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Ferulic acid

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https://www.readbyqxmd.com/read/28078397/optimized-synthesis-of-novel-prenyl-ferulate-performed-by-feruloyl-esterases-from-myceliophthora-thermophila-in-microemulsions
#1
Io Antonopoulou, Laura Leonov, Peter Jütten, Gabriella Cerullo, Vincenza Faraco, Adamantia Papadopoulou, Dimitris Kletsas, Marianna Ralli, Ulrika Rova, Paul Christakopoulos
Five feruloyl esterases (FAEs; EC 3.1.1.73), FaeA1, FaeA2, FaeB1, and FaeB2 from Myceliophthora thermophila C1 and MtFae1a from M. thermophila ATCC 42464, were tested for their ability to catalyze the transesterification of vinyl ferulate (VFA) with prenol in detergentless microemulsions. Reaction conditions were optimized investigating parameters such as the medium composition, the substrate concentration, the enzyme load, the pH, the temperature, and agitation. FaeB2 offered the highest transesterification yield (71...
January 11, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28077028/ferulic-acid-suppresses-expression-of-tryptophan-metabolic-key-enzyme-indoleamine-2-3-dioxygenase-via-nf%C3%AE%C2%BAb-and-p38-mapk-in-lipopolysaccharide-stimulated-microglial-cells
#2
Manami Koshiguchi, Hitoshi Komazaki, Shizuka Hirai, Yukari Egashira
Ferulic acid (FA) is a phenol compound found in plants that has anti-inflammatory properties. Indoleamine 2, 3-dioxygenase (IDO) is a tryptophan catabolic enzyme induced in immune cells, including glial cells, during inflammation. Enhanced IDO expression leads to reduced tryptophan levels and increased levels of toxic metabolites, including quinolinic acid. Therefore, inhibition of IDO expression may be effective in suppressing progression of neurodegenerative diseases. In this study, we examined the effect of FA in microglial cells on IDO expression levels and related inflammatory signal molecules...
January 12, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28076453/ferulic-acid-lowers-body-weight-and-visceral-fat-accumulation-via-modulation-of-enzymatic-hormonal-and-inflammatory-changes-in-a-mouse-model-of-high-fat-diet-induced-obesity
#3
T S de Melo, P R Lima, K M M B Carvalho, T M Fontenele, F R N Solon, A R Tomé, T L G de Lemos, S G da Cruz Fonseca, F A Santos, V S Rao, M G R de Queiroz
Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20-25 g (n=6-8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed...
January 5, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28074863/herb-pair-danggui-honghua-mechanisms-underlying-blood-stasis-syndrome-by-system-pharmacology-approach
#4
Shi-Jun Yue, Lan-Ting Xin, Ya-Chu Fan, Shu-Jiao Li, Yu-Ping Tang, Jin-Ao Duan, Hua-Shi Guan, Chang-Yun Wang
Herb pair Danggui-Honghua has been frequently used for treatment of blood stasis syndrome (BSS) in China, one of the most common clinical pathological syndromes in traditional Chinese medicine (TCM). However, its therapeutic mechanism has not been clearly elucidated. In the present study, a feasible system pharmacology model based on chemical, pharmacokinetic and pharmacological data was developed via network construction approach to clarify the mechanisms of this herb pair. Thirty-one active ingredients of Danggui-Honghua possessing favorable pharmacokinetic profiles and biological activities were selected, interacting with 42 BSS-related targets to provide potential synergistic therapeutic actions...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28074659/ferulic-acid-fa-abrogates-%C3%AE-radiation-induced-oxidative-stress-and-dna-damage-by-up-regulating-nuclear-translocation-of-nrf2-and-activation-of-nhej-pathway
#5
Ujjal Das, Krishnendu Manna, Amitava Khan, Mahuya Sinha, Sushobhan Biswas, Aaveri Sengupta, Anindita Chakraborty, Sanjit Dey
The present study was aimed to evaluate the radioprotective effect of ferulic acid (FA), a naturally occurring plant flavonoid in terms of DNA damage and damage related alterations of repair pathways by gamma radiation. FA was administered at a dose of 50 mg/kg body weight for five consecutive days prior to exposing the swiss albino mice to a single dose of 10 Gy gamma radiation. Ionising radiation induces oxidative damage manifested by decreased expression of Cu, Zn-SOD (SOD stands for super oxide dismutase), Mn-SOD and catalase...
January 11, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28064494/influence-of-protein-phenolic-complex-on-the-antioxidant-capacity-of-flaxseed-linum-usitatissimum-l-products
#6
Fernanda Guimarães Drummond E Silva, Beatriz Miralles, Blanca Hernández-Ledesma, Lourdes Amigo, Amadeu Hoshi Iglesias, Felix Guillermo Reyes Reyes, Flavia Maria Netto
The impact of the naturally-present phenolic compounds and/or proteins on the antioxidant capacity of flaxseed products- phenolic fraction, protein concentrates and hydrolysates- before and after simulated gastrointestinal- digestion was studied. For that, whole and phenolic reduced products were assessed. Four glycosylated phenolic compounds - secoisolariciresinol and ferulic, p-coumaric and caffeic acids - were identified in flaxseed products. Phenolic fraction exerts the highest antioxidant capacity that increased by alkaline hydrolysis and by simulated gastrointestinal digestion...
January 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28063518/role-of-nutraceutical-sirt1-modulators-in-ampk-and-mtor-pathway-evidence-of-a-synergistic-effect
#7
Luca Giovannini, Sara Bianchi
OBJECTIVE: The aim of this study was to evaluate the effect of different natural substances on SIRT1 expression and on AMPK and mTOR phosphorylation. Moreover, we investigated the presence of a synergistic effect between the substances. METHODS: Human cervical carcinoma cells were seeded in 12-well plates, then incubated with the nine tested substances (resveratrol, quercetin, berberine, catechin, tyrosol, ferulic acid, niclosamide, curcumin, and malvidin) at different concentrations and left in incubation for 3, 6, and 24 h...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28062240/isolation-and-further-structural-characterization-of-lignins-from-the-valonea-of-quercus-variabilis
#8
Lina Yang, Dongmei Wang, Dan Zhou, Yawei Zhang, Tingting Yang
The isolation process of alkali lignin (AL) from the valonea of Quercus variabilis Blume was optimized (liquid/solid ratio, 12.21; isolation time, 4.21h; isolation temperature, 42.21°C; and alkali concentration, 0.85mol/L) using the response surface method (RSM), with the highest isolation rate obtained being 22.67%. Then, the apparent structures of AL, enzymatic hydrolysis lignin (CEL) and milled wood lignin (MWL) were studied by scanning electron microscopy (SEM), which indicated that the isolation processes of AL and CEL caused some damage to the apparent structure of lignin...
January 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28053654/comparison-of-chemical-profiles-and-effectiveness-between-erxian-decoction-and-mixtures-of-decoctions-of-its-individual-herbs-a-novel-approach-for-identification-of-the-standard-chemicals
#9
H P Cheung, S W Wang, T B Ng, Y B Zhang, L X Lao, Z J Zhang, Y Tong, F W S Chung, S C W Sze
BACKGROUND: Identification of bioactive standard chemicals is a major challenge in the study of the Chinese medicinal formula. In particular, the chemical components may interact differently depending on the preparative methods, therefore affecting the amounts of bioactive components and their pharmacological properties in the medicinal formula. With the use of Erxian decoction (EXD) as a study model-a  well-known Chinese medicinal formula for treating menopausal symptoms, a novel and rapid approach in seeking standard chemicals has been established by differentially comparing the HPLC profiles and the menopause-related biochemical parameters of combined decoction of EXD (EXD-C) and mixtures of the decoctions of its individual herbs (EXD-S)...
2017: Chinese Medicine
https://www.readbyqxmd.com/read/28045590/molecular-cloning-purification-and-characterization-of-a-novel-thermostable-cinnamoyl-esterase-from-lactobacillus-helveticus-kccm-11223
#10
Young-Ran Song, Sang-Ho Baik
A gene encoding cinnamoyl esterase (CE), which breaks down chlorogenic acid (ChA) into caffeic and quinic acids, was cloned from Lactobacillus helveticus KCCM 11223. The gene with an open reading frame (ORF) of 759 nucleotides was expressed in Escherichia coli, which resulted in a 51.6-fold increase in specific activity compared to L. helveticus KCCM 11223. The recombinant CE exists as a monomeric enzyme having a molecular weight of 27.4 kDa. Although the highest activity was observed at pH 7, the enzyme showed stable activity at pH 4...
January 3, 2017: Preparative Biochemistry & Biotechnology
https://www.readbyqxmd.com/read/28042012/biotechnological-production-of-vanillin-using-immobilized-enzymes
#11
Toshiki Furuya, Mari Kuroiwa, Kuniki Kino
Vanillin is an important and popular plant flavor, but the amount of this compound available from plant sources is very limited. Biotechnological methods have high potential for vanillin production as an alternative to extraction from plant sources. Here, we report a new approach using immobilized enzymes for the production of vanillin. The recently discovered oxygenase Cso2 has coenzyme-independent catalytic activity for the conversion of isoeugenol and 4-vinylguaiacol to vanillin. Immobilization of Cso2 on Sepabeads EC-EA anion-exchange carrier conferred enhanced operational stability enabling repetitive use...
December 29, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/28035161/composition-bioactive-compounds-and-antioxidant-activity-of-common-indian-fruits-and-vegetables
#12
Jatinder Pal Singh, Amritpal Kaur, Khetan Shevkani, Narpinder Singh
The present work was undertaken to evaluate the chemical composition (proximate, minerals and dietary fibre), colour parameters, antioxidant activity and polyphenol profiles of different fruits (pomegranate, kinnow, mango, banana, jambolan, grapes and sapodilla) and vegetables (beetroot, brinjal, orange carrot, bitter gourd, mentha and spinach). The amount of insoluble dietary fibre was higher than soluble dietary fibre for all fruits and vegetables. Vegetables showed superior mineral composition (higher amounts of K, Ca and Fe) as compared to fruits...
November 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28035160/impact-of-different-types-of-stoppers-on-sensorial-and-phenolic-characteristics-evolution-during-a-bottle-storage-time-of-a-white-wine-from-chardonnay-grape-variety
#13
Ran-Ran Xing, Di Liu, Zheng Li, Yuan Tian, Xiao-Xu Zhang, Jing-Ming Li, Qiu-Hong Pan
The objective of this work was to study the correlation between the variation of phenolic compounds and sensory characteristics in white wine during bottle storage and to explore the compounds that affected sensory evolution. Chardonnay (Vitis vinifera L. cv.) dry white wines were bottled under six types of stoppers and stored for 18 months. The composition of phenolic compounds was analyzed, and the sensory attributes of these wines were evaluated by professional panel. Multivariate statistical analysis demonstrated that bottle aging period exhibited a more important effect on phenolic compound evolution than stopper type...
November 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28035114/an-in-vitro-study-of-antileishmanial-effect-of-portulaca-oleracea-extract
#14
Elham Gharirvand Eskandari, Monir Doudi, Saeid Abedi
BACKGROUND & OBJECTIVES: Leishmaniasis is caused by protozoa of Leishmania genus and is considered as a zoonotic disease. It is a major public health problem worldwide, with high endemicity in developing countries like Iran. Various chemical drugs are used for leishmaniasis treatment, but their side-effects and the emergence of drug resistance have led to look for new effective compounds. The aim of this study was to introduce purslane (Portulaca oleracea) as a traditional and medicinal herb which might act as a valuable source for designing new pharmaceutical drug/lead against Leishmania sp...
October 2016: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28024731/olive-oil-polyphenols-a-quantitative-method-by-high-performance-liquid-chromatography-diode-array-detection-for-their-determination-and-the-assessment-of-the-related-health-claim
#15
Massimo Ricciutelli, Shara Marconi, Maria Chiara Boarelli, Giovanni Caprioli, Gianni Sagratini, Roberto Ballini, Dennis Fiorini
In order to assess if an extra virgin olive oil (EVOO) can be acknowledged with the health claim related to olive oil polyphenols (Reg. EU n.432/2012), a new method to quantify these species in EVOO, by means of liquid-liquid extraction followed by HPLC-DAD/MS/MS of the hydroalcoholic extract, has been developed and validated. Different extraction procedures, different types of reverse-phase analytical columns (Synergi Polar, Spherisorb ODS2 and Kinetex) and eluents have been tested. The chromatographic column Synergi Polar (250×4...
December 11, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28024413/ferulic-acid-induces-proliferation-and-differentiation-of-rat-osteoblasts-in-vitro-through-cgmp-pkgii-enac-signaling
#16
Jian-Lin Gao, Jun Chen, Guo-Zhu Yang, Li Lu, Xing-Yan Lu, Huan-Huan Jia, Xiao-Dong Jin, Hao Zhang, Qing-Nan Li
Ferulic acid (FA) is an active component of the traditional Chinese herb Angelica sinensis. Numerous health benefits have been attributed to FA, but few studies have investigated the effects of FA on osteoblasts (Obs). Our work studied the effects of FA on proliferation, differentiation, and mineralization of rat calvarial Obs and examined the signaling pathways involved. Cell proliferation and differentiation were evaluated by Cell Counting Kit-8 (CCK-8) and alkaline phosphatase (ALP) assay kit, respectively...
December 27, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28017997/nutraceutical-properties-of-cumin-residue-generated-from-ayurvedic-industries-using-cell-line-models
#17
K B Arun, U Aswathi, V V Venugopal, T S Madhavankutty, P Nisha
Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe(2+) ion (89.68 µM AA/g dry weight), scavenged DPPH radical (IC50-238...
October 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28012692/mediation-of-coffee-induced-improvements-in-human-vascular-function-by-chlorogenic-acids-and-its-metabolites-two-randomized-controlled-crossover-intervention-trials
#18
Charlotte E Mills, Andreas Flury, Cynthia Marmet, Laura Poquet, Stefano F Rimoldi, Claudio Sartori, Emrush Rexhaj, Roman Brenner, Yves Allemann, Diane Zimmermann, Glenn R Gibson, Don S Mottram, Maria-Jose Oruna-Concha, Lucas Actis-Goretta, Jeremy P E Spencer
BACKGROUND & AIMS: Polyphenol intake has been linked to improvements in human vascular function, although data on hydroxycinnamates, such as chlorogenic acid (CGA) have not yet been studied. We aimed to investigate the impact of coffee intake rich in chlorogenic acid on human vascular function and whether CGAs are involved in potential effects. METHODS: Two acute randomized, controlled, cross-over human intervention trials were conducted. The impact of coffee intake, matched for caffeine but differing in CGA content (89, and 310 mg) on flow-mediated dilatation (FMD) was assessed in 15 healthy male subjects...
November 30, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28012309/development-of-new-efficient-method-for-isolation-of-phenolics-from-sea-algae-prior-to-their-rapid-resolution-liquid-chromatographic-tandem-mass-spectrometric-determination
#19
Bořivoj Klejdus, Merichel Plaza, Marie Šnóblová, Lea Lojková
The extraction of phenolic compounds from 4 different sea algae samples, three brown algae (Cystoseira abies-marina, C. abies-marina grinded under cryogenic conditions with liquid nitrogen, Undaria pinnatifida and Sargassum muticum) and one red algae (Chondrus crispus) via solid phase extraction using micro-elution solid-phase extraction (μ-SPE) plate method was studied. Prior to μ-SPE, 50mg of algae with 80% methanol mixture was extracted in hyphenated series by various extraction techniques, such as pressurized liquid extraction and Ika Ultra-Turrax(®) Tube Drive, in combination with ultrasound assisted extraction...
December 14, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28008757/identification-and-quantification-of-potential-anti-inflammatory-hydroxycinnamic-acid-amides-from-wolfberries-fruits-of-lycium-barbarum
#20
Siyu Wang, Joonhyuk Suh, Xi Zheng, Yu Wang, Chi-Tang Ho
Wolfberry or Goji berry, the fruit of Lycium barbarum, exhibits health-promoting properties that leads to an extensive study of their active components. We synthesized a set of hydroxycinnamic acid amide (HCCA) compounds, including trans-caffeic acid, trans-ferulic acid and 3,4-dihydroxyhydrocinnamic acid with extended phenolic amine components as standards to identify and quantify the corresponding compounds from wolfberry, and to investigate anti-inflammatory properties of these compounds using in vitro model...
December 23, 2016: Journal of Agricultural and Food Chemistry
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