHCs) as well as human hepatocyte L02 cell line, we aimed to investigate the involvement of SIRTs during the application of metformin for the therapy of T2D. Our data evidenced that during HFD-induced obesity, there was elevation of nucleus protein acetylation. Analysis of liver tissue showed that among all SIRT members, SIRT6 expression was significantly downregulated during HFD feeding, which was sustained to regular level with metformin administration...
October 31, 2022: Clinical Science (1979-)
https://read.qxmd.com/read/36230974/metformin-prevents-or-delays-the-development-and-progression-of-osteoarthritis-new-insight-and-mechanism-of-action
#34
REVIEW
Miao He, Bangbao Lu, Michael Opoku, Liang Zhang, Wenqing Xie, Hongfu Jin, Siyu Chen, Yusheng Li, Zhenhan Deng
For over 60 years, metformin has been widely prescribed by physicians to treat type 2 diabetes. Along with more in-depth research on metformin and its molecular mechanism in recent decades, metformin has also been proposed as an effective drug to prevent or delay musculoskeletal disorders, including osteoarthritis (OA). The occurrence and development of OA are deemed to be associated with the impaired mitochondrial functions of articular chondrocytes. Metformin can activate the pathways and expressions of both AMPK and SIRT1 so as to protect the mitochondrial function of chondrocytes, thereby promoting osteoblast production...
September 27, 2022: Cells
https://read.qxmd.com/read/36206595/metformin-mitigates-cholesterol-accumulation-via-the-ampk-sirt1-pathway-to-protect-osteoarthritis-chondrocytes
#35
JOURNAL ARTICLE
Hengte Xing, Chuancai Liang, Chenyu Wang, Xiongfeng Xu, Yong Hu, Bo Qiu
In this study, we aim to investigate the effect of metformin on cholesterol synthesis and efflux-related genes in chondrocytes during osteoarthritis (OA) and explore the underlying mechanisms. Primary chondrocytes were harvested from Wistar rat cartilage and divided into control and treatment groups. Chondrocytes in the treatment group were treated with interleukin-1β (IL-1β) mimicking the inflammatory environment of osteoarthritis. Subsequently, RT-qPCR, Western blotting, immunofluorescence staining, and Cell Counting Kit-8 (CCK-8) were conducted...
September 29, 2022: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/36046822/characterization-of-the-sglt2-interaction-network-and-its-regulation-by-sglt2-inhibitors-a-bioinformatic-analysis
#36
JOURNAL ARTICLE
Zofia Wicik, Anna Nowak, Joanna Jarosz-Popek, Marta Wolska, Ceren Eyileten, Jolanta M Siller-Matula, Dirk von Lewinski, Harald Sourij, Krzysztof J Filipiak, Marek Postuła
Background: Sodium-glucose cotransporter 2 (SGLT2), also known as solute carrier family 5 member 2 (SLC5A2), is a promising target for a new class of drugs primarily established as kidney-targeting, effective glucose-lowering agents used in diabetes mellitus (DM) patients. Increasing evidence indicates that besides renal effects, SGLT2 inhibitors (SGLT2i) have also a systemic impact via indirectly targeting the heart and other tissues. Our hypothesis states that the pleiotropic effects of SGLT2i are associated with their binding force, location of targets in the SGLT2 networks, targets involvement in signaling pathways, and their tissue-specific expression...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35956936/-molineria-recurvata-ameliorates-streptozotocin-induced-diabetic-nephropathy-through-antioxidant-and-anti-inflammatory-pathways
#37
JOURNAL ARTICLE
Prasanta Dey, Amit Kundu, Ha Eun Lee, Babli Kar, Vineet Vishal, Suvakanta Dash, In Su Kim, Tejendra Bhakta, Hyung Sik Kim
Molineria recurvata (MR) has been traditionally used to manage diabetes mellitus in India. However, the molecular mechanism of MR on the diabetic-induced nephropathy has not been clearly investigated. Thus, this study investigates the protective effects of the MR extract on nephropathy in streptozotocin (STZ)-induced diabetic rats. Diabetes was instigated by a single intraperitoneal injection of STZ (45 mg/kg) in male Sprague-Dawley rats. Once the diabetes was successfully induced, the MR extract (200 mg/kg/day) or metformin (200 mg/kg/day) was orally administered for 14 days...
August 5, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/35910360/metformin-alleviates-lps-induced-acute-lung-injury-by-regulating-the-sirt1-nf-%C3%AE%C2%BAb-nlrp3-pathway-and-inhibiting-endothelial-cell-pyroptosis
#38
JOURNAL ARTICLE
Yunqian Zhang, Hui Zhang, Siyuan Li, Kai Huang, Lai Jiang, Yan Wang
Acute respiratory distress syndrome (ARDS), a devastating complication of numerous conditions, is often associated with high mortality. It is well known that endothelial cell (EC) damage and inflammation are vital processes in the pathogenesis of ARDS. Nevertheless, the mechanisms of EC damage are largely unknown. In the present study, we investigated the role of pyroptosis in the initiation of ARDS and demonstrated that endothelial pyroptosis might play a pivotal role in the pathophysiology of ARDS. Metformin, an antidiabetic drug, exhibited a protective effect in lipopolysaccharide (LPS)-induced lung injury, and we hypothesized that metformin alleviated LPS-induced lung injury via inhibiting ECs pyroptosis...
2022: Frontiers in Pharmacology
https://read.qxmd.com/read/35852765/metformin-alleviates-delayed-hydrocephalus-after-intraventricular-hemorrhage-by-inhibiting-inflammation-and-fibrosis
#39
JOURNAL ARTICLE
Yi Cao, Chang Liu, Gaowei Li, Weina Gao, Hui Tang, Shuanmin Fan, Xin Tang, Long Zhao, Haoxiang Wang, Aijun Peng, Chao You, Aiping Tong, Liangxue Zhou
Intraventricular hemorrhage (IVH) is a subtype of intracerebral hemorrhage (ICH) with high morbidity and mortality. Posthemorrhagic hydrocephalus (PHH) is a common and major complication that affects prognosis, but the mechanism is still unclear. Inflammation and fibrosis have been well established as the major causes of PHH after IVH. In this study, we aimed to investigate the effects of metformin on IVH in adult male mice and further explored the underlying molecular mechanisms of these effects. In the acute phase, metformin treatment exerted dose-dependent neuroprotective effects by reducing periependymal apoptosis and neuronal degeneration and decreasing brain edema...
July 19, 2022: Translational Stroke Research
https://read.qxmd.com/read/35796227/anti-oxidant-effect-of-metformin-through-ampk-sirt1-pgc-1%C3%AE-sirt3-independent-gpx1-expression-in-the-heart-of-mice-with-endometriosis
#40
JOURNAL ARTICLE
Rodrigo Felgueiras, Ana C Neto, Adriana R Rodrigues, Alexandra M Gouveia, Henrique Almeida, Delminda Neves
OBJECTIVES: Endometriosis is a gynecological disease associated with an imbalance between oxidative species production and anti-oxidative defenses. In women, endometriosis has been reported to associate with increased incidence of cardiovascular events. As such, this study aimed to analyze the oxidation-responsive AMPK/SIRT1/PGC-1α/SIRT3 pathway in the heart of a mouse model of endometriosis. The effect of metformin, an insulin-sensitizing and anti-oxidative drug with already shown positive results in endometriotic tissue was studied...
July 7, 2022: Hormone Molecular Biology and Clinical Investigation
keyword
keyword
72002
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.