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https://www.readbyqxmd.com/read/27926987/impact-of-everolimus-on-japanese-patients-with-advanced-pancreatic-neuroendocrine-neoplasms
#1
Lingaku Lee, Tetsuhide Ito, Hisato Igarashi, Keijiro Ueda, Takashi Fujiyama, Ken Kawabe, Yoshihiro Ogawa
BACKGROUND: Although everolimus has become a key therapeutic agent in patients with advanced pancreatic neuroendocrine neoplasms (PNEN), its efficacy and safety in clinical practice remains unclear. METHODS: Forty-seven patients with advanced PNEN treated with everolimus were reviewed retrospectively. To evaluate the safety of everolimus as a long-term treatment, the patients were divided into 2 groups according to treatment duration: group A, ≤1 year (n = 21); group B, >1 year (n = 26)...
December 7, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27923222/pediatric-primary-diffuse-leptomeningeal-primitive-neuroectodermal-tumor-a-case-report-and-literature-review
#2
Jesna Mathew Sublett, Caitlin Davenport, Howard Eisenbrock, Shamsher Dalal, Syed A Jaffar Kazmi, Amir Kershenovich
BACKGROUND: Primary diffuse leptomeningeal primitive neuroectodermal tumor (PDL PNET) is extremely rare, with only 19 cases reported in the literature to date. We present a case of a child with rapidly progressive PDL PNET and a literature review. A 10-year-old boy presented with mood lability, hallucinations, generalized pain, enuresis, and headaches. Initial investigation failed to produce a diagnosis. The symptoms progressed to seizure, back pain, and papilledema. Imaging showed acute hydrocephalus and mild diffuse leptomeningeal enhancement without an identifiable primary lesion...
December 7, 2016: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27920700/primary-ewing-sarcoma-primitive-neuroectodermal-tumor-of-the-stomach
#3
Safi Khuri, Hayim Gilshtein, Sa'd Sayidaa, Bishara Bishara, Yoram Kluger
Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) is a tumor of small round cells arising in skeletal tissues. These tumors rarely arise in the stomach. We present a 31-year-old healthy female patient who was admitted to our surgical ward due to upper gastrointestinal hemorrhage. Upper endoscopy revealed a large ulcerated bleeding mass originating from the lesser curvature. Biopsy revealed tumor cell immunoreactivity positive for CD99, vimentin, and Ki67 (an index of proliferation). These findings were compatible with gastric ES/PNET...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27919713/primary-primitive-neuroectodermal-tumor-pnet-arising-from-an-ovarian-mature-cystic-teratoma-in-a-12-year-old-female-a-case-report
#4
Ashley Jaramillo-Huff, Rania Bakkar, Jason Q McKee, Nancy Sokkary
BACKGROUND: Ovarian mature cystic teratomas (MCT) rarely transform to a primary primitive neuroectodermal tumor (PNET)(1). This case report offers evidence that MCTs may have undetected micro-focuses of malignant neural tumors. CASE: We describe the case of a 12-year-old female that presented with right-sided abdominal pain and distention. Intra-operative findings revealed a right ovarian MCT. However, pathology showed a 0.5 centimeter focus of malignant neural tumor within the 11 centimeter MCT...
December 2, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27919009/successful-percutaneous-ct-guided-microwave-ablation-of-adrenal-gland-for-ectopic-cushing-syndrome
#5
Rebecca Zener, Andrew Zaleski, Stan H Van Uum, Daryl K Gray, Amol Mujoomdar
Adrenocorticotropic hormone production by pancreatic neuroendocrine tumor (PNET) is rare and results in hyperstimulation of the adrenal gland to produce ectopic Cushing syndrome. Our case showcases the safety and effectiveness of percutaneous CT-guided microwave ablation of the adrenal gland in a 49-year-old female with PNET and hepatic metastases who presented with ectopic Cushing syndrome despite surgical resection of the primary pancreatic tumor and left adrenal gland. Prior to ablation, the right adrenal gland measured 4...
November 29, 2016: Clinical Imaging
https://www.readbyqxmd.com/read/27916439/adult-supratentorial-primitive-neuroectodermal-tumour-presenting-as-intracranial-haemorrhage-case-report
#6
Sean P Black-Tiong, Simon J I Sandler, Sophia Otto, Adam J Wells
Primitive neuroectodermal tumours (PNET) are highly malignant tumours with an aggressive clinical behaviour. Commonly seen in children, they are uncommon in the adult population, and rare in the supratentorial location. Adult supratentorial PNETs (ST-PNET) typically present with symptoms relating to raised intracranial pressure, seizures, or focal neurological deficits. Presentation with intracranial haemorrhage has been reported only twice before in the literature, one of which was fatal. We report the case of intracranial haemorrhage secondary to ST-PNET in a young adult and her immediate management...
December 1, 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27900001/expression-of-glucose-transporter-1-is-correlated-with-hypoxia-inducible-factor-1%C3%AE-and-malignant-potential-in-pancreatic-neuroendocrine-tumors
#7
Minoru Fujino, Shinichi Aishima, Koji Shindo, Yasunori Oda, Katsuya Morimatsu, Kosuke Tsutsumi, Takao Otsuka, Masao Tanaka, Yoshinao Oda
The present study aimed to investigate the prognostic usefulness of the expression of glucose transporter type 1 (GLUT-1) and GLUT-2, hypoxia-inducible factor 1α (HIF-1α) and insulin-like growth factor II messenger RNA-binding protein 3 (IMP3) in pancreatic neuroendocrine tumors (pNETs). Immunohistochemical staining for GLUT-1, GLUT-2, HIF-1α and IMP3 was performed in 70 pNET specimens. The expression of GLUT-1 and HIF-1α was significantly higher in the World Health Organization grade 2 (G2), neuroendocrine carcinoma cases and mixed-type pNETs compared with the G1 cases...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27896509/shape-and-enhancement-characteristics-of-pancreatic-neuroendocrine-tumor-on-preoperative-contrast-enhanced-computed-tomography-may-be-prognostic-indicators
#8
Hirohisa Okabe, Daisuke Hashimoto, Akira Chikamoto, Morikatsu Yoshida, Katsunobu Taki, Kota Arima, Katsunori Imai, Yoshitaka Tamura, Osamu Ikeda, Takatoshi Ishiko, Hideaki Uchiyama, Toru Ikegami, Norifumi Harimoto, Shinji Itoh, Yo-Ichi Yamashita, Tomoharu Yoshizumi, Toru Beppu, Yasuyuki Yamashita, Hideo Baba, Yoshihiko Maehara
BACKGROUND: Prognostic indicators of the malignant potential of pancreatic neuroendocrine tumors (PNET) are limited. We assessed tumor shape and enhancement pattern on contrast-enhanced computed tomography as predictors of malignant potential. METHODS: Sixty cases of PNET patients undergoing curative surgery from 2001 to 2014 were enrolled onto our retrospective study. Preoperative enhanced CTs were assessed, and criteria defined for regularly shaped and enhancing tumors (group 1), and irregularly shaped and/or enhancing tumors (group 2)...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27894508/intrapancreatic-accessory-spleen-ipas-a-single-institution-experience-and-review-of-the-literature
#9
Neal Bhutiani, Michael E Egger, Catherine A Doughtie, Elizabeth S Burkardt, Charles R Scoggins, Robert C G Martin, Kelly M McMasters
INTRODUCTION: Accessory spleens located within the pancreatic parenchyma (intrapancreatic accessory spleen, IPAS) pose a unique clinical challenge. In many cases, despite imaging and other diagnostic studies, malignancy cannot be excluded and patients are subjected to pancreatic resection. We review our experience with the presentation, diagnosis, and treatment of patients with IPAS to provide insight into improving pre-operative evaluation of these patients METHODS: A retrospective chart review identified seven patients who underwent surgical resection of an intrapancreatic spleen at University of Louisville Hospital between 2004 and 2015...
November 23, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27890421/contrast-enhanced-mdct-in-patients-with-pancreatic-neuroendocrine-tumours-correlation-with-histological-findings-and-diagnostic-performance-in-differentiation-between-tumour-grades
#10
E Belousova, G Karmazanovsky, A Kriger, D Kalinin, L Mannelli, A Glotov, N Karelskaya, O Paklina, A Kaldarov
AIM: To identify the multidetector computed tomography (MDCT) features of pancreatic neuroendocrine tumours (pNETs), which correlate with tumour histology and enable preoperative grading. MATERIALS AND METHODS: Thirty-nine patients with histologically confirmed pNET who underwent preoperative contrast-enhanced MDCT were included in this study. Nineteen tumours were classified as Grade 1 (G1) and 20 as Grade 2 (G2). Histopathology slides were reviewed to assess the intratumoural microvascular density (MVD) and the amount of tumour stroma...
November 24, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27878756/imaging-findings-of-adrenal-primitive-neuroectodermal-tumors-a-series-of-seven-cases
#11
Y Zhang, P Cai, M Chen, X Yi, L Li, D Xiao, W Liu, W Li, Y Li
OBJECTIVE: To explore the imaging features of adrenal primitive neuroectodermal tumors (PNETs). MATERIALS AND METHODS: This retrospective study included seven patients with surgically and pathologically confirmed adrenal PNETs. Among them, six underwent computed tomography (CT) scans, and one underwent magnetic resonance imaging. The imaging findings, including size, shape, margin, hemorrhage, calcification, cystic degeneration, regional lymph nodes involvement, tumor thrombus formation and enhancement pattern, were retrospectively analyzed...
November 23, 2016: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27876341/imaging-of-neuroendocrine-tumors-of-the-pancreas
#12
C Dromain, D Déandréis, J-Y Scoazec, D Goere, M Ducreux, E Baudin, L Tselikas
Pancreatic neuroendocrine tumors (PNETs) are rare and represent a heterogeneous disease. PNET can be functioning or non-functioning with different clinical presentations and different prognosis based on WHO and pTNM classifications. The role of imaging includes the localization of small functioning tumor, differentiation of these tumors from adenocarcinoma, identification of signs of malignancy and evaluation of extent. PNETs have a broad spectrum of appearance. On CT and MRI, most of functioning PNETs are well defined small tumors with intense and homogeneous enhancement on arterial and portal phases...
December 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27865287/surgical-management-of-pancreatic-neuroendocrine-tumors
#13
REVIEW
Jason B Liu, Marshall S Baker
Pancreatic neuroendocrine tumors (PNETs) are a rare, heterogeneous group of neoplasms infamous for their endocrinopathies. Up to 90% of PNETs, however, are nonfunctional and are frequently detected incidentally on axial imaging during the evaluation of vague abdominal symptoms. Surgery remains the mainstay of therapy for patients diagnosed with both functional and nonfunctional PNETs. However, the multifaceted nature of PNETs challenges treatment decision making. In general, resection is recommended for patients with acceptable perioperative risk and amenable lesions...
December 2016: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27864705/the-clinical-and-financial-impact-of-a-pediatric-surgical-neuro-oncology-clinical-trial
#14
Eric M Thompson, Sridharan Gururangan, Gerald Grant, Duane Mitchell, John H Sampson
Pediatric surgical trials are rare and the impact of such trials on the institutions in which they are conducted is unknown. The purpose of this study was to analyze the clinical and financial impact of The Re-MATCH trial, a Phase I clinical trial requiring the biopsy or resection of recurrent medulloblastoma or PNET for enrollment. Inpatient financial and clinical volume information was collected during the 3 years of trial enrollment and the years preceding and following it. The primary endpoints were the difference in direct contribution margin (DCM), or net gain, of study and non-study patients and the difference in surgical volume during the study and non-study periods...
November 18, 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27863178/fine-needle-aspiration-biopsy-of-pancreatic-neuroendocrine-tumors-correlation-between-ki-67-index-in-cytological-samples-and-clinical-behavior
#15
Cristina Díaz Del Arco, J Miguel Esteban López-Jamar, Luis Ortega Medina, J Ángel Díaz Pérez, Ma Jesús Fernández Aceñero
BACKGROUND: Mitotic count in hematoxylin-eosin stained slides and Ki-67 index allow stratification of patients for prognosis and therapeutic decision making in pancreatic neuroendocrine tumors (PNETs). However, the utility of Ki-67 determination in cytological material and its association to PNET prognosis are under discussion. METHODS: We have retrospectively reviewed all cases of EUS-FNA cytology of pancreatic lesions performed in the Hospital Clínico San Carlos (Madrid) between 2006 and 2016...
November 14, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/27822631/pancreatic-duct-involvement-in-well-differentiated-neuroendocrine-tumors-is-an-independent-poor-prognostic-factor
#16
Yoshihide Nanno, Ippei Matsumoto, Yoh Zen, Kyoko Otani, Jun Uemura, Hirochika Toyama, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Keiichi Okano, Yasuyuki Suzuki, Yoshifumi Takeyama, Takumi Fukumoto, Yonson Ku
BACKGROUND: The biological behavior of well-differentiated neuroendocrine tumors of the pancreas (PNETs) is difficult to predict. This study was designed to determine whether involvement of the main pancreatic duct (MPD) serves as a poor prognostic factor for PNETs. METHODS: The involvement of the MPD in PNETs was defined as ductal stenosis inside the tumor mass associated with distal MPDs more than twofold larger in diameter than the proximal ducts. We examined the correlation between MPD involvement and other clinicopathological parameters, including nodal metastasis and recurrence-free survival, in 101 patients treated consecutively at three referral centers in Japan...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27822490/primitive-neuroectodermal-tumor-of-the-uterus
#17
C R Elizalde, A Yagüe, J Fernandez, P Dieste, M J Puente, J Hernandez
•PNET of the uterus is rare and requires early diagnoses and treatment.•Molecular analysis is important to distinguish it from other tumors.•Different combinations of adjuvant chemotherapy have been report.
November 2016: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/27811505/early-and-late-complications-after-surgery-for-men1-related-nonfunctioning-pancreatic-neuroendocrine-tumors
#18
Sjoerd Nell, Inne H M Borel Rinkes, Helena M Verkooijen, Bert A Bonsing, Casper H van Eijck, Harry van Goor, Ruben H J de Kleine, Geert Kazemier, Elisabeth J Nieveen van Dijkum, Cornelis H C Dejong, Gerlof D Valk, Menno R Vriens
OBJECTIVE: To estimate short and long-term morbidity after pancreatic surgery for multiple endocrine neoplasia type 1 (MEN1)-related nonfunctioning pancreatic neuroendocrine tumors (NF-pNETs). BACKGROUND: Fifty percent of the MEN1 patients harbor multiple NF-pNETs. The decision to proceed to NF-pNET surgery is a balance between the risk of disease progression versus the risk of surgery-related morbidity. Currently, there are insufficient data on the surgical complications after MEN1 NF-pNET surgery...
November 1, 2016: Annals of Surgery
https://www.readbyqxmd.com/read/27804208/birth-weight-and-subsequent-risk-of-childhood-primary-brain-tumors-an-updated-meta-analysis
#19
Anne Dahlhaus, Peggy Prengel, Logan Spector, Dawid Pieper
BACKGROUND: Primary brain tumors are common in childhood, but the etiology is largely unclear. As studies on birth weight as a risk factor for the occurrence of histologically specified tumors have been inconclusive, we decided to update a 2008 meta-analysis on the subject. METHODS: A search strategy was performed in Medline and EMBASE for the period 2007-2016. We included six new studies and performed further subgroup analyses for medulloblastoma and primitive neuroectodermal tumors (PNETs)...
November 2, 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27802780/capecitabine-and-temozolomide-in-grade-1-2-neuroendocrine-tumors-a-spanish-multicenter-experience
#20
Guillermo Crespo, Paula Jiménez-Fonseca, Ana Custodio, Carlos López, Alberto Carmona-Bayonas, Vicente Alonso, Miguel Navarro, Javier Aller, Isabel Sevilla, Enrique Grande, Pablo Gajate, Teresa Alonso-Gordoa, Ignacio Matos, Jaume Capdevila, Beatriz Nieto, Jorge Barriuso
BACKGROUND & METHODS: Capecitabine and temozolomide chemotherapy was used in 65 patients with grade 1/2 neuroendocrine tumors (NETs). 46 patients (70.8%) had pancreatic NETs (pNETs). RESULTS: Response rate was 47.7%, with two complete responses (3.1%), 29 partial responses (44.6%) and 27 patients (41.5%) achieved stable disease. Median progression-free survival was 16.1 months (95% CI: 10.7-21.6) and overall survival was 38.3 months (95% CI: 24.6-51.9). Differences in progression-free survival and overall survival between pNETs and non-pNETs were not found...
November 2, 2016: Future Oncology
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