keyword
https://read.qxmd.com/read/38417906/metformin-attenuates-manganese-induced-oxidative-stress-in-n27-a-dopaminergic-neuronal-cells
#1
JOURNAL ARTICLE
Jae-Sung Kim, Jeong-Yeon Seo, Kyeong-Rok Kang, HyangI Lim, Do Kyung Kim, Hong Sung Chun
Metformin is an anti-diabetic drug that exerts protective effects against neurodegenerative diseases. In this study, we investigated the protective effects of metformin against manganese (Mn)-induced cytotoxicity associated with Parkinson's disease-like symptoms in N27-A dopaminergic (DA) cells. Metformin (0.1-1 mM) suppressed Mn (0.4 mM)-induced cell death in a concentration-dependent manner. Metformin pretreatment effectively suppressed the Mn-mediated increase in the levels of oxidative stress markers, such as reactive oxygen species (ROS) and thiobarbituric acid reactive substances...
2024: Biological & Pharmaceutical Bulletin
https://read.qxmd.com/read/38345758/metformin-protects-against-acute-kidney-injury-induced-by-lipopolysaccharide-via-up-regulating-the-mcpip1-sirt1-pathway
#2
JOURNAL ARTICLE
Wen-Long Zhang, Long-Jun Zhang, Piao Liang, Hui-Long Fang, Xiao-Li Wang, Yan-Juan Liu, Hua-Fei Deng
In the present study, we aimed to explore the effect and underlying mechanism of metformin on lipopolysaccharide (LPS)-induced acute kidney injury (AKI). A total of 24 BALB/C mice were randomly divided into four groups: control group, LPS group and metformin group (50 or 100 mg/kg). The histological changes and cell apoptosis in kidney tissues were detected by hematoxylin-eosin staining and terminal-deoxynucleotidyl transferase-mediated nick end labeling assay, respectively. Enzyme-linked immunosorbent assay was applied to determine serum levels of blood urea nitrogen (BUN), kidney injury molecule-1 (Kim-1), creatinine (Cre), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)...
February 12, 2024: Biochemical Genetics
https://read.qxmd.com/read/38301977/met-exo-attenuates-mitochondrial-dysfunction-after-hepatic-ischemia-reperfusion-injury-in-rats-by-modulating-ampk-sirt1-signaling-pathway
#3
JOURNAL ARTICLE
Chenxi Piao, Yue Wang, Xiangyu Lu, Tao Liu, Yajun Ma, Yuepeng Li, Jiantao Zhang, Hongbin Wang
Hepatic ischemia-reperfusion injury (IRI) results in significant postoperative liver dysfunction, and the intricate mechanism of IRI poses challenges in developing effective therapeutic drugs. Mitigating the damage caused by hepatic IRI and promoting the repair of postoperative liver injury have become focal points in recent years, holding crucial clinical significance. Adipose mesenchymal stem cell derived exosomes (ADSCs-Exo) and metformin (Met) can play a mitochondrial protective role in the treatment of hepatic IRI, but whether there is a synergistic mechanism for their intervention is not yet known...
January 30, 2024: Free Radical Biology & Medicine
https://read.qxmd.com/read/38270305/metformin-inhibits-high-glucose-induced-apoptosis-of-renal-podocyte-through-regulating-mir-34a-sirt1-axis
#4
JOURNAL ARTICLE
Xudong Zhuang, Zhuye Sun, Huasheng Du, Tianhui Zhou, Jing Zou, Wei Fu
BACKGROUND: Previous studies have reported SIRT1 was inversely modulated by miR-34a, However, mechanism of metformin (MFN)'s renal podocyte protection under high glucose (HG) conditions and the connection between miR-34a and SIRT1 expression in diabetic nephropathy (DN) remain unclear. METHOD: We aimed to further elucidate the role of miR-34a in HG-treated podocytes in DN. A conditionally immortalized human podocyte cell line was cultivated in d-glucose (30 mM)...
January 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38255232/anti-aging-drugs-and-the-related-signal-pathways
#5
REVIEW
Nannan Du, Ruigang Yang, Shengrong Jiang, Zubiao Niu, Wenzhao Zhou, Chenyu Liu, Lihua Gao, Qiang Sun
Aging is a multifactorial biological process involving chronic diseases that manifest from the molecular level to the systemic level. From its inception to 31 May 2022, this study searched the PubMed, Web of Science, EBSCO, and Cochrane library databases to identify relevant research from 15,983 articles. Multiple approaches have been employed to combat aging, such as dietary restriction (DR), exercise, exchanging circulating factors, gene therapy, and anti-aging drugs. Among them, anti-aging drugs are advantageous in their ease of adherence and wide prevalence...
January 8, 2024: Biomedicines
https://read.qxmd.com/read/38228655/metformin-protects-ovarian-granulosa-cells-in-chemotherapy-induced-premature-ovarian-failure-mice-through-ampk-ppar-%C3%AE-sirt1-pathway
#6
JOURNAL ARTICLE
Yuxin Yang, Xiangting Tang, Ting Yao, Yiqing Zhang, Yufei Zhong, Shuqing Wu, Yurou Wang, Zezheng Pan
Premature ovarian failure (POF) caused by chemotherapy is a growing concern for female reproductive health. The use of metformin (MET), which has anti-oxidative and anti-inflammatory effects, in the treatment of POF damaged by chemotherapy drugs remains unclear. In this study, we investigated the impact of MET on POF caused by cyclophosphamide (CTX) combined with busulfan (BUS) and M1 macrophages using POF model mice and primary granule cells (GCs). Our findings demonstrate that intragastric administration of MET ameliorates ovarian damage and alleviates hormonal disruption in chemotherapy-induced POF mice...
January 16, 2024: Scientific Reports
https://read.qxmd.com/read/38116565/hepatic-steatosis-alleviated-by-a-novel-metformin-and-quercetin-combination-activating-autophagy-through-the-camp-ampk-sirt1-pathway
#7
JOURNAL ARTICLE
Havva Afshari, Shokoofe Noori, Afshin Zarghi
Non-alcoholic fatty liver disease (NAFLD) incidence and prevalence are rapidly increasing globally. The combined effects of metformin and quercetin (Que) have yet to be investigated. However, both have demonstrated the potential to reduce triglyceride (TG) levels and treat NAFLD by promoting autophagy. The objective of the present study was to elucidate the mechanism of action and assess the role of autophagy in the lipid-lowering effects of Que, both individually and in combination with metformin, in a HepG2 cell model of hepatic steatosis...
2023: Iranian Journal of Pharmaceutical Research: IJPR
https://read.qxmd.com/read/38079523/bnc1-deficiency-induces-mitochondrial-dysfunction-triggered-spermatogonia-apoptosis-through-the-creb-sirt1-foxo3-pathway-the-therapeutic-potential-of-nicotinamide-riboside-and-metformin
#8
JOURNAL ARTICLE
Feida Ni, Feixia Wang, Jingyi Li, Yifeng Liu, Xiao Sun, Jianpeng Chen, Jiaqun Li, Yanye Zhang, Jiani Jin, Xiaohang Ye, Mixue Tu, Jianhua Chen, Chuan Chen, Dan Zhang
Male infertility is a global health problem that disturbs numerous couples worldwide. Basonuclin 1 (BNC1) is a transcription factor mainly expressed in proliferative keratinocytes and germ cells. A frameshift mutation of BNC1 was identified in a large Chinese primary ovarian insufficiency pedigree. The expression of BNC1 was significantly decreased in the testis biopsies of infertile patients with nonobstructive azoospermia. Previous studies have revealed that mice with BNC1 deficiency are generally subfertile and undergo gradual spermatogenic failure...
December 11, 2023: Biology of Reproduction
https://read.qxmd.com/read/38070792/sirt1-srebps-mediated-regulation-of-lipid-metabolism
#9
REVIEW
Shan Shen, Mingyang Shen, Lirun Kuang, Keyu Yang, Shiran Wu, Xinde Liu, Yuting Wang, Yong Wang
Sirtuins, also called silent information regulator 2, are enzymes that rely on nicotinamide adenine dinucleotide (NAD+) to function as histone deacetylases. Further investigation is warranted to explore the advantageous impacts of Sirtuin 1 (SIRT1), a constituent of the sirtuin group, on lipid metabolism, in addition to its well-researched involvement in extending lifespan. The regulation of gene expression has been extensively linked to SIRT1. Sterol regulatory element-binding protein (SREBP) is a substrate of SIRT1 that has attracted significant interest due to its role in multiple cellular processes including cell cycle regulation, DNA damage repair, and metabolic functions...
December 7, 2023: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/37985173/sglt-2-inhibitors-enhance-the-effect-of-metformin-to-ameliorate-hormonal-changes-and-inflammatory-markers-in-a-rat-pcos-model
#10
JOURNAL ARTICLE
Manal Moustafa Mahmoud, Laila Ahmed Rashed, Somia Abdulatif Soliman, Safaa Mostafa Sayed, Omneya Kamel, Samaa Samir Kamar, Rania El Sayed Hussien
Polycystic ovary syndrome (PCOS) is a common endocrine, reproductive, and metabolic disorder affecting females. The management of PCOS is challenging and current interventions are not enough to deal with all consequences of this syndrome. We explored the beneficial effect of combined sodium glucose co transporter-2 inhibitor (SGLT-2i); (empagliflozin) and metformin on hormonal and metabolic parameters in an animal model of PCOS and insulin resistance (IR). Forty adult female Wistar rats divided into five groups: control, PCOS-IR, PCOS-IR treated with metformin, PCOS-IR treated with empagliflozin, and PCOS-IR treated with combined metformin and empagliflozin...
November 2023: Physiological Reports
https://read.qxmd.com/read/37968424/therapeutic-efficacies-of-mitochondria-targeted-esculetin-and-metformin-in-the-improvement-of-age-associated-atherosclerosis-via-regulating-ampk-activation
#11
JOURNAL ARTICLE
Sriravali Pulipaka, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Rajamannar Thennati, Srigiridhar Kotamraju
Atherosclerosis, in general, is an age-associated cardiovascular disease wherein a progressive decline in mitochondrial function due to aging majorly contributes to the disease development. Mitochondria-derived ROS due to dysregulated endothelial cell function accentuates the progression of atherosclerotic plaque formation. To circumvent this, mitochondrially targeted antioxidants are emerging as potential candidates to combat metabolic abnormalities. Recently, we synthesized an alkyl TPP+ tagged esculetin (Mito-Esc), and in the current study, we investigated the therapeutic efficacies of Mito-Esc and metformin, a well-known anti-diabetic drug, in the amelioration of age-associated plaque formation in the aortas of 12 months aged Apoe-/- and 20 months aged C57BL/6 mice, in comparison to young C57BL/6 control mice...
November 16, 2023: GeroScience
https://read.qxmd.com/read/37816397/dapagliflozin-and-metformin-in-combination-ameliorates-diabetic-nephropathy-by-suppressing-oxidative-stress-inflammation-and-apoptosis-and-activating-autophagy-in-diabetic-rats
#12
JOURNAL ARTICLE
Krit Jaikumkao, Laongdao Thongnak, Khin Thandar Htun, Nattavadee Pengrattanachot, Nichakorn Phengpol, Prempree Sutthasupha, Sasivimon Promsan, Napatsorn Montha, Sompong Sriburee, Suchart Kothan, Anusorn Lungkaphin
Considering the effects of sodium-glucose cotransporter inhibitors and metformin on the kidneys, a combination of both agents is postulated to provide protection against diabetic nephropathy (DN). We examined the potential protective effects of dapagliflozin, metformin, and their combination on kidney injury in rats with type 2 diabetes. Diabetic (DM) rats were administered dapagliflozin (1.0 mg/kg/day), metformin (100 mg/kg/day), or a combination (dapagliflozin 0.5 mg/kg/day plus metformin 50 mg/kg/day) by oral gavage for 4 weeks...
October 8, 2023: Biochimica et Biophysica Acta. Molecular Basis of Disease
https://read.qxmd.com/read/37796743/cd74-deficiency-reduces-trophoblast-invasion-and-proliferation-mediated-by-sirt1-in-preeclampsia
#13
JOURNAL ARTICLE
Zhenzhen Liu, Jiangnan Pei, Xiaoyue Zhang, Chengjie Wang, Yao Tang, Haiyan Liu, Yi Yu, Shouling Luo, Weirong Gu
Preeclampsia (PE) is a severe hypertensive disorder during pregnancy, and one of the causes is the dysfunction of extravillous trophoblast cells (EVTs). In this study, we analyzed single-cell RNA sequencing (scRNA-seq) data of placentas from PE patients and the sirtuin 1 (SIRT1) heterozygous knockout mouse model, which exhibited typical PE-like symptoms. We identified 134 differentially expressed genes (DEGs) with similar trends in EVTs of PE patients and in parietal trophoblast giant cells (P-TGCs) of Sirt1-/- (HO) placentas from Sirt1+/- (HE) pregnant mice...
October 1, 2023: Reproduction
https://read.qxmd.com/read/37780174/exploring-the-mechanism-of-metformin-action-in-alzheimer-s-disease-and-type-2-diabetes-based-on-network-pharmacology-molecular-docking-and-molecular-dynamic-simulation
#14
JOURNAL ARTICLE
Xin Shi, Lingling Li, Zhiyao Liu, Fangqi Wang, Hailiang Huang
BACKGROUND: Metformin, which has been shown to be highly effective in treating type 2 diabetes (T2D), is also believed to be valuable for Alzheimer's disease (AD). Computer simulation techniques have emerged as an innovative approach to explore mechanisms. OBJECTIVE: To study the potential mechanism of metformin action in AD and T2D. METHODS: The chemical structure of metformin was obtained from PubChem. The targets of metformin were obtained from PubChem, Pharm Mapper, Batman, SwissTargetPrediction, DrugBank, and PubMed...
2023: Therapeutic Advances in Endocrinology and Metabolism
https://read.qxmd.com/read/37735113/metformin-ameliorates-postoperative-cognitive-dysfunction-through-regulation-of-the-ampk-sirt1-pathway
#15
JOURNAL ARTICLE
Peiyu Jia, Ji Che, Junfeng Zhang, Haibing Li, Quanhong Zhou, Yong Guo
BACKGROUND: Postoperative cognitive dysfunction (POCD) is a common postoperative complication in elderly patients. The purpose of this study was to investigate the mechanism through which metformin improves postoperative cognitive function. METHODS: In the in vivo experiment, 18-month-old Sprague-Dawley (SD) rats were randomly divided into four groups (n = 12 in each group): the control, metformin, operation, and operation plus metformin groups. The animals were pretreated with metformin by gavage once daily for two weeks...
August 9, 2023: Journal of Integrative Neuroscience
https://read.qxmd.com/read/37723077/gallic-acid-improves-the-metformin-effects-on-diabetic-kidney-disease-in-mice
#16
JOURNAL ARTICLE
Yan Hong, Jidong Wang, Wenjuan Sun, Lai Zhang, Xuefang Xu, Kaiyue Zhang
OBJECTIVES: Metformin is an antidiabetic agent that is used as the first-line treatment of type 2 diabetes mellitus. Gallic acid is a type of phenolic acid that has been shown to be a potential drug candidate to treat diabetic kidney disease, an important complication of diabetes. We aimed to test whether a combination of gallic acid and metformin can exert synergetic effect on diabetic kidney disease in diabetic mice model. METHODS: Streptozotocin (65 mg/kg) intraperitoneal injection was used to induce diabetic kidney disease in mice...
December 2023: Renal Failure
https://read.qxmd.com/read/37644328/metformin-protects-human-lens-epithelial-cells-from-high-glucose-induced-senescence-and-autophagy-inhibition-by-upregulating-sirt1
#17
JOURNAL ARTICLE
Yushan Fu, Ruitong Wu, Su Dong, Jianfeng Chen, Nan Zhou
PURPOSE: The aim of this study is to explore whether metformin (MET) protects the human lens epithelial cells (HLECs) from high glucose-induced senescence and to identify the underlying mechanisms. METHODS: A cellular senescence model was established by treating HLE-B3 cells with D-glucose and then intervened with MET. Concentrations of high glucose (HG) and MET were detected using CCK-8 and western blot. qRT-PCR, western blot, and senescence-associated β-galactosidase (SA-β-gal) were performed to verify the protective effect of MET on senescent HLE-B3 cells...
August 30, 2023: Graefe's Archive for Clinical and Experimental Ophthalmology
https://read.qxmd.com/read/37597099/mir-601-induced-bmscs-senescence-accelerates-steroid-induced-osteonecrosis-of-the-femoral-head-progression-by-targeting-sirt1
#18
JOURNAL ARTICLE
Boyu Tang, Yu Chen, Pei Zhao, Wenlong Yan, Xiao Huang, Weiqian Jiang, Mingjie Sun, Hongrui Zhang, Dulei Xiang, Tingmei Chen, Chengjie Lian, Jian Zhang
BACKGROUND: The imbalance between osteogenic and adipogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) is not only the primary pathological feature but also a major contributor to the pathogenesis of steroid-induced osteonecrosis of the femoral head (SONFH). Cellular senescence is one of the main causes of imbalanced BMSCs differentiation. The purpose of this study was to reveal whether cellular senescence could participate in the progression of SONFH and the related mechanisms...
August 19, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37581324/salvia-officinalis-improves-glucose-uptake-and-suppresses-ectopic-lipid-deposition-in-obese-rats-with-metabolic-syndrome
#19
JOURNAL ARTICLE
Diana A ALsherif, Mohammed A Hussein, Suzan S Abuelkasem, Soha A Hassan, Michael Wink
OBJECTIVES: Obesity is regarded as the main cause of metabolic diseases and a core factor for all-cause mortality in the general population, notably from cardiovascular disease. The majority of people with type 2 diabetes have obesity and insulin resistance. Some evidence indicates that an individual with obesity is approximately 10 times more likely to develop type 2 diabetes than someone with moderate body weight. One of the most significant therapeutic herbs, Salvia officinalis (Lamiaceae) (SAGE), possesses potent medicinal importance...
August 11, 2023: Current Pharmaceutical Biotechnology
https://read.qxmd.com/read/37478963/pterostilbene-ameliorates-type-2-diabetes-mellitus-induced-depressive-like-behavior-by-mitigating-insulin-resistance-inflammation-and-ameliorating-hpa-axis-dysfunction-in-rat-brain
#20
JOURNAL ARTICLE
Rashmi Patil, Urmila Aswar, Nishant Vyas
One of the most serious mental health comorbidities associated with diabetes mellitus is depression. The occurrence is almost double in type 2 diabetes mellitus (T2DM) compared with the general population. Pterostilbene (PTE), a dimethylated analog of resveratrol, has been reported for significant neuroprotective, anti-inflammatory, hypolipidemic, hypoglycaemic and antioxidant effects. However, its effect on diabetes-induced depression-like behavior (DID) has not been studied. The current study aimed at studying the effects of PTE on depressive-like behavior in male Wistar rats with T2DM...
July 20, 2023: Brain Research
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