keyword
MENU ▼
Read by QxMD icon Read
search

TTP

keyword
https://www.readbyqxmd.com/read/29143276/long-term-impact-of-temozolomide-on-1p-19q-codeleted-low-grade-glioma-growth-kinetics
#1
C Izquierdo, A Alentorn, A Idbaih, M Simó, G Kaloshi, D Ricard, M Barritault, D Meyronet, J Bruna, J Honnorat, J Y Delattre, F Ducray
Although upfront temozolomide (TMZ) has been widely-used to treat 1p/19q-codeleted diffuse low-grade gliomas (LGG), its long-term impact on the growth kinetics of these tumors has not been determined. Based on serial magnetic resonance images we retrospectively evaluated the evolution of the mean tumor diameter (MTD) in 36 progressive 1p/19q-codeleted LGG treated with upfront TMZ. After TMZ onset, all but two patients (94.4%) presented a progressive MTD decrease that lasted for a median duration of 23 months (range 3-114)...
November 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29138529/matrix-metalloproteinases-polymorphisms-as-prognostic-biomarkers-in-malignant-pleural-mesothelioma
#2
Danijela Štrbac, Katja Goričar, Vita Dolžan, Viljem Kovač
Background: Malignant pleural mesothelioma (MPM) is a rare disease with a relatively short overall survival (OS). Metalloproteinases (MMPs) have a vast biological effect on tumor progression, invasion, metastasis formation, and apoptosis. MMP expression was previously associated with survival in MPM. Our aim was to evaluate if genetic variability of MMP genes could also serve as a prognostic biomarker in MPM. Methods: We genotyped 199 MPM patients for ten polymorphisms: rs243865, rs243849 and rs7201, in MMP2; rs17576, rs17577, rs20544, and rs2250889 in MMP9; and rs1042703, rs1042704, and rs743257 in MMP14...
2017: Disease Markers
https://www.readbyqxmd.com/read/29138453/the-prognostic-value-of-agr2-expression-in-solid-tumours-a-systematic-review-and-meta-analysis
#3
Shao-Bo Tian, Kai-Xiong Tao, Jia Hu, Zhi-Bo Liu, Xue-Liang Ding, Ya-Nan Chu, Jin-Yuan Cui, Xiao-Ming Shuai, Jin-Bo Gao, Kai-Lin Cai, Ji-Liang Wang, Guo-Bin Wang, Lin Wang, Zheng Wang
The prognostic value of anterior gradient-2 (AGR2) in tumours remains inconclusive. Here, we systematically reviewed the literature evidence and assessed the association between AGR2 expression and prognosis in solid tumours. The primary outcomes were overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS)/recurrence-free survival (RFS)/progression-free survival (PFS). All analyses were performed by STATA 12.0, with the hazard ratio (HR) or odds ratios (OR), and 95% confidence interval (CI) as the effect size estimate...
November 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29138385/parameters-for-contrast-enhanced-ultrasound-ceus-of-enlarged-superficial-lymph-nodes-for-the-evaluation-of-therapeutic-response-in-lymphoma-a-preliminary-study
#4
Lei Xin, Zhimei Yan, Xiaojuan Zhang, Yichen Zang, Zhaoyan Ding, Hongwei Xue, Cheng Zhao
BACKGROUND The aims of this preliminary study were to evaluate contrast-enhanced ultrasound (CEUS) imaging and the therapeutic response of enlarged superficial lymph nodes in patients with lymphoma before and after chemotherapy and to determine the most useful CEUS response parameters. MATERIAL AND METHODS Forty-three patients with lymphoma, with 43 enlarged superficial lymph nodes, underwent CEUS and conventional ultrasound (US), before treatment and after the first three cycles of chemotherapy. Clinical responses included overall response (OR) and no response (NR)...
November 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29130141/sj%C3%A3-gren-s-syndrome-initially-presented-as-thrombotic-thrombocytopenic-purpura-in-a-male-patient-a-case-report-and-literature-review
#5
REVIEW
Xiaohan Xu, Tienan Zhu, Di Wu, Lu Zhang
Thrombotic thrombocytopenic purpura (TTP) is a potentially lethal multisystem disorder which could be caused by autoimmune diseases. However, the concomitant occurrence of TTP and Sjögren's syndrome (SS) is an extremely uncommon scenario, especially in male patients. A 56-year-old Chinese male was admitted for the appearance of diffuse ecchymosis. Then he gradually developed transient slurred speech, progressive confusion, agitation, extremity weakness, and fever. Laboratory investigations suggested anemia, thrombocytopenia, significantly increased lactic dehydrogenase, schistocytes in peripheral blood smear, and a disintegrin-like metalloproteinase with thrombospondin motif type 1 member 13 (ADAMTS13) activity deficiency with high inhibitor titers...
November 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29128684/mapk-p38-regulates-inflammatory-gene-expression-via-tristetraprolin-doing-good-by-stealth
#6
J D O'Neil, A J Ammit, A R Clark
Tristetraprolin (TTP) is an RNA-destabilizing protein that exerts profound anti-inflammatory effects by inhibiting the expression of tumour necrosis factor and many other inflammatory mediators. The mitogen-activated protein kinase (MAPK) p38 signaling pathway controls the strength and duration of inflammatory responses by regulating both the expression and function of TTP. The kinase MK2 (MAPK activated kinase 2) is activated by MAPK p38, and in turn phosphorylates TTP at two critical serine residues. One consequence of these phosphorylations is the protection of TTP from proteasome-mediated degradation...
November 8, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29126395/contrast-enhanced-ultrasound-of-small-cell-carcinoma-in-urinary-bladder-a-case-report-and-review-of-literature
#7
Meixiang Zhang, Chengcheng Niu, Ming Zhang, Qinghai Peng, Minzhi Ouyang
BACKGROUND: Small cell carcinoma of the urinary bladder (SCCB) is a relatively rare malignant bladder tumor, and few reports have investigated the microvasculature of SCCB imaged using contrast-enhanced ultrasound (CEUS). CASE PRESENTATION: A 63-year-old female was admitted to our hospital after experiencing painless gross hematuria for one week. The gray-scale ultrasound (US) demonstrated a 4.8 × 3.4 × 3.6-cm(3) hypoechoic mass in the apex of the urinary bladder with a wide base and an irregular surface; the mass did not move with changes in body position...
November 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29124894/combined-transcatheter-arterial-chemoembolization-and-radiofrequency-ablation-in-single-session-for-solitary-hepatocellular-carcinoma-larger-than-7%C3%A2-cm
#8
Jie-Yu Yan, Jin-Long Zhang, Mao-Qiang Wang, Kai Yuan, Yan-Hua Bai, Yan Wang, Hai-Nan Xin, Zhi-Jun Wang, Feng-Yong Liu, Feng Duan, Jin-Xin Fu
AIMS: To evaluate technical feasibility and treatment results of combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) in single-session for solitary hepatocellular carcinoma (HCC) larger than 7 cm in diameter. METHODS: Institutional review board approved this retrospective study. Written informed consent was obtained from all patients. Between June 2007 and July 2013, 87 patients (75 men, 12 women; mean age, 55.5 years ± 15...
November 10, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29124560/maintenance-treatment-using-the-purine-synthesis-inhibitor-mizoribine-in-a-patient-with-relapsing-thrombotic-thrombocytopenic-purpura
#9
Tetsuya Kawamura, Joichi Usui, Kei Nagai, Kentaro Sakai, Itaru Ebihara, Kunihiro Yamagata
Thrombotic thrombocytopenic purpura (TTP) is a rare but life-threatening disease. Although plasma exchange (PE) therapy and corticosteroids are standard remission induction and maintenance therapies, some patients are easily refractory and frequently relapse under treatment with this therapy, and require additional treatment. However, there are limited data about additional treatment interventions. We report a case of 56-year-old man who was hospitalized for fever, general fatigue and hemoglobinuria. Owing to the symptoms and the laboratory findings of hemolysis, he was diagnosed with TTP...
November 9, 2017: CEN Case Reports
https://www.readbyqxmd.com/read/29124478/the-role-of-rna-binding-protein-tristetraprolin-in-cancer-and-immunity
#10
REVIEW
Jian Guo, Huiheng Qu, Ye Chen, Jiazeng Xia
RNA-binding protein tristetraprolin (TTP) plays a fundamental role in various physiological and pathological processes including differentiation, reprogramming, metabolism, proliferation, pluripotency, tumorigenesis and immunity. Due to its ability to bind and target ARE-containing mRNAs for rapid degradation, TTP down-regulates the expression of a mass of critical genes, thereby functioning as cancer suppressor gene. The loss of TTP has been reported in several human cancers and is relevant to poor prognosis...
November 9, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29121438/platelet-rescue-by-macrophage-depletion-in-obese-adamts13-deficient-mice-at-risk-for-thrombotic-thrombocytopenic-purpura
#11
Lotte Geys, Elien Roose, Ilse Scroyen, Hanspeter Rottensteiner, Claudia Tersteeg, Marc F Hoylaerts, Karen Vanhoorelbeke, H Roger Lijnen
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is caused by the absence of ADAMTS13 activity. Thrombocytopenia is presumably related to the formation of microthrombi rich in von Willebrand Factor (VWF) and platelets. Obesity may be a risk factor for TTP; it is associated with abundance of macrophages that may phagocytose platelets. OBJECTIVES: To evaluate the role of obesity and ADAMTS13 deficiency in TTP, and to establish whether macrophages contribute to thrombocytopenia...
November 9, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29118793/feasibility-of-real-time-angiographic-perfusion-imaging-in-the-treatment-of-cerebral-vasospasm
#12
Christopher Donaldson, Anthea H O'Neill, Lee-Anne Slater, Winston Chong, Leon T Lai, Ronil V Chandra
Background: Objective assessment and quantification of the severity of cerebral vasospasm following aneurysmal subarachnoid hemorrhage is not routinely utilized. We investigated the feasibility of angiographic perfusion imaging derived from digital subtraction angiography (DSA) following endovascular vasospasm treatment procedures. Methodology: Real-time blood flow analysis was performed using parametric color coding on pre- and postintervention DSA. Semiquantitative parenchymal perfusion parameters (arrival time [AT] of contrast, time to peak [TTP] opacification, and mean transit time [MTT] of contrast) were calculated across 3 vascular territories (anterior cerebral artery [ACA], middle cerebral artery [MCA], and lenticulostriate arteries) using standard 2-D angiographic perfusion software...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29113370/serum-insulin-like-growth-factor-1-and-its-binding-protein-3-as-prognostic-factors-for-the-incidence-progression-and-outcome-of-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#13
Jing Wang, Yu-Chuan Li, Min Deng, Hai-Yin Jiang, Li-Hua Guo, Wen-Juan Zhou, Bing Ruan
Purpose: Previous studies have supported an association between serum insulin-like growth factor-1 (IGF1) and IGF-binding protein 3 (IGFBP3) levels and hepatocellular carcinoma (HCC), but the results were inaccurate. It has recently been proposed that IGF1 and IGFBP3 play roles in the time-to-progression (TTP) and overall survival (OS) of HCC patients. Our results revealed that serum IGF1 level is predictive of the progression and survival of HCC patients. Results: HCC was associated with a significant reduction in serum IGF-1 and IGFBP-3 levels compared to cirrhosis (p = 0...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109951/rna-binding-protein-regulation-and-cross-talk-in-the-control-of-au-rich-mrna-fate
#14
REVIEW
Sofía M García-Mauriño, Francisco Rivero-Rodríguez, Alejandro Velázquez-Cruz, Marian Hernández-Vellisca, Antonio Díaz-Quintana, Miguel A De la Rosa, Irene Díaz-Moreno
mRNA metabolism is tightly orchestrated by highly-regulated RNA Binding Proteins (RBPs) that determine mRNA fate, thereby influencing multiple cellular functions across biological contexts. Here, we review the interplay between six well-known RBPs (TTP, AUF-1, KSRP, HuR, TIA-1, and TIAR) that recognize AU-rich elements (AREs) at the 3' untranslated regions of mRNAs, namely ARE-RBPs. Examples of the links between their cross-regulations and modulation of their targets are analyzed during mRNA processing, turnover, localization, and translational control...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29108428/the-effect-of-transarterial-chemoembolization-in-combination-with-kang-ai-injection-on-patients-with-intermediate-stage-hepatocellular-carcinoma-a-prospective-study
#15
Yue-Meng Wan, Yu-Hua Li, Zhi-Yuan Xu, Hua-Mei Wu, Ying Xu, Mei Yang, Xi-Nan Wu
BACKGROUND: The outcome of patients with intermediate stage hepatocellular carcinoma (HCC) treated by transarterial chemoembolization (TACE) remains poor. Search for a more effective therapy is still necessary. OBJECTIVE: This study aimed to investigate the effect of combining TACE with Kang'ai (KA) injection for treating patients with intermediate stage HCC. METHODS: A total of 89 patients with intermediate stage HCC were enrolled and divided into TACE +KA group (n = 48) receiving repeated TACE plus KA injection, and TACE group (n = 41) receiving repeated TACE alone...
October 1, 2017: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29105955/right-ventricular-systolic-function-and-mechanical-dispersion-identify-patients-with-arrhythmogenic-right-ventricular-cardiomyopathy
#16
Meriam Åström Aneq, Eva Maret, Lars Brudin, Anneli Svensson, Jan Engvall
PURPOSE: To assess right ventricular (RV) regional and global systolic function using feature tracking (FT) in patients with a definite diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC) and to investigate if changes in strain amplitude and mechanical dispersion indicate a propensity for arrhythmia. MATERIALS AND METHODS: Twenty-seven patients fulfilling Task Force Criteria for ARVC and 24 healthy volunteers underwent MR at 1·5 Tesla. Steady-state free precession cine of long-axis slices and a short-axis stack of the RV was acquired...
November 6, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29101040/rv2477c-is-an-antibiotic-sensitive-manganese-dependent-abc-f-atpase-in-mycobacterium-tuberculosis
#17
Jaiyanth Daniel, Liz Abraham, Amanda Martin, Xyryl Pablo, Shelby Reyes
The Rv2477c protein of Mycobacterium tuberculosis (Mtb) belongs to the ATP-binding cassette (ABC) subfamily F that contains proteins with tandem nucleotide-binding domains but lacking transmembrane domains. ABC-F subfamily proteins have been implicated in diverse cellular processes such as translation, antibiotic resistance, cell growth and nutrient sensing. In order to investigate the biochemical characteristics of Rv2477c, we expressed it in Escherichia coli, purified it and characterized its enzymatic functions...
October 31, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29081762/a-comparison-of-relative-time-to-peak-and-tmax-for-mismatch-based-patient-selection
#18
Anke Wouters, Søren Christensen, Matus Straka, Michael Mlynash, John Liggins, Roland Bammer, Vincent Thijs, Robin Lemmens, Gregory W Albers, Maarten G Lansberg
BACKGROUND AND PURPOSE: The perfusion-weighted imaging (PWI)/diffusion-weighted imaging (DWI) mismatch profile is used to select patients for endovascular treatment. A PWI map of Tmax is commonly used to identify tissue with critical hypoperfusion. A time to peak (TTP) map reflects similar hemodynamic properties with the added benefit that it does not require arterial input function (AIF) selection and deconvolution. We aimed to determine if TTP could substitute Tmax for mismatch categorization...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29081454/assessment-of-liver-fibrosis-by-ultrasound-elastography-and-contrast-enhanced-ultrasound-a-randomized-prospective-animal-study
#19
Tingting Qiu, Hong Wang, Jinzhen Song, Wenwu Ling, Yujun Shi, Gang Guo, Yan Luo
This study aimed to assess liver fibrosis by contrast-enhanced ultrasound (CEUS) and point shear-wave elastography (pSWE) in rabbits and compare the performance of the two techniques. Eighty rabbits were divided into experimental (n=60) and control group (n=20). In the experimental group, liver fibrosis (F1-F4) was induced by subcutaneous injection of carbon tetrachloride. CEUS and pSWE of the liver was performed for the two groups at a 4-week interval for 40 weeks. The portal vein rise time (PV-RT), time to peak (PV-TTP), mean transit time (PV-MTT) and the maximum signal intensity (PV-Imax) were analyzed with time-intensity curves (TICs)...
October 27, 2017: Experimental Animals
https://www.readbyqxmd.com/read/29080274/low-dose-ct-perfusion-with-projection-view-sharing
#20
Thomas Martin, John Hoffman, Jeff R Alger, Michael McNitt-Gray, Danny Jj Wang
PURPOSE: CT Perfusion (CTP) is a widely used clinical imaging modality. However, CTP typically involves the use of substantial radiation dose (CTDIvol ≥~200mGy). The purpose of this study is to present a low dose CTP technique using a projection view-sharing reconstruction algorithm originally developed for dynamic MRI - "K-space Weighted Image Contrast" (KWIC). METHODS: The KWIC reconstruction is based on an angle bisection scheme. In KWIC, a Fourier transform was performed along each projection to form a "k-space" like CT data space, based on the central slice theorem...
October 27, 2017: Medical Physics
keyword
keyword
7199
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"