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Pancreatic neuroendocrine tumor

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https://www.readbyqxmd.com/read/28068959/pancreatic-neuroendocrine-tumor-with-metastasis-to-the-spleen-a-case-report
#1
Yasunaru Sakuma, Yoshikazu Yasuda, Naohiro Sata, Yoshinori Hosoya, Atsushi Shimizu, Hirofumi Fujii, Daisuke Matsubara, Noriyuki Fukushima, Atsushi Miki, Misato Maeno, Alan Kawarai Lefor
BACKGROUND: Long-term term survival in patients with pancreatic neuroendocrine tumors has been reported, even in patients with metastatic disease. Metastases to the spleen are extremely rare, but have been reported from a number of primary malignancies, such as breast cancer, lung cancer, melanoma and ovarian cancer. This is the first report of a splenic metastasis from a primary pancreatic neuroendocrine tumor. CASE PRESENTATION: The patient presented as a 53 years old white male with anemia and fatigue...
January 9, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28068084/molecular-modeling-evaluation-of-the-enantiomers-of-a-novel-adenylyl-cyclase-2-inhibitor
#2
Neha Rana, Jason M Conley, Monica Soto-Velasquez, Francisco Leon, Stephen J Cutler, Val J Watts, Markus A Lill
Adenylyl cyclase 2 (AC2) is one of nine membrane-bound isoforms of adenylyl cyclase that converts ATP into cyclic AMP (cAMP), an important second messenger molecule. Up-regulation of AC2 is linked to cancers like pancreatic and small intestinal neuroendocrine tumors (NETs). The structures of the various isoforms of adenylyl cyclases are highly homologous, posing a significant challenge to drug discovery efforts for an effective, isoform-selective modulator of AC2. In a previous study, a screen identified a potential isoform-selective and non-competitive inhibitor of AC2, SKF83566...
January 9, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28058079/zollinger-ellison-syndrome-a-rare-case-of-chronic-diarrhea
#3
Ali Aamar, Kamraan Madhani, Hafeezulhassan Virk, Zeeshan Butt
Zollinger-Ellison syndrome (ZES) is caused by hypersecretion of gastrin from duodenal or pancreatic gastrinomas. We report a case of a 57-year-old female who presented with chronic diarrhea. CT abdomen showed multiple liver masses. Liver biopsy suggested metastatic well-differentiated neuroendocrine tumor. Serum gastrin level was markedly elevated. MRI abdomen, somatostatin receptor scintigraphy and endoscopic ultrasound failed to reveal primary site of the tumor. Upper gastrointestinal endoscopy showed hyperplastic gastric folds and multiple duodenal ulcers consistent with ZES...
December 2016: Gastroenterology Research
https://www.readbyqxmd.com/read/28058023/laparoscopic-and-endoscopic-co-operative-surgery-for-non-ampullary-duodenal-tumors
#4
Daisuke Ichikawa, Shuhei Komatsu, Osamu Dohi, Yuji Naito, Toshiyuki Kosuga, Kazuhiro Kamada, Kazuma Okamoto, Yoshito Itoh, Eigo Otsuji
AIM: To assess the safety and feasibility of laparoscopic and endoscopic co-operative surgery (LECS) for early non-ampullary duodenal tumors. METHODS: Twelve patients with a non-ampullary duodenal tumor underwent LECS at our hospital. One patient had two mucosal lesions in the duodenum. The indication for this procedure was the presence of duodenal tumors with a low risk for lymph node metastasis. In particular, the tumors included small (less than 10 mm) submucosal tumors (SMT) and epithelial mucosal tumors, such as mucosal cancers or large mucosal adenomas with malignant suspicion...
December 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28057354/neuroendrocrine-tumors-of-the-uterine-cervix-a-therapeutic-challenge-for-gynecologic-oncologists
#5
REVIEW
Gadducci Angiolo, Carinelli Silvestro, Aletti Giovanni
Neuroendocrine tumors (NETs) are aggressive diseases developing from neuroendocrine cells that most frequently involve the gastro-entero-pancreatic tract and the lung, but more rarely are found in almost all body tissues. Limited biological and clinical data are currently available for NETs in uncommon sites, such as female genital tract. NETs represent 0.9% to 1.5% of the tumors of the uterine cervix. They are more likely to have lymph-vascular space invasion and lymph node involvement, and to develop local and distant relapses when compared with the mostly common cervical squamous cell carcinomas or adenocarcinomas...
January 2, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28055239/the-evolving-role-of-pathology-in-new-developments-classification-terminology-and-diagnosis-of-pancreatobiliary-neoplasms
#6
Michelle D Reid, Melinda M Lewis, Field F Willingham, Volkan Adsay
Pancreatobiliary tract lesions are increasingly being discovered because of more sensitive imaging modalities. Magnetic resonance imaging has identified incidental pancreatic cysts in 13.5% of patients of progressively increasing age. Pancreatobiliary tissue is more accessible through endoscopic ultrasound and magnetic resonance imaging-guided biopsy procedures, and is now an integral part of pathologists' routine practice. Accordingly, several new tumor categories have been recently recognized, including intraductal tubulopapillary neoplasm, a new addition to tumoral intraepithelial neoplasms...
January 5, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28052461/hepatobiliary-and-pancreatic-a-rare-case-of-a-well-differentiated-neuroendocrine-tumor-in-the-bile-duct-with-spontaneous-regression-diagnosed-by-eus-fna
#7
I Sano, M Kuwatani, R Sugiura, S Kato, K Kawakubo, T Ueno, Y Nakanishi, T Mitsuhashi, H Hirata, S Haba, S Hirano, N Sakamoto
No abstract text is available yet for this article.
January 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28043759/baseline-plasma-chromogranin-a-levels-in-patients-with-well-differentiated-neuroendocrine-tumors-of-the-pancreas-a-potential-predictor-of-postoperative-recurrence
#8
Yoshihide Nanno, Hirochika Toyama, Ippei Matsumoto, Kyoko Otani, Sadaki Asari, Tadahiro Goto, Tetsuo Ajiki, Yoh Zen, Takumi Fukumoto, Yonson Ku
BACKGROUND: The present study aimed to elucidate prognostic values of baseline plasma chromogranin A (CgA) concentrations in patients with resectable, well-differentiated pancreatic neuroendocrine tumors (PNETs). METHODS: Preoperative CgA levels in 21 patients with PNET were correlated with clinicopathological factors and patients' survival. RESULTS: Plasma CgA levels ranged 2.9-30.8 pmol/mL (median 6.0), and were significantly elevated in patients with post-operative recurrence (P = 0...
December 29, 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/28042953/cervical-small-cell-neuroendocrine-tumor-mutation-profiles-via-whole-exome-sequencing
#9
Soo Young Cho, Minhye Choi, Hyo-Jeong Ban, Chang Hyeon Lee, Soojun Park, HanKyeom Kim, Young-Sik Kim, Young Seek Lee, Ji-Yun Lee
Cervical small cell neuroendocrine tumors (CSCNETs) are rare, aggressive neuroendocrine tumors (NETs). Reliable diagnostic and prognostic CSCNET markers are lacking, making diagnosis and prognosis prediction difficult, and treatment strategies limited. Here we provide mutation profiles for five tumor-normal paired CSCNETs using whole exome sequencing (WES). We expanded our assessment of frequently mutated genes to include publicly available data from 55 small intestine neuroendocrine tumors, 10 pancreatic neuroendocrine tumors, 42 small cell lung cancers, six NET cell lines, and 188 cervical cancers, along with our five CSCNETs...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28036293/a-retrospective-study-of-nens-and-mir-224-promotes-apoptosis-of-bon-1-cells-by-targeting-pcsk9-inhibition
#10
Jian'an Bai, He Na, Xiumei Hua, Yaling Wei, Tian Ye, Yiqiang Zhang, Guo Jian, Weiwen Zeng, Lijun Yan, Qiyun Tang
Neuroendocrine neoplasms (NENs) represent relatively rare tumors. The lack of diagnostic, therapeutic method and prognostic factors makes them a challenge to us. We retrospectively reviewed the data of 205 NENs patients among which 157 cases were followed-up. Proprotein convertase subtilisin/kexin 9 (PCSK9), a regulator of low density lipoprotein cholesterol (LDL-C), was confirmed as a target gene of microRNA-224. We found an increased incidence of NENs from 2012 to 2015. Women were usually diagnosed at earlier stages than men (P < 0...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035372/surgery-management-for-sporadic-small-%C3%A2-2-cm-non-functioning-pancreatic-neuroendocrine-tumors-a-consensus-statement-by-the-chinese-study-group-for-neuroendocrine-tumors-csnet
#11
Guang Yang, Meng Ji, Jie Chen, Rufu Chen, Ye Chen, Deliang Fu, Baohua Hou, Heguang Huang, Liming Jiang, Kaizhou Jin, Nengwen Ke, Ying Li, Yong Li, Houjie Liang, An'an Liu, Jie Luo, Quanxing Ni, Chengwei Shao, Boyong Shen, Weiqi Sheng, Bin Song, Jian Sun, Chunlu Tan, Huangying Tan, Qiyun Tang, Yingmei Tang, Xiaodong Tian, Jian Wang, Jie Wang, Wei Wang, Wei Wang, Zheng Wu, Jin Xu, Qiang Yan, Ning Yang, Yinmo Yang, Xiaoyu Yin, Xianjun Yu, Chunhui Yuan, Shan Zeng, Guochao Zhang, Renchao Zhang, Zhiwei Zhou, Zhaohui Zhu, Chenghao Shao
The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death. Understanding and formulating an appropriate strategy for the patients with sporadic small, non-functioning pancreatic neuroendocrine tumors have been controversial for some time...
December 29, 2016: International Journal of Oncology
https://www.readbyqxmd.com/read/28008994/common-germline-variants-within-the-cdkn2a-2b-region-affect-risk-of-pancreatic-neuroendocrine-tumors
#12
Daniele Campa, Gabriele Capurso, Manuela Pastore, Renata Talar-Wojnarowska, Anna Caterina Milanetto, Luca Landoni, Evaristo Maiello, Rita T Lawlor, Ewa Malecka-Panas, Niccola Funel, Maria Gazouli, Antonio De Bonis, Harald Klüter, Maria Rinzivillo, Gianfranco Delle Fave, Thilo Hackert, Stefano Landi, Peter Bugert, Franco Bambi, Livia Archibugi, Aldo Scarpa, Verena Katzke, Christos Dervenis, Valbona Liço, Sara Furlanello, Oliver Strobel, Francesca Tavano, Daniela Basso, Rudolf Kaaks, Claudio Pasquali, Manuel Gentiluomo, Cosmeri Rizzato, Federico Canzian
Pancreatic neuroendocrine tumors (PNETs) are heterogeneous neoplasms which represent only 2% of all pancreatic neoplasms by incidence, but 10% by prevalence. Genetic risk factors could have an important role in the disease aetiology, however only a small number of case control studies have been performed yet. To further our knowledge, we genotyped 13 SNPs belonging to the pleiotropic CDKN2A/B gene region in 320 PNET cases and 4436 controls, the largest study on the disease so far. We observed a statistically significant association between the homozygotes for the minor allele of the rs2518719 SNP and an increased risk of developing PNET (ORhom = 2...
December 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000628/role-of-contrast-harmonic-endoscopic-ultrasonography-in-other-pancreatic-solid-lesions-neuroendocrine-tumors-autoimmune-pancreatitis-and-metastases
#13
REVIEW
Maxime Palazzo
Contrast harmonic endoscopic ultrasonography (CH-EUS) is a new technique which allows the dynamic study of the microvascularization of a target tissue. Its application is validated for the diagnosis of pancreatic adenocarcinoma but remains unclear for other solid pancreatic tumors (neuroendocrine tumors [NETs], autoimmune pancreatitis [AIP], metastases). The purpose of this review is to outline the potential role of the CH-EUS in these indications. NETs are typically iso/hyperenhanced at CH-EUS, and a heterogeneous enhancement seems a good predictor of malignancy in neuroendocrine pancreatic tumor...
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28000627/the-role-of-contrast-enhanced-endoscopic-ultrasound-in-pancreatic-adenocarcinoma
#14
REVIEW
Adrian Saftoiu, Peter Vilmann, Manoop S Bhutani
Contrast-enhanced endoscopic ultrasound (CE-EUS) allows characterization, differentiation, and staging of focal pancreatic masses. The method has a high sensitivity and specificity for the diagnosis of pancreatic adenocarcinoma which is visualized as hypo-enhanced as compared to the rest of the parenchyma while chronic pancreatitis and neuroendocrine tumors are generally either iso-enhanced or hyper-enhanced. The development of contrast-enhanced low mechanical index harmonic imaging techniques used in real time during endoscopic ultrasound (EUS) allowed perfusion imaging and the quantification of intensity of the contrast signal through time-intensity curve analysis...
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/28000626/role-of-contrast-enhanced-harmonic-endoscopic-ultrasound-in-submucosal-tumors
#15
REVIEW
Maria Victoria Alvarez-Sanchez, Rodica Gincul, Christine Lefort, Bertrand Napoleon
With the widespread use of endoscopy, gastrointestinal submucosal lesions are now more commonly discovered. Although endoscopic ultrasound (EUS) is superior to all other imaging techniques for the diagnosis of submucosal tumors (SMTs), it is still suboptimal for differentiating hypoechoic lesions arising from the fourth sonographic gastrointestinal wall layer, which encompass tumors with very different prognosis. EUS tissue acquisition has provided with the unique opportunity to obtain histological confirmation, but it is not accurate enough to evaluate the malignant potential of gastrointestinal stromal tumors (GISTs)...
November 2016: Endoscopic Ultrasound
https://www.readbyqxmd.com/read/27998470/-surgical-treatment-and-prognosis-of-pancreatic-neuroendocrine-carcinoma
#16
J W Zhang, X Che, Z M Lan, Y T Chen, X H Huang, Q L Jiang, C F Wang
Objective: Pancreatic neuroendocrine carcinoma (pNEC) is a highly malignant tumor.This study aimed to evaluate the role of surgery and the prognosis for patients with pancreatic neuroendocrine carcinoma (pNEC). Methods: We collected and reviewed all clinical data of patients who underwent radical surgery for pNEC from Jan 2000 through Jan 2016 in our hospital. Cox-regression analysis wasused to evaluate the factors potentially influencing survival. Results: Twenty patients including 11 males and 9 females (median age, 62...
December 23, 2016: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/27997429/combined-18f-fdg-pet-ct-and-68ga-dotatate-pet-ct-superscan-in-metastatic-pancreatic-neuroendocrine-tumor
#17
Mico Chan, Geoffrey Paul Schembri
Metastatic neureoendocrine tumor to bone is well recognized. Typically, this has an appearance of multiple focal lesions. We present an example of diffuse skeletal involvement on both F-FDG PET/CT and Ga DOTATATE PET/CT with a pattern similar to the superscan appearance described on skeletal scintigraphy.
December 16, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27994516/genes-involved-in-angiogenesis-and-mtor-pathways-are-frequently-mutated-in-asian-patients-with-pancreatic-neuroendocrine-tumors
#18
Wen-Chi Chou, Po-Han Lin, Yi-Chen Yeh, Yi-Ming Shyr, Wen-Liang Fang, Shin-E Wang, Chun-Yu Liu, Peter Mu-Hsin Chang, Ming-Han Chen, Yi-Ping Hung, Chung-Pin Li, Yee Chao, Ming-Huang Chen
Introduction: To address the issue of limited data on and inconsistent findings for genetic alterations in pancreatic neuroendocrine tumors (pNETs), we analyzed sequences of known pNET-associated genes for their impact on clinical outcomes in a Taiwanese cohort. Methods: Tissue samples from 40 patients with sporadic pNETs were sequenced using a customized sequencing panel that analyzed 43 genes with either an established or potential association with pNETs. Genetic mutations and clinical outcomes were analyzed for potential associations...
2016: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/27991926/chronic-inflammation-initiates-multiple-forms-of-k-ras-independent-mouse-pancreatic-cancer-in-the-absence-of-tp53
#19
A K Swidnicka-Siergiejko, S B Gomez-Chou, Z Cruz-Monserrate, D Deng, Y Liu, H Huang, B Ji, N Azizian, J Daniluk, W Lu, H Wang, A Maitra, C D Logsdon
Chronic inflammation (CI) is a risk factor for pancreatic cancer (PC) including the most common type, ductal adenocarcinoma (PDAC), but its role and the mechanisms involved are unclear. To investigate the role of CI in PC, we generated genetic mouse models with pancreatic specific CI in the presence or absence of TP53. Mice were engineered to express either cyclooxygenase-2 (COX-2) or IκB kinase-2 (IKK2), and TP53(+/+) or TP53(f/f) specifically in adult pancreatic acinar cells by using a full-length pancreatic elastase promoter-driven Cre...
December 19, 2016: Oncogene
https://www.readbyqxmd.com/read/27984486/a-clinicopathological-study-of-malignant-insulinoma-in-a-contemporary-series
#20
Run Yu, Nicholas N Nissen, Andrew Hendifar, Laura Tang, Yu-Li Song, Yuan-Jia Chen, Xuemo Fan
OBJECTIVE: The aim of the study was to address the origin and natural history of malignant insulinoma. METHODS: Retrospective review of medical records of patients diagnosed with insulinoma at Cedars-Sinai Medical Center between 2000 and 2015 was conducted. Hormonal expression in tumor specimens was examined by immunostaining. RESULTS: All the 9 patients with malignant insulinoma (35% of 26 patients with insulinoma) already had liver metastasis at hypoglycemia presentation with bulky cumulative tumor burden...
January 2017: Pancreas
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