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Neoplastic meningitis

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https://www.readbyqxmd.com/read/28379128/-associated-factors-with-the-presence-of-secondary-neoplastic-cells-in-the-cerebrospinal-fluid-of-patients-with-suspected-carcinomatous-meningitis
#1
Fernando Warley, María Belén Binella, Diego Hernan Giunta, Cristina M Elizondo, Bruno Leonel Ferreyro, Lucia Caraballo
BACKGROUND: Improvement in oncologic therapy has increased survival in oncologic patients. There has been a concomitant increase in the incidence of secondary meningeal involvement. Early diagnosis is mandatory. OBJECTIVE: To identify factors associated with the presence of secondary neoplastic cells in cerebrospinal fluid of patients with suspected carcinomatous meningitis (CM) Methods: Cross-sectional study involving adult patients with solid cancer diagnosis and suspected CM between 2004 and 2014 at Hospital Italiano de Buenos Aires...
2017: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/28345737/-meningeal-carcinomatosis-in-breast-cancer-from-diagnosis-to-treatment
#2
REVIEW
C Elm'hadi, Z Es Sbai, M Reda Khmamouche, M Toreis, R Tanz, H Errihani, M Ichou
The appearance of meningeal carcinomatosis in breast cancer is an event that is being reported increasingly more frequently in the literature. It seems to be related with the lengthening of the patients' lives, improved sensitivity to diagnostic imaging and impermeability of the blood-brain barrier to the chemotherapeutic agents. It is an evolutionary form that affirms the metastatic invasion of the subarachnoidal space and is correlated with limited survival. Its diagnosis is difficult, due to the lack of specificity of the clinical signs dominated by headaches, cognitive disorders and possible signs and symptoms of progressive focal lesions...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28332472/primary-diffuse-leptomeningeal-gliomatosis-do-we-miss-the-diagnosis
#3
Sébastien Lepreux, Sharmilla Sagnier, Jean-Thomas Perez, François Léger, Igor Sibon, Anne Vital
Primary diffuse leptomeningeal gliomatosis (PDLG) is characterized by diffuse infiltration of the leptomeningeal space by neoplastic glial cells without evidence of intra-parenchymatous primary tumor. We report a case of PDLG in a 68-year-old man, who died 1 month after onset of symptoms. The diagnosis was made on autopsy data. We discuss the particularities of this entity, which is not registered in the WHO classification of tumors of the central nervous system (2016). In case of an unexplained inflammatory meningeal process and in the presence of atypical cells in the cerebrospinal fluid, PDLG needs to be considered...
March 23, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28242865/metronomic-capecitabine-effectively-blocks-leptomeningeal-carcinomatosis-from-breast-cancer-a-case-report-and-literature-review
#4
REVIEW
Michela Maur, Claudia Omarini, Federico Piacentini, Annalisa Fontana, Elisa Pettorelli, Stefano Cascinu
BACKGROUND Meningeal carcinomatosis is a rare complication in breast cancer patients. At present, there are no defined guidelines for its management. The efficacy of systemic treatment seems to depend on its ability to cross the blood-brain-barrier and its interaction with tumor vasculature. Metronomic chemotherapy is a known modality of drug administration able to inhibit tumor angiogenesis. CASE REPORT We present a case of symptomatic leptomeningeal carcinomatosis from breast cancer successfully treated with capecitabine...
February 28, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28178723/neoplastic-meningitis-one-of-the-last-frontiers-of-oncology
#5
Frank D Vrionis
No abstract text is available yet for this article.
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28178709/neoplastic-meningitis-due-to-lung-breast-and-melanoma-metastases
#6
REVIEW
Emilie Le Rhun, Sophie Taillibert, Marc C Chamberlain
BACKGROUND: Neoplastic meningitis, a central nervous system (CNS) complication of cancer metastatic to the meninges and cerebrospinal fluid (CSF), is relevant to oncologists due to the impact of the disease on patient quality of life and survival rates. METHODS: A review of the literature of articles published in English was conducted with regard to neoplastic meningitis. RESULTS: The incidence of neoplastic meningitis is increasing because patients with cancer are surviving longer in part because of the use of novel therapies with poor CNS penetration...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28178708/clinical-presentation-diagnosis-and-radiological-findings-of-neoplastic-meningitis
#7
REVIEW
Georgios Rigakos, Chrysoula I Liakou, Naillid Felipe, Dennis Orkoulas-Razis, Evangelia Razis
BACKGROUND: Neoplastic meningitis is a complication of solid and hematological malignancies. It consists of the spread of malignant cells to the leptomeninges and subarachnoid space and their dissemination within the cerebrospinal fluid. METHODS: A literature review was conducted to summarize the clinical presentation, differential diagnosis, laboratory values, and imaging findings of neoplastic meningitis. RESULTS: Neoplastic meningitis is an event in the course of cancer with a variable clinical presentation and a wide differential diagnosis...
January 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28174184/multiple-myeloma-presenting-with-bilateral-ankle-pain-microangiopathy-and-complicated-by-streptococcal-meningitis-and-pneumocystis-carinii-pneumonia
#8
Louise Dunphy, Neeraj Singh, Elizabeth Keating
Multiple myeloma is characterised by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow, resulting in extensive skeletal destruction with osteolytic lesions, osteopenia and pathological fractures. Additional disease-related complications include hypercalcaemia, renal insufficiency, anaemia and infection. We present the case of a 64-year-old woman presenting with rapid onset, painful distal symmetrical lower limb weakness and an acute kidney injury...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28045655/practical-aspects-of-the-use-of-intrathecal-chemotherapy
#9
Raquel Olmos-Jiménez, Alberto Espuny-Miró, Carlos Cárceles Rodríguez, María Sacramento Díaz-Carrasco
INTRODUCTION: Intrathecal chemotherapy is frequently used in clinical practice for treatment and prevention of neoplastic meningitis. Despite its widespread use, there is little information about practical aspects such as the volume of drug to be administered or its preparation and administration. OBJECTIVE: To conduct a literature review about practical aspects of the use of intrathecal chemotherapy. MATERIALS: Search in PubMed/ Medline using the terms "chemotherapy AND intrathecal", analysis of secondary and tertiary information sources...
January 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27870071/eosinophilic-meningomyelitis-associated-with-t-cell-lymphoma-in-a-cat
#10
Kathryn Y Bray, Karen R Muñana, Kristina Meichner, Laura A White, Gabriela Seiler
A 12-year-old cat was presented for evaluation of progressive tetraparesis. Magnetic resonance imaging of the cervical spine demonstrated T2-hyperintensity, and contrast enhancement within the C4-C7 spinal cord, with marked meningeal contrast enhancement and segmental nerve root thickening. Lumbar cerebrospinal fluid contained 407 total nucleated cells/μL, with 99% eosinophils. The cat transiently improved with prednisolone, clindamycin, and ivermectin therapy, but subsequently worsened and was euthanized...
December 2016: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/27843910/primary-orbital-cystic-pilocytic-astrocytoma
#11
Hardeep Singh Mudhar, Murtuza Nuruddin, Soma Roy
PURPOSE: To describe the clinical, radiological and histopathological features of a highly unusual primary orbital glioma. PROCEDURES: A 6-year-old female presented with right-sided proptosis that revealed a well-defined intraconal mass on CT imaging with intact orbital bony walls. During the removal of the lesion, it dissected away freely from the muscles and was separated from the optic nerve and globe. There was no communication with the brain. RESULTS: Histology showed histological features highly favouring a pilocytic astrocytoma enveloped by meninges...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27544802/pancreatic-involvement-by-mesenchymal-chondrosarcoma-harboring-the-hey1-ncoa2-gene-fusion
#12
Jarish N Cohen, David A Solomon, Andrew E Horvai, Sanjay Kakar
Mesenchymal chondrosarcoma (MC) is an aggressive small round blue cell tumor with chondrogenic differentiation that typically arises in bony sites. Approximately a third of these tumors develop in extra-skeletal sites such as the meninges, and somatic soft tissue. MCs are well-circumscribed, lobulated masses, with focal calcification. Histologically, two distinct populations of neoplastic cells characterize MC: sheets of primitive small, round, blue cells surrounding islands of well-developed hyaline cartilage with mature chondrocytes in lacunae...
August 17, 2016: Human Pathology
https://www.readbyqxmd.com/read/27468633/endoscopic-facial-nerve-surgery
#13
REVIEW
Daniele Marchioni, Davide Soloperto, Alessia Rubini, João Flávio Nogueira, Mohamed Badr-El-Dine, Livio Presutti
Tympanic facial nerve segment surgery has been traditionally performed using microscopic approaches, but currently, exclusive endoscopic approaches have been performed for traumatic, neoplastic, or inflammatory diseases, specially located at the geniculate ganglion, greater petrosal nerve, and second tract of the facial nerve, until the second genu. The tympanic segment of the facial nerve can be reached and visualized using an exclusive transcanal endoscopic approach, even in poorly accessible regions such as the second genu and geniculate ganglion, avoiding mastoidectomy, bony demolition, and meningeal or cerebral lobe tractions, with low complication rates using a minimally invasive surgical route...
October 2016: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/27465275/-non-neoplastic-lesions-of-the-mediastinum
#14
A Tzankov
The mediastinum is a complex body region of limited space but containing numerous organs of different embryonic origins. A variety of lesions that are difficult to distinguish from each other can occur here. Non-neoplastic lesions of the mediastinum represent important differential diagnostic pitfalls to mediastinal tumors, clinically, radiologically and histopathologically. It is important to bear these lesions in mind and to adequately verify or exclude them before starting further differential diagnostic considerations on mediastinal neoplasms...
September 2016: Der Pathologe
https://www.readbyqxmd.com/read/27439913/nras-q61k-mutated-primary-leptomeningeal-melanoma-in-a-child-case-presentation-and-discussion-on-clinical-and-diagnostic-implications
#15
Giulia Angelino, Maria Debora De Pasquale, Luigi De Sio, Annalisa Serra, Luca Massimi, Rita De Vito, Antonio Marrazzo, Laura Lancella, Andrea Carai, Manila Antonelli, Felice Giangaspero, Marco Gessi, Laura Menchini, Laura Scarciolla, Daniela Longo, Angela Mastronuzzi
BACKGROUND: Primary melanocytic neoplasms are rare in the pediatric age. Among them, the pattern of neoplastic meningitis represents a peculiar diagnostic challenge since neuroradiological features may be subtle and cerebrospinal fluid analysis may not be informative. Clinical misdiagnosis of neoplastic meningitis with tuberculous meningitis has been described in few pediatric cases, leading to a significant delay in appropriate management of patients. We describe the case of a child with primary leptomeningeal melanoma (LMM) that was initially misdiagnosed with tuberculous meningitis...
2016: BMC Cancer
https://www.readbyqxmd.com/read/27432675/infection
#16
REVIEW
Gaurav Saigal, Natalya Nagornaya, M Judith D Post
Imaging is useful in the diagnosis and management of infections of the central nervous system. Typically, imaging findings at the outset of the disease are subtle and nonspecific, but they often evolve to more definite imaging patterns in a few days, with less rapidity than for stroke but faster than for neoplastic lesions. This timing is similar to that of noninfectious inflammatory brain disease, such as multiple sclerosis. Fortunately, imaging patterns help to distinguish the two kinds of processes. Other than for sarcoidosis, the meninges are seldom involved in noninfectious inflammation; in contrast, many infectious processes involve the meninges, which then enhance with contrast on computed tomography (CT) or magnetic resonance imaging (MRI)...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27363042/egyptian-eosinophilic-and-infectious-meningoencepha-litis-and-their-impact-on-psychological-aspects
#17
REVIEW
Mamdouh M M El-Bahnasawy, Mohammad Reda El Feky, Ayman T A Morsy, Mousa A M Ismail, Tosson A Morsy
Meningoencephalitis is an acute inflammation of the brain and spinal cord & their covering protective membranes. Meningitis can be life-threatening because of the inflammation's proximity to the brain and spinal cord; therefore, the condition is classified as a medical emergency. The commonest symptoms of meningitis are headache and neck stiffness associated with fever, confusion or altered consciousness, vomiting, and an inability to tolerate light (photophobia) or loud noises (phonophobia). Children often exhibit only nonspecific symptoms, such as irritability and drowsiness...
April 2016: Journal of the Egyptian Society of Parasitology
https://www.readbyqxmd.com/read/27315003/-injury-by-skull-osteolytic-secundary-syphilis
#18
Lucas Alessandro, Julieta Piar Camporro, Naomi Arakaki, Nora Orellana, Claudia Andrea Mora
Bone involvement of syphilis can be observed in tertiary and congenital syphilis. It is infrequent during the secondary stage. The skull is the most affected bone in secondary syphilis, and its most frequent form of presentation is proliferative osteitis. If the skull is affected, headache is usual and can be as intense as in meningitis. Osteolyitic lesions may be seen in complimentary imaging studies, with a moth eaten aspect. These lesions raise concern over a number of differential diagnoses, among which are infectious, inflammatory and neoplastic diseases...
April 2016: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
https://www.readbyqxmd.com/read/27215452/-efficacy-and-security-of-intrathecal-with-methotrexate-in-the-treatment-of-meningeal-carcinomatosis
#19
Xi Wu, Junling Li, Jianping Xiao, Boyan Yang, Lei Yu, Xiaoming Wu, Jinghai Wan, Haiyan Xu, Jianxin Kong
BACKGROUND: Leptomeningeal carcinomatosis is a rare type of metastatic tumors of the central nervous system. In recent years, with the improvement of neoplasms therapies and longer survival of patients by better systemic control, incidence of leptomeningeal metastases has increased every year. However, there is still lack of effective therapies. The aim of this study is to investigate the efficacy, security and prognosis of intrathecal chemotherapy with methotrexate (MTX) in the treatment of neoplastic meningitis...
May 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/27098625/analysis-of-cerebrospinal-fluid-and-serum-cea-concentration-in-non-neoplastic-diseases
#20
Qiang Shi, Chenglin Tian, Xusheng Huang, Chuanqiang Pu
BACKGROUND: Carcinoembryonic antigen (CEA) in cerebrospinal fluid (CSF) is important for the diagnosis of meningeal carcinomatosis. Its relationship with CSF and serum in non-neoplastic diseases may be beneficial for earlier diagnosis and treatment. METHODS: CSF samples were obtained from 346 non-neoplastic inpatients. Among them, 238 pairs of CSF and serum were obtained and compared. The 97.5(th) percentile and maximum value of CSF CEA were obtained. RESULTS: The 97...
2016: Annals of Clinical and Laboratory Science
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