keyword
MENU ▼
Read by QxMD icon Read
search

Pnet

keyword
https://www.readbyqxmd.com/read/29449689/current-and-emerging-therapies-for-pnets-in-patients-with-or-without-men1
#1
REVIEW
Morten Frost, Kate E Lines, Rajesh V Thakker
Pancreatic neuroendocrine tumours (PNETs) might occur as a non-familial isolated endocrinopathy or as part of a complex hereditary syndrome, such as multiple endocrine neoplasia type 1 (MEN1). MEN1 is an autosomal dominant disorder characterized by the combined occurrence of PNETs with tumours of the parathyroids and anterior pituitary. Treatments for primary PNETs include surgery. Treatments for non-resectable PNETs and metastases include biotherapy (for example, somatostatin analogues, inhibitors of receptors and monoclonal antibodies), chemotherapy and radiological therapy...
February 16, 2018: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/29443778/a-primitive-neuroectodermal-tumor-in-an-adult-case-report-of-a-unique-location-and-mri-characteristics
#2
Xin He, Zhongping Chen, Yutong Dong, Dan Tong
RATIONALE: Central nervous system primitive neuroectodermal tumors (CNS PNETs) mostly occur in children and present as cerebellar medulloblastoma. A few cases of PNETs occur in the cerebral hemisphere. The presence of a PNET in ventricles is extremely rare. The prognosis of CNS PNET is extremely poor, and the 5-year survival rate does not exceed 35%. In the present study, we describe the first case of a PNET in the ventricles with good prognosis. PATIENT CONCERNS: The case of a 36-year-old man is reported, who presented with a progressively worsening headache for 2 months...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29433805/proactive-multi-modality-treatment-of-pancreatic-neuroendocrine-tumours-pnets-potential-survival-benefits
#3
L Tanno, D Mayo, S Mills, A Takhar, J Cave, L Nolan, B Stedman, F X Sundram, M Abu Hilal, H Connor, N Pearce, T Armstrong
BACKGROUND/OBJECTIVES: Primary and metastatic pancreatic neuroendocrine tumours (PNET) can be treated with combination of surgery, locoregional and systemic therapy. Survival benefits from individual treatments have been well reported, however, the combined outcome from multimodal treatments are not well described in the literature. We report outcomes in a cohort of PNET patients treated with proactive, multimodality therapy. METHODS: 106 patients were identified from a single tertiary referral centre prospective database...
December 14, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29397338/preoperative-imaging-and-pathologic-classification-for-pancreatic-neuroendocrine-tumors
#4
S Deguelte, L de Mestier, O Hentic, J Cros, R Lebtahi, P Hammel, R Kianmanesh
The management of patients with pancreatic neuroendocrine tumor (PNET), whether hormonally secretory or not, is multidisciplinary and often multimodal. Surgical treatment plays a central role because complete resection is the only potentially curative treatment. The choice of the therapeutic plan for a PNET requires precise localization of the primary tumor (which may sometimes be multiple in case of genetic predisposition), confirmation of the diagnosis of PNET, a search for metastases (mainly hepatic), and identification of the main histoprognostic factors...
January 31, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29395620/high-throughput-gene-sequencing-reveals-altered-landscape-in-dna-damage-responses-and-chromatin-remodeling-in-sporadic-pancreatic-neuroendocrine-tumors
#5
Shunrong Ji, Wenting Yang, Jiang Liu, Jingjing Zhao, Liang Chen, Quanxing Ni, Jiang Long, Xianjun Yu
PURPOSE: The main objectives of this retrospective study were to survey the genetic landscape of PNETs in a clinical cohort by using the high throughput gene sequencing method and to determine cellular signaling networks affected by the uncovered gene mutations. MATERIALS AND METHODS: We retrieved the demographics and tumor characteristics of 13 patients. Cellular DNA was extracted from fresh snap frozen tumor tissues and was subject to high throughput gene sequencing analysis using the Illumina NextSeq500 System...
January 30, 2018: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29394725/-a-case-of-non-functioning-pancreatic-neuroendocrine-tumor-accompanied-by-stenosis-of-the-main-pancreatic-duct
#6
Takeshi Ishii, Noriaki Nakamura, Toshifumi Saitou, Kouji Yonekura, Yuichiro Watanabe, Takahiro Sanada, Hiroshi Kuwabara, Narihide Goseki, Morio Koike
We experienced a rare case of pancreatic neuroendocrine tumor(pNET)in which stenosis of the main pancreatic duct occurred despite the tumor diameter being less than 1 cm; therefore, here, we report this case with some literature review.A 41-year-old woman showed dilation of the main pancreatic duct on an abdominal ultrasound as part of a health examination, and she visited our department for a more detailed examination.Enhanced CT scan showed a 7mm subtle enhancing mass in the head of the pancreas and the upstream main pancreatic duct was dilated up to 7 mm...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29390485/antiangiogenic-therapy-for-primitive-neuroectodermal-tumor-with-thalidomide-a-case-report-and-review-of-literature
#7
REVIEW
Qing Li, Yong Liu, Yang Yu
RATIONALE: Peripheral primitive neuroectodermal tumor (PNET) is a kind of small round cell tumor derived from primitive neuroectodermal tumor. PATIENT CONCERNS: PNET is a highly malignant tumor that is subordinated to Ewing sarcoma. It occurs predominantly in soft tissue and bone and rarely in the bronchi and lung. Traditional surgery, radiotherapy, and chemotherapy are used for the treatment of PNET, but are usually ineffective. DIAGNOSES: There was a rare case of a 17 year-old man diagnoses with primary pulmonary PNET...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29387511/extraosseous-ewing-s-sarcoma-of-the-pancreas-an-uncommon-but-treatable-disease
#8
Muhammad W Saif, Kristin Kaley
Extraosseous Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) is a rare but aggressive and malignant tumor, and has been reported in various sites such as the lungs, biliary tract, kidney, prostate, stomach, esophagus, oral cavity, salivary glands, urinary bladder, uterus, cervix, gonads, and vagina. However, the pancreas is considered to be an extremely uncommon site and only a handful of cases have been published to date. We present here another case of a pancreatic ES/PNET. Our case intensifies the importance to recognize this rare type of tumor in the pancreas as there is a broad spectrum of tumors with a similar morphology that includes sheets of small, round blue cells...
November 26, 2017: Curēus
https://www.readbyqxmd.com/read/29383678/hepatic-intra-arterial-therapies-in-metastatic-neuroendocrine-tumors-lessons-from-clinical-practice
#9
S Grozinsky-Glasberg, G Kaltsas, M Kaltsatou, N Lev-Cohain, A Klimov, V Vergadis, I Uri, A I Bloom, D J Gross
BACKGROUND: Liver metastases are common in patients with neuroendocrine tumors (NETs), having a negative impact on disease prognosis. The options for selective therapy in patients with unresectable multiple liver metastases are limited to TACE (transarterial chemoembolization), TAE (transarterial embolization), or SIRT (selective internal radiation therapy). AIM: To explore the clinical outcome, survival and safety of these therapies in NETs patients. METHODS: Retrospective case series of consecutive patients (mean age 56...
January 30, 2018: Endocrine
https://www.readbyqxmd.com/read/29383428/from-initial-description-by-wermer-to-present-day-men1-what-have-we-learned
#10
Nancy D Perrier
INTRODUCTION: Pancreas, parathyroid, and pituitary, are referred to as the "3 Ps" of MEN1. The time has come to move beyond those Ps and begin to discuss (1) prediction, (2) pausing progression, and (3) prevention of MEN1. METHODS: In preparation for the International Association of Endocrine Surgeons State of the Art address, updates and uncertainties of MEN were reviewed. This included a detailed examination of the MEN1 gene and the library of implicated mutations, exon sequencing databases and cell cycle pathways...
January 30, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29380547/assessment-of-the-american-joint-commission-on-cancer-8th-edition-staging-system-for-patients-with-pancreatic-neuroendocrine-tumors-a-surveillance-epidemiology-and-end-results-analysis
#11
Xiaogang Li, Shanmiao Gou, Zhiqiang Liu, Zeng Ye, Chunyou Wang
Although several staging systems have been proposed for pancreatic neuroendocrine tumors (pNETs), the optimal staging system remains unclear. Here, we aimed to assess the application of the newly revised 8th edition American Joint Committee on Cancer (AJCC) staging system for exocrine pancreatic carcinoma (EPC) to pNETs, in comparison with that of other staging systems. We identified pNETs patients from the Surveillance, Epidemiology, and End Results (SEER) database (2004-2014). Overall survival was analyzed using Kaplan-Meier curves with the log-rank test...
January 29, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29376950/-surgical-management-of-non-functioning-pancreatic-neuroendocrine-tumors
#12
G A Shatveryan, G A Karagyozyan, N K Chardarov, N N Bagmet, N P Ratnikova
AIM: To analyze immediate and long-term results of surgical treatment of patients with non-functioning pancreatic neuroendocrine tumors (pNETs). MATERIAL AND METHODS: Outcomes in 21 patients with non-functioning pNETs were retrospectively analyzed. RESULTS: Long-term results were followed-up in 18 (85%) cases, median follow-up was 39 months. Postoperative mortality was 4.7%. The incidence of postoperative complications Clavien-Dindo degree IIIA and over was 20...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29359266/the-place-of-liver-transplantation-in-the-treatment-of-hepatic-metastases-from-neuroendocrine-tumors-pros-and-cons
#13
REVIEW
Carlo Sposito, Michele Droz Dit Busset, Davide Citterio, Marco Bongini, Vincenzo Mazzaferro
Liver metastases occur in nearly half of NET patients (MNETs) and heavily affect prognosis, with 5-yr. OS around 19-38%. Although it is difficult to show outcome differences for available treatments, due to the long course of disease, surgery for MNETs remains the most effective option in terms of survival and symptom control. Since MNETs frequently present as an oligo-metastatic, liver-limited disease, unresectable in 80% of cases, liver transplantation (LT) has emerged as a potential curative treatment. Nevertheless, experience with LT for MNETs is limited and burdened by highly heterogeneous outcomes and significant recurrence rate, mostly explained by the variability of selection criteria...
January 23, 2018: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/29334442/a-rare-initial-presentation-of-primary-diffuse-leptomeningeal-pnet-in-a-10-year-old-male
#14
Peter Paul Lim, Jagadeesh Ramdas, Michal Ann Miller, Conrad Schuerch, George Wu
Primary leptomeningeal primitive neuroectodermal tumors (PNETs) are extremely rare childhood central nervous system malignancies harboring a very poor prognosis. There is no consensus treatment for these tumors to date. We report a case of a 10-year-old male who presented with mental status change, hydrocephalus, intracranial and spinal diffuse leptomeningeal enhancement without a primary mass upon cranial imaging and a negative initial biopsy until five months into his presentation. He responded significantly well to initial chemotherapy and radiotherapy...
December 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/29325706/contrast-harmonic-eus-for-the-prediction-of-pancreatic-neuroendocrine-tumor-aggressiveness-with-videos
#15
Maxime Palazzo, Bertrand Napoléon, Rodica Gincul, Mathieu Pioche, Bertrand Pujol, Christine Lefort, Fabien Fumex, Vincent Hautefeuille, Monique Fabre, Jérome Cros, Michèle Felce, Anne Couvelard, Alain Sauvanet, Philippe Lévy, Philippe Ruszniewski, Laurent Palazzo
BACKGROUND AND AIM: Contrast-harmonic EUS (CH-EUS) has the ability to depict a tumor microvasculature. Decreased microvascular density has been identified as a factor associated with tumor aggressiveness. We aimed to study the accuracy of CH-EUS for the prediction of pancreatic neuroendocrine tumor (PNET) aggressiveness. METHODS: Between June 2009 and March 2015, all consecutive patients with histology-proven PNETs and CH-EUS examination were included. Nine endosonographers analyzed blindly all the videos...
January 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29313698/cystic-pancreatic-neuroendocrine-tumor-pancreatic-endocrine-or-neuroendocrine-tumor-endoscopic-ultrasonography
#16
Modesto J Varas, Carme Loras, Agustí Balboa
Cystic pancreatic neuroendocrine tumors (cPNETs) represent less than 8% of all pancreatic cysts and approximately 13% of pancreatic endocrine tumors (PNETs). According to a recent review, the percentage of non-functional (NF) PNETs is 85% and 44.6% are incidentalomas. In our series of 75 PNET cases, ten cPNET cases (13%) were identified which are discussed and summarized below.
January 9, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29309627/functional-defects-from-endocrine-disease-associated-mutations-in-hlxb9-and-its-interacting-partner-nono
#17
Sampada S Kharade, Vaishali I Parekh, Sunita K Agarwal
The insulin-secreting pancreatic neuroendocrine tumors (PNETs), insulinomas, characterized by increased pancreatic islet β-cell proliferation express the phosphorylated isoform of the β-cell differentiation factor HLXB9 that interacts with NONO/p54NRB, a survival factor. Interestingly, two different homozygous germline mutations in HLXB9, p.F248L and p.F272L, were reported in neonatal diabetes, a condition characterized by inadequate number of functional β-cells. Also, two somatic heterozygous NONO mutations were found in endocrine-related tumors, p...
January 4, 2018: Endocrinology
https://www.readbyqxmd.com/read/29307515/clinical-outcome-and-long-term-survival-of-150%C3%A2-consecutive-patients-with-pancreatic-neuroendocrine-tumors-a-comprehensive-analysis-by-the-world-health-organization-2010-grading-classification
#18
Ben-Yuan Deng, Fei Liu, Si-Neng Yin, An-Ping Chen, Lin Xu, Bo Li
BACKGROUND AND OBJECTIVE: The World Health Organization (WHO) has revised its grading system for pancreatic neuroendocrine tumors (PNETs) in 2010 into three main group, which has not been widely and comprehensively evaluated. We aimed to validate the clinical valve of this system associated with the clinical outcome and long-term survival when applied to PNETs, which were rare and heterogeneous. METHODS: We retrospectively collected and analyzed the data of 150 consecutive patients with PNETs who underwent a resection...
January 4, 2018: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/29301477/eus-guided-reverse-bevel-fine-needle-biopsy-sampling-and-open-tip-fine-needle-aspiration-in-solid-pancreatic-lesions-a-prospective-comparative-study
#19
Per Hedenström, Akif Demir, Kaveh Khodakaram, Ola Nilsson, Riadh Sadik
OBJECTIVES: Different diagnostic entities can present as solid pancreatic lesions (SPL). This study aimed to explore the utility of endoscopic ultrasound-guided reverse bevel fine-needle biopsy sampling (EUS-FNB) in SPLs. MATERIAL AND METHODS: In 2012-2015, consecutive patients with SPLs were prospectively included in a tertiary center setting and subjected to dual needle sampling with a 22 gauge reverse bevel biopsy needle and a conventional 25 gauge open tip aspiration needle (EUS-FNA)...
January 4, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29299687/the-incidence-of-brainstem-primitive-neuroectodermal-tumors-of-childhood-based-on-seer-data
#20
Omar Chamdine, Ghada Ahmad Saad Elhawary, Ahmad Samir Alfaar, Ibrahim Qaddoumi
PURPOSE: Incidence of BS primitive neuroectodermal tumors (BS-PNET) in children is not reported to date. Our main objectives were to estimate the incidence and report the outcome of BS-PNET in children. METHODS: Data were collected using the Surveillance Epidemiology and End Results cancer registry. RESULTS: From 1973 to 2013, we identified 83 pediatric patients (aged 0-21 years). Patients were divided into two age groups (0-3 years and 4-21 years)...
January 3, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
keyword
keyword
7198
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"