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https://www.readbyqxmd.com/read/28630226/thyrotoxic-periodic-paralysis-as-an-initial-presentation-of-graves-disease-in-a-saudi-patient
#1
S F Alqahtani, M M Aleithan
Thyrotoxic periodic paralysis (TPP) is a well-known complication of hyperthyroidism, characterised by recurrent flaccid paralysis with hypokalaemia. To date, only five cases of this rare disorder have been reported in Saudi Arabia. Here, we report an additional case involving a 25-year-old Saudi man who presented with lower limb paralysis and severe hypokalaemia. Clinically, he showed symptoms and signs suggestive of Graves' disease, which was confirmed by laboratory investigations. Carbimazole, a beta-blocker and potassium replacement were administered, resulting in dramatic improvement of the TTP...
June 19, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28626733/the-overall-survival-of-patients-with-hepatocellular-carcinoma-correlates-with-the-newly-defined-time-to-progression-after-transarterial-chemoembolization
#2
Tadaaki Arizumi, Kazuomi Ueshima, Mina Iwanishi, Tomohiro Minami, Hirokazu Chishina, Masashi Kono, Masahiro Takita, Norihisa Yada, Satoru Hagiwara, Yasunori Minami, Hiroshi Ida, Yoriaki Komeda, Mamoru Takenaka, Toshiharu Sakurai, Tomohiro Watanabe, Naoshi Nishida, Masatoshi Kudo
AIM/BACKGROUND: The ultimate aim of any treatment for hepatocellular carcinoma (HCC) is to improve overall survival (OS); however, the clinical significance of time to progression (TTP) after transarterial chemoembolization (TACE) is unclear. This retrospective study examined the association between OS and the newly defined time to TACE progression (TTTP) to assess whether TTTP can be an alternative to OS in HCC patients with Barcelona Clinic Liver Cancer (BCLC) stage B. METHODS: Between January 2006 and December 2013, 592 patients with HCC (BCLC B1, n = 118; BCLC B2, n = 170) underwent TACE...
June 2017: Liver Cancer
https://www.readbyqxmd.com/read/28624975/deleterious-acute-and-chronic-effects-of-bradycardic-right-ventricular-apex-pacing-consequences-for-arrhythmic-outcome
#3
T R G Stams, A Dunnink, W M van Everdingen, H D M Beekman, R van der Nagel, B Kok, M F A Bierhuizen, M J Cramer, M Meine, M A Vos
In the chronic complete atrioventricular (AV) block dog (CAVB) model, both bradycardia and altered ventricular activation due to the uncontrolled idioventricular rhythm contribute to ventricular remodeling and the enhanced susceptibility to Torsade de Pointes (TdP) arrhythmias. We investigated the effect of permanent bradycardic right ventricular apex (RVA) pacing on mechanical and electrical remodeling and TdP. In 23 anesthetized dogs, serial experiments were performed at sinus rhythm (SR), acutely after AV block (AAVB) and 3 weeks of remodeling CAVB at a fixed pacing rate of 60/min...
July 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28623277/in-vivo-quantification-of-placental-insufficiency-by-bold-mri-a-human-study
#4
Jie Luo, Esra Abaci Turk, Carolina Bibbo, Borjan Gagoski, Drucilla J Roberts, Mark Vangel, Clare M Tempany-Afdhal, Carol Barnewolt, Judy Estroff, Arvind Palanisamy, William H Barth, Chloe Zera, Norberto Malpica, Polina Golland, Elfar Adalsteinsson, Julian N Robinson, Patricia Ellen Grant
Fetal health is critically dependent on placental function, especially placental transport of oxygen from mother to fetus. When fetal growth is compromised, placental insufficiency must be distinguished from modest genetic growth potential. If placental insufficiency is present, the physician must trade off the risk of prolonged fetal exposure to placental insufficiency against the risks of preterm delivery. Current ultrasound methods to evaluate the placenta are indirect and insensitive. We propose to use Blood-Oxygenation-Level-Dependent (BOLD) MRI with maternal hyperoxia to quantitatively assess mismatch in placental function in seven monozygotic twin pairs naturally matched for genetic growth potential...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28621004/epirubicin-in-the-treatment-of-canine-histiocytic-sarcoma-sequential-alternating-and-rescue-chemotherapy
#5
S L Mason, R Finotello, L Blackwood
The aims of this study were to report treatment outcomes for dogs with histiocytic sarcoma (HS) treated with both lomustine and epirubicin, and to report response rates to epirubicin as a rescue therapy in dogs previously treated with lomustine. Medical records of dogs with a diagnosis of HS that were treated with both lomustine and epirubicin were retrospectively evaluated. Of 29 dogs receiving epirubicin alternating with, or subsequent to lomustine treatment, including in a rescue setting, response to epirubicin could be assessed in 20 with an overall response rate (ORR) of 29% and biological response rate (BRR) of 71%...
June 15, 2017: Veterinary and Comparative Oncology
https://www.readbyqxmd.com/read/28619633/time-to-progression-after-first-line-tyrosine-kinase-inhibitor-predicts-survival-in-patients-with-metastatic-renal-cell-carcinoma-receiving-second-line-molecular-targeted-therapy
#6
Hiroki Ishihara, Tsunenori Kondo, Kazuhiko Yoshida, Kenji Omae, Toshio Takagi, Junpei Iizuka, Kazunari Tanabe
OBJECTIVES: The effect of response to first-line tyrosine kinase inhibitor (TKI) therapy on second-line survival in patients with metastatic renal cell carcinoma who receive second-line molecular-targeted therapy (mTT) after first-line failure remains unclear. MATERIALS AND METHODS: Sixty patients who developed disease progression after first-line TKI, without prior cytokine therapy, were enrolled. According to the median first-line time to progression (1L-TTP), patients were divided into 2 groups (i...
June 12, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28617697/evaluation-of-the-temple-touch-pro-a-novel-noninvasive-core-temperature-monitoring-system
#7
Shmuel Evron, Avi Weissman, Vadim Toivis, Dana Baron Shahaf, Jing You, Daniel I Sessler, Tiberiu Ezri
BACKGROUND: The Temple Touch Pro (TTP) is a novel system that estimates core temperature from skin over the temporal artery. We tested the hypothesis that this noninvasive system estimates core temperature to an accuracy within 0.5°C. METHODS: Core temperature was continuously monitored in 50 adult and pediatric surgical patients by positioning the sensor patch of a TTP over one temporal artery. The sensor consists of a thermistor array near the skin surface, another set of thermistors above an insulator, and a second insulator between the upper unit and the environment...
July 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28613118/initial-experience-with-a-new-quantitative-assessment-tool-for-fluorescent-imaging-in-peripheral-artery-disease
#8
Henrik Christian Rieß, Anna Duprée, Christian-Alexander Behrendt, Tilo Kölbel, Eike Sebastian Debus, Axel Larena-Avellaneda, Detlef Russ, Sabine Wipper
BACKGROUND: Perioperative evaluation in peripheral artery disease (PAD) by common vascular diagnostic tools is limited by open wounds, medial calcinosis or an altered collateral supply of the foot. Indocyanine green fluorescent imaging (ICG-FI) has recently been introduced as an alternative tool, but so far a standardized quantitative assessment of tissue perfusion in vascular surgery has not been performed for this purpose. The aim of this feasibility study was to investigate a new software for quantitative assessment of tissue perfusion in patients with PAD using indocyanine green fluorescent imaging (ICG-FI) before and after peripheral bypass grafting...
June 14, 2017: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/28610782/assessment-of-treatment-response-by-colony-forming-units-time-to-culture-positivity-and-the-molecular-bacterial-load-assay-compared-in-a-mouse-tuberculosis-model
#9
Gerjo J de Knegt, Laura Dickinson, Henry Pertinez, Dimitrios Evangelopoulos, Timothy D McHugh, Irma A J M Bakker-Woudenberg, Gerry R Davies, Jurriaan E M de Steenwinkel
The aim of the study is to compare counting of colony forming units (CFU), the time to positivity (TTP) assay and the molecular bacterial load (MBL) assay, and explore whether the last assays can detect a subpopulation which is unable to grown on solid media. CFU counting, TTP and the MBL assay were used to determine the mycobacterial load in matched lung samples of a murine tuberculosis model. Mice were treated for 24 weeks with 4 treatment arms: isoniazid (H) - rifampicin (R) - pyrazinamide (Z), HRZ-Streptomycin (S), HRZ - ethambutol (E) or ZES...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28610781/pilot-studies-of-a-human-bcg-challenge-model
#10
Azra Blazevic, Mei Xia, Aldin Turan, Janice Tennant, Daniel F Hoft
Despite the great effort to develop an effective vaccine against tuberculosis (TB) there is currently no reliable and safe human challenge model that can be used for in vivo evaluation of new TB vaccine candidates and/or elucidation of the mechanisms of TB protective immunity. In this study, five volunteers were challenged with BCG intradermally (ID). Swab specimens were collected at multiple time points from the vaccination site pre- and post-vaccination to quantitate mycobacterial shedding as a surrogate of in vivo mycobacterial immunity...
July 2017: Tuberculosis
https://www.readbyqxmd.com/read/28608162/diffusion-weighted-imaging-for-assessment-of-synovial-inflammation-in-juvenile-idiopathic-arthritis-a-promising-imaging-biomarker-as-an-alternative-to-gadolinium-based-contrast-agents
#11
Anouk M Barendregt, E Charlotte van Gulik, Cristina Lavini, Charlotte M Nusman, J Merlijn van den Berg, Dieneke Schonenberg-Meinema, Koert M Dolman, Taco W Kuijpers, Robert Hemke, Mario Maas
OBJECTIVES: To compare dynamic-contrast-enhanced MRI (DCE) and diffusion-weighted imaging (DWI) in quantifying synovial inflammation in juvenile idiopathic arthritis (JIA). METHODS: Regions of interest (ROI) were drawn in the synovium of JIA patients on T1 DCE and T2 DWI, followed by extraction of the maximum enhancement (ME), maximum initial slope (MIS), time to peak (TTP), % of different time intensity curve shapes (TIC) and apparent diffusion coefficient (ADC) of the ROIs...
June 12, 2017: European Radiology
https://www.readbyqxmd.com/read/28607779/thrombotic-microangiopathy-secondary-to-intravenous-abuse-of-opana%C3%A2-er
#12
Kamia Thakur, Vaibhav Agrawal, Ashley Kass, Lauren M Dimarino, R Patrick Dorion, Joseph Vadakara
Opana ER (oxymorphone) is an opioid drug available throughout the United States, and intravenous abuse of the crushed oral formulation has been associated with drug-induced thrombotic microangiopathy. In this abstract, we describe two young patients who lived together and used Opana ER intravenously. Both presented with microangiopathic hemolytic anemia that mimicked thrombotic thrombocytopenic purpura (TTP). Treating this condition poses a clinical challenge, as it is difficult to distinguish it from TTP. The role for plasma exchange is not clear but can be used while awaiting the results of the ADAMTS-13 activity, but ultimately supportive care with drug discontinuation is the recommended therapy of choice...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28607633/pterostilbene-4-%C3%AE-glucoside-protects-against-dss-induced-colitis-via-induction-of-tristetraprolin
#13
Yingqing Chen, Jeongmin Park, Yeonsoo Joe, Hyeok-Jun Park, Seung-Joo Jekal, Daisuke Sato, Hiroki Hamada, Hun Taeg Chung
Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3'-untranslated regions of mRNAs. Here, we utilized pterostilbene 4'-β-glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28603426/efficacy-and-safety-of-tace-in-combination-with-sorafenib-for-the-treatment-of-tace-refractory-advanced-hepatocellular-carcinoma-in-chinese-patients-a-retrospective-study
#14
Jianbing Wu, An Li, Jiajin Yang, Yanjun Lu, Jie Li
BACKGROUND: Transarterial chemoembolization (TACE) and sorafenib (SOR) are well-established treatments for hepatocellular carcinoma (HCC). This study evaluates the efficacy and safety of SOR combined with TACE in the treatment of patients with TACE-refractory, advanced-stage HCC. METHODS: This retrospective study included 61 patients with TACE-refractory advanced HCC. Patients were divided into TACE + SOR (n=30) and TACE (n=31) treatment groups. Patient demographic and clinical characteristics, overall survival (OS), time to progression (TTP), disease control rate (DCR), and adverse events (AEs) were compared between the two groups...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28603091/gemcitabine-based-combination-therapy-compared-with-gemcitabine-alone-for-advanced-pancreatic-cancer-a-meta-analysis-of-nine-randomized-controlled-trials
#15
Shui-Fang Jin, Zhao-Kun Fan, Lei Pan, Li-Ming Jin
BACKGROUND: Pancreatic cancer is one of the most aggressive malignancies and chemotherapy is an effective strategy for advanced pancreatic cancer. Gemcitabine (GEM) is one of first-line agents. However, GEM-based combination therapy has shown promising efficacy in patients with advanced pancreatic cancer. This meta-analysis aimed to compare the efficacy and safety of GEM-based combination therapy versus GEM alone in the treatment of advanced pancreatic cancer. DATA SOURCES: A comprehensive search of literature was performed using PubMed, EMBASE, Web of Science and Cochrane Central Register of Controlled Trials...
June 2017: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/28598141/evaluation-of-cerebral-perfusion-by-contrast-enhanced-ultrasound-at-low-mechanical-index-in-cerebral-ischemia-rat-model
#16
Xiaolei Wang, Bo Liu, Jiongou Liu, Aitong Sun, Yan Cui, Rui Xiao, Chunyang Li
BACKGROUND: No data is available for brain low mechanical index (low-MI) contrast-enhanced ultrasound (CEUS). This study aimed to assess low-MI CEUS for cerebral ischemia in rats. METHODS: Twenty adult Wistar rats were divided to the brain ischemia (n=12) and sham (n=8) groups. A Logiq E9 (GE; ML6-15 probe) was used. Bolus injection of SonoVue (Bracco) at 3.6 ml/kg was performed. Cerebral perfusion was evaluated using time to peak (TTP) and area under the curve (AUC) of time-intensity curves (TIC)...
June 9, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28596255/thrombotic-thrombocytopenic-purpura-associated-with-pegylated-interferon-alfa-2a-use-in-a-patient-with-polycythemia-vera
#17
Radhika Gangaraju, Soo J Kim, Jing-Fei Dong, Sabina Swierczek, Josef T Prchal
Pegylated interferon alfa-2a (pegIFNa) is being increasingly used for treatment of myeloproliferative neoplasms; however, its side effects, including autoimmune complications, are not unusual. We report on a 47-year-old woman with polycythemia vera (PV) treated with pegIFNa and in complete hematologic remission who developed thrombotic thrombocytopenic purpura (TTP). To our knowledge, thrombotic microangiopathy has been reported as a side effect of interferon (IFN) use in patients with hepatitis and chronic myeloid leukemia, but not in those with PV...
June 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28592771/ttp-and-ahus-new-insights
#18
Yoshitaka Miyakawa
Both TTP and aHUS are officially designated as intractable diseases by a new Japanese law in 2015. New clinical practice guidelines for TTP and aHUS have been published. Both conditions share some common pathophysiology such as thrombotic microangiopathy. Unfortunately, most professionals in the fields of hematology/oncology are unaware of these diseases. Therefore, I will provide an updated overview of TTP and aHUS in this article.
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28591667/exposure-to-residential-road-traffic-noise-prior-to-conception-and-time-to-pregnancy
#19
Jeppe Schultz Christensen, Ole Raaschou-Nielsen, Matthias Ketzel, Cecilia Høst Ramlau-Hansen, Bodil Hammer Bech, Jørn Olsen, Mette Sørensen
OBJECTIVES: To examine the association between residential road traffic noise and fecundity estimated by time to pregnancy (TTP). DESIGN: We identified 65,201 mothers from the Danish National Birth Cohort with self-reported information on TTP collected through computer assisted telephone interviews. Road traffic noise was modelled at all historical addresses and expressed as time-weighted means for periods corresponding to individual TTP. Associations were analyzed using logistic regression for analyses of dichotomous outcomes and ordinal logistic regression for TTP in four categories, adjusting for maternal age at conception, disposable household income, education and air pollution (NOx)...
June 4, 2017: Environment International
https://www.readbyqxmd.com/read/28587770/functional-communication-between-pkc-targeted-cardiac-troponin-i-phosphorylation-sites
#20
Sarah E Lang, Tamara K Stevenson, Tabea M Schatz, Brandon J Biesiadecki, Margaret V Westfall
Increased protein kinase C (PKC) activity is associated with heart failure, and can target multiple cardiac troponin I (cTnI) residues in myocytes, including S23/24, S43/45 and T144. In earlier studies, cTnI-S43D and/or -S45D augmented S23/24 and T144 phosphorylation, which suggested there is communication between clusters. This communication is now explored by evaluating the impact of phospho-mimetic cTnI S43/45D combined with S23/24D (cTnIS4D) or T144D (cTnISDTD). Gene transfer of epitope-tagged cTnIS4D and cTnISDTD into adult cardiac myocytes progressively replaced endogenous cTnI...
June 3, 2017: Archives of Biochemistry and Biophysics
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