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Ferulic acid

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https://www.readbyqxmd.com/read/28213267/ferulic-acid-inhibits-neuro-inflammation-in-mice-exposed-to-chronic-unpredictable-mild-stress
#1
Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Yi
Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can attenuate depressive-like behaviors in both forced swimming test and tail suspension test. Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS)...
February 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28206756/effect-of-bioprocessing-on-the-in-vitro-colonic-microbial-metabolism-of-phenolic-acids-from-rye-bran-fortified-breads
#2
Ville Mikael Koistinen, Emilia Nordlund, Kati Katina, Ismo Mattila, Kaisa Poutanen, Kati Hanhineva, Anna-Marja Aura
Cereal bran is an important source of dietary fiber and bioactive compounds, such as phenolic acids. We aimed to study the phenolic acid metabolism of native and bioprocessed rye bran fortified refined wheat bread and to elucidate the microbial metabolic route of phenolic acids. After incubation in an in vitro colon model, the metabolites were analyzed using two different methods applying mass spectrometry. While phenolic acids were released more extensively from the bioprocessed bran bread and ferulic acid had consistently higher concentrations in the bread type during fermentation, there were only minor differences in the appearance of microbial metabolites, including the diminished levels of certain phenylacetic acids in the bioprocessed bran...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28205618/ald5-pad1-atf1-and-atf2-facilitate-the-catabolism-of-coniferyl-aldehyde-ferulic-acid-and-p-coumaric-acid-in-saccharomyces-cerevisiae
#3
Peter Temitope Adeboye, Maurizio Bettiga, Lisbeth Olsson
The ability of Saccharomyces cerevisiae to catabolize phenolic compounds remains to be fully elucidated. Conversion of coniferyl aldehyde, ferulic acid and p-coumaric acid by S. cerevisiae under aerobic conditions was previously reported. A conversion pathway was also proposed. In the present study, possible enzymes involved in the reported conversion were investigated. Aldehyde dehydrogenase Ald5, phenylacrylic acid decarboxylase Pad1, and alcohol acetyltransferases Atf1 and Atf2, were hypothesised to be involved...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28202307/influence-of-rice-straw-polyphenols-on-cellulase-production-by-trichoderma-reesei
#4
Wei Zheng, Qin Zheng, Yiyun Xue, Jiajun Hu, Min-Tian Gao
In this study, we found that during cellulase production by Trichoderma reesei large amounts of polyphenols were released from rice straw when the latter was used as the carbon source. We identified and quantified the phenolic compounds in rice straw and investigated the effects of the phenolic compounds on cellulase production by T. reesei. The phenolic compounds of rice straw mainly consisted of phenolic acids and tannins. Coumaric acid (CA) and ferulic acid (FA) were the predominant phenolic acids, which inhibited cellulase production by T...
February 12, 2017: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/28202014/defensive-changes-in-maize-leaves-induced-by-feeding-of-mediterranean-corn-borer-larvae
#5
Rogelio Santiago, Ana Cao, Ana Butrón, Ana López-Malvar, Víctor M Rodríguez, Germán V Sandoya, Rosa A Malvar
BACKGROUND: Plants can respond to insect attack via defense mechanisms that reduce insect performance. In this study, we examined the effects of several treatments applied to two maize genotypes (one resistant, one susceptible) on the subsequent growth and survival of Sesamia nonagrioides Lef. (Mediterranean corn borer, MCB) larvae. The treatments were infestation with MCB larvae, application of MCB regurgitant upon wounding, wounding alone, or exposure to methyl jasmonate, and they were applied at the V6-V8 stage of maize development...
February 15, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28193407/mechanism-of-action-and-interactions-between-xanthine-oxidase-inhibitors-derived-from-natural-sources-of-chlorogenic-and-ferulic-acids
#6
Urszula Gawlik-Dziki, Dariusz Dziki, Michał Świeca, Renata Nowak
The aim of this study was to estimate the phenolic composition and xanthine oxidase (XO) inhibitory activity of green coffee beans (GCB) and wholemeal wheat flour (WF). Additionally, the type and strength of interaction (expressed as the combination index, CI) and mode of XO inhibition were analyzed. The major phenolic in GCB was 5-caffeoylquinic acid (39.92mg/g dw). The main phenolic acids in WF were trans- and cis-ferulic acids (257 and 165.57mg/100g dw, respectively). Both ferulic and chlorogenic acids individually inhibited XO, and for their combination moderate synergism was found...
June 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28192494/edible-solid-lipid-nanoparticles-sln-as-carrier-system-for-antioxidants-of-different-lipophilicity
#7
Kathleen Oehlke, Diana Behsnilian, Esther Mayer-Miebach, Peter G Weidler, Ralf Greiner
Ferulic acid (FA) and tocopherol (Toc) loaded solid lipid nanoparticles (SLN) were prepared by a hot homogenisation method. The particle size distribution, zeta potential and melting behaviour of the SLN as well as the stability, encapsulation efficiency and radical scavenging activity of FA and Toc in the SLN were analysed. The different formulations containing up to 2.8 mg g-1 of FA or Toc were stable during at least 15 weeks of storage at room temperature. Despite partial degradation and / or release of FA and Toc during storage, significant radical scavenging activity was maintained...
2017: PloS One
https://www.readbyqxmd.com/read/28191037/understanding-the-structural-and-chemical-changes-of-plant-biomass-following-steam-explosion-pretreatment
#8
Thomas Auxenfans, David Crônier, Brigitte Chabbert, Gabriel Paës
BACKGROUND: Biorefining of lignocellulosic biomass has become one of the most valuable alternatives for the production of multi-products such as biofuels. Pretreatment is a prerequisite to increase the enzymatic conversion of the recalcitrant lignocellulose. However, there is still considerable debate regarding the key features of biomass impacting the cellulase accessibility. In this study, we evaluate the structural and chemical features of three different representative biomasses (Miscanthus × giganteus, poplar and wheat straw), before and after steam explosion pretreatment at increasing severities, by monitoring chemical analysis, SEM, FTIR and 2D NMR...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/28188935/model-based-characterisation-of-growth-performance-and-l-lactic-acid-production-with-high-optical-purity-by-thermophilic-bacillus-coagulans-in-a-lignin-supplemented-mixed-substrate-medium
#9
Robert Glaser, Joachim Venus
Three Bacillus coagulans strains were characterised in terms of their ability to grow in lignin-containing fermentation media and to consume the lignocellulose-related sugars glucose, xylose, and arabinose. An optical-density high-throughput screening was used for precharacterisation by means of different mathematical models for comparison (Logistic, Gompertz, Baranyi, Richards & Stannard, and Schnute). The growth response was characterised by the maximum growth rate and lag time. For a comparison of the screening and fermentation results, an unstructured mathematical model was proposed to characterise the lactate production, bacterial growth and substrate consumption...
February 7, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28188206/insight-into-the-carbon-source-dependent-inducible-veratrylalcohol-and-ferulic-acid-metabolism-in-pseudomonas-putida-csv86
#10
Karishma Mohan, Prashant S Phale
Pseudomonas putida CSV86 degrades lignin-derived metabolic intermediates viz veratrylalcohol, ferulic acid, vanillin and vanillic acid as a sole source of carbon and energy. Strain CSV86 also displayed the ability to degrade lignin sulphonate. Cell respiration, enzyme activity, biotransformation and HPLC analysis suggests that veratyralcohol and ferulic acid are metabolized to vanillic acid by two distinct carbon-source dependent inducible pathways. Vanillic acid was further metabolized to protocatechuic acid and enters the central carbon pathway viaβ-ketoadipate route after ortho ring-cleavage...
February 10, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28179945/synthesis-and-evaluation-of-anti-oxidant-and-cytotoxic-activities-of-novel-10-undecenoic-acid-methyl-ester-based-lipoconjugates-of-phenolic-acids
#11
Naganna Narra, Shiva Shanker Kaki, Rachapudi Badari Narayana Prasad, Sunil Misra, Koude Dhevendar, Venkateshwarlu Kontham, Padmaja V Korlipara
The synthesis of five novel methyl 10-undecenoate-based lipoconjugates of phenolic acids from undecenoic acid was carried out. Undecenoic acid was methylated to methyl 10-undecenoate which was subjected to a thiol-ene reaction with cysteamine hydrochloride. Further amidation of the amine was carried out with different phenolic acids such as caffeic, ferulic, sinapic, coumaric and cinnamic acid. All synthesized compounds were fully characterized and their structures were confirmed by spectral data. The anti-oxidant activity of the synthesized lipoconjugates of phenolic acids was studied by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and also by the inhibition of linoleic acid oxidation in micellar medium by differential scanning calorimetry (DSC)...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28177659/effects-of-ferulic-acid-on-oxidative-stress-heat-shock-protein-70-connexin-43-and-monoamines-in-hippocampus-of-pentylenetetrazole-kindled-rats
#12
Abdelaziz M Hussein, Khalid M Abbas, Osama A Abulseoud, Elhussainy Mohamed Abouelez Elhussainy
The present study investigated the effects of ferulic acid on pentylenetetrazole (PTZ)-induced seizures, oxidative stress markers (malondialdhyde (MDA), catalase (CAT) and reduced glutathione (GSH)), connexin (Cx) 43, heat shock protein (Hsp) 70 and monoamines (serotonin (5HT) and norepinephrine (NE) levels in a rat model of PTZ-induced kindling. Sixty Sprague Dawley rats were divided into 5 equal groups, a) normal group, b) FA group: normal rats received FA at a dose of 40 mg/kg daily, c) PTZ group: rats received PTZ at a dose of 50 mg/kg i...
February 3, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28177054/propolis-from-southwest-of-parana-produced-by-selected-bees-influence-of-seasonality-and-food-supplementation-on-antioxidant-activity-and-phenolic-profile
#13
Matheus A Calegari, Anaclara Prasniewski, Cleidiane DA Silva, Ricardo Y Sado, Fabiana M C Maia, Larissa M S Tonial, Tatiane L C Oldoni
Propolis produced by selected bees Apis mellifera were collected from March to June of 2013 and in March of 2015 and analyzed in order to evaluate the influence of climate, colony of origin, and food supplementation of colonies on the content of total phenolic and flavonoid by chromatographic analysis and antioxidant activity by radical scavenging of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods...
February 6, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28170016/the-anti-obesity-effect-of-fermented-barley-extracts-with-lactobacillus-plantarum-dy-1-and-saccharomyces-cerevisiae-in-diet-induced-obese-rats
#14
Jiayan Zhang, Xiang Xiao, Ying Dong, Lani Shi, Tian Xu, Fei Wu
Fermented cereals have significant potential for improving the nutritional quality and health effects of foods and ingredients. In the present study, aqueous extracts of fermented barley with either Lactobacillus plantarum dy-1 or Saccharomyces cerevisiae were investigated for their anti-adipogenic effects in vitro and in vivo. Oral administration of an aqueous extract of fermented barley with Lactobacillus plantarum dy-1 (LFBE) significantly prevented body weight gain and fat mass increase, and improved lipid profiles and glucose tolerance in high fat diet-induced obese male rats...
February 7, 2017: Food & Function
https://www.readbyqxmd.com/read/28165411/isolation-and-characterization-of-gramineae-and-fabaceae-soda-lignins
#15
Juan Domínguez-Robles, Rafael Sánchez, Eduardo Espinosa, Davide Savy, Pierluigi Mazzei, Alessandro Piccolo, Alejandro Rodríguez
Some agricultural residues such as wheat or barley straw, as well as certain fast-growing plants like Leucaena leucocephala and Chamaecytisus proliferus, could be used as raw materials for the paper industry as an alternative to traditional plants (eucalyptus, pine, etc.). In the present study, four types of lignin obtained from the spent liquors produced by the pulping processes using the abovementioned feedstocks were isolated and characterized. Lignin samples were acquired through an acid precipitation from these spent liquors...
February 4, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28159727/a-p-coumaroyl-esterase-from-rhizoctonia-solani-with-a-pronounced-chlorogenic-acid-esterase-activity
#16
Annabel Nieter, Sebastian Kelle, Diana Linke, Ralf G Berger
Extracellular esterase activity was detected in submerged cultures of Rhizoctonia solani grown in the presence of sugar beet pectin or Tween 80. Putative type B feruloyl esterase (FAE) coding sequences found in the genome data of the basidiomycete were heterologously expressed in Pichia pastoris. Recombinant enzyme production on the 5-L bioreactor scale (RspCAE: 3245UL(-1)) exceeded the productivity of the wild type strain by a factor of 800. Based on substrate specificity profiling, the purified recombinant RspCAE was classified as a p-coumaroyl esterase (pCAE) with a pronounced chlorogenic acid esterase side activity...
January 31, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28157221/microbial-modulation-of-bacoside-a-biosynthetic-pathway-and-systemic-defense-mechanism-in-bacopa-monnieri-under-meloidogyne-incognita-stress
#17
Rupali Gupta, Akanksha Singh, Madhumita Srivastava, Vivek Singh, M M Gupta, Rakesh Pandey
Plant-associated beneficial microbes have been explored to fulfill the imperative function for plant health. However, their impact on the host secondary metabolite production and nematode disease management remains elusive. Our present work has shown that chitinolytic microbes viz., Chitiniphilus sp. MTN22 and Streptomyces sp. MTN14 singly as well as in combination modulated the biosynthetic pathway of bacoside A and systemic defense mechanism against Meloidogyne incognita in Bacopa monnieri. Interestingly, expression of bacoside biosynthetic pathway genes (3-Hydroxy-3-methylglutaryl coenzyme A reductase, mevalonate diphosphate decarboxylase, and squalene synthase) were upregulated in plants treated with the microbial combination in the presence as well as in absence of M...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28147890/astragaloside-iv-synergizes-with-ferulic-acid-to-suppress-hepatic-stellate-cells-activation-in-vitro
#18
Haiying Dong, Hongyan Guo, Yini Liang, Xing Wang, Yingcai Niu
Because hepatic fibrosis usually involves more than one pathological process, combination therapy with modalities that target aberrant signaling cascade in activated hepatic stellate cells (HSCs) represents an alternative strategy. This study evaluates the hypothesis that astragaloside IV (AS-IV) and ferulic acid (FA) synergize to inhibit HSCs activation via simultaneous activating nuclear factor erythroid 2-related factor 2 (Nrf2) and blocking transforming growth factor β (TGF-β) pathways. The combination of FA and AS-IV, hereafter referred to as the AS-IV/FA, at suboptimal concentrations synergistically inhibited HSCs activation, as measured by expressions of α-smooth muscle actin (α-SMA), collagen α type I (Col I), and fibronectin...
February 1, 2017: Free Radical Research
https://www.readbyqxmd.com/read/28144249/cloning-functional-characterization-and-site-directed-mutagenesis-of-4-coumarate-coenzyme-a-ligase-4cl-involved-in-coumarin-biosynthesis-in-peucedanum-praeruptorum-dunn
#19
Tingting Liu, Ruolan Yao, Yucheng Zhao, Sheng Xu, Chuanlong Huang, Jun Luo, Lingyi Kong
Coumarins are the main bioactive compounds in Peucedanum praeruptorum Dunn, a common Chinese herbal medicine. Nevertheless, the genes involved in the biosynthesis of core structure of coumarin in P. praeruptorum have not been identified yet. 4-Coumarate: CoA ligase (4CL) catalyzes the formation of hydroxycinnamates CoA esters, and plays an essential role at the divergence point from general phenylpropanoid metabolism to major branch pathway of coumarin. Here, three novel putative 4CL genes (Pp4CL1, Pp4CL7, and Pp4CL10) were isolated from P...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28138677/potential-roles-of-chemical-degradation-in-the-biological-activities-of-curcumin
#20
REVIEW
Julia Zhu, Katherine Z Sanidad, Elvira Sukamtoh, Guodong Zhang
Substantial pre-clinical and human studies have shown that curcumin, a dietary compound from turmeric, has a variety of health-promoting biological activities. A better understanding of the biochemical mechanisms for the health-promoting effects of curcumin could facilitate the development of effective strategies for disease prevention. Recent studies have shown that in aqueous buffer, curcumin rapidly degrades and leads to formation of various degradation products. In this review, we summarized and discussed the biological activities of chemical degradation products of curcumin, including alkaline hydrolysis products (such as ferulic acid, vanillin, ferulaldehyde, and feruloyl methane), and autoxidation products (such as bicyclopentadione)...
January 31, 2017: Food & Function
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