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Ferulic acid

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https://www.readbyqxmd.com/read/28433923/uhplc-q-orbitrap-hrms-based-global-metabolomics-reveal-metabolome-modifications-in-plasma-of-young-women-after-cranberry-juice-consumption
#1
Haiyan Liu, Timothy J Garrett, Zhihua Su, Christina Khoo, Liwei Gu
Plasma metabolome in young women following cranberry juice consumption were investigated using a global UHPLC-Q-Orbitrap-HRMS approach. Seventeen female college students, between 21 and 29 years old, were given either cranberry juice or apple juice for three days using a cross-over design. Plasma samples were collected before and after juice consumption. Plasma metabolomes were analyzed using UHPLC-Q-Orbitrap-HRMS followed by orthogonal partial least squares-discriminant analyses (OPLS-DA). S-plot was used to identify discriminant metabolites...
April 7, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28433594/favouring-no-over-h2o2-production-will-increase-pb-tolerance-in-prosopis-farcta-via-altered-primary-metabolism
#2
Somaieh Zafari, Mohsen Sharifi, Luis A J Mur, Najmeh Ahmadian Chashmi
Reactive oxygen species (ROS) and nitric oxide (NO) are known in triggering defense functions to detoxify heavy metal stresses. To investigate the relevance of ROS production, Pb treatment (400µM) alone and in combination with 400µM sodium ascorbate (Asc: as H2O2 scavenger) were given to hydroponically grown Prosopis farcta seedlings over a time course of 72h. Data presented here indicate that, the low extent of H2O2 due to scavenging by ascorbate, together with high level of NO improved Pb+Asc- treated Prosopis growth...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28432440/application-of-recombinant-pediococcus-acidilactici-bd16-fcs-ech-for-bioconversion-of-agrowaste-to-vanillin
#3
Debkumar Chakraborty, Ammaiyappan Selvam, Baljinder Kaur, Jonathan Woon Chung Wong, Obulisamy Parthiba Karthikeyan
Biotechnological production of vanillin is gaining momentum as the natural synthesis of vanillin that is very expensive. Ferulic acid (FA), a costly compound, is used as the substrate to produce vanillin biotechnologically and the making process is still expensive. Therefore, this study investigated the practical use of an agrobiomass waste, rice bran, and provides the first evidence of a cost-effective production of vanillin within 24 h of incubation using recombinant Pediococcus acidilactici BD16 (fcs (+)/ech (+))...
April 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28431483/bioassay-guided-isolation-identification-of-compounds-from-origanum-rotundifolium-and-investigation-of-their-antiproliferative-and-antioxidant-activities
#4
Ramazan Erenler, Bilal Meral, Ozkan Sen, Mahfuz Elmastas, Ali Aydin, Ozgur Eminagaoglu, Gulacti Topcu
CONTEXT: Origanum (Lamiaceae) has been used in food and pharmaceutical industries. OBJECTIVE: Isolation and identification of bioactive compounds from Origanum rotundifolium Boiss. and investigation of their antiproliferative and antioxidant activities. MATERIALS AND METHODS: The aerial part of O. rotundifolium was dried and powdered (1.0 kg ±2.0 g) then extracted with hexane, ethyl acetate, methanol and water. Solvent (3 × 1 L) was used for each extraction for a week at room temperature...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28428087/searching-for-new-sources-of-innovative-products-for-the-food-industry-within-halophyte-aromatic-plants-in-vitro-antioxidant-activity-and-phenolic-and-mineral-contents-of-infusions-and-decoctions-of-crithmum-maritimum-l
#5
Catarina Guerreiro Pereira, Luísa Barreira, Nuno da Rosa Neng, José Manuel Florêncio Nogueira, Cátia Marques, Tamára F Santos, João Varela, Luísa Custódio
Aromatic halophyte plants are an outstanding source of bioactive compounds and natural products with potential use in the food industry. This work reports the in vitro antioxidant activity, toxicity, polyphenolic profile and mineral contents of infusions and decoctions from stems, leaves and flowers of Crithmum maritimum L., an aromatic and edible maritime halophyte (sea fennel). Aspalathus linearis (Burm.f.) Dahlg. (rooibos) herbal tea was used as a reference. Sea fennel's tisanes, particularly from leaves, were rich in phenolic compounds and five of them (p-hydroxybenzoic and ferulic acids, epicatechin, pyrocatechol and 4-hydroxybenzaldehyde) were here described in C...
April 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28425165/melanogenesis-inhibitory-and-cytotoxic-activities-of-limonoids-alkaloids-and-phenolic-compounds-from-phellodendron-amurense-bark
#6
Toshihiro Akihisa, Satoru Yokokawa, Eri Ogihara, Masahiro Matsumoto, Jie Zhang, Takashi Kikuchi, Kazuo Koike, Masahiko Abe
Four limonoids, 1-4, five alkaloids, 5-9, and four phenolic compounds, 10-13, were isolated from a MeOH extract of the bark of Phellodendron amurense (Rutaceae). Among these, compound 13 was a new, and its structure was established as rel-(1R,2R,3R)-5-hydroxy-3-(4-hydroxy-3-methoxyphenyl)-6-methoxy-1-(methoxycarbonylmethyl)indane-2-carboxylic acid methyl ester (γ-di(methyl ferulate)) based on the spectrometric analysis. Upon evaluation of compounds 1-13 against the melanogenesis in the B16 melanoma cells induced with α-melanocyte-stimulating hormone (α-MSH), four compounds, limonin (1), noroxyhydrastinine (6), haplopine (7), and 4-methoxy-N-methyl-2-quiolone (8), exhibited potent melanogenesis-inhibitory activities with almost no toxicity to the cells...
April 20, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28414046/caffeoyl-and-coumaroyl-derivatives-from-acacia-cochliacantha-exhibit-ovicidal-activity-against-haemonchus-contortus
#7
G F Castillo-Mitre, A Olmedo-Juárez, R Rojo-Rubio, M Cortázar-González, P Mendoza-de Gives, E E Hernández-Beteta, D E Reyes-Guerrero, M E López-Arellano, J F Vázquez-Armijo, G Ramírez-Vargas, A Zamilpa
Ethnopharmacology relevance: Acacia cochliacantha is a small tree whose foliage is traditionally used in Mexico for treatment of kidney pain, gastrointestinal illnesses and to kill intestinal parasites. In recent decades, the study of vegetal extracts has offered other possible alternatives for the control of Haemonchus contortus. Considering that this nematode affects dramatically the health and productivity of small ruminants, the aim of this study was to identify the anthelmintic compounds from A. cochliacantha hydro-alcoholic extract (HA-E) through an ovicidal test...
April 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28412883/polyphenols-of-virgin-coconut-oil-prevent-pro-oxidant-mediated-cell-death
#8
Soorya Parathodi Illam, Arunaksharan Narayanankutty, Achuthan C Raghavamenon
Virgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol contents (VCOP), the mechanistic basis of which is less explored. LC/MS analysis of VCOP documented the presence of gallic acid, ferulic acid, quercetin, methyl catechin, dihydrokaempferol, and myricetin glycoside...
April 16, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/28411511/elevated-co2-and-salinity-are-responsible-for-phenolics-enrichment-in-two-differently-pigmented-lettuces
#9
Cristina Sgherri, Usue Pérez-López, Francesco Micaelli, Jon Miranda-Apodaca, Amaia Mena-Petite, Alberto Muñoz-Rueda, Mike Frank Quartacci
Both salt stress and high CO2 level, besides influencing secondary metabolism, can affect oxidative status of plants mainly acting in an opposite way with salinity provoking oxidative stress and elevated CO2 alleviating it. The aim of the present work was to study the changes in the composition of phenolic acids and flavonoids as well as in the antioxidant activity in two differently pigmented lettuce cvs (green or red leaf) when submitted to salinity (200 mM NaCl) or elevated CO2 (700 ppm) or to their combination in order to evaluate how a future global change can affect lettuce quality...
April 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28411481/a-re-evaluation-of-the-final-step-of-vanillin-biosynthesis-in-the-orchid-vanilla-planifolia
#10
Hailian Yang, Jaime Barros-Rios, Galina Kourteva, Xiaolan Rao, Fang Chen, Hui Shen, Chenggang Liu, Andrzej Podstolski, Faith Belanger, Daphna Havkin-Frenkel, Richard A Dixon
A recent publication describes an enzyme from the vanilla orchid Vanilla planifolia with the ability to convert ferulic acid directly to vanillin. The authors propose that this represents the final step in the biosynthesis of vanillin, which is then converted to its storage form, glucovanillin, by glycosylation. The existence of such a "vanillin synthase" could enable biotechnological production of vanillin from ferulic acid using a "natural" vanilla enzyme. The proposed vanillin synthase exhibits high identity to cysteine proteases, and is identical at the protein sequence level to a protein identified in 2003 as being associated with the conversion of 4-coumaric acid to 4-hydroxybenzaldehyde...
April 12, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28411365/analysis-of-glycosylated-flavonoids-extracted-from-sweet-cherry-stems-as-antibacterial-agents-against-pathogenic-escherichia-coli-isolates
#11
Alfredo Aires, Carla Dias, Rosa Carvalho, Maria José Saavedra
The aim of this study was to evaluate the bioactivity of flavonoids extracted from sweet-cherry stems which are often used by a traditional system of medicine to treat gastro-intestinal and urinary tract infections but lacking any consistent scientific evidence; moreover the information about the class of phenolics, their content and the potential bioactivity of such material is very scarce. Thus, in this context, we have set a research study in which we evaluated the profile and content of phenolics extracted from sweet-cherry stems through a conventional (70ºC and 20 min) and ultrasound assisted extraction (40 kHz, room temperature and 20 min)...
April 14, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28411049/impact-of-ultrasounds-and-high-voltage-electrical-discharges-on-physico-chemical-properties-of-rapeseed-straw-s-lignin-and-pulps
#12
M Brahim, B L Checa Fernandez, O Regnier, N Boussetta, N Grimi, C Sarazin, E Husson, E Vorobiev, N Brosse
In this study, ultrasound (US) and high voltage electrical discharges (HVED) were combined with chemical treatments (soda or organosolv) for rapeseed straw delignification. Delignification was improved by both physical pretreatments. US increased the extractability of hemicelluloses and HVED induced a partial degradation of cellulose. Best synergies were observed for HVED-soda and US-organosolv treatments. The obtained lignin fractions were characterized with (13)C NMR and 2D (1)H-(13)C HSQC. It was observed that the physical treatments affected the syringyl/guaiacyl (S/G) ratios...
April 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28409157/ferulic-acid-suppresses-amyloid-%C3%AE-production-in-the-human-lens-epithelial-cell-stimulated-with-hydrogen-peroxide
#13
Noriaki Nagai, Sachiyo Kotani, Yu Mano, Akina Ueno, Yoshimasa Ito, Toshio Kitaba, Takumi Takata, Noriko Fujii
It is well known that oxidative stresses induce the production of amyloid β (Aβ) in the brain, lens, and retina, leading to age-related diseases. In the present study, we investigated the effects of ferulic acid on the Aβ levels in H2O2-stimulated human lens epithelial (HLE) SRA 01/04 cells. Three types of Aβ peptides (Aβ1-40, Aβ1-42, and Aβ1-43) were measured by ELISA, and the levels of mRNA for the expressed proteins related to Aβ production (APP, BACE1, and PS proteins) and degradation (ADAM10, NEP, and ECE1 proteins) were determined by quantitative real-time RT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28403674/haemoglobin-site-specifically-modified-with-ferulic-acid-to-suppress-the-autoxidation
#14
Donglai Qi, Qian Li, Pei Wang, Xiang Wang
Haemoglobin site-specifically modified with ferulic acid (FA-Hb), was synthesized. The effects on the characteristic absorption and the oxygen saturation curve of FA-Hb were investigated by UV-Vis spectrophotometry and oxygen analyzer. Furthermore, the autoxidation rates of Hb and FA-Hb were also discussed with or without sodium azide in the system. The results showed that there was no obvious transformation of the heme structure of FA-Hb. It was also demonstrated that the oxygen-carrying capacity of FA-Hb was similar to the natural Hb, but the autoxidation rate of FA-Hb was much lower than Hb in different systems...
April 12, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28401287/graphene-oxide-for-solid-phase-extraction-of-bioactive-phenolic-acids
#15
Xiudan Hou, Xusheng Wang, Yingxin Sun, Licheng Wang, Yong Guo
A solid-phase extraction (SPE) method for the efficient analysis of trace phenolic acids (PAs, caffeic acid, ferulic acid, protocatechuic acid, cinnamic acid) in urine was established. In this work, a graphene oxide (GO) coating was grafted onto pure silica to be investigated as SPE material. The prepared GO surface had a layered and wrinkled structure that was rough and well organized, which could provide more open adsorption sites. Owing to its hydrophilicity and polarity, GO showed higher extraction efficiency toward PAs than reduced GO did, in agreement with the theoretical calculation results performed by Gaussian 09 software...
April 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28392279/a-novel-serum-stable-liver-targeted-cytotoxic-system-using-valerate-conjugated-chitosan-nanoparticles-surface-decorated-with-glycyrrhizin
#16
Eman M El-Marakby, Rania M Hathout, Ismail Taha, Samar Mansour, Nahed D Mortada
The aim of this study was to target a naturally chemotherapeutic agent; ferulic acid to the liver using a biocompatible and an in-vivo stable carrier. Accordingly, chitosan as a biopolymer was modified using a hydrophobic moiety; valeric acid in order to increase its in-vivo stability. The structure of the newly synthesized product was confirmed using FTIR and NMR techniques together with the ninhydrin assay. Ferulic acid was conjugated to the modified nanoparticles that were further characterized for particle size, PDI and zeta potential and subjected to ex-vivo stability study in serum and cytotoxicity studies in Hep G2 cell lines...
April 6, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28391725/identification-and-in-vitro-antioxidant-activities-of-phenolic-compounds-isolated-from-cynoglossum-cheirifolium-l
#17
Bensaid Ilhem, Atik Bekkara Fawzia, El Haci Imad Abdelhamid, Belarbi Karima, Beddou Fawzia, Bekhechi Chahrazed
In an extensive search for bioactive compounds from plant sources, the quantitative and qualitative characterisation of the compounds present in Cynoglossum cheirifolium extracts was studied. Total phenolic and flavonoid contents were determined by spectrophotometric techniques. In vitro antioxidant and radical scavenging profiling was determined through DPPH(•) scavenging activity and Ferric reducing antioxidant power (FRAP). Our study showed that leaves produce more phenolic compounds, followed by flowering aerial part...
April 9, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28391055/ferulic-acid-4-o-sulfate-rather-than-ferulic-acid-relaxes-arteries-and-lowers-blood-pressure-in-mice
#18
Evelien Van Rymenant, John Van Camp, Bart Pauwels, Charlotte Boydens, Laura Vanden Daele, Katrijn Beerens, Peter Brouckaert, Guy Smagghe, Asimina Kerimi, Gary Williamson, Charlotte Grootaert, Johan Van de Voorde
Consumption of foods rich in ferulic acid (FA) such as wholegrain cereals, or FA precursors such as chlorogenic acids in coffee, is inversely correlated with risk of cardiovascular disease and type 2 diabetes. As a result of digestion and phase II metabolism in the gut and liver, FA is converted predominantly into ferulic acid-4-O-sulfate (FA-sul), an abundant plasma metabolite. Although FA-sul is the main metabolite, very little has been reported regarding its bioactivities. We have compared the ex vivo vasorelaxing effect of FA and FA-sul (10(-7)-3...
March 23, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28378127/evaluation-of-photosynthetic-performance-and-carbon-isotope-discrimination-in-perennial-ryegrass-lolium-perenne-l-under-allelochemicals-stress
#19
M Iftikhar Hussain, Manuel J Reigosa
Ferulic (FA) and p-hydroxybenzoic acid (pHBA) are commonly found as phenolic compounds (PHC) in many forage and cereal crops. Although the effects of these PHC on seedling growth are relatively explored, not many information is available regarding the phytotoxicity on ecophysiological processes of perennial ryegrass adult plants. The experiment was conducted with the aim to evaluate the phytotoxic potential of PHC on the seedling growth, leaf water relation, chlorophyll fluorescence attributes and carbon isotope discrimination adult plants of perennial ryegrass (Lolium perenne L...
April 4, 2017: Ecotoxicology
https://www.readbyqxmd.com/read/28377319/development-of-extended-voyaging-anti-oxidant-linked-amphiphilic-polymeric-nanomicelles-for-anti-tuberculosis-drug-delivery
#20
Rajendran Amarnath Praphakar, Murugan A Munusamy, Mariappan Rajan
Amphiphilic chitosan-graft-poly(caprolactone)/(ferulic acid) (CS-g-PCL/FA) multi-co-polymers were fabricated by microwave-assisted ring opening polymerization followed by an 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide (EDC)-mediated coupling reaction and characterized by Fourier transformed infrared (FTIR) spectroscopy. Graft copolymers self-assembled into nanomicelles, and were able to incorporate rifampicin (RF) into their hydrophobic inner cores. X-ray diffraction (XRD) patterns were applied to characterize the crystal structures of graft polymers and the effects of RF on micelle morphology...
April 2, 2017: International Journal of Pharmaceutics
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