Jialyu Huang, Yuxin Liu, Dingfei Xu, Mengyi Chen, Qiqi Xie, Jia Chen, Leizhen Xia, Lamei Yu, Qiongfang Wu, Zengming Li, Jiawei Wang, Lifeng Tian
BACKGROUND: Observational studies have reported that Helicobacter pylori ( H. pylori ) infection is associated with a series of pregnancy and neonatal outcomes. However, the results have been inconsistent, and the causal effect is unknown. METHODS: A two-sample Mendelian randomization (MR) study was performed using summary-level statistics for anti- H. pylori IgG levels from the Avon Longitudinal Study of Parents and Children Cohort. Outcome data for pregnancy (miscarriage, preeclampsia-eclampsia, gestational diabetes mellitus, placental abruption, premature rupture of membranes, postpartum hemorrhage) and neonates (birthweight, gestational age, and preterm birth) were sourced from genome-wide association meta-analysis as well as the FinnGen and Early Growth Genetics Consortium...
2024: Frontiers in Cellular and Infection Microbiology