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Leptomeningeal carcinoma

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https://www.readbyqxmd.com/read/27716413/pulmonary-tumor-diagnosed-as-an-undifferentiated-sarcoma-with-epithelioid-features-a-case-report
#1
Mohamed Réda El Ochi, Mohammed Massine El Hammoumi, Abdelhamid Biyi, Mohamed Allaoui, El Hassane Kabiri, Abderrahman Albouzidi, Mohamed Oukabli
BACKGROUND: Pulmonary sarcomas are uncommon accounting for 0.5 % of all primary lung cancers. Undifferentiated sarcomas account for up to 20 % of soft tissue sarcomas. A lung tumor revealed to be an undifferentiated sarcoma with epithelioid features has never been reported in the literature. CASE PRESENTATION: A 61-year-old white Moroccan man presented with 2 months' history of hemoptysis and dyspnea. Chest computed tomography showed a cystic mass involving the lower field of his right lung evoking first a hydatid cyst...
October 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27672788/poster-21-leptomeningeal-carcinomatosis-presenting-as-tetraparesis-a-very-rare-case-of-small-cell-prostate-carcinoma
#2
Sean Bemanian, Viswanath Aluru, Pouyan Gohari, Marc Ross
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27554216/-a-case-of-isolated-leptomeningeal-carcinomatosis-from-advanced-gastric-cancer
#3
Jung Geun Ji, Joo Won Chung, Seung Woo Nam, Seung Kyu Choi, Dong Won Lee, Dae In Kim, Byung Gwan Jeon, Yun Jae Shin
Leptomeningeal carcinomatosis (LMC) is rare metastatic form of gastric cancer. Most cases are diagnosed in the final stage after multiple distant metastasis. An 84-year-old woman was admitted with melena, headache and vomiting. Esophagogastroduodenoscopy showed an ulceroinfiltrating lesion at the stomach (Borrmann class III), and biopsy revealed a signet ring cell carcinoma. The abdominal-pelvic CT showed no evidence of metastasis. A sudden decrease of consciousness was noted, but the brain CT showed no active lesion while the brain MRI revealed enhancement of leptomeninges...
August 25, 2016: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/27446350/leptomeningeal-carcinomatosis-as-the-primary-presentation-of-relapse-in-breast-cancer
#4
Keith Sacco, Aun Muhammad, Waqar Saleem, Heba Alshaker, Leonardo Monzon, Mohammad Rafiqul Islam, Dmitri Pchejetski
Leptomeningeal metastasis (LM) is an uncommon presentation of relapse in breast cancer, which is associated with poor clinical outcomes and poor prognosis. Notably, LM most commonly occurs in breast cancer. The aim of the present review was to investigate the occurrence of LM as the primary presentation of relapse following remission in breast cancer patients and to determine whether specific histological subtypes are predisposed to meningeal metastases. In addition, the present review evaluated whether patients presenting with LM as the primary site of relapse exhibit differences in survival when compared with patients exhibiting metastasis to other sites...
August 2016: Oncology Letters
https://www.readbyqxmd.com/read/27306442/whole-brain-radiotherapy-in-management-of-non-small-cell-lung-carcinoma-associated-leptomeningeal-carcinomatosis-evaluation-of-prognostic-factors
#5
Yurday Ozdemir, Berna Akkus Yildirim, Erkan Topkan
To assess the efficacy of whole-brain radiotherapy (WBRT) and prognostic factors in leptomeningeal carcinomatosis (LMC) of non-small-cell lung cancer (NSCLC) patients. WBRT records of 51 LMC patients confined to brain were reviewed. Eligible patients had squamous-cell carcinoma (SCC) or adenocarcinoma, and Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-3. The WBRT was either 20 or 30 Gray. The primary and secondary objectives were to determine overall survival (OS) and prognostic factors for improved treatment response, respectively...
September 2016: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/27295918/leptomeningeal-carcinomatosis-can-be-presenting-manifestation-of-breast-carcinoma
#6
Gorana Mandić Stojmenović, Aleksandra M Pavlović, Milica Skender Gazibara, Danica Grujicić, Aleksandra Radojicić, Nadezda Covicković Sternić
INTRODUCTION: Leptomeningeal carcinomatosis (LC) is a serious complication occuring in solid cancer patients with rather poor prognosis. CASE REPORT: We presented a 47-year-old woman with the 6-month history of diffuse headache, nausea and visual obscuration. Initially, clinical status and brain magnetic resonance imaging (MRI) indicated syndrome of idiopathic intracranial hypertension. Due to clinical progression and high papillary stasis, cerebrospinal fluid (CSF) examination was performed only after ventriculoperitoneal shunt was implanted...
March 2016: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
https://www.readbyqxmd.com/read/27162421/profile-of-malignant-spinal-cord-compression-one-year-study-at-regional-cancer-center
#7
Malik Tariq Rasool, Kaneez Fatima, Najmi Arshad Manzoor, Syed Arshad Mustafa, Lone Mohammad Maqbool, Wani Shaqul Qamar, Fir Afroz, Nazir Ahmad Khan, Saqib Ahmad Shah, Manan Shah
BACKGROUND AND OBJECTIVES: Malignant spinal cord compression is an oncologic emergency, unless diagnosed early and treated appropriately, can lead to permanent neurological impairment and compromised quality of life of patients. We analyzed the epidemiology and the effect of common interventions on the outcome in these patients. PATIENTS AND METHODS: We conducted a prospective study of 77 patients in the year 2014 and recorded relevant patient and disease characteristics...
April 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27150544/response-of-silent-corticotroph-pituitary-carcinoma-to-chemotherapy-case-report
#8
Lucy He, Jonathan A Forbes, Kevin Carr, Hilary Highfield Nickols, Andrea Utz, Paul Moots, Kyle Weaver
Silent pituitary corticotroph carcinomas are rare, with only six previously described cases in the literature. We report a patient with a silent pituitary corticotroph adenoma treated with multiple trans-sphenoidal resections. Twelve years after her initial presentation, she returned with leptomeningeal metastases to the posterior fossa, foramen magnum, and numerous other subarachnoid locations involving the spine. Histopathology obtained from the metastatic foci was identical to previous trans-sphenoidal specimens - consistent with the diagnosis of corticotroph pituitary carcinoma...
June 2016: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/27123391/intracranial-management-of-perineural-spread-in-the-trigeminal-nerve
#9
Michael J Redmond, Benedict J Panizza
Since the mid-1960s surgeons have attempted to cure intracranial perineural spread (PNS) of cutaneous malignancies. Untreated patients with trigeminal PNS die from brainstem invasion and leptomeningeal disease. It was understood that resection with clear margins was potentially curative, but early surgical attempts were unsuccessful. The prevailing wisdom considered that this surgery failed to improve the results achieved with radiation therapy alone and was associated with high morbidity. However, with improved imaging, surgical equipment, and better understanding of cavernous sinus (CS) anatomy and access, contemporary surgeons can improve outcomes for this disease...
April 2016: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/27123295/malignant-pleural-and-pericardial-effusions-and-meningeal-infiltrates-without-other-metastases-in-breast-cancer-a-case-report
#10
Xingxing Lv, Jinlan He, Yuan Shen, Hong Zheng
Breast cancer metastasizing to the pleura, pericardium and leptomeninges, but not to other sites, is rare. Although malignant pericardial and pleural effusions are common complications during the course of malignancies, they are rarely the initial manifestations of malignant disease, particularly pericardial effusion with cardiac tamponade. This report describes a case of breast carcinoma in a 44-year-old woman who initially presented with malignant pleural effusion and pericardial tamponade and suffered from meningeal metastases after 4...
May 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/26972704/leptomeningeal-carcinomatosis-as-primary-manifestation-of-pancreatic-cancer
#11
Victoria T Trinh, Rafael Medina-Flores, Muhammad O Chohan
Leptomeningeal carcinomatosis (LMC) is a rare complication of cancer that often presents at an advanced stage after obvious metastasis of a primary cancer or locally advanced disease. We present an uncommon case of LMC secondary to pancreatic carcinoma presenting with headache, unilateral VII nerve palsy, and lower extremity weakness. Initial cerebrospinal fluid (CSF) studies were concerning for chronic aseptic meningitis but negative for malignant cells; the diagnosis of tuberculous meningitis was erroneously evoked...
August 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/26834903/muscle-invasive-bladder-cancer-culminating-with-leptomeningeal-carcinomatosis
#12
Tom W Swallow, Scott Mabbutt, Charles R W Bell
This case reports highlights a rare metastatic manifestation of transitional cell carcinoma of the bladder. The onset of symptoms associated with meningeal irritation should be investigated. However, there is little consensus in the treatment of leptomeningeal carcinomatosis and it should be considered a poor prognostic sign with symptomatic management.
November 2015: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/26722263/leptomeningeal-metastasis-from-early-glottic-laryngeal-cancer-a-case-report
#13
Zhenyu Pan, Guozi Yang, Limei Qu, Tingting Yuan, Xiaochuan Pang, Yongxiang Wang, Weiyan Shi, Lihua Dong
The present study reports the case of a 53-year-old man with leptomeningeal metastasis from early glottic laryngeal cancer. The patient had been diagnosed with squamous cell carcinoma of the glottic larynx 9 years previously. The current symptoms included a recurring headache that had persisted for 1 month and vomiting for 1 week. A magnetic resonance imaging scan of the head revealed multiple enhancing lesions in the brain and multiple line-like enhancements in the brain fold. Computed tomography scans of the head, neck, chest and abdomen showed no nodular lesions...
November 2015: Oncology Letters
https://www.readbyqxmd.com/read/26679260/primary-intracranial-epidermoid-carcinoma-with-diffuse-leptomeningeal-carcinomatosis-report-of-two-cases
#14
Amol Raheja, Ilyas M Eli, Christian A Bowers, Cheryl Ann Palmer, William T Couldwell
BACKGROUND: Malignant degeneration of epidermoid cyst (EC) with accompanying leptomeningeal carcinomatosis (LC) at presentation is extremely rare. We add two cases to the literature, including the first case of primary brainstem involvement with simultaneous diffuse LC, and discuss clinical and radiological cues to differentiate benign and malignant epidermoid tumors for early diagnosis. CASE DESCRIPTION: The first patient in this report was a 54-year-old woman with recurrent aseptic meningitis and hydrocephalus...
April 2016: World Neurosurgery
https://www.readbyqxmd.com/read/26277099/survival-of-breast-cancer-patients-with-synchronous-or-metachronous-central-nervous-system-metastases
#15
V K Y Ho, J M M Gijtenbeek, D Brandsma, L V Beerepoot, G S Sonke, M van der Heiden-van der Loo
BACKGROUND: Central nervous system (CNS) metastases represent a devastating complication for advanced breast cancer patients. This observational study examines the influence of patient, tumour and treatment characteristics on overall survival after synchronous or metachronous CNS metastases. METHODS: Information on 992 breast cancer patients with CNS metastases (whose primary tumour was diagnosed between 2004 and 2010) was retrieved from the Netherlands Cancer Registry (NCR)...
November 2015: European Journal of Cancer
https://www.readbyqxmd.com/read/26112812/management-of-neoplastic-meningitis
#16
REVIEW
Patrick Roth, Michael Weller
Leptomeningeal dissemination of tumor cells, also referred to as neoplastic meningitis, is most frequently seen in patients with late-stage cancer and mostly associated with a poor prognosis. Basically, neoplastic meningitis may affect all patients with a malignant tumor but is most common in patients affected by lung cancer, breast carcinoma, melanoma or hematologic neoplasms such as lymphoma and leukemia. Controlled clinical trials are largely lacking which results in various non-standardized treatment regimens...
June 2015: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/26093620/leptomeningeal-disease-following-stereotactic-radiosurgery-for-brain-metastases-from-breast-cancer
#17
Daniel M Trifiletti, Kara D Romano, Zhiyuan Xu, Kelli A Reardon, Jason Sheehan
Leptomeningeal disease (LMD) is a highly aggressive and usually rapidly fatal condition. The purpose of this study is to identify clinical factors that can serve to predict for LMD at the time of stereotactic radiosurgery (SRS) for brain metastases from breast carcinoma. We conducted a retrospective review of patients with brain metastases from breast cancer treated with SRS from 1995 to 2014 at our institution. Clinical, radiographic, and dosimetric data were collected. LMD was diagnosed by cerebrospinal fluid (CSF) cytology or MRI demonstrating CSF seeding...
September 2015: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/25984375/a-rare-initial-presentation-of-gastric-cancer-with-multiple-osteolytic-lesions
#18
Asad Jehangir, Kim Aderhold, Priya Rajagopalan, Oluwaseun Shogbesan, Sharon Swierczynski, Anam Qureshi, Qasim Jehangir, Christian Espana Schmidt
Gastric cancer is the 12th leading cause of cancer-related deaths in the United States and commonly metastasizes to the bones. However, the presentation of gastric cancer as bony metastases without preceding gastrointestinal symptoms is rare which has been infrequently reported in the literature. Moreover, leptomeningeal carcinomatosis is an unusual complication of gastric cancer accounting for less than 1 percent of these patients. We present a unique case of a middle aged male who presented to the emergency department with worsening backache which started one month priorly...
2015: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/25927947/genetic-drivers-of-metastatic-dissemination-in-sonic-hedgehog-medulloblastoma
#19
Noah C Jenkins, Ricky R Kalra, Adrian Dubuc, Walavan Sivakumar, Carolyn A Pedone, Xiaochong Wu, Michael D Taylor, Daniel W Fults
Leptomeningeal dissemination (LMD), the metastatic spread of tumor cells via the cerebrospinal fluid to the brain and spinal cord, is an ominous prognostic sign for patients with the pediatric brain tumor medulloblastoma. The need to reduce the risk of LMD has driven the development of aggressive treatment regimens, which cause disabling neurotoxic side effects in long-term survivors. Transposon-mediated mutagenesis studies in mice have revealed numerous candidate metastasis genes. Understanding how these genes drive LMD will require functional assessment using in vivo and cell culture models of medulloblastoma...
2014: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/25923831/intravascular-carcinomatosis-of-central-nervous-system-due-to-metastatic-inflammatory-breast-cancer-a-case-report
#20
Hidehiro Takei, Emilie Rouah, Roberto Barrios
Central nervous system (CNS) involvement by metastatic cancer is well-recognized and typically presents with multifocal solid tumors within the brain parenchyma or leptomeningeal dissemination. We describe herein a histologically very rare case of CNS metastasis in a 52-year-old woman who presented with mental status changes. Post mortem examination revealed extensive CNS involvement by metastatic inflammatory breast carcinoma, characterized by the presence of single tumor cells diffusely present within capillaries without parenchymal or perivascular invasion, and acute ischemic changes/infarcts bilaterally involving multiple areas...
October 2015: Neuropathology: Official Journal of the Japanese Society of Neuropathology
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