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Ferulic acid

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https://www.readbyqxmd.com/read/29449812/calycosin-orchestrates-osteogenesis-of-danggui-buxue-tang-in-cultured-osteoblasts-evaluating-the-mechanism-of-action-by-omics-and-chemical-knock-out-methodologies
#1
Amy G W Gong, Ran Duan, Huai Y Wang, Tina T X Dong, Karl W K Tsim
Danggui Buxue Tang (DBT), an ancient Chinese herbal decoction commonly used to mitigate menopausal osteoporosis, contains two herbs: Astragali Radix (AR) and Angelicae Sinensis Radix (ASR). The exact efficacy of individual chemical(s) within DBT, or in any herbal mixture, is hard to be revealed. Calycosin and ferulic acid have been reported to be the predominant chemicals found within DBT, and its roles in regulating osteoblastic differentiation have been proposed here. To probe the roles of calycosin and ferulic acid, these chemicals were specifically depleted from the DBT extracts...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29448207/ferulic-acid-protects-lipopolysaccharide-induced-acute-kidney-injury-by-suppressing-inflammatory-events-and-upregulating-antioxidant-defenses-in-balb-c-mice
#2
Salma Mukhtar Mir, Halley Gora Ravuri, Raj Kumar Pradhan, Sairam Narra, Jerald Mahesh Kumar, Madhusudana Kuncha, Sanjit Kanjilal, Ramakrishna Sistla
Sepsis-induced acute kidney injury (AKI) is responsible for 70-80% mortality in intensive care patients due to elevated levels of endotoxin, Lipopolysaccharide (LPS) caused by gram-negative infections. Ferulic acid (FA), a phenolic phytochemical is known for its renal protection on various induced models of nephrotoxicity. However, the curative effect of FA in LPS-induced AKI is not well studied. This study aimed to investigate the effect of FA on LPS-induced AKI in mice model and to understand the protective mechanisms involved, to provide evidence for FA in the treatment of AKI...
February 12, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29441985/total-phenolic-and-tannins-determination-a-modification-of-ph-eur-2-8-14-for-higher-throughput
#3
S Wiesneth, G Jürgenliemk
A principle mostly being used to quantify phenols and tannins is the Folin-Ciocalteu's reagent method described in the European Pharmacopeia's method 2.8.14. Aim of the present study was to simplify this procedure in order to handle larger sample numbers. By changing the wavelength, the amounts of reagents, miniaturizing the setting to microtiter scale and changing the incubation time before measurement, the Ph. Eur. method 2.8.14 was optimized for a larger number of experiments. Calibration curves and time kinetics with different phenolic compounds (catechol, procyanidin B1, gallic acid, (+)-catechin, tannic acid, salicylic acid, ferulic acid) were determined...
April 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29435999/the-effect-of-greenhouse-covering-materials-on-phytochemical-composition-and-antioxidant-capacity-of-tomato-cultivars
#4
Latifeh Ahmadi, Xiuming Hao, Rong Tsao
BACKGROUND: The effect of light transmission (direct and diffuse) on the phenolic compounds of five tomato cultivars was investigated under controlled conditions in greenhouses covered with different covering materials. RESULTS: The type of covering materials and type of diffusion of light simultaneously affected the reducing power of cultivars. In the present study, a two-way analysis of variance showed statistically significant differences in total phenolic compound (TPC) for the different cultivars (P<0...
February 13, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29435700/the-content-of-dietary-fibre-and-polyphenols-in-morphological-parts-of-buckwheat-fagopyrum-tataricum
#5
Krzysztof Dziedzic, Danuta Górecka, Artur Szwengiel, Hanna Sulewska, Ivan Kreft, Elżbieta Gujska, Jarosław Walkowiak
In this report, we presented the profile of polyphenolic substances in flowers, leaves, stalk and roots of Fagopyrum tataricum estimated by using RP-UHPLC-ESI-MS equipment (reversed-phase ultra-high-performance liquid chromatography electrospray ionisation mass spectrometry). The neutral detergent fibre, acid detergent fibre, acid detergent lignin, cellulose and hemicellulose were also determined. Flowers, leaves, stalk and roots showed varying levels of dietary fibre and polyphenols. The highest content of neutral and acid detergent fibre were found in the roots (63...
February 12, 2018: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29435688/cloning-and-expression-of-ferulic-acid-esterase-gene-and-its-effect-on-wort-filterability
#6
Dianhui Wu, Guolin Cai, Xiaomin Li, Bing Li, Jian Lu
OBJECTIVES: To optimize the expression of type A ferulic acid esterase (FaeA) from Aspergillus niger in Pichia pastoris X-33 using codon optimization. RESULTS: Recombinant FaeA was purified from the fermentation broth, with the maximum specific activity of 48.4 ± 0.1 U mg-1. Adding it during mashing process for beer brewing raised the filtration rate by 14.5% while the turbidity and viscosity declined by 22 and 6.9%, respectively. Addition of FaeA increased the concentrations of free ferulic acid (FA) and arabinoxylan (AX) in the wort, while the polymeric arabinoxylans content declined significantly...
February 12, 2018: Biotechnology Letters
https://www.readbyqxmd.com/read/29434776/phytochemical-screening-and-biological-activity-of-lamiaceae-family-plant-extracts
#7
Ileana Cocan, Ersilia Alexa, Corina Danciu, Isidora Radulov, Atena Galuscan, Diana Obistioiu, Attila Alexandru Morvay, Renata Maria Sumalan, Mariana-Atena Poiana, Georgeta Pop, Cristina Adriana Dehelean
The current study aimed to investigate ethanolic extracts from the following medicinal plant species cultivated in western Romania: Melissa officinalis L., Rosmarinus officinalis L. (RO) and Salvia officinalis L. (SO). Antioxidant activity, total phenolics content and a profile of the main hydroxycinnamic acids (HCAs), including caffeic, ferulic, coumaric and rosmarinic acids, was determined for each plant extract. The in vitro antimicrobial activity against four bacterial strains ( Escherichia coli , Listeria -, Pseudomonas aeruginosa and Staphylococcus aureus ), and the effect on cell viability in two melanoma cell lines (B164A5 murine melanoma and A375 human melanoma) was also assessed...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29426537/rapid-determination-of-hydrophilic-phenols-in-olive-oil-by-vortex-assisted-reversed-phase-dispersive-liquid-liquid-microextraction-and-screen-printed-carbon-electrodes
#8
Elena Fernández, Lorena Vidal, Antonio Canals
A novel approach is presented to determine hydrophilic phenols in olive oil samples, employing vortex-assisted reversed-phase dispersive liquid-liquid microextraction (RP-DLLME) for sample preparation and screen-printed carbon electrodes for voltammetric analysis. The oxidation of oleuropein, hydroxytyrosol, caffeic acid, ferulic acid and tyrosol was investigated, being caffeic acid and tyrosol selected for quantification. A matrix-matching calibration using sunflower oil as analyte-free sample diluted with hexane was employed to compensate matrix effects...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29423882/growth-promotion-of-euglena-gracilis-by-ferulic-acid-from-rice-bran
#9
Jiangyu Zhu, Minato Wakisaka
A significant growth promotion of Euglena gracilis was achieved by simply adding ferulic acid from rice bran without diminishing the accumulation of valuable products like paramylon. E. gracilis is a freshwater microalga that is widely applied in cosmetics, food, medicine, and supplements, and it is considered a potential source of biofuel. It is therefore important to enhance its yield at a lower cost for its commercial viability. Introducing a growth regulator derived from agro waste is considered a cheaper and safer strategy to improve biomass productivity compared with other alternatives such as implementing genetic engineering or adding nutrients and plant hormones as growth stimulator...
February 8, 2018: AMB Express
https://www.readbyqxmd.com/read/29419760/comparative-evaluation-of-soluble-and-insoluble-bound-phenolics-and-antioxidant-activity-of-two-chinese-mistletoes
#10
Qing Li, Shihua Yang, Yongqiang Li, Xiaofeng Xue, Yonghua Huang, Hengguo Luo, Yiming Zhang, Zhichao Lu
Mistletoes are used medicinally in order to treat various human illnesses. Few studies have reported on the phenolic content and antioxidant properties of Chinese mistletoes (CMs). In this work, the total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities of soluble and insoluble-bound phenolic extracts from CMs hosted by Camellia assamica (Mast.) Chang (CMC) and Pyrus, i, f. (CMP) were compared. Phenolic compounds in CMC and CMP were identified and quantified using high-performance liquid chromatography (HPLC)...
February 8, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29417471/neuroprotective-effects-of-phenolic-and-carboxylic-acids-on-oxidative-stress-induced-toxicity-in-human-neuroblastoma-sh-sy5y-cells
#11
Naw Hser Gay, Kamonrat Phopin, Wilasinee Suwanjang, Napat Songtawee, Waralee Ruankham, Prapimpun Wongchitrat, Supaluk Prachayasittikul, Virapong Prachayasittikul
An increase in oxidative stress is a key factor responsible for neurotoxicity induction and cell death leading to neurodegenerative diseases including Parkinson's and Alzheimer's diseases. Plant phenolics exert diverse bioactivities i.e., antioxidant, anti-inflammatory, and neuroprotective effects. Herein, phenolic compounds, namely protocatechuic aldehyde (PCA) constituents of Hydnophytum formicarum Jack. including vanillic acid (VA) and trans-ferulic acid (FA) found in Spilanthes acmella Murr., were explored for anti-neurodegenerative properties using an in vitro model of oxidative stress-induced neuroblastoma SH-SY5Y cells...
February 7, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29414866/weed-suppressing-potential-and-isolation-of-potent-plant-growth-inhibitors-from-castanea-crenata-sieb-et-zucc
#12
Phung Thi Tuyen, Tran Dang Xuan, Truong Thi Tu Anh, Truong Mai Van, Ateeque Ahmad, Abdelnaser Abdelghany Elzaawely, Tran Dang Khanh
This study isolated, determined, and quantified plant growth inhibitors in Japanese chestnut (Castanea crenata Sieb. et Zucc), a deciduous species native to Japan and Korea. In laboratory assays, C. crenata leaves showed strong inhibition on germination and seedling growth of Echinochloa crus-galli (barnyardgrass), Lactuca sativa (lettuce), and Raphanus sativus (radish). Laboratory and greenhouse trials showed that leaves of C. crenata appeared as a promising material to manage weeds, especially the dicot weeds...
February 7, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29414239/effects-of-highland-barley-bran-extract-rich-in-phenolic-acids-on-the-formation-of-n%C3%AE%C2%B5-carboxymethyllysine-in-a-biscuit-model
#13
Huilin Liu, Xiaomo Chen, Dianwei Zhang, Jing Wang, Shuo Wang, Baoguo Sun
Highland barley, a staple food in northwest China, is a well-known source of bioactive phytochemicals, including phenolic compounds. This study evaluated the inhibitory effects of highland barley bran extracts (HBBE) on the advanced glycation end products (AGEs) levels in a biscuit model, as measured by Nε-carboxymethyllysine (CML) contents. CML was detected in all inhibition models using HBBE extracted with different solvents. Under optimal conditions, CML formation in the heated model system composed of glucose/lysine/linoleic acid was effectively inhibited by HBBE...
February 7, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29407994/regioselective-synthesis-of-7-o-esters-of-the-flavonolignan-silibinin-and-sars-lead-to-compounds-with-overadditive-neuroprotective-effects
#14
Simon Schramm, Guozheng Huang, Sandra Gunesch, Florian Lang, Judit Roa, Petra Högger, Raimon Sabaté, Pamela Maher, Michael Decker
A series of neuroprotective hybrid compounds was synthesized by conjugation of the flavonolignan silibinin with natural phenolic acids, such as ferulic, cinnamic and syringic acid. Selective 7-O-esterfication without protection groups was achieved by applying the respective acyl chlorides. Sixteen compounds were obtained and SARs were established by evaluating antioxidative properties in the physicochemical FRAP assay, as well as in a cell-based neuroprotection assay using murine hippocampal HT-22 cells. Despite weak activities in the FRAP assay, esters of the α,β-unsaturated acids showed pronounced overadditive effects at low concentrations greatly exceeding the effects of equimolar mixtures of silibinin and the respective acids in the neuroprotection assay...
January 12, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29405075/synthesis-pharmacology-and-molecular-docking-on-multifunctional-tacrine-ferulic-acid-hybrids-as-cholinesterase-inhibitors-against-alzheimer-s-disease
#15
Jie Zhu, Hongyu Yang, Yao Chen, Hongzhi Lin, Qi Li, Jun Mo, Yaoyao Bian, Yuqiong Pei, Haopeng Sun
The cholinergic hypothesis has long been a "polar star" in drug discovery for Alzheimer's disease (AD), resulting in many small molecules and biological drug candidates. Most of the drugs marketed for AD are cholinergic. Herein, we report our efforts in the discovery of cholinesterases inhibitors (ChEIs) as multi-target-directed ligands. A series of tacrine-ferulic acid hybrids have been designed and synthesised. All these compounds showed potent acetyl-(AChE) and butyryl cholinesterase(BuChE) inhibition. Among them, the optimal compound 10g, was the most potent inhibitor against AChE (electrophorus electricus (eeAChE) half maximal inhibitory concentration (IC50) = 37...
December 2018: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/29397771/dual-hiv-1-reverse-transcriptase-and-integrase-inhibitors-from-limonium-morisianum-arrigoni-an-endemic-species-of-sardinia-italy
#16
Cinzia Sanna, Daniela Rigano, Angela Corona, Dario Piano, Carmen Formisano, Domenica Farci, Genni Franzini, Mauro Ballero, Giuseppina Chianese, Enzo Tramontano, Orazio Taglialatela-Scafati, Francesca Esposito
During our search for potential templates of HIV-1 reverse transcriptase (RT) and integrase (IN) dual inhibitors, the methanolic extract obtained from aerial parts of Limonium morisianum was investigated. Repeated bioassay-guided chromatographic purifications led to the isolation of the following secondary metabolites: myricetin, myricetin 3-O-rutinoside, myricetin-3-O-(6″-O-galloyl)-β-d-galactopyranoside, (-)-epigallocatechin 3-O-gallate, tryptamine, ferulic and phloretic acids. The isolated compounds were tested on both HIV-1 RT-associated RNase H and IN activities...
February 4, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29396922/simultaneous-determination-and-qualitative-analysis-of-six-types-of-components-in-naoxintong-capsule-by-miniaturized-matrix-solid-phase-dispersion-extraction-coupled-with-uhplc-with-photodiode-array-detection-and-q-tof-ms
#17
Huilin Wang, Yan Jiang, Mingya Ding, Jin Li, Jia Hao, Jun He, Hui Wang, Xiu-Mei Gao, Yan-Xu Chang
A simple and effective sample preparation process based on miniaturized matrix solid-phase dispersion was developed for simultaneous determination of phenolic acids (gallic acid, chlorogenic acid, ferulic acid, 3,5-dicaffeoylqunic acid, 1,5-dicaffeoylqunic acid, rosmarinic acid, lithospermic acid, salvianolic acid B), flavonoids (kaempferol-3-O-rutinoside, calycosin, formononetin), lactones (ligustilide, butyllidephthalide), monoterpenoids (paeoniflorin), phenanthraquinones (cryptotanshinone) and furans (5-hydroxymethylfurfural) in Naoxintong capsule by ultra high performance liquid chromatography...
February 3, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29392706/effect-of-olive-oil-phenolic-compounds-on-osteoblast-differentiation
#18
L Melguizo-Rodríguez, F J Manzano-Moreno, E De Luna-Bertos, A Rivas, J Ramos-Torrecillas, C Ruiz, O García-Martínez
BACKGROUND: Osteoporosis is a skeletal disorder characterized by compromised bone strength that predisposes individuals to an increased risk of fracture. Previous in vivo and in vitro studies have reported that phenolic compounds present in extra virgin olive oil have a beneficial effect on osteoblasts in terms of increase cell proliferation. The aim of this study was to determine whether phenolic compounds present in olive oil could modify the expression of cell differentiation markers on osteoblasts...
February 2, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29391628/optimal-germination-condition-impacts-on-the-antioxidant-activity-and-phenolic-acids-profile-in-pigmented-desi-chickpea-cicer-arietinum-l-seeds
#19
D M Domínguez-Arispuro, E O Cuevas-Rodríguez, J Milán-Carrillo, L León-López, R Gutiérrez-Dorado, C Reyes-Moreno
Legume sprouts are considered natural, healthy products that provide a source of bioactive compounds to fight against chronic diseases. This study aims to identify the optimal germination temperature (GT) and germination time (Gt) to maximize total phenolic and flavonoid contents (TPC, FC), and antioxidant activity (AoxA) of desi chickpea. Response surface methodology was used as an optimization tool. An experimental design with two factors (GT and Gt) and five levels was used (13 treatments). The sprouts from each treatment were lyophilized, tempered, and milled to obtain germinated chickpea flours (GCF)...
February 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29391540/4-hydroxy-3-methoxycinnamic-acid-regulates-orexigenic-peptides-and-hepatic-glucose-homeostasis-through-phosphorylation-of-foxo1
#20
Ann W Kinyua, Chang Mann Ko, Khanh V Doan, Dong Joo Yang, My Khanh Q Huynh, Sang Hyun Moh, Yun-Hee Choi, Ki Woo Kim
4-hydroxy-3-methoxycinnamic acid (ferulic acid, FA) is known to have numerous beneficial health effects, including anti-obesity and anti-hyperglycemic properties. However, the molecular networks that modulate the beneficial FA-induced metabolic effects have not been well elucidated. In this study, we explored the molecular mechanisms mediating the beneficial metabolic effects of FA. In mice, FA protected against high-fat diet-induced weight gain, reduced food intake and exhibited an overall improved metabolic phenotype...
February 2, 2018: Experimental & Molecular Medicine
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