keyword
https://read.qxmd.com/read/38492993/survival-disparities-in-rural-versus-urban-patients-with-pancreatic-neuroendocrine-tumor-a-multi-institutional-study-from-the-us-neuroendocrine-tumor-study-group
#1
JOURNAL ARTICLE
Muhammad Bilal Mirza, Jordan J Baechle, Paula Marincola Smith, Mary Dillhoff, George Poultsides, Flavio G Rocha, Clifford S Cho, Emily R Winslow, Ryan C Fields, Shishir K Maithel, Kamran Idrees
BACKGROUND: Pancreatic Neuroendocrine Tumors (PNETs) are indolent malignancies that often have a prolonged clinical course. This study assesses disparities in outcomes between PNET patients who live in urban (UA) and rural areas (RA). METHODS: A retrospective cohort study was performed using the US Neuroendocrine Tumor Study Group database. PNET patients with a home zip code recorded were included and categorized as RA or UA according to the Federal Office of Rural Health Policy...
March 11, 2024: American Journal of Surgery
https://read.qxmd.com/read/38490902/premalignant-lesions-in-the-kidney-transplant-candidate
#2
REVIEW
Paul M Schroder, Ben E Biesterveld, David P Al-Adra
End-stage kidney disease patients who are referred for transplant undergo an extensive evaluation process to ensure their health prior to transplant due in part to the shortage of available organs. Although management and surveillance guidelines exist for malignancies identified in the transplant and waitlist populations, less is written about the management of premalignant lesions in this population. This review covers the less common premalignant lesions (intraductal papillary mucinous neoplasm, gastrointestinal stromal tumor, thymoma, and pancreatic neuroendocrine tumor) that can be found in the transplant candidate population...
March 14, 2024: Seminars in Nephrology
https://read.qxmd.com/read/38490841/clinical-and-ct-quantitative-features-for-predicting-liver-metastases-in-patients-with-pancreatic-neuroendocrine-tumors-a-study-with-prospective-external-validation
#3
JOURNAL ARTICLE
Yao Pan, Hai-Yan Chen, Jie-Yu Chen, Xiao-Jie Wang, Jia-Ping Zhou, Lei Shi, Ri-Sheng Yu
RATIONALE AND OBJECTIVES: We aimed to evaluate clinical characteristics and quantitative CT imaging features for the prediction of liver metastases (LMs) in patients with pancreatic neuroendocrine tumors (PNETs). METHODS: Patients diagnosed with pathologically confirmed PNETs were included, 133 patients were in the training group, 22 patients in the prospective internal validation group, and 28 patients in the external validation group. Clinical information and quantitative features were collected...
March 14, 2024: Academic Radiology
https://read.qxmd.com/read/38486254/correction-multiregion-wes-of-metastatic-pancreatic-neuroendocrine-tumors-revealed-heterogeneity-in-genomic-alterations-immune-microenvironment-and-evolutionary-patterns
#4
Yu Jiang, Yi-Han Dong, Shi-Wei Zhao, Dong-Yu Liu, Ji-Yang Zhang, Xiao-Ya Xu, Hao Chen, Hao Chen, Jia-Bin Jin
No abstract text is available yet for this article.
March 14, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38486208/prognostic-factors-of-pancreatic-tumors-in-children-and-adolescents-a-population-study-based-on-the-surveillance-epidemiology-and-end-results-database
#5
JOURNAL ARTICLE
Xianzhong Qi, Bi Zhou, Fuhua Liang, Xinxin Wang
PURPOSE: Pancreatic tumors in children are uncommon, and data is scarce. The purpose of this study is to examine the prognostic factors of pediatric pancreatic tumors in a population-based cohort. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify all pediatric patients with pancreatic tumors diagnosed between 1975 and 2018. The overall survival (OS) rates were determined using a Kaplan-Meier analysis. The log-rank test was used for univariate survival analysis...
March 14, 2024: BMC Gastroenterology
https://read.qxmd.com/read/38478398/primary-resistance-to-ret-inhibition-in-a-ret-fusion-positive-pancreatic-neuroendocrine-carcinoma
#6
JOURNAL ARTICLE
Blake J McKinley, Tucker W Coston, Jason S Starr
We present a 54-year-old White male with a diagnosis of stage IV pancreatic neuroendocrine carcinoma. Next-generation sequencing of the tumor/blood identified a complex tumor genome, which included a rearranged during transfection (RET) gene fusion. The patient initially received cytotoxic chemotherapy with a significant radiographic response. After 4 cycles of chemotherapy, the patient was transitioned to a clinical trial using selpercatinib, a RET inhibitor, as maintenance therapy. Unfortunately, our patient developed progression of disease at the first treatment monitoring scan...
March 13, 2024: Oncologist
https://read.qxmd.com/read/38476778/a-rare-cause-of-hypoglycemia-in-elderly-patients-insulinoma
#7
Ahmet Baris Dirim, Ahmet Seker
Insulinoma is the most common pancreatic neuroendocrine tumor and is often solitary and benign. To make a diagnosis, high insulin levels must be demonstrated, and proinsulin and C-peptide measurements must be done. The presence of hypoglycemic measurements and symptoms in the 72-hour fasting test is diagnostic. We present a case of a 91-year-old patient with no known diagnosis of diabetes mellitus who was admitted to the emergency department due to confusion. As a result of the clinical evaluation and differential diagnosis, it was determined that her complaint was due to hypoglycemia, and she was admitted to the internal medicine service for further examination, diagnosis, and treatment...
February 2024: Curēus
https://read.qxmd.com/read/38476152/pancreatic-insulinoma-when-surgery-is-not-an-option
#8
Maria Azevedo Silva, André Ruge, Nuno Vicente, Alexandra Fernandes, Eduardo Pereira, Helena Vasconcelos
No abstract text is available yet for this article.
December 2023: GE Portuguese Journal of Gastroenterology
https://read.qxmd.com/read/38473332/the-disproportionate-rise-in-pancreatic-cancer-in-younger-women-is-due-to-a-rise-in-adenocarcinoma-and-not-neuroendocrine-tumors-a-nationwide-time-trend-analysis-using-2001-2018-united-states-cancer-statistics-databases
#9
JOURNAL ARTICLE
Yi Jiang, Yazan Abboud, Jeff Liang, Brent Larson, Arsen Osipov, Jun Gong, Andrew E Hendifar, Katelyn Atkins, Quin Liu, Nicholas N Nissen, Debiao Li, Stephen J Pandol, Simon K Lo, Srinivas Gaddam
In previous studies, a significant increase in the incidence of pancreatic cancer among younger women compared to men in the United States was noted. However, the specific histopathologic characteristics were not delineated. This population-based study aimed to assess whether this disproportionate rise in pancreatic cancer in younger women was contributed by pancreatic ductal adenocarcinoma (PDAC) or pancreatic neuroendocrine tumors (PanNET). The United States Cancer Statistics (USCS) database was used to identify patients with pancreatic cancer between 2001 and 2018...
February 28, 2024: Cancers
https://read.qxmd.com/read/38471465/heterogeneity-of-multiple-pancreatic-neuroendocrine-tumors-identified-by-68ga-dotanoc-and-68ga-exendin-4-pet-ct-in-a-patient-with-endogenous-hyperinsulinemic-hypoglycemia-and-multiple-endocrine-neoplasia-1
#10
Junyan Xu, Xiaoping Xu, Meng Zhang, Wensheng Liu, Jie Chen, Shaoli Song
Insulinomas are the most frequent functional neuroendocrine tumors of pancreas. In about 10% cases, insulinomas are associated with hereditary syndrome including multiple endocrine neoplasia 1 (MEN1). Herein, we presented a case of 44-year-old female with recurrent hypoglycemia. In December 1998, this patient has undergone resection of two pancreatic lesions due to hypoglycemia and diagnosed as insulinoma. After operation, the symptom of hypoglycemia disappeared. However, from 2021, hypoglycemic symptoms reappeared frequently and even coma...
March 12, 2024: Neuroendocrinology
https://read.qxmd.com/read/38470548/molecular-classification-of-gastrointestinal-and-pancreatic-neuroendocrine-neoplasms-are-we-ready-for-that
#11
REVIEW
Silvia Uccella
In the last two decades, the increasing availability of technologies for molecular analyses has allowed an insight in the genomic alterations of neuroendocrine neoplasms (NEN) of the gastrointestinal tract and pancreas. This knowledge has confirmed, supported, and informed the pathological classification of NEN, clarifying the differences between neuroendocrine carcinomas (NEC) and neuroendocrine tumors (NET) and helping to define the G3 NET category. At the same time, the identification genomic alterations, in terms of gene mutation, structural abnormalities, and epigenetic changes differentially involved in the pathogenesis of NEC and NET has identified potential molecular targets for precision therapy...
March 12, 2024: Endocrine Pathology
https://read.qxmd.com/read/38461463/the-value-of-textbook-outcome-in-benchmarking-pancreatoduodenectomy-for-nonfunctioning-pancreatic-neuroendocrine-tumors
#12
JOURNAL ARTICLE
Stefano Partelli, Francesca Fermi, Giuseppe K Fusai, Domenico Tamburrino, Panagis Lykoudis, Nassiba Beghdadi, Safi Dokmak, Dominik Wiese, Luca Landoni, Federico Reich, O R C Busch, Niccolò Napoli, Jin-Young Jang, Wooil Kwon, Thomas Armstrong, Peter J Allen, Jin He, Ammar Javed, Alain Sauvanet, Detlef K Bartsch, Roberto Salvia, E J M Nieveen van Dijkum, Mark G Besselink, Ugo Boggi, Sun-Whe Kim, Christofer L Wolfgang, Massimo Falconi
BACKGROUND: Textbook outcome (TO) is a composite variable that can define the quality of pancreatic surgery. The aim of this study is to evaluate TO after pancreatoduodenectomy (PD) for nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). PATIENTS AND METHODS: All patients who underwent PD for NF-PanNETs (2007-2016) in different centers were included in this retrospective study. TO was defined as the absence of severe postoperative complications and mortality, length of hospital stay ≤ 19 days, R0 resection, and at least 12 lymph nodes harvested...
March 10, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38460151/multidisciplinary-approach-for-the-management-of-metastatic-poorly-differentiated-neuroendocrine-carcinoma-of-the-pancreas-a-case-report-of-an-exceptional-responder
#13
JOURNAL ARTICLE
Elizabeth S Nakasone, Hannah C Bustillos, Xianyong Gui, Eric Q Konnick, Jonathan G Sham, Stacey A Cohen
Poorly differentiated pancreatic neuroendocrine carcinomas (pNECs) are rare, highly aggressive neoplasms. Frequently metastatic at diagnosis, prognosis is poor with median overall survival estimated to be less than 1 year. Although multidisciplinary management, including systemic medications and locoregional therapies aimed at reducing and preventing symptoms caused by mass effect, is the mainstay of treatment for patients with metastatic well-differentiated pancreatic neuroendocrine tumors, rapid progression, organ dysfunction, and poor performance status often preclude initiation of even single-modality palliative chemotherapy for patients with metastatic pNEC, limiting the use of and recommendation for multidisciplinary management...
March 6, 2024: Pancreas
https://read.qxmd.com/read/38452580/cadherin-17-cdh17-expression-in-human-cancer-a-tissue-microarray-study-on-18-131-tumors
#14
JOURNAL ARTICLE
Frank Jacobsen, Ramesh Pushpadevan, Florian Viehweger, Morton Freytag, Ria Schlichter, Natalia Gorbokon, Franziska Büscheck, Andreas M Luebke, Devita Putri, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Christoph Fraune, Christian Bernreuther, Patrick Lebok, Guido Sauter, Sarah Minner, Stefan Steurer, Ronald Simon, Eike Burandt, David Dum, Florian Lutz, Andreas H Marx, Till Krech, Till S Clauditz
Cadherin-17 (CDH17) is a membranous cell adhesion protein predominantly expressed in intestinal epithelial cells. CDH17 is therefore considered a possible diagnostic and therapeutic target. This study was to comprehensively determine the expression of CDH17 in cancer and to further assess the diagnostic utility of CDH17 immunohistochemistry (IHC). A tissue microarray containing 14,948 interpretable samples from 150 different tumor types and subtypes as well as 76 different normal tissue types was analyzed by IHC...
January 28, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38451475/multi-omic-dataset-of-patient-derived-tumor-organoids-of-neuroendocrine-neoplasms
#15
JOURNAL ARTICLE
Nicolas Alcala, Catherine Voegele, Lise Mangiante, Alexandra Sexton-Oates, Hans Clevers, Lynnette Fernandez-Cuesta, Talya L Dayton, Matthieu Foll
BACKGROUND: Organoids are 3-dimensional experimental models that summarize the anatomical and functional structure of an organ. Although a promising experimental model for precision medicine, patient-derived tumor organoids (PDTOs) have currently been developed only for a fraction of tumor types. RESULTS: We have generated the first multi-omic dataset (whole-genome sequencing [WGS] and RNA-sequencing [RNA-seq]) of PDTOs from the rare and understudied pulmonary neuroendocrine tumors (n = 12; 6 grade 1, 6 grade 2) and provide data from other rare neuroendocrine neoplasms: small intestine (ileal) neuroendocrine tumors (n = 6; 2 grade 1 and 4 grade 2) and large-cell neuroendocrine carcinoma (n = 5; 1 pancreatic and 4 pulmonary)...
January 2, 2024: GigaScience
https://read.qxmd.com/read/38449894/radioligand-therapy-rlt-used-to-treat-cardiac-metastasis-of-pancreatic-neuroendocrine-tumor
#16
Kieran J Ved, Arjun Bhatt, Aidan M Burke, Michael C Larkins, Dishita Pandya, Constantin B Marcu
Radioligand Therapy (RLT) in the form of [177Lu] Lu-DOTA-TATE (Lutathera®) is a promising treatment for pancreatic neuroendocrine tumors (pNETs) with cardiac metastasis. We present a patient treated with [177Lu] Lu-DOTA-TATE that showed shrinkage of metastasis after four treatments at 7.4 GBq every 8 weeks.
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38448900/multiregion-wes-of-metastatic-pancreatic-neuroendocrine-tumors-revealed-heterogeneity-in-genomic-alterations-immune-microenvironment-and-evolutionary-patterns
#17
JOURNAL ARTICLE
Yu Jiang, Yi-Han Dong, Shi-Wei Zhao, Dong-Yu Liu, Ji-Yang Zhang, Xiao-Ya Xu, Hao Chen, Jia-Bin Jin
Pancreatic neuroendocrine tumors (PanNETs), though uncommon, have a high likelihood of spreading to other body parts. Previously, the genetic diversity and evolutionary patterns in metastatic PanNETs were not well understood. To investigate this, we performed multiregion sampling whole-exome sequencing (MRS-WES) on samples from 10 patients who had not received prior treatment for metastatic PanNETs. This included 29 primary tumor samples, 31 lymph node metastases, and 15 liver metastases. We used the MSK-MET dataset for survival analysis and validation of our findings...
March 6, 2024: Cell Communication and Signaling: CCS
https://read.qxmd.com/read/38448766/dosing-lutetium-lu-177-dotatate-for-a-hemodialysis-patient
#18
Lindsay Taylor, Richard Meades, Ann-Marie Quigley, Christos Toumpanakis, Catriona Goodlad, Andrew Davenport
Lu177-dotatate (Lutathera™) is a radioactive drug approved for the treatment of adults with gastro-entero-pancreatic neuroendocrine tumors and is predominantly renally excreted. Currently all patients receive 7400 MBq (200 mCi), and there are no guidelines for treating hemodialysis patients. We measured radioactivity prior to and post administration of two cycles of Lu177-dotatate in a hemodialysis patient, and radiation exposure to staff. We reduced the standard 7400 MBq by 33% for the first cycle and patient radioactivity fell by 40% following postdilution hemodiafiltration started 6 h post dosing, and by 45% for the second cycle and radioactivity fell by 47% with postdilution hemodiafiltration started 5 h post administration...
March 6, 2024: Hemodialysis International
https://read.qxmd.com/read/38442699/multifocal-insulinoma-as-the-unique-presenting-feature-of-men1-in-an-adolescent
#19
Alison Murray, Sonia Priscila Rodas Marquez, Mansa Krishnamurthy, Oscar Lopez-Nunez, Juan P Gurria, Andrew T Trout, Susan Almazan, Krishnamallika Mutyala, Amy Shah, Jonathan Howell
Introduction Multiple Endocrine Neoplasia Type 1 (MEN1) is an autosomal dominant inherited disorder defined by the presence of two of the following endocrinopathies: primary hyperparathyroidism, anterior pituitary tumors, and duodenopancreatic neuroendocrine tumors (NETs). NETs, which can secrete hormones including insulin, gastrin, and glucagon, among others, are common in patients with MEN1 and are a major cause of morbidity and premature death. NETs are more common later in life, with very few cases described in children...
March 5, 2024: Hormone Research in Pædiatrics
https://read.qxmd.com/read/38438098/the-stromal-microenvironment-endows-pancreatic-neuroendocrine-tumors-with-spatially-specific-invasive-and-metastatic-phenotypes
#20
JOURNAL ARTICLE
Zeng Ye, Qiang Li, Yuheng Hu, Haifeng Hu, Junfeng Xu, Muzi Guo, Wuhu Zhang, Xin Lou, Yan Wang, Heli Gao, Desheng Jing, Guixiong Fan, Yi Qin, Yue Zhang, Xuemin Chen, Jie Chen, Xiaowu Xu, Xianjun Yu, Mingyang Liu, Shunrong Ji
Cancer-associated fibroblasts (CAFs) play an important role in a variety of cancers. However, the role of tumor stroma in nonfunctional pancreatic neuroendocrine tumors (NF-PanNETs) is often neglected. Profiling the heterogeneity of CAFs can reveal the causes of malignant phenotypes in NF-PanNETs. Here, we found that patients with high stromal proportion had poor prognosis, especially for that with infiltrating stroma (stroma and tumor cells that presented an infiltrative growth pattern and no regular boundary)...
March 2, 2024: Cancer Letters
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