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https://www.readbyqxmd.com/read/27404487/fast-track-endovascular-aortic-repair-interim-report-from-the-prospective-life-registry
#1
Zvonimir Krajcer, Venkatesh G Ramaiah, Meredith Huetter, Larry E Miller
OBJECTIVE: To assess the feasibility, safety, and clinical utility of a fast-track endovascular aneurysm repair (EVAR) protocol. BACKGROUND: Despite recent advances in EVAR technology and techniques, considerable opportunity exists to further improve EVAR efficiency and outcomes. METHODS: Eligible patients underwent elective EVAR with the Ovation Prime stent graft. Successful completion of the fast-track protocol required bilateral percutaneous access, avoidance of general anesthesia and intensive care unit admission, and next-day discharge...
July 12, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27327216/women-and-men-derive-comparable-benefits-with-an-ultra-low-profile-endograft-1-year-results-of-the-european-ovation-registry
#2
Martin Storck, Thomas Nolte, Matthias Tenholt, Lieven Maene, Geert Maleux, Dierk Scheinert
BACKGROUND: Female patients are underrepresented in most stentgraft (EVAR) trials due to a reduced anatomical eligibility for endovascular treatment. The purpose of this analysis was to determine the performance of the Ovation® and Ovation Prime® stent graft in women versus men for elective abdominal aortic aneurysm (AAA) repair. METHODS: From May 2011 to December 2013, 501 patients (86% men, mean age 73 yr) from 30 sites were prospectively enrolled in the OVATION Registry and electively treated with endovascular aneurysm repair...
June 21, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/26685936/fast-track-endovascular-aneurysm-repair-rationale-and-design-of-the-multicenter-least-invasive-fast-track-evar-life-registry
#3
Zvonimir Krajcer, Venkatesh Ramaiah, Meredith Huetter
BACKGROUND: Considerable technological advancements have recently been made with endovascular stent grafts for the treatment of abdominal aortic aneurysm (AAA). However, there is opportunity to further improve the efficiency of endovascular aneurysm repair (EVAR), which may yield better patient outcomes and lower perioperative treatment costs. METHODS/DESIGN: The Least Invasive Fast-Track EVAR (LIFE) registry was developed to determine the clinical utility and cost effectiveness of the Ovation® Prime stent graft when used under least invasive conditions using a defined fast-track protocol...
2015: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/25592276/trivascular-ovation%C3%A2-it-s-role-in-solving-current-endograft-deficiencies
#4
EDITORIAL
Z Krajcer
Endovascular aneurysm repair (EVAR) techniques and technologies have rapidly advanced over the last two decades. The basic premise of EVAR is to durably exclude flow from the aneurysmal sac without exerting untoward effects on the non-diseased anatomy by using minimally invasive surgical techniques. However, these fundamental components have not yet been perfected with traditional stent grafts and remain important areas for further EVAR refinement. Latest-generation stent grafts are in development to accommodate these therapeutic goals...
June 2015: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/25077492/a-comparison-of-sperm-rna-seq-methods
#5
COMPARATIVE STUDY
Shihong Mao, Edward Sendler, Robert J Goodrich, Russ Hauser, Stephen A Krawetz
A significant challenge to the effective application of RNA-seq to the complete transcript analysis of low quantity and/or degraded samples is the amplification of minimal input RNA to enable sequencing library construction. Several strategies have been commercialized in order to facilitate this goal. However, each strategy has its own specific protocols and methodology, and each may introduce unique bias and in some cases show specific preference for a collection of sequences. Our wider investigation of human spermatozoal RNAs was able to reveal their complexity despite being generally characterized by low quantity and high fragmentation...
October 2014: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/24619891/open-conversion-after-endovascular-aortic-aneurysm-repair-with-the-ovation-prime%C3%A2-endograft
#6
George S Georgiadis, Dimitrios Charalampidis, Efstratios I Georgakarakos, George A Antoniou, George Trellopoulos, Theodosia Vogiatzaki, Miltos K Lazarides
Advances in abdominal aortic aneurysm (AAA) endograft device technology have contributed to improved outcomes and durability of endovascular aortic aneurysm repair (EVAR), even in complex infrarenal aortic anatomies. However, stent graft failure secondary to endoleaks, migration, endotension and sac enlargement are persistent problems that can result in aneurysm rupture following EVAR.A symptomatic infrarenal AAA (4mm proximal neck) was treated initially with an Ovation Prime™ device (TriVascular, Inc., Santa Rosa, CA) in an off-label fashion, leading to type Ia endoleak moderately reduced by additional proximal neck ballooning...
February 2014: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/24356044/ultra-low-profile-ovation-device-is-it-the-definitive-solution-for-evar
#7
REVIEW
G de Donato, F Setacci, P Sirignano, G Galzerano, M P Borrelli, L di Marzo, C Setacci
When Juan Parodi implanted an endograft in a human body for the first time on September 7, 1990 in Buenos Aires, Argentina, the delivery system of the handmade device was primitive, extremely rigid, and had a bulky profile of 27 French (F). Since then, stent-graft technology has evolved rapidly, limitations of earlier-generation devices have been overtaken, and endovascular aneurysm repair (EVAR) eligibility has increased enormously. Nevertheless (still) challenging aortoiliac anatomy such as short and complex proximal aortic neck seal zones and narrow access vessels are responsible for EVAR ineligibility in up to 50% of cases...
February 2014: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/21743826/gene-expression-profiles-from-peripheral-blood-mononuclear-cells-are-sensitive-to-short-processing-delays
#8
Michael G Barnes, Alexei A Grom, Thomas A Griffin, Robert A Colbert, Susan D Thompson
In the analysis of peripheral blood gene expression, timely processing of samples is essential to ensure that measurements reflect in vivo biology, rather than ex vivo sample processing variables. The effect of processing delays on global gene expression patterns in peripheral blood mononuclear cells (PBMCs) was assessed by isolating and stabilizing PBMC-derived RNA from 3 individuals either immediately after phlebotomy or after a 4 h delay. RNA was labeled using NuGEN Ovation labeling and probed using the Affymetrix HG U133 Plus 2...
September 29, 2010: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/20690647/peptidyl-alpha-ketoamides-with-nucleobases-methylpiperazine-and-dimethylaminoalkyl-substituents-as-calpain-inhibitors
#9
Asli Ovat, Zhao Zhao Li, Christina Y Hampton, Seneshaw A Asress, Facundo M Fernández, Jonathan D Glass, James C Powers
A series of peptidyl alpha-ketoamides with the general structure Cbz-L-Leu-D,L-AA-CONH-R were synthesized and evaluated as inhibitors for the cysteine proteases calpain I, calpain II, and cathepsin B. Nucleobases, methylpiperazine, and dimethylaminoalkyl groups were incorporated into the primed region of the inhibitors to generate compounds that potentially cross the blood-brain barrier. Two of these compounds (Cbz-Leu-D,L-Abu-CONH-(CH(2))(3)-adenin-9-yl and Cbz-Leu-D,L-Abu-CONH-(CH(2))(3)-(4-methylpiperazin-1-yl) have been shown to have useful concentrations in the brain in animals...
September 9, 2010: Journal of Medicinal Chemistry
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