keyword
MENU ▼
Read by QxMD icon Read
search

intoxicated

keyword
https://www.readbyqxmd.com/read/29158500/use-dependent-potentiation-of-voltage-gated-calcium-channels-rescues-neurotransmission-in-nerve-terminals-intoxicated-by-botulinum-neurotoxin-serotype-a
#1
Phillip H Beske, Katie M Hoffman, James B Machamer, Margaret R Eisen, Patrick M McNutt
Botulinum neurotoxins (BoNTs) are highly potent toxins that cleave neuronal SNARE proteins required for neurotransmission, causing flaccid paralysis and death by asphyxiation. Currently, there are no clinical treatments to delay or reverse BoNT-induced blockade of neuromuscular transmission. While aminopyridines have demonstrated varying efficacy in transiently reducing paralysis following BoNT poisoning, the precise mechanisms by which aminopyridines symptomatically treat botulism are not understood. Here we found that activity-dependent potentiation of presynaptic voltage-gated calcium channels (VGCCs) underlies 3,4-diaminopyridine (3,4-DAP)-mediated rescue of neurotransmission in central nervous system synapses and mouse diaphragm neuromuscular junctions fully intoxicated by BoNT serotype A...
November 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29158111/brain-derived-neurotrophic-factor-bdnf-determines-a-sex-difference-in-cue-conditioned-alcohol-seeking-in-rats
#2
Samuel J Hogarth, Emily J Jaehne, Maarten van den Buuse, Elvan Djouma
Alcohol use disorder is a detrimental addictive disease that develops through prolonged ethanol exposure and regular intoxication. However, the changes in the underlying neurobiology leading to alcohol addiction remain unclear. Brain-Derived Neurotrophic Factor (BDNF) is implicated in substance abuse disorders including alcoholism. As the vast majority of previous animal model studies have concentrated on males only, the aim of this study was to determine whether endogenous BDNF mediates alcohol seeking in a sex-specific manner...
November 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29157803/iridoid-glycosides-fraction-from-picrorhiza-kurroa-attenuates-cyclophosphamide-induced-renal-toxicity-and-peripheral-neuropathy-via-ppar-%C3%AE-mediated-inhibition-of-inflammation-and-apoptosis
#3
Supriya Sharma, Pallavi Sharma, Pankaj Kulurkar, Damanpreet Singh, Dinesh Kumar, Vikram Patial
BACKGROUND: Picrorhiza kurroa Royle (Scrophulariaceae) is an important medicinal herb being widely used in variety of ailments. PURPOSE: The present study was envisaged to evaluate the effects of iridoid glycosides enriched fraction (IGs) from Picrorhiza kurroa rhizome against cyclophosphamide (CP) -induced renal toxicity and peripheral neuropathy. METHODS: Mice in different groups were pretreated with 25, 50 and 100 mg/kg; p.o. doses of IGs for 21 days, followed by cyclophosphamide intoxication for consecutive two days...
December 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29157755/-acetaminophen-induced-5-oxoproline-acidosis-an-uncommon-case-of-high-anion-gap-metabolic-acidosis
#4
A Lanot, P Henri, M Nowoczyn, M H Read, C Maucorps, M Sassier, T Lobbedez
The most common causes of high anion gap metabolic acidosis (HAGMA) are lactic acidosis, ketoacidosis, and intoxications. Nevertheless, clinicians can be faced with unexplained HAGMA, with a need to look for less common etiologies. We describe a case of 5-oxoproline (pyroglutamate) acidosis due to chronic acetaminophen ingestion at therapeutic dose in a 79-year-old inpatient. The pathophysiology of this condition is detailed, with abnormalities in the gamma-glutamyl cycle due to acetaminophen ingestion and severe chronic morbidities, resulting in glutathione and cysteine deficiency and then accumulation of 5-oxoproline...
November 17, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29156993/phenolic-compounds-analysis-antioxidant-and-hepatoprotective-effects-of-periploca-angustifolia-extract-on-cadmium-induced-oxidative-damage-in-hepg2-cell-line-and-rats
#5
Khaled Athmouni, Dalel Belhaj, Khaoula Mkadmini Hammi, Abdelfattah El Feki, Habib Ayadi
A total of five components (Catechin, Caffeic acid, Ferulic acid, Rosmarinic acid, and Amentoflavone) were identified in Periploca angustifolia leaf methanolic extract. This extract did not cause any cytotoxic effect on HepG2 cell line within the range of concentrations tested (0-400 µg mL(-1)). Thus, pre-treatment with 100 µg mL(-1) of P. angustifolia leaf methanolic extract (PAE) significantly (p < .05) protective HepG2 cells against cytotoxicity induced by cadmium exposure. However, Cd-intoxication significantly (p < ...
November 20, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29155885/alcohol-intoxication-at-swedish-football-matches-a-study-using-biological-sampling-to-assess-blood-alcohol-concentration-levels-among-spectators
#6
Natalie Durbeej, Tobias H Elgán, Camilla Jalling, Johanna Gripenberg
Alcohol use and alcohol-related problems, including accidents, vandalism and violence, at sporting events are of increased concern in Sweden and other countries. The relationship between alcohol use and violence has been established and can be explained by the level of intoxication. Given the occurrence of alcohol use and alcohol-related problems at sporting events, research has assessed intoxication levels measured through biological sampling among spectators. This cross-sectional study aimed to assess the level of alcohol intoxication among spectators at football matches in the Swedish Premier Football League...
2017: PloS One
https://www.readbyqxmd.com/read/29155471/alcohol-related-harm-in-emergency-departments-a-prospective-multicentre-study
#7
Assoc Prof Diana Egerton-Warburton, Andrew Gosbell, Katie Moore, Angela Wadsworth, Drew Richardson, Daniel M Fatovich
BACKGROUND: Emergency department alcohol-related presentation data are not routinely collected. It is likely that previous research has underestimated the numbers of patients presenting with alcohol-related conditions. DESIGN: Multicentre, prospective study. Patients were prospectively screened for alcohol-related presentations over a seven-day period in December 2014. Part one involved screening to determine alcohol positive ED presentations, and data collection of patient demographic and clinical information...
November 20, 2017: Addiction
https://www.readbyqxmd.com/read/29155232/refusal-of-cervical-spine-immobilization-after-blunt-trauma-implications-for-initial-evaluation-and-management-a-retrospective-cohort-study
#8
James M Tatum, Navpreet K Dhillon, Ara Ko, Eric J T Smith, Nicolas Melo, Galinos Barmparas, Eric J Ley
INTRODUCTION: Rigid cervical collars are routinely placed in the pre-hospital setting after significant blunt trauma. Patients who are deemed competent by field personnel (Glasgow Coma Scale (GCS) ≥13, no major distracting injury and not grossly intoxicated) may refuse cervical collar placement. MATERIAL AND METHODS: A retrospective review was conducted of all adult trauma patients presenting to a Level 1 trauma center after blunt trauma with a GCS≥13 and no distracting injury or gross intoxication from January 2014 to December 2014...
November 15, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29154688/substance-use-and-cognitive-function-as-drivers-of-condomless-anal-sex-among-hiv-positive-gay-bisexual-and-other-men-who-have-sex-with-men-aged-50-and-older-the-gold-studies
#9
Sandra A Kupprat, Kristen D Krause, Danielle C Ompad, Perry N Halkitis
PURPOSE: Substance use has been linked to the sexual transmission of HIV among gay, bisexual, and other men who have sex with men (MSM) across the lifespan. Among older, HIV-positive, MSM populations, cognitive dysfunction associated with age and HIV disease progression also may play a role in sexual risk-taking. People aged 50 years and older represent a growing proportion of the overall HIV-positive population. This study aimed to explore relationships between substance use and cognitive function, and their impact on condomless anal sex (CAS) among HIV-positive gay, bisexual, and other MSM aged 50 years and older...
November 20, 2017: LGBT Health
https://www.readbyqxmd.com/read/29152755/interviewing-intoxicated-witnesses-memory-performance-in-theory-and%C3%A2-practice
#10
Malin Hildebrand Karlén
Memory encoding and recall involving complex, effortful cognitive processes are impaired by alcohol primarily due to impairment of a select few, but crucial, cortical areas. This review shows how alcohol affects some, but not all, aspects of eyewitnesses' oral free recall performance. The principal results, so far, are that: a) free recall reports by intoxicated witnesses (at the investigated BAC-levels) may contain less, but as accurate, information as reports by sober witnesses; b) immediate reports given by intoxicated witnesses may yield more information compared to reports by sober witnesses given after a one week delay; c) an immediate interview may enhance both intoxicated and sober witnesses' ability to report information in a later interview; and d) reminiscence seems to occur over repeated interviews and the new information seems to be as accurate as the previously reported information...
November 20, 2017: Scandinavian Journal of Psychology
https://www.readbyqxmd.com/read/29152707/ethylene-glycol-toxicity-a-retrospective-pathological-study-in-cats
#11
Livia Amoroso, Cristiano Cocumelli, Giampaolo Bruni, Alberto Brozzi, Francesco Tancredi, Goffredo Grifoni, Antonio Mastromattei, Roberta Meoli, Giovanni Di Guardo, Claudia Eleni
Ethylene glycol (EG) is a well known toxic compound, the assumption of which can be fatal to pet animals as well as to humans. Limited information is available on the pathological features of EG poisoning in pet animals, with special emphasis on cats. Twenty-five cats with histologically confirmed EG intoxication were retrospectively investigated, in order to define more precisely the gross pathological findings and improve the diagnostic process. Furthermore, a brief comparison with the lesions reported in EG-poisoned human patients and dogs was also made...
September 30, 2017: Veterinaria Italiana
https://www.readbyqxmd.com/read/29152699/comparative-analysis-of-the-protective-effects-of-curcumin-and-n-acetyl-cysteine-against-paracetamol-induced-hepatic-renal-and-testicular-toxicity-in-wistar-rats
#12
Zeynab Kh El-Maddawy, Yasser S El-Sayed
This study aimed to investigate the possible protective role of curcumin (CUR) vs. N-acetyl cysteine (NAC) against paracetamol (PCM)-induced oxidative damage and impairment of liver, kidney, and testicular functions, as well as hematotoxicity, in albino rats. A large single dose of PCM induced lipid peroxidation along with a significant decline in glutathione content and catalase activity in the liver, kidneys, and testicles. The apparent oxidative damage was associated with evident hepatic, renal, and testicular dysfunction, which was confirmed in histopathological lesions, and increased serum aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase activities...
November 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29151272/changes-in-alcohol-policies-and-practices-in-bars-and-restaurants-after-completion-of-manager-focused-responsible-service-training
#13
Kathleen M Lenk, Darin J Erickson, Toben F Nelson, Keith J Horvath, Dawn M Nederhoff, Shanda L Hunt, Alexandra M Ecklund, Traci L Toomey
INTRODUCTION AND AIMS: Irresponsible and illegal serving practices at bars and restaurants, such as sales to obviously intoxicated patrons, can lead to various public health harms. Training managers of bars and restaurants in the development and promotion of responsible alcohol policies may help prevent risky and illegal alcohol serving practices. DESIGN AND METHODS: We implemented a training program for managers of bars/restaurants designed to establish and promote responsible beverage service policies/practices...
November 19, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29151242/a-qualitative-examination-of-increased-alcohol-use-after-bariatric-surgery-among-racially-ethnically-diverse-young-adults
#14
Christine E Spadola, Eric F Wagner, Leah M Varga, Jennifer L Syvertsen, Nestor F De La Cruz Munoz, Sarah E Messiah
INTRODUCTION: Mounting evidence suggests that bariatric surgery, or weight loss surgery (WLS), patients might be vulnerable to developing post-operative alcohol use problems. While the majority of published research offers information concerning the prevalence of problematic alcohol use post-WLS, the literature lacks comprehensive, qualitative explorations examining why alcohol misuse might emerge after WLS. Such data-driven hypotheses are needed to effectively target this emerging concern...
November 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29150919/a-focus-on-the-beneficial-effects-of-alpha-synuclein-and-a-re-appraisal-of-synucleinopathies
#15
Larisa Ryskalin, Carla L Busceti, Fiona Limanaqi, Francesca Biagioni, Stefano Gambardella, Francesco Fornai
Alpha synuclein (α-syn) belongs to a class of proteins which are commonly considered to play a detrimental role in neuronal survival. This assumption is based on the occurrence of a severe neuronal degeneration in patients carrying a multiplication of the α-syn gene (SNCA) and in a variety of experimental models, where overexpression of α-syn leads to cell death and neurological impairment. In these conditions, a higher amount of normally structured α-syn produces a damage, which is even worse compared with that produced by α-syn owing an abnormal structure (as occurring following point gene mutations)...
November 16, 2017: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29148292/cholestatic-liver-injury-as-a-side-effect-of-dabigatran-and-the-use-of-coagulation-tests-in-dabigatran-intoxication-and-after-reversal-by-idarucizumab-in-bleeding-and-sepsis
#16
Willemijn J Comuth, Anne-Mette Haase, Linda Ø Henriksen, Jerzy Malczynski, Daan van de Kerkhof, Anna-Marie B Münster
Idarucizumab, an antidote specific for dabigatran, became available recently. Dabigatran is not associated with increased risk of hepatotoxicity in comparison with warfarin, but it is seen as a rare side-effect. Cases of cholestatic liver injury due to dabigatran have not been reported previously. We present a case of severe gastro-intestinal bleeding with underlying dabigatran intoxication in a patient with renal failure and the effect of reversal of dabigatran using idaruzicumab on coagulation assays. International normalized ratio (INR) and activated partial thromboplastin time (APTT) results were elevated in a setting of sepsis, possibly due to liver failure...
November 17, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/29148267/detection-of-teschovirus-type-13-from-two-swine-herds-exhibiting-nervous-clinical-signs-in-growing-pigs
#17
J Carnero, C Prieto, L Polledo, F J Martínez-Lobo
Recently, the number of clinical reports of growing pigs showing neurological signs possibly related to viral infections has increased. The objective of this report was to describe two outbreaks of an atypical condition observed in 6- to 7-week-old pigs with a morbidity of 20% and a fatality rate of 60% in two unrelated farms of the same company. During the acute phase of the disease, fever, sudden death, neurological signs, ear necrosis and occasional corneal opacity were observed. Histopathological examination revealed interstitial pneumonia, lymphoid depletion and lymphocytic vasculitis in different organs and mild polioencephalomyelitis suggesting a potential viral infection...
November 16, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29146503/methodology-for-controlled-administration-of-smoked-synthetic-cannabinoids-jwh-018-and-jwh-073
#18
REVIEW
Ziva D Cooper, Justin L Poklis, Fei Liu
Synthetic cannabinoids (SCs) are a significant public health concern given their widespread use and severe effects associated with intoxication. However, there is a paucity of controlled human studies investigating the behavioral and physiological effects and pharmacokinetics of these compounds. Designing a reliable method to administer consistent, concentration-dependent synthetic cannabinoids is an integral component of controlled study of these compounds. Further, optimizing methods to assess the parent compounds and metabolites in plasma is critical in order to be able to establish their pharmacokinetics after administration...
November 13, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29145741/a-cohort-approach-to-real-time-detection-of-acute-hiv-infections-among-people-who-inject-drugs-in-st-petersburg-russia
#19
Olga Toussova, Andrei Kozlov, Sergei Verevochkin, Kathryn Lancaster, Alla Shaboltas, Alexey Masharsky, Elena Dukhovlinova, William C Miller, Irving Hoffman
OBJECTIVES: To detect acute HIV infections (AHI) in real time among people who inject drugs (PWID) in St. Petersburg, Russia and to test the feasibility of this approach. DESIGN: Prospective cohort study. METHODS: 100 seronegative or acutely HIV-infected at screening PWID were enrolled and followed until the end of the 12 month pilot period. Each participant was evaluated, tested and counseled for HIV monthly. Two HIV tests were used: HIV antibody and HIV RNA PCR...
November 16, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29145145/alleviation-of-ginsenoside-rg1-on-hematopoietic-homeostasis-defects-caused-by-lead-acetate
#20
Shi-Zhong Cai, Yue Zhou, Jun Liu, Cheng-Peng Li, Dao-Yong Jia, Meng-Si Zhang, Ya-Ping Wang
The hematopoietic system is one of the potential targets of lead intoxication. Recognition of the lead-related deleterious outcomes promotes us to explore the potential therapeutic intervention. Here, we show that ginsenoside Rg1 (Rg1), extracted from the Chinese herb Panax ginseng, remarkably ameliorates the lead acetate-caused hematological index distortion as well as advanced hematopoietic stem cells (HSCs) aging and aging associated inflammation response. Specifically, Rg1 administration alleviated the increment of aging associated p53-p21-Rb signaling in aged HSCs induced by lead acetate...
November 10, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
keyword
keyword
71970
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"