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mitochondrial MTFA

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https://www.readbyqxmd.com/read/25556274/the-inhibitory-role-of-mir-214-in-cervical-cancer-cells-through-directly-targeting-mitochondrial-transcription-factor-a-tfam
#1
Z Wen, Z Lei, M Jin-An, L Xue-Zhen, Z Xing-Nan, D Xiu-Wen
Mitochondrial transcription factor A (TFAM) is a high-mobility group (HMG) protein and acts as a key regulator in mitochondrial DNA (mtDNA) replication, transcription, and inheritance. Accumulating evidence has demonstrated that TFAM plays an important role in tumorigenesis; however, the regulatory mechanism of TFAM in cervical cancer has not been revealed. In the current study, the au- thors found that with malignancy of cervical cancer, the protein expression of TFAM was gradually increased, while the expression of miRNA-214 was gradually downregulated...
2014: European Journal of Gynaecological Oncology
https://www.readbyqxmd.com/read/24895245/impaired-peripheral-glucose-sensing-in-f1-offspring-of-diabetic-pregnancy
#2
Maher A Kamel, Madiha H Helmy, Mervat Y Hanafi, Shimaa A Mahmoud, Hanan Abo Elfetooh
Maternal diabetes can induce permanent changes in glucose homeostasis that can occur pre- and post-natal and leads to type 2 diabetes in adulthood. This study aimed to investigate the effect of maternal diabetes on the F1 offspring peripheral glucose sensing and mitochondrial biogenesis in an attempt to clarify the mechanism of diabetogenic programming. Two groups of female Wistar rats were used (diabetic and control); diabetes was neonatally induced by STZ injection to 5-day old rats. After the pregnancy and delivery, the offspring were weaned to control diet or high-caloric (HCD) diet and followed up for 30 weeks...
September 2014: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/22627788/three-weeks-of-erythropoietin-treatment-hampers-skeletal-muscle-mitochondrial-biogenesis-in-rats
#3
Vladimir E Martinez-Bello, Fabian Sanchis-Gomar, Marco Romagnoli, Frederic Derbre, Mari Carmen Gomez-Cabrera, Jose ViƱa
The blood O(2)-carrying capacity is maintained by the O(2)-regulated production of erythropoietin (Epo), which stimulates the proliferation and survival of red blood cell progenitors. Epo has been thought to act exclusively on erythroid progenitor cells. However, recent studies have identified the erythropoietin receptor (EpoR) in other cells, such as neurons, astrocytes, microglia, heart, cancer cell lines, and skeletal muscle provides evidence for a potential role of Epo in other tissues. In this study we aimed to determine the effect of recombinant human erythropoietin (rHuEpo) on skeletal muscle adaptations such as mitochondrial biogenesis, myogenesis, and angiogenesis in different muscle fibre types...
December 2012: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/18079123/modest-pgc-1alpha-overexpression-in-muscle-in-vivo-is-sufficient-to-increase-insulin-sensitivity-and-palmitate-oxidation-in-subsarcolemmal-not-intermyofibrillar-mitochondria
#4
Carley R Benton, James G Nickerson, James Lally, Xiao-Xia Han, Graham P Holloway, Jan F C Glatz, Joost J F P Luiken, Terry E Graham, John J Heikkila, Arend Bonen
PGC-1alpha overexpression in skeletal muscle, in vivo, has yielded disappointing and unexpected effects, including disrupted cellular integrity and insulin resistance. These unanticipated results may stem from an excessive PGC-1alpha overexpression in transgenic animals. Therefore, we examined the effects of a modest PGC-1alpha overexpression in a single rat muscle, in vivo, on fuel-handling proteins and insulin sensitivity. We also examined whether modest PGC-1alpha overexpression selectively targeted subsarcolemmal (SS) mitochondrial proteins and fatty acid oxidation, because SS mitochondria are metabolically more plastic than intermyofibrillar (IMF) mitochondria...
February 15, 2008: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/9309692/regulation-of-mitochondrial-transcription-by-mitochondrial-transcription-factor-a
#5
J Montoya, A Perez-Martos, H L Garstka, R J Wiesner
In order to test the hypothesis that mitochondrial transcription factor A (mtTFA) regulates mitochondrial transcription in vivo, mtTFA was overexpressed in HeLa cells and imported into isolated rat liver mitochondria. Five hours after transfection with an eukaryotic expression vector, mitochondrial transcripts for cytochrome-c-oxidase subunit I and 12 S rRNA were increased over controls. In the presence of rat liver mitochondria, the 29 kDa mtTFA, generated by in vitro translation, was processed to a 24 kDa protein which was protected from protease digestion...
September 1997: Molecular and Cellular Biochemistry
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